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Book ; Online: Graph Regularized Nonnegative Latent Factor Analysis Model for Temporal Link Prediction in Cryptocurrency Transaction Networks

Yue, Zhou / ZhiGang, Liu / Ye, Yuan

2022

Abstract: With the development of blockchain technology, the cryptocurrency based on blockchain technology is becoming more and more popular. This gave birth to a huge cryptocurrency transaction network has received widespread attention. Link prediction learning ... ...

Abstract	With the development of blockchain technology, the cryptocurrency based on blockchain technology is becoming more and more popular. This gave birth to a huge cryptocurrency transaction network has received widespread attention. Link prediction learning structure of network is helpful to understand the mechanism of network, so it is also widely studied in cryptocurrency network. However, the dynamics of cryptocurrency transaction networks have been neglected in the past researches. We use graph regularized method to link past transaction records with future transactions. Based on this, we propose a single latent factor-dependent, non-negative, multiplicative and graph regularized-incorporated update (SLF-NMGRU) algorithm and further propose graph regularized nonnegative latent factor analysis (GrNLFA) model. Finally, experiments on a real cryptocurrency transaction network show that the proposed method improves both the accuracy and the computational efficiency
Keywords	Computer Science - Machine Learning ; Computer Science - Social and Information Networks
Subject code	006
Publishing date	2022-08-03
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A prediction model for new-onset atrial fibrillation following coronary artery bypass graft surgery

Ren-Jian-Zhi Zhang / Xin-Yi Yu / Jing Wang / Jian Lv / Yan Zheng / Ming-Huan Yu / Yi-Rui Zang / Jian-Wei Shi / Jia-Hui Wang / Li Wang / Zhi-Gang Liu

Heliyon, Vol 9, Iss 3, Pp e14656- (2023)

A multicenter retrospective study

2023

Abstract: Objective: Developing and assessing a risk prediction model of postoperative atrial fibrillation (POAF) after coronary artery bypass grafting (CABG), and aims to provide a reference for the prediction and prevention. Design: A retrospective case-control ... ...

Abstract	Objective: Developing and assessing a risk prediction model of postoperative atrial fibrillation (POAF) after coronary artery bypass grafting (CABG), and aims to provide a reference for the prediction and prevention. Design: A retrospective case-control study. Setting: Three major urban teaching and university hospitals and tertiary referral centers. Participants: consecutive patients undergoing CABG. Interventions: The study was retrospective and no interventions were administered to patients. Measurements and main results: In the study, the overall new-onset POAF prevalence was approximately 28%. A prediction model for POAF with nine significant indicators was developed, and identified new predictors of POAF: left ventricular end diastolic diameter (LVEDD), intraoperative defibrillation, and intraoperative temporary pacing lead implantation. The model had good discrimination in both the derivation and validation cohorts, with the area under the receiver operating characteristic curves (AUCs) of 0.621 (95% CI = 0.602–0.640) and 0.616 (95% CI = 0.579–0.651), respectively, and showed good calibration. Compared with CHA2DS2-VASc, HATCH score, and the prediction model of POAF after CABG developed based on a small sample of clinical data from a single center in China, the model in this study had better discrimination. Conclusion: We have developed and validated a new prediction model of POAF after CABG using multicenter data that can be used in the clinic for early identification of high-risk patients of POAF, and to help effectively prevent POAF in postoperative patients.
Keywords	Coronary artery bypass grafting ; Atrial fibrillation ; Prediction ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Subject code	610
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Inhibition of the Activating Transcription Factor 6 Branch of Endoplasmic Reticulum Stress Ameliorates Brain Injury after Deep Hypothermic Circulatory Arrest

You-Peng Zhang / Qin Yang / Yi-Ai Li / Ming-Huan Yu / Guo-Wei He / Yu-Xiang Zhu / Zhi-Gang Liu / Xiao-Cheng Liu

Journal of Clinical Medicine, Vol 12, Iss 814, p

2023 Volume 814

Abstract: Neurological dysfunction is a common complication of deep hypothermic circulatory arrest (DHCA). Endoplasmic reticulum (ER) stress plays a role in neuronal ischemia-reperfusion injury; however, it is unknown whether it contributes to DHCA-induced brain ... ...

Abstract	Neurological dysfunction is a common complication of deep hypothermic circulatory arrest (DHCA). Endoplasmic reticulum (ER) stress plays a role in neuronal ischemia-reperfusion injury; however, it is unknown whether it contributes to DHCA-induced brain injury. Here, we aimed to investigate the role of ER stress in a rat DHCA model and cell hypothermic oxygen–glucose deprivation reoxygenation (OGD/R) model. ER stress and apoptosis-related protein expression were identified using Western blot analysis. Cell counting assay-8 and flow cytometry were used to determine cell viability and apoptosis, respectively. Brain injury was evaluated using modified neurological severity scores, whereas brain injury markers were detected through histological examinations and immunoassays. We observed significant ER stress molecule upregulation in the DHCA rat hippocampus and in hypothermic OGD/R PC-12 cells. In vivo and in vitro experiments showed that ER stress or activating transcription factor 6 (ATF6) inhibition alleviated rat DHCA-induced brain injury, increased cell viability, and decreased apoptosis accompanied by C/EBP homologous protein (CHOP). ER stress is involved in DHCA-induced brain injury, and the inhibition of the ATF6 branch of ER stress may ameliorate this injury by inhibiting CHOP-mediated apoptosis. This study establishes a scientific foundation for identifying new therapeutic targets for perioperative brain protection in clinical DHCA.
Keywords	apoptosis ; ATF6 ; brain injury ; deep hypothermic circulatory arrest ; endoplasmic reticulum stress ; Medicine ; R
Subject code	610
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Nile tilapia DNA sensor STING is involved in the IFN-β and AP-1 signaling pathways in the immune response dependent on DDX41.

Feng-Ying, Gao / Mai-Xin, Lu / Miao, Wang / Zhi-Gang, Liu / Xiao-Li, Ke / De-Feng, Zhang / Jian-Meng, Cao

International journal of biological macromolecules

2022 Volume 225, Page(s) 27–39

Abstract: Stimulator of interferon genes (STING) plays important roles in innate immunology. In this study, we isolated the STING gene in Nile tilapia, termed OnSTING. Using quantitative RT-PCR, we explored the expression patterns of the OnSTING gene. Using dual- ... ...

Abstract	Stimulator of interferon genes (STING) plays important roles in innate immunology. In this study, we isolated the STING gene in Nile tilapia, termed OnSTING. Using quantitative RT-PCR, we explored the expression patterns of the OnSTING gene. Using dual-luciferase reporter assays, we revealed the effect of STING overexpression on nuclear factor κB (NF-κB), IFN and AP activation in HEK 293 cells. Using coimmunoprecipitation, the interaction of STING and TRIF was studied. The effect of OnSTING overexpression on the antibacterial activity in tilapia was investigated. The results showed that upon stimulation with Streptococcus agalactiae, the OnSTING transcript was upregulated in all the tested tissues. OnSTING mRNA levels were very stable from 2.5 to 8.5 dpf. Moreover, OnSTING, OnIFN and IRF3 expression was induced by LPS, Poly (I:C), S. agalactiae WC1535 and DCPS in Nile tilapia macrophages. Overexpression of OnSTING and OnDDX41 increased NF-κB activation in HEK293T cells and slightly increased IFN-β activation but had no effect on AP-1 activation. OnSTING interacted with OnDDX41 and OnTBK1. However, OnSTING did not interact with TRIF. OnSTING overexpression in vivo decreased the sensitivity of tilapia to S. agalactiae infection. These results are helpful for clarifying the innate immune response against bacterial infection in Nile tilapia.
Language	English
Publishing date	2022-12-07
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2022.11.319
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Article ; Online: Effect of vitrectomy with intravitreal injection of triamcinolone acetonide in the treatment of proliferative diabetic retinopathy

Heng Li / Zhi-Gang Liu / Xue Mi

Guoji Yanke Zazhi, Vol 15, Iss 10, Pp 1769-

2015 Volume 1771

Abstract: AIM:To study the effect of vitrectomy with intravitreal injection of triamcinolone acetonide for the treatment of proliferative diabetic retinopathy. METHODS: Vitrectomy with intravitreal injection of triamcinolone acetonide 2mg was performed on 47 eyes ... ...

Abstract	AIM:To study the effect of vitrectomy with intravitreal injection of triamcinolone acetonide for the treatment of proliferative diabetic retinopathy. METHODS: Vitrectomy with intravitreal injection of triamcinolone acetonide 2mg was performed on 47 eyes of 45 patients. The intraoperative and postoperative complications, postoperative visual acuity, intraocular pressure and the changes of macula central fovea thickness were observed. RESULTS: Intraoperative complications: 7 eyes(15%)happened Iatrogenic tear hole, 13 eyes(28%)happened retinal hemorrhage; Postoperative complications: 13 eyes(28%)found triamcinolone acetonide entered anterior chamber, 9 eyes(19%)found hyphema, 6 eyes(13%)presented fundus hemorrhage. Visual acuity was improved in 35 eyes(74%)after 3mo and 27 eyes(57%)after 6mo, with statistical difference with preoperative( P <0.05). the intraocular pressure of postoperative were 23.47±5.21, 26.58±6.35, 19.12±5.76 and 17.43±4.91mmHg at 7d, 1, 3 and 6mo respectively. Compared with preoperative(16.32±4.64mmHg), the differences had statistically significant at 7d and 1mo( P <0.05). Macula central fovea thickness were 404.05±89.71, 277.14±41.25, 254.82±33.64 and 226.49±28.57μm at7d, 1, 3 and 6mo respectively. The differences had statistically significant at 1, 3 and 6mo compared with preoperative 433.51±101.02μm( P <0.05). CONCLUSION: Vitrectomy combined with intravitreal injection of triamcinolone acetonide 2mg can reduce macular edema and improve visual acuity. It is an effective and safe procedure for proliferative diabetic retinopathy.
Keywords	vitrectomy ; diabetic retinopathy ; triamcinolone acetonide ; Ophthalmology ; RE1-994 ; Medicine ; R
Subject code	610
Language	Chinese
Publishing date	2015-10-01T00:00:00Z
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Rno_circRNA_008646 regulates formaldehyde induced lung injury through Rno-miR-224 mediated FOXI1/CFTR axis

Yan-Qi Yang / Pan Ge / Mo-Qi Lv / Peng-Fei Yu / Zhi-Gang Liu / Jian Zhang / Wen-Bao Zhao / Shui-Ping Han / Rui-Fang Sun / Dang-Xia Zhou

Ecotoxicology and Environmental Safety, Vol 243, Iss , Pp 113999- (2022)

2022

Abstract: Formaldehyde (FA) serves as a prevailing air pollutant, which has seriously threatened public health in recent years. Of all the known health effects, lung injury is one of the most severe risks. However, little is known about the circRNAs related ... ...

Abstract	Formaldehyde (FA) serves as a prevailing air pollutant, which has seriously threatened public health in recent years. Of all the known health effects, lung injury is one of the most severe risks. However, little is known about the circRNAs related molecular mechanism in the development of lung injury induced by FA. This study was designed to explore the potential roles of dysregulated circRNAs as well as its mechanism in FA-induced lung injury. In the present study, 24 male SD rats were exposed to formaldehyde (control, 0.5, 2.46 and 5 mg/m3) for 8 h per day for 8 weeks to induce lung injury. We used H&E staining to evaluate the histopathological changes of lung injury indifferent groups. The expression of circRNAs in lung tissue was detected by real-time PCR. Meanwhile, circRNA/miRNA/mRNA interaction networks were predicted by bioinformatics analysis. Our study revealed that formaldehyde exposure resulted in abnormal histopathological changes in lung tissues. Moreover, the expression of rno_circRNA_008646 was significantly higher in lung tissues of formaldehyde exposure rats than in control. Bioinformatics analysis showed that one potential target miRNA/mRNA for rno_circRNA_008646 was rno-miR-224/Forkhead Box I1 (FOXI1). Besides, luciferase report gene confirmed that there was targeted binding relationship between rno_circRNA_008646 and rno-miR-224, rno-miR-224 and FOXI1. Further verification experiments indicated that the expression of rno_circRNA_008646 was negatively correlated rno-miR-224, while it was positively correlated with FOXI1. JASPAR database showed transcription factor FOXI1 located in promotor of CF Transmembrane Conductance Regulator (CFTR). Both FOXI1 and CFTR were up-regulated in lung tissues after formaldehyde exposure. In conclusion, our findings suggested that formaldehyde may induce lung injury, and this may be caused by up-regulatedrno_circRNA_008646, which medicated rno-miR-224/FOXI1/CFTR axis.
Keywords	Rno_circRNA_008646 ; Rno-miR-224 ; FOXI1 ; CFTR ; Formaldehyde ; Lung injury ; Environmental pollution ; TD172-193.5 ; Environmental sciences ; GE1-350
Subject code	610
Language	English
Publishing date	2022-09-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effect of naturally derived surgical hemostatic materials on the proliferation of A549 human lung adenocarcinoma cells

Wei-Dong Lü / Yi-Zhi Liu / Yan-Qi Yang / Zhi-Gang Liu / Kun Zhao / Jian-Rong Lu / Guang-Yan Lei / Yi-Yu Wang / Lin Cai / Rui-Fang Sun

Materials Today Bio, Vol 14, Iss , Pp 100233- (2022)

2022

Abstract: Hemostatic materials are generally applied in surgical operations for cancer, but their effects on the growth and recurrence of tumors are unclear. Herein, three commonly used naturally derived hemostatic materials, gelatin sponge, Surgicel (oxidized ... ...

Abstract	Hemostatic materials are generally applied in surgical operations for cancer, but their effects on the growth and recurrence of tumors are unclear. Herein, three commonly used naturally derived hemostatic materials, gelatin sponge, Surgicel (oxidized regenerated cellulose), and biopaper (mixture of sodium hyaluronate and carboxymethyl chitosan), were cocultured with A549 human lung adenocarcinoma cells in vitro. Furthermore, the performance of hemostatic materials and the tumorigenicity of the materials with A549 cells were observed after subcutaneous implantation into BALB/c mice. The in vitro results showed that biopaper was dissolved quickly, with the highest cell numbers at 2 and 4 days of culture. Gelatin sponges retained their structure and elicited the least cell infiltration during the 2- to 10-day culture. Surgicel partially dissolved and supported cell growth over time. The in vivo results showed that biopaper degraded rapidly and elicited an acute Th1 lymphocyte reaction at 3 days after implantation, which was decreased at 7 days after implantation. The gelatin sponge resisted degradation and evoked a hybrid M1/M2 macrophage reaction at 7–21 days after implantation, and a protumor M2d subset was confirmed. Surgicel resisted early degradation and caused obvious antitumor M2a macrophage reactions. Mice subjected to subcutaneous implantation of A549 cells and hemostatic materials in the gelatin sponge group had the largest tumor volumes and the shortest overall survival (OS), while the Surgicel and the biopaper group had the smallest volumes and the longest OS. Therefore, although gelatin sponges exhibited cytotoxicity to A549 cells in vitro, they promoted the growth of A549 cells in vivo, which was related to chronic M2d macrophage reaction. Surgicel and biopaper inhibited A549 cell growth in vivo, which is associated with chronic M2a macrophage reaction or acute Th1 lymphocyte reaction.
Keywords	Hemostatic materials ; Gelatin sponge (GS) ; Surgicel ; Macrophage ; Lymphocyte reaction ; Medicine (General) ; R5-920 ; Biology (General) ; QH301-705.5
Subject code	630
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Puerarin ameliorates allodynia and hyperalgesia in rats with peripheral nerve injury

Heng-Tao Xie / Zhong-Yuan Xia / Xia Pan / Bo Zhao / Zhi-Gang Liu

Neural Regeneration Research, Vol 13, Iss 7, Pp 1263-

2018 Volume 1268

Abstract: Puerarin is a major active ingredient of the traditional Chinese plant medicine, Radix Puerariae, and commonly used in the treatment of myocardial and cerebral ischemia. However, the effects of puerarin on neuropathic pain are still unclear. In this ... ...

Abstract	Puerarin is a major active ingredient of the traditional Chinese plant medicine, Radix Puerariae, and commonly used in the treatment of myocardial and cerebral ischemia. However, the effects of puerarin on neuropathic pain are still unclear. In this study, a neuropathic pain animal model was created by partial sciatic nerve ligation. Puerarin (30 or 60 mg/kg) was intraperitoneally injected once a day for 7 days. Mechanical allodynia and thermal hyperalgesia were examined at 1 day after model establishment. Mechanical threshold and paw withdrawal latency markedly increased in a dose-dependent manner in puerarin-treated rats, especially at 7 days after model establishment. At 7 days after model establishment, quantitative real-time reverse transcriptase-polymerase chain reaction results showed that puerarin administration reversed mRNA expression of transient receptor potential vanilloid 1 (Trpv1) and transient receptor potential ankyrin 1 (Trpa1) in a dose-dependent manner in dorsal root ganglion neurons after peripheral nerve injury. These results suggest that puerarin dose-dependently ameliorates neuropathic pain by suppressing Trpv1 and Trpa1 up-regulation in dorsal root ganglion of neuropathic pain rats.
Keywords	nerve regeneration ; puerarin ; Radix Puerariae ; traditional Chinese medicine ; Trpv1 ; Trpa1 ; dorsal root ganglion ; peripheral nerve injury ; neuropathic pain ; mechanical allodynia ; thermal hyperalgesia ; neural regeneration ; Neurology. Diseases of the nervous system ; RC346-429
Subject code	610
Language	English
Publishing date	2018-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Vitrectomy combined with inferior scleral buckling for a special kind of retinal detachment

Heng Li / Zhi-Gang Liu / Xue Mi

Guoji Yanke Zazhi, Vol 14, Iss 8, Pp 1519-

2014 Volume 1521

Abstract: AIM: To evaluate the efficiency of vitrectomy combined with inferior scleral buckling for a special kind of retinal detachment. METHODS: Nineteen eyes of special retinal detachment had following features: 1)the course was more than 6mo; 2)there were at ... ...

Abstract	AIM: To evaluate the efficiency of vitrectomy combined with inferior scleral buckling for a special kind of retinal detachment. METHODS: Nineteen eyes of special retinal detachment had following features: 1)the course was more than 6mo; 2)there were at least one hole located in the 5:00-7:00 of the marginal retina; 3)the detachment range of retina more than 270 degrees and retinal proliferation in retinal detachment. The 19 eyes who received vitrectomy combined with inferior scleral buckling, retinal anatomic reattachment and visual function recovery was observed. RESULTS: Among these 19 eyes, all eyes retinal anatomic reattachment and best corrected visual acuity(BCVA)was improved in various degrees. The BCVA was 0.01-0.1 in 5 eyes, 0.12-0.3 in 9 eyes, and ≥0.4 in 5 eyes. CONCLUSION: It is an effective method to vitrectomy combined with inferior scleral buckling for the special kind of retinal detachment which has following features: 1)the course was more than 6mo; 2)there were at least one hole located in the 5:00-7:00 of the marginal retina; 3)the detachment range of retina more than 270 degrees and retinal proliferation of cable in retinal detachment.
Keywords	vitrectomy ; scleral buckling ; retinal detachment ; special type ; Ophthalmology ; RE1-994 ; Medicine ; R
Subject code	290
Language	Chinese
Publishing date	2014-08-01T00:00:00Z
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Author Correction

Bo Yang / Lin-Jing Li / Ling-Zhi Xu / Jiang-Qi Liu / Huan-Ping Zhang / Xiao-Rui Geng / Zhi-Gang Liu / Ping-Chang Yang

Scientific Reports, Vol 11, Iss 1, Pp 1-

Histone acetyltransferease p300 modulates TIM4 expression in dendritic cells

2021 Volume 2

Abstract: An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

Abstract	An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2021-05-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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