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Article ; Online: Revision of the Genus

Ng, Peter K L / Tan, Zhi Wan / Ngo, Van Tri

2023 Volume 62, Page(s) e20

Abstract: The taxonomy of the potamid ... ...

Abstract	The taxonomy of the potamid genus
Language	English
Publishing date	2023-05-22
Publishing country	China (Republic : 1949- )
Document type	Journal Article
ZDB-ID	2105348-0
ISSN	1810-522X ; 1810-522X
ISSN (online)	1810-522X
ISSN	1810-522X
DOI	10.6620/ZS.2023.62-20
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Article ; Online: Stoliczia setoiyenica, a new species of freshwater crab from southern Thailand (Crustacea: Decapoda: Brachyura: Potamidae).

Tan, Zhi Wan / Lheknim, Vachira / Ng, Peter K L

Zootaxa

2023 Volume 5360, Issue 4, Page(s) 531–544

Abstract: A new species of freshwater crab is described from southern Thailand, near the border with Peninsular Malaysia. Species of Stoliczia are characterised by their relatively flat carapace, a third maxilliped exopod that possesses no or a very short ... ...

Abstract	A new species of freshwater crab is described from southern Thailand, near the border with Peninsular Malaysia. Species of Stoliczia are characterised by their relatively flat carapace, a third maxilliped exopod that possesses no or a very short flagellum, and a conical male gonopod terminal segment that lacks or only has a very low dorsal fold. Stoliczia setoiyenica, new species, most closely resembles S. perlensis and S. kedahensis from northern Peninsula Malaysia but can be easily distinguished from congeners by differences in carapace and male gonopod morphology. Comparisons to the two known Thai Stoliczia species, S. panhai and S. ekavibhathai, are also provided for completeness.
MeSH term(s)	Male ; Animals ; Brachyura/anatomy & histology ; Thailand ; Fresh Water
Language	English
Publishing date	2023-10-30
Publishing country	New Zealand
Document type	Journal Article
ISSN	1175-5334
ISSN (online)	1175-5334
DOI	10.11646/zootaxa.5360.4.4
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Article ; Online: Anaemia secondary to

Wong, Zhi Wan / Ong, Kevin

BMJ case reports

2021 Volume 14, Issue 1

Abstract: Mycotic aneurysms can pose a diagnostic dilemma due to their variable presentations. We present a case of a 93-year-old man initially presenting with fevers, intermittent chest pain and normocytic anaemia refractory to repeated blood transfusions. He ... ...

Abstract	Mycotic aneurysms can pose a diagnostic dilemma due to their variable presentations. We present a case of a 93-year-old man initially presenting with fevers, intermittent chest pain and normocytic anaemia refractory to repeated blood transfusions. He received intravenous ceftriaxone as
MeSH term(s)	Aged, 80 and over ; Anemia/diagnosis ; Anemia/etiology ; Aneurysm, Infected/complications ; Aneurysm, Infected/diagnosis ; Aneurysm, Infected/drug therapy ; Aortic Aneurysm, Thoracic/complications ; Aortic Aneurysm, Thoracic/diagnosis ; Aortic Aneurysm, Thoracic/surgery ; Bacteremia/complications ; Bacteremia/diagnosis ; Bacteremia/drug therapy ; Blood Culture ; Chest Pain/etiology ; Endovascular Procedures ; Escherichia coli Infections/complications ; Escherichia coli Infections/diagnosis ; Escherichia coli Infections/drug therapy ; Fever ; Humans ; Male ; Tomography, X-Ray Computed
Language	English
Publishing date	2021-01-28
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2020-237997
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Article ; Online: Hyperbranched polymer functionalized flexible perovskite solar cells with mechanical robustness and reduced lead leakage

Zhihao Li / Chunmei Jia / Zhi Wan / Jiayi Xue / Junchao Cao / Meng Zhang / Can Li / Jianghua Shen / Chao Zhang / Zhen Li

Nature Communications, Vol 14, Iss 1, Pp 1-

2023 Volume 12

Abstract: Abstract Perovskite solar cells (PSCs) are multilayer structures. The interface between electron transport layer and perovskite is the mechanical weakest point in flexible PSCs due to its low fracture energy. Herein, we develop a highly adhesive ... ...

Abstract	Abstract Perovskite solar cells (PSCs) are multilayer structures. The interface between electron transport layer and perovskite is the mechanical weakest point in flexible PSCs due to its low fracture energy. Herein, we develop a highly adhesive polyamide-amine-based hyperbranched polymers to reinforce the interface. The interface fracture energy is improved from 1.08 to 2.13 J·m−2 by the hyperbranched polymers with adhesive groups and dynamic hydrogen bond networks. The polymer functionalized perovskite solar cells achieve superior power conversion efficiencies of 25.05% and 23.86% for rigid and flexible devices, respectively. Furthermore, the hyperbranched polymer contains abundant intramolecular cavities that can capture Pb2+. Pb leakage after solar cell damage is effectively suppressed. Our findings provide insights on designing adhesive interface layers towards high-efficiency, mechanical-stable and environment-friendly flexible perovskite solar cells.
Keywords	Science ; Q
Subject code	600
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
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Article: [Serum metabolomics of chronic obstructive pulmonary disease with lung-Qi deficiency syndrome].

Duan, Fei / Li, Man-Man / Li, Wei-Xia / Tang, Jin-Fa / Wang, Zhi-Wan

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

2022 Volume 47, Issue 8, Page(s) 2251–2256

Abstract: The present study analyzed the potential biomarkers of chronic obstructive pulmonary disease(COPD) with lung-Qi deficiency syndrome by non-targeted metabolomics and explored the biological basis of this syndrome. Blood samples of 96 COPD patients with ... ...

Abstract	The present study analyzed the potential biomarkers of chronic obstructive pulmonary disease(COPD) with lung-Qi deficiency syndrome by non-targeted metabolomics and explored the biological basis of this syndrome. Blood samples of 96 COPD patients with lung-Qi deficiency syndrome(COPD with lung-Qi deficiency syndrome group) and 106 healthy people(healthy control group) were collected, and the metabolic profiles of both groups were analyzed by ultra-high performance liquid chromatography-quadrupole-time-of-flight mass spectrometry(UPLC-Q-TOF-MS). Multivariate statistical analysis and differential metabolite screening were carried out by using Progenesis QI and Simca-P. Metabolic pathways were constructed through the MetaboAnalyst. Seven potential biomarkers, such as L-cystathionine, protoporphyrinogen Ⅸ, and citalopram aldehyde, were identified. Compared with the results in the healthy control group, the content of citalopram aldehyde, N1-methyl-2-pyridone-5-carboxamide, and 11β,17β-dihydroxy-4-androsten-3-one was significantly up-regulated, while that of the other four compounds such as L-cystathionine, dihydrotestosterone, protoporphyrinogen Ⅸ, and D-urobilinogen was down-regulated. These potential biomarkers involved six metabolic pathways, including cysteine and methionine metabolism, porphyrin and chlorophyll metabolism, drug metabolism of cytochrome P450, steroid hormone biosynthesis, glycine, serine, and threonine metabolism, and nicotinate and nicotinamide meta-bolism. This study is expected to provide a certain scientific basis for the research on traditional Chinese medicine syndrome of COPD with lung-Qi deficiency syndrome from the molecular biology level.
MeSH term(s)	Aldehydes ; Biomarkers ; Chromatography, High Pressure Liquid ; Citalopram ; Cystathionine ; Humans ; Lung ; Metabolomics/methods ; Pulmonary Disease, Chronic Obstructive
Chemical Substances	Aldehydes ; Biomarkers ; Citalopram (0DHU5B8D6V) ; Cystathionine (375YFJ481O)
Language	Chinese
Publishing date	2022-03-05
Publishing country	China
Document type	Journal Article
ZDB-ID	1004649-5
ISSN	1001-5302 ; 0254-0029
ISSN	1001-5302 ; 0254-0029
DOI	10.19540/j.cnki.cjcmm.20211203.501
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Article ; Online: Exercise improves sleep quality in older adults

Yi Liu / Wei Zhang / Qin Zhang / Wei Wei / Jing Yu / Dongze Li / Yu Jia / Zhi Wan / Yongli Gao

BMJ Open, Vol 12, Iss

a protocol for a systematic review and meta-analysis

2022 Volume 1

Keywords	Medicine ; R
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	BMJ Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Clinical and prognostic characteristics of 95 cases of Langerhans cell histiocytosis in children

Xue Tang / Ju Gao / Zhi-gui Ma / Xia Guo / Qiang Li / Zhi Wan / Jing-jing Sun

Annals of Medicine, Vol 53, Iss 1, Pp 1537-

a single-institute experience from 2013 to 2020

2021 Volume 1546

Abstract: AbstractBackground This study aimed to understand the clinical characteristics and outcomes of children with Langerhans cell histiocytosis (LCH) in China.Methods We conducted a retrospective study of 95 paediatric patients with LCH in West China Second ... ...

Abstract	AbstractBackground This study aimed to understand the clinical characteristics and outcomes of children with Langerhans cell histiocytosis (LCH) in China.Methods We conducted a retrospective study of 95 paediatric patients with LCH in West China Second University Hospital of Sichuan University between July 2013 and August 2020.Results The onset age of multisystem LCH (MS-LCH) patients with risk organ (RO) involvement was younger than that of MS-LCH without RO involvement (p = .002) and single system LCH (p < .001) patients; bone was the most frequently involved organ, followed by the skin. Of all, the BRAF-V600E mutation was detected in 48 out of 84 patients who underwent gene analysis. Additionally, in our study, BRAF p.N486_T491 > K, BRAF p.L485_P490delinsF, BRAF p.R506_K507insLLR, ARAF p.Q349_F351delinsL and MAP2K1 p.Q58_E62del were known mutations in the mitogen-activated protein kinase (MAPK) pathway. The BRAF-V600E genotype in the tissue and plasma prior to therapy were detected in 16 patients, and the concordance was only 37.5% (6/16). According to the modified LCH-III-based-protocol, JLSG-02 protocol chemotherapy, and vemurafenib, the estimated five-year overall survival, event-free survival (EFS) and cumulative reactivation rates of 95 patients were 98.8%, 74.6% and 24.5%, respectively. The EFS rate in good responders was better than that in poor responders at 12-week (HR = 0.022, 95%CI 0.002–0.231, p = .002), and EFS was not affected by age, RO involvement or BRAF-V600E mutation. Regarding sequelae, nine patients had central diabetes insipidus and two had growth retardation.Conclusions In this study, LCH was a highly heterogeneous disease characterized molecularly by MAPK-pathway activating mutations. Vincristine, prednisone and cytarabine-based chemotherapy combined with vemurafenib improved the prognosis of childhood LCH. In future, prospective clinical trials and novel therapeutic strategies should be developed to improve outcomes in paediatric patients with LCH.KEY MESSAGEChildren with ...
Keywords	Langerhans cell histiocytosis ; clinical characteristics ; therapy ; prognosis ; children ; Medicine ; R
Subject code	610 ; 616
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Taylor & Francis Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Usability of the Surprise Question by Nurses and Patients’ Families for Risk Stratification in Emergency Patients

Yi Liu RN, BSc / Dongze Li MD, PhD / Yu Jia MD, PhD / Jing Yu MBBS / Fanghui Li MBBS / Yongli Gao RN, BS / Yan Ma PhD / Zhi Wan MD / Zhi Zeng MD / Wei Zhang RN, BS

Inquiry: The Journal of Health Care Organization, Provision, and Financing, Vol

A Prospective Cohort Study

2023 Volume 60

Abstract: The Surprise Question is an effective tool to identify patients in need of palliative care. But it is unknown whether the Surprise Question can effectively predict adverse outcomes in Emergency patients. Therefor this study is to determine the utility of ...

Abstract	The Surprise Question is an effective tool to identify patients in need of palliative care. But it is unknown whether the Surprise Question can effectively predict adverse outcomes in Emergency patients. Therefor this study is to determine the utility of the modified Surprise Question for risk stratification in emergency patients. And assessed if the modified Surprise Question could be used by different healthcare personnel. Nurses and patients’ families were asked to respond as “Yes” or “No” to the modified Surprise Question for each patient. The outcome was resuscitation unit admission. Logistic regression was used to determine covariant significantly associated with resuscitation unit admission. The area under the curve for the second Surprise Question response by nurses was 0.620, which improved to 0.704 when the responses of nurses and patients’ families were in agreement. The clinical impression of nurses is a valuable tool to predict altered conditions for medium-acuity patients, and the diagnostic accuracy improves when responses of patients’ families and nurses agreed. The clinical impression of nurses is a valuable tool to predict altered conditions for medium-acuity patients, and the diagnostic accuracy improves when responses of patients’ families and nurses agreed.
Keywords	Public aspects of medicine ; RA1-1270
Subject code	610
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	SAGE Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: LncRNA TSLNC8 synergizes with EGFR inhibitor osimertinib to inhibit lung cancer tumorigenesis by blocking the EGFR-STAT3 pathway.

Zhou, Su-Zhen / Li, Han / Wang, Zhi-Wan / Wang, Ming-Hang / Li, Ning / Wang, Yan-Fang

Cell cycle (Georgetown, Tex.)

2020 Volume 19, Issue 21, Page(s) 2776–2792

Abstract: The roles of lncRNA TSLNC8 and its synergetic effects with osimertinib remain unknown in lung cancer. qRT-PCR or western blotting was performed to determine the expression levels of TSLNC8, EGFR and STAT3. Colony formation and MTT assays were used to ... ...

Abstract	The roles of lncRNA TSLNC8 and its synergetic effects with osimertinib remain unknown in lung cancer. qRT-PCR or western blotting was performed to determine the expression levels of TSLNC8, EGFR and STAT3. Colony formation and MTT assays were used to evaluate cell proliferation. Transwell and wound healing assays were performed to assess migration and invasion abilities. Flow cytometry with Annexin V/PI staining was used to detect changes in cell apoptosis. Nude mice subcutaneous tumor model was constructed and used for validating the effects of TSLNC8 and osimertinib
MeSH term(s)	A549 Cells ; Acrylamides/therapeutic use ; Aniline Compounds/therapeutic use ; Animals ; Apoptosis/drug effects ; Apoptosis/genetics ; Carcinogenesis/drug effects ; Carcinogenesis/genetics ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Proliferation/genetics ; ErbB Receptors/genetics ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; Gene Expression Regulation, Neoplastic/genetics ; Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Middle Aged ; Protein Kinase Inhibitors/therapeutic use ; RNA, Long Noncoding/genetics ; STAT3 Transcription Factor/genetics ; Signal Transduction/drug effects ; Signal Transduction/genetics
Chemical Substances	Acrylamides ; Aniline Compounds ; Protein Kinase Inhibitors ; RNA, Long Noncoding ; STAT3 Transcription Factor ; STAT3 protein, human ; osimertinib (3C06JJ0Z2O) ; EGFR protein, human (EC 2.7.10.1) ; ErbB Receptors (EC 2.7.10.1)
Language	English
Publishing date	2020-10-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	2146183-1
ISSN	1551-4005 ; 1538-4101 ; 1554-8627
ISSN (online)	1551-4005
ISSN	1538-4101 ; 1554-8627
DOI	10.1080/15384101.2020.1820697
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Article ; Online: Biomarker-based risk model to predict cardiovascular events in patients with acute coronary syndromes – Results from BIPass registry

Jiali Wang / Wei Gao / Guanghui Chen / Ming Chen / Zhi Wan / Wen Zheng / Jingjing Ma / Jiaojiao Pang / Guangmei Wang / Shuo Wu / Shuo Wang / Feng Xu / Derek P. Chew / Yuguo Chen

The Lancet Regional Health. Western Pacific, Vol 25, Iss , Pp 100479- (2022)

2022

Abstract: Summary: Background: Risk models integrating new biomarkers to predict cardiovascular events in acute coronary syndromes (ACS) are lacking. Therefore, we evaluated the prognostic value of biomarkers in addition to clinical predictors and developed a ... ...

Abstract	Summary: Background: Risk models integrating new biomarkers to predict cardiovascular events in acute coronary syndromes (ACS) are lacking. Therefore, we evaluated the prognostic value of biomarkers in addition to clinical predictors and developed a biomarker-based risk model for major adverse cardiovascular events (MACE) within 12 months after hospital admission with ACS. Methods: Patients (n = 4407) consecutively enrolled from November, 2017 to October, 2019 in three hospitals of a prospective Chinese registry (BIomarker-based Prognostic Assessment for Patients with Stable Angina and Acute Coronary Syndromes, BIPass) were designated as the risk model development cohort. Validation was performed in 1409 patients enrolled in two independent hospitals. Cox proportional hazards regression analysis was used to generate a risk prediction model and evaluate the incremental prognostic value of each biomarker. Findings: Over 12 months, 196 patients experienced MACE (5.1%/year). Among twelve candidate biomarkers, N-terminal pro-B-type natriuretic peptide (NT-proBNP) measured at baseline showed the most prognostic capability independent of clinical predictors. The developed BIPass risk model included age, hypertension, previous myocardial infarction, stroke, Killip class, heart rate, and NT-proBNP. It displayed improved discrimination (C-statistic 0.79, 95% CI 0.73-0.85), calibration (GOF = 9.82, p = 0.28) and clinical decision curve in the validation cohort, outperforming the GRACE and TIMI risk scores. Cumulative rates for MACE demonstrated good separation in the BIPass predicted low, intermediate, and high-risk groups. Interpretation: The BIPass risk model, integrating clinical variables and NT-proBNP, is useful for predicting 12-month MACE in ACS. It effectively identifies a gradient risk of cardiovascular events to aid personalized care. Funding: National Key R&D Program of China (2017YFC0908700, 2020YFC0846600), National S&T Fundamental Resources Investigation Project (2018FY100600, 2018FY100602), Taishan ...
Keywords	Acute coronary syndromes ; Prognosis ; Biomarker ; Risk prediction model ; Public aspects of medicine ; RA1-1270
Subject code	610
Language	English
Publishing date	2022-08-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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