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  1. Article: [No title information]

    Drobyazgin, E A / Kudryavtsev, A / Chikinev, Yu V / Zheravin, A A / Blagitko, E M / Shtofin, S G / Shumkov, O A

    Vestnik khirurgii imeni I. I. Grekova

    2018  Volume 175, Issue 5, Page(s) 32–35

    MeSH term(s) Biopsy, Needle/methods ; Diagnosis, Differential ; Female ; Humans ; Image-Guided Biopsy/methods ; Lung/diagnostic imaging ; Lung/pathology ; Lung Neoplasms/diagnosis ; Lung Neoplasms/pathology ; Male ; Middle Aged ; Thoracic Surgical Procedures/methods ; Tomography, X-Ray Computed/methods
    Language Russian
    Publishing date 2018-11-13
    Publishing country Russia (Federation)
    Document type Journal Article
    ZDB-ID 603433-0
    ISSN 0042-4625
    ISSN 0042-4625
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 747: Show issues Location:
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  2. Article: Sternomediastinit posle transplantatsii serdtsa.

    Ruzmatov, T M / Zheravin, A A / Doronin, D V / Tarkova, A R / Nesmachny, A S / Chernyavsky, A M

    Khirurgiia

    2017  , Issue 11, Page(s) 77–81

    Title translation Sternomediastinitis after cardiac transplantation.
    MeSH term(s) Adult ; Cardiomyopathy, Dilated/complications ; Heart Failure/etiology ; Heart Failure/surgery ; Heart Transplantation/adverse effects ; Heart Transplantation/methods ; Humans ; Immunosuppression/adverse effects ; Immunosuppression/methods ; Male ; Mediastinitis/diagnosis ; Mediastinitis/etiology ; Mediastinitis/therapy ; Myocutaneous Flap ; Osteomyelitis/diagnosis ; Osteomyelitis/etiology ; Osteomyelitis/surgery ; Postoperative Complications/diagnosis ; Postoperative Complications/etiology ; Postoperative Complications/surgery ; Reoperation/methods ; Sternotomy/adverse effects ; Sternum/diagnostic imaging ; Sternum/pathology ; Sternum/surgery ; Tomography, Spiral Computed ; Treatment Outcome ; Wound Closure Techniques
    Language Russian
    Publishing date 2017
    Publishing country Russia (Federation)
    Document type Case Reports ; Journal Article
    ZDB-ID 419230-8
    ISSN 2309-5628 ; 0023-1207
    ISSN (online) 2309-5628
    ISSN 0023-1207
    DOI 10.17116/hirurgia20171177-81
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 740: Show issues Location:
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  3. Article ; Online: Data analysis algorithm for the development of extracellular miRNA-based diagnostic systems for prostate cancer.

    Bryzgunova, O E / Zaporozhchenko, I A / Lekchnov, E A / Amelina, E V / Konoshenko, M Yu / Yarmoschuk, S V / Pashkovskaya, O A / Zheravin, A A / Pak, S V / Rykova, E Yu / Laktionov, P P

    PloS one

    2019  Volume 14, Issue 4, Page(s) e0215003

    Abstract: Urine of prostate cancer (PCa) carries miRNAs originated from prostate cancer cells as a part of both nucleoprotein complexes and cell-secreted extracellular vesicles. The analysis of such miRNA-markers in urine can be a convenient option for PCa ... ...

    Abstract Urine of prostate cancer (PCa) carries miRNAs originated from prostate cancer cells as a part of both nucleoprotein complexes and cell-secreted extracellular vesicles. The analysis of such miRNA-markers in urine can be a convenient option for PCa screening. The aims of this study were to reveal miRNA-markers of PCa in urine and design a robust and precise diagnostic test, based on miRNA expression analysis. The expression analysis of the 84 miRNAs in paired urine extracellular vesicles (EVs) and cell free urine supernatant samples from healthy donors, patients with benign and malignant prostate tumours was done using miRCURY LNA miRNA qPCR Panels (Exiqon, Denmark). Sets of miRNAs differentially expressed between the donor groups were found in urine EVs and urine supernatant. Diagnostically significant miRNAs were selected and algorithm of data analysis, based on expression data on 24-miRNA in urine and obtained using 17 analytical systems, was designed. The developed algorithm of data analysis describes a series of steps necessary to define cut-off values and sequentially analyze miRNA expression data according to the cut-offs to facilitate classification of subjects in case/control groups and allows to detect PCa patients with 97.5% accuracy.
    MeSH term(s) Aged ; Aged, 80 and over ; Algorithms ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/urine ; Case-Control Studies ; Data Interpretation, Statistical ; Extracellular Vesicles/genetics ; Gene Regulatory Networks ; Humans ; Male ; MicroRNAs/genetics ; MicroRNAs/urine ; Middle Aged ; Prostatic Hyperplasia/diagnosis ; Prostatic Hyperplasia/genetics ; Prostatic Hyperplasia/urine ; Prostatic Neoplasms/diagnosis ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/urine
    Chemical Substances Biomarkers, Tumor ; MicroRNAs
    Language English
    Publishing date 2019-04-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0215003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Analiz predstavlennosti mikroRNK v mikrovezikulakh mochi i beskletochnoĭ moche pri zabolevaniiakh predstatel'noĭ zhelezy.

    Zaporozhchenko, I A / Bryzgunova, O E / Lekchnov, E A / Osipov, I D / Zaripov, M M / Yurchenko, Yu B / Yarmoschuk, S V / Pashkovskaya, O A / Rykova, E Yu / Zheravin, A A / Laktionov, P P

    Biomeditsinskaia khimiia

    2018  Volume 64, Issue 1, Page(s) 38–45

    Abstract: Urine of prostate cancer patients contains tumor-specific biopolymers, including protein- and microvesiclesassociated miRNAs that can potentially be used as oncomarkers. Previously we have characterized urine extracellular vesicles and demonstrated ... ...

    Title translation Representation analysis of miRNA from clarified urine and urine microvesicles in prostate malignancies and non-malignant neoplasms.
    Abstract Urine of prostate cancer patients contains tumor-specific biopolymers, including protein- and microvesiclesassociated miRNAs that can potentially be used as oncomarkers. Previously we have characterized urine extracellular vesicles and demonstrated diagnostic potential of their miRNA cargo. In this study, we have performed a comparative analysis of the expression of 84 miRNA in paired samples of urine microvesicles and clarified urine from healthy men, patients with benign hyperplasia and cancer of the prostate using miRCURY LNA miRNA qPCR Panels. Subsets of miRNAs with differences in expression between the fractions of the urine were found in all three groups. Two groups of miRNA were identified based on the patterns of their differential expression. They regulate several key signaling pathways associated with prostate cancer development.
    MeSH term(s) Body Fluids ; Cell-Derived Microparticles ; Extracellular Vesicles ; Humans ; Male ; MicroRNAs ; Prostatic Neoplasms
    Chemical Substances MicroRNAs
    Language Russian
    Publishing date 2018-03-12
    Publishing country Russia (Federation)
    Document type Journal Article
    ZDB-ID 2130758-1
    ISSN 2310-6905 ; 2310-6972 ; 0042-8809
    ISSN (online) 2310-6905
    ISSN 2310-6972 ; 0042-8809
    DOI 10.18097/PBMC20186401038
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Sravnitel'naia biokhimicheskaia i morfologicheskaia kharakteristika khondrosarkomy i gigantokletochnoĭ opukholi kosti.

    Akbasheva, O E / Shchepetkin, I A / Vasil'ev, N V / Zheravin, A A / Anisenia, I I / Buél', E V / Zhukova, Ia A

    Voprosy onkologii

    2000  Volume 46, Issue 3, Page(s) 298–301

    Abstract: Spectrometry has been employed to assess the levels of collagenase, catepsin D, trypsin-like proteinases and their inhibitors as well as bone acid and alkaline phosphatase both in the center and along the periphery of giant cell tumor of bone (GCTB) and ... ...

    Title translation The comparative biochemical and morphological characteristics of chondrosarcoma and giant-cell tumor of the bone.
    Abstract Spectrometry has been employed to assess the levels of collagenase, catepsin D, trypsin-like proteinases and their inhibitors as well as bone acid and alkaline phosphatase both in the center and along the periphery of giant cell tumor of bone (GCTB) and chondrosarcoma. The levels of collagenase, trypsin-like proteinases and their inhibitors in the center of chondrosarcoma were much higher while those of alkaline phosphatase--lower than along tumor periphery. The catepsin D and acid phosphatase concentrations of the center and periphery of chondrosarcoma were similar. It was suggested that an extremely low concentration of trypsin-like inhibitors may contribute to degradation of the matrix in tissues adjacent to chondrosarcoma and, consequently, to tumor invasion development.
    MeSH term(s) Acid Phosphatase/metabolism ; Alkaline Phosphatase/metabolism ; Bone Neoplasms/enzymology ; Bone Neoplasms/pathology ; Cathepsin D/metabolism ; Chondrosarcoma/enzymology ; Chondrosarcoma/pathology ; Collagenases/metabolism ; Femoral Neoplasms/enzymology ; Femoral Neoplasms/pathology ; Femur/enzymology ; Femur/pathology ; Giant Cell Tumor of Bone/enzymology ; Giant Cell Tumor of Bone/pathology ; Humans ; Ilium/enzymology ; Ilium/pathology ; Statistics, Nonparametric ; Tibia/enzymology ; Tibia/pathology ; Trypsin/metabolism ; Trypsin Inhibitors/metabolism
    Chemical Substances Trypsin Inhibitors ; Alkaline Phosphatase (EC 3.1.3.1) ; Acid Phosphatase (EC 3.1.3.2) ; Trypsin (EC 3.4.21.4) ; Cathepsin D (EC 3.4.23.5) ; Collagenases (EC 3.4.24.-)
    Language Russian
    Publishing date 2000
    Publishing country Russia (Federation)
    Document type Comparative Study ; English Abstract ; Journal Article
    ZDB-ID 955397-6
    ISSN 0507-3758
    ISSN 0507-3758
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 1164: Show issues Location:
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