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  1. Article ; Online: Fabrication of Cocatalyst NiO-Modified BiVO4 Composites for Enhanced Photoelectrochemical Performances

    Zhi-Qiang Wang / HongJun Wang

    Frontiers in Chemistry, Vol

    2022  Volume 10

    Abstract: In this work, NiO modified BiVO4 (BiVO4/NiO) nanocomposite was synthesized using hydrothermal and calcination method. The composite of BiVO4/NiO, further employed as a low-overpotential photoanode, was consisted of BiVO4 nanoparticles and NiO nanosheets, ...

    Abstract In this work, NiO modified BiVO4 (BiVO4/NiO) nanocomposite was synthesized using hydrothermal and calcination method. The composite of BiVO4/NiO, further employed as a low-overpotential photoanode, was consisted of BiVO4 nanoparticles and NiO nanosheets, in which the BiVO4 nanoelectrode served as the matrix for the attachment of NiO nanosheets. Photoelectrochemical (PEC) tests show that BiVO4/NiO displayed improved PEC performance compared with pure BiVO4. The BiVO4/NiO photoanode delivers a photocurrent density of 1.2 mA/cm2 at 1.23 V vs. RHE in a Na2SO4 electrolyte under an AM 1.5G solar simulator, which is 0.3 mA/cm2 higher than pure BiVO4 photoanode. Meanwhile, the onset potential also generates a 350 mV cathodic shift. The enhanced performance of the BiVO4/NiO nanocomposite is attributed to NiO unique lamellar structure capable of providing a large number of active sites. Measurements of electrochemical impedance spectra (EIS) and the incident photon-to-current efficiency (IPCE) illustrate that the enhanced PEC activities are ascribed to the improved charge carrier separation/transport and the promoted water oxidation kinetics furnished by the decoration of NiO cocatalyst.
    Keywords bismuth vanadate ; nickel oxide ; photoelectrochemical ; cocatalyst ; water oxidation ; Chemistry ; QD1-999
    Subject code 620
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Ex Vivo Pharmacokinetics and Pharmacodynamics Modeling and Optimal Regimens Evaluation of Cefquinome Against Bovine Mastitis Caused by Staphylococcus aureus

    Li-jie Jiang / Xia Xiao / Ke-xu Yan / Tian Deng / Zhi-qiang Wang

    Frontiers in Veterinary Science, Vol

    2022  Volume 9

    Abstract: Cefquinome, the fourth-generation cephalosporin applied solely for veterinary medicine, is commonly used for bovine mastitis caused by Staphylococcus aureus. The present study aims to establish an optimal dose and provide a PK/PD Cutoff value (COPD) for ... ...

    Abstract Cefquinome, the fourth-generation cephalosporin applied solely for veterinary medicine, is commonly used for bovine mastitis caused by Staphylococcus aureus. The present study aims to establish an optimal dose and provide a PK/PD Cutoff value (COPD) for cefquinome against S. aureus based on ex vivo pharmacokinetics and pharmacodynamics (PK/PD) integration. This study investigated the pharmacokinetics (PK) of cefquinome when administered as three consecutive intramammary (IMM) doses of cefquinome in three healthy dairy cows at 75 mg/gland. Drug concentration was determined by HPLC-MS/MS assay. The ex vivo pharmacodynamics (PD) of cefquinome were evaluated by using a milk sample from a PK experiment. The relationship between the AUC/ MIC of cefquinome and bacterial loading reduction was simulated using a Sigmoid Emax model. The cefquinome concentration in milk attained a maximum level of 1.55 ± 0.21 mg/mL at 1.8 h after the third administration. The mean value of the area under the concentration-time curve (AUC0−24) was 26.12 ± 2.42 mg·h/mL after the third administration. The elimination half-life was 10.6 h. For PD profile, the MICs of cefquinome in milk were 2–4 times higher than those in the broth. In vitro time-killing curve shows that initial bacterial concentration has a huge impact on antibacterial effect on three strains. The antibacterial effect was weakened with the initial bacterial concentration increasing from 106 to 108 CFU/mL. The AUC0−24h/MIC index correlated well with ex vivo efficacy both for the initial inoculum of 106 CFU/mL and 108 CFU/mL (R2 > 0.84). According to the inhibitory sigmoid Emax model analysis, the PK/PD surrogate (AUC0−24/MIC) values were 8,638, 1,397, and 3,851 for bactericidal effect (E = −3) with an initial inoculum of 106 CFU/mL, while the corresponding values were 12,266, 2,295, and 5,337, respectively, with the initial inoculum of 108 CFU/mL. The ex vivo PK/PD based population dose prediction indicated a target attainment rate (TAR) of 90% of 55 mg/gland/12 h. The COPD ...
    Keywords cefquinome ; S. aureus ; ex vivo ; PK/PD modeling ; cutoff ; bovine mastitis ; Veterinary medicine ; SF600-1100
    Subject code 630
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Bromodomain and extraterminal (BET) proteins

    Zhi-Qiang Wang / Zhao-Cong Zhang / Yu-Yang Wu / Ya-Nan Pi / Sheng-Han Lou / Tian-Bo Liu / Ge Lou / Chang Yang

    Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-

    biological functions, diseases, and targeted therapy

    2023  Volume 26

    Abstract: Abstract BET proteins, which influence gene expression and contribute to the development of cancer, are epigenetic interpreters. Thus, BET inhibitors represent a novel form of epigenetic anticancer treatment. Although preliminary clinical trials have ... ...

    Abstract Abstract BET proteins, which influence gene expression and contribute to the development of cancer, are epigenetic interpreters. Thus, BET inhibitors represent a novel form of epigenetic anticancer treatment. Although preliminary clinical trials have shown the anticancer potential of BET inhibitors, it appears that these drugs have limited effectiveness when used alone. Therefore, given the limited monotherapeutic activity of BET inhibitors, their use in combination with other drugs warrants attention, including the meaningful variations in pharmacodynamic activity among chosen drug combinations. In this paper, we review the function of BET proteins, the preclinical justification for BET protein targeting in cancer, recent advances in small-molecule BET inhibitors, and preliminary clinical trial findings. We elucidate BET inhibitor resistance mechanisms, shed light on the associated adverse events, investigate the potential of combining these inhibitors with diverse therapeutic agents, present a comprehensive compilation of synergistic treatments involving BET inhibitors, and provide an outlook on their future prospects as potent antitumor agents. We conclude by suggesting that combining BET inhibitors with other anticancer drugs and innovative next-generation agents holds great potential for advancing the effective targeting of BET proteins as a promising anticancer strategy.
    Keywords Medicine ; R ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Biological Functions and Therapeutic Potential of Autophagy in Spinal Cord Injury

    Hai-Yang Liao / Zhi-Qiang Wang / Rui Ran / Kai-Sheng Zhou / Chun-Wei Ma / Hai-Hong Zhang

    Frontiers in Cell and Developmental Biology, Vol

    2021  Volume 9

    Abstract: Autophagy is an evolutionarily conserved lysosomal degradation pathway that maintains metabolism and homeostasis by eliminating protein aggregates and damaged organelles. Many studies have reported that autophagy plays an important role in spinal cord ... ...

    Abstract Autophagy is an evolutionarily conserved lysosomal degradation pathway that maintains metabolism and homeostasis by eliminating protein aggregates and damaged organelles. Many studies have reported that autophagy plays an important role in spinal cord injury (SCI). However, the spatiotemporal patterns of autophagy activation after traumatic SCI are contradictory. Most studies show that the activation of autophagy and inhibition of apoptosis have neuroprotective effects on traumatic SCI. However, reports demonstrate that autophagy is strongly associated with distal neuronal death and the impaired functional recovery following traumatic SCI. This article introduces SCI pathophysiology, the physiology and mechanism of autophagy, and our current review on its role in traumatic SCI. We also discuss the interaction between autophagy and apoptosis and the therapeutic effect of activating or inhibiting autophagy in promoting functional recovery. Thus, we aim to provide a theoretical basis for the biological therapy of SCI.
    Keywords spinal cord injury ; autophagy ; autophagy-regulated ; therapeutic target ; biological functions ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2021-12-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Oxidative Dehydrogenation of Hydrazobenzenes toward Azo Compounds Catalyzed by tert-Butyl Nitrite in EtOH

    Zhi-Qiang Wang / Jiang-Xi Yu / Shan-Qin Bai / Bang Liu / Cheng-Yong Wang / Jin-Heng Li

    ACS Omega, Vol 5, Iss 44, Pp 28856-

    2020  Volume 28862

    Keywords Chemistry ; QD1-999
    Language English
    Publishing date 2020-10-01T00:00:00Z
    Publisher American Chemical Society
    Document type Article ; Online
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  6. Article ; Online: Stability of traveling-wave solutions for a Schrodinger system with power-type nonlinearities

    Nghiem V. Nguyen / Rushun Tian / Zhi-Qiang Wang

    Electronic Journal of Differential Equations, Vol 2014, Iss 217,, Pp 1-

    2014  Volume 16

    Abstract: In this article, we consider the Schrodinger system with power-type nonlinearities, $$ i\frac{\partial}{\partial t}u_j+ \Delta u_j + a|u_j|^{2p-2} u_j + \sum_{k=1, k\neq j}^m b |u_k|^{p}|u_j|^{p-2} u_j=0; \quad x\in \mathbb{R}^N, $$ where $j=1,\dots,m$, $ ...

    Abstract In this article, we consider the Schrodinger system with power-type nonlinearities, $$ i\frac{\partial}{\partial t}u_j+ \Delta u_j + a|u_j|^{2p-2} u_j + \sum_{k=1, k\neq j}^m b |u_k|^{p}|u_j|^{p-2} u_j=0; \quad x\in \mathbb{R}^N, $$ where $j=1,\dots,m$, $u_j$ are complex-valued functions of $(x,t)\in \mathbb{R}^{N+1}$, a,b are real numbers. It is shown that when $b>0$, and $a+(m-1)b>0$, for a certain range of p, traveling-wave solutions of this system exist, and are orbitally stable.
    Keywords solitary wave solutions ; stability ; nonlinear Schrodinger system ; traveling-wave solutions ; Mathematics ; QA1-939 ; Science ; Q
    Language English
    Publishing date 2014-10-01T00:00:00Z
    Publisher Texas State University
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: A unique Co@CoO catalyst for hydrogenolysis of biomass-derived 5-hydroxymethylfurfural to 2,5-dimethylfuran

    Shuang Xiang / Lin Dong / Zhi-Qiang Wang / Xue Han / Luke L. Daemen / Jiong Li / Yongqiang Cheng / Yong Guo / Xiaohui Liu / Yongfeng Hu / Anibal J. Ramirez-Cuesta / Sihai Yang / Xue-Qing Gong / Yanqin Wang

    Nature Communications, Vol 13, Iss 1, Pp 1-

    2022  Volume 9

    Abstract: The development of precious-metal-free catalysts to promote the sustainable production of fuels and chemicals from biomass challenging. Here the authors report a unique core-shell structured Co@CoO catalyst which exhibits excellent performance in the ... ...

    Abstract The development of precious-metal-free catalysts to promote the sustainable production of fuels and chemicals from biomass challenging. Here the authors report a unique core-shell structured Co@CoO catalyst which exhibits excellent performance in the hydrogenolysis of biomass-derived compounds.
    Keywords Science ; Q
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher Nature Portfolio
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    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Dysferlinopathy in a cohort of Chinese patients

    Qi-Fu Guo / Zhi-Xian Ye / Liang-Liang Qiu / Xin Lin / Jia-He Lai / Min-Ting Lin / Zhi-Qiang Wang / Ning Wang / Feng Lin / Jing Ni

    Chinese Medical Journal, Vol 134, Iss 5, Pp 622-

    clinical features, mutation spectrum, and imaging findings

    2021  Volume 624

    Keywords Medicine ; R
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher Wolters Kluwer
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Selective hydrogenation of 5-(hydroxymethyl)furfural to 5-methylfurfural over single atomic metals anchored on Nb2O5

    Shaopeng Li / Minghua Dong / Junjuan Yang / Xiaomeng Cheng / Xiaojun Shen / Shulin Liu / Zhi-Qiang Wang / Xue-Qing Gong / Huizhen Liu / Buxing Han

    Nature Communications, Vol 12, Iss 1, Pp 1-

    2021  Volume 9

    Abstract: Selective hydrogenation of 5-(hydroxymethyl)furfural (HMF) to 5-Methylfurfural using H2 as reductant is very attractive, but remains challenging. Here, the authors report that isolated single atomic catalysts can catalyze the reaction efficiently with ... ...

    Abstract Selective hydrogenation of 5-(hydroxymethyl)furfural (HMF) to 5-Methylfurfural using H2 as reductant is very attractive, but remains challenging. Here, the authors report that isolated single atomic catalysts can catalyze the reaction efficiently with selectivity >99% at complete conversion of HMF.
    Keywords Science ; Q
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Nature Portfolio
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    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Efficient Separation of Phytochemicals from Muehlenbeckia volcanica (Benth.) Endl. by Polarity-Stepwise Elution Counter-Current Chromatography and Their Antioxidant, Antiglycation, and Aldose Reductase Inhibition Potentials

    Guang-Lei Zuo / Hyun Yong Kim / Yanymee N. Guillen Quispe / Zhi-Qiang Wang / Seung Hwan Hwang / Kyong-Oh Shin / Soon Sung Lim

    Molecules, Vol 26, Iss 224, p

    2021  Volume 224

    Abstract: Muehlenbeckia volcanica (Benth.) Endl. ( M. volcanica ), native to South America, is a traditional Peruvian medicinal plant that has multi-therapeutic properties; however, no phytochemicals have been identified from it yet. In this study, a five-step ... ...

    Abstract Muehlenbeckia volcanica (Benth.) Endl. ( M. volcanica ), native to South America, is a traditional Peruvian medicinal plant that has multi-therapeutic properties; however, no phytochemicals have been identified from it yet. In this study, a five-step polarity-stepwise elution counter-current chromatography (CCC) was developed using methanol/water (1:5, v / v ) as the stationary phase and different ratios of n -hexane, ethyl acetate, and n -butanol as mobile phases to separate the compounds from the 70% methanol extract of M. volcanica, by which six compounds with a wide range of polarities were separated in a single run of CCC and were identified as gallic acid, protocatechuic acid, 4,4′-dihydroxy-3,3′-imino-di-benzoic acid, rutin, quercitrin, and quercetin. Then, two compounds from the fractions of stepwise elution CCC were separated using conventional high-speed CCC, pH-zone-refining CCC, and preparative high-performance liquid chromatography, and identified as shikimic acid and miquelianin. These compounds are reported from M. volcanica for the first time. Notably, except for shikimic acid, all other compounds showed anti-diabetic potentials via antioxidant, antiglycation, and aldose reductase inhibition. The results suggest that the polarity-stepwise elution CCC can be used to efficiently separate or fractionate compounds with a wide range of polarities from natural products. Moreover, M. volcanica and its bioactive compounds are potent anti-diabetic agents.
    Keywords antioxidant ; antiglycation ; aldose reductase inhibition ; counter-current chromatography ; Muehlenbeckia volcanica (Benth.) Endl ; stepwise elution ; Organic chemistry ; QD241-441
    Subject code 540
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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