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Article ; Online: Integrating metabolic profile and network pharmacology to explore the chemical essence of Radix Ginseng Rubra for attenuating heart failure

Yinjie Wang / Wenhui Han / Qianyi Feng / Baolin Xie / Xiaoshan Chen / Zhonghui Zheng / Zhilong Zhao

Arabian Journal of Chemistry, Vol 17, Iss 1, Pp 105383- (2024)

1481

Abstract: Radix Ginseng Rubra (RGR), a well-known edible-medicinal herb, has been widely used to attenuate heart failure (HF). However, the active ingredients and mechanism of RGR for attenuating HF have not been illuminated. Thus, the metabolic profile in vivo of ...

Abstract	Radix Ginseng Rubra (RGR), a well-known edible-medicinal herb, has been widely used to attenuate heart failure (HF). However, the active ingredients and mechanism of RGR for attenuating HF have not been illuminated. Thus, the metabolic profile in vivo of RGR was investigated by ultra-performance liquid chromatography quadrupole time-of-flight tandem mass spectrometry and further the compounds identified in serum and heart were employed to search for the potential active compounds and targets via network pharmacology and molecular docking. 41 chemical compounds were identified in RGR aqueous extract. 10 prototypes and 8 metabolites were identified or tentatively characterized in vivo. Additionally, two compounds with 51 corresponding targets had been speculated to improve HF, and the role of ginsenoside Rh4 (P8) in RGR for attenuating HF by interfering with MAP2K1 and SRC targets was verified by molecular docking. Therefore, the potential active ingredients and targets were expected to be the basis of RGR therapy for HF.
Keywords	Radix Ginseng Rubra ; UPLC-Q-TOF-MS ; Metabolism ; In vivo ; Network pharmacology ; Chemistry ; QD1-999
Subject code	540
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Research on an Identification Method for Gas Disaster Risk Based on the Selective Ensemble Classification Model

Rong Liang / Qiaolin Lv / Pengtao Jia / Zhilong Zhao / Chengyixiong Xu

ACS Omega, Vol 6, Iss 22, Pp 14059-

2021 Volume 14067

Keywords	Chemistry ; QD1-999
Language	English
Publishing date	2021-05-01T00:00:00Z
Publisher	American Chemical Society
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The impact of drought on vegetation conditions within the Damqu River Basin, Yangtze River Source Region, China.

Zhilong Zhao / Yili Zhang / Linshan Liu / Zengzeng Hu

PLoS ONE, Vol 13, Iss 8, p e

2018 Volume 0202966

Abstract: Drought and vegetation conditions within the Damqu River Basin, part of the Yangtze River Source Region (YRSR), are assessed here using the standardized precipitation index (SPI), the standardized precipitation evapotranspiration index (SPEI), the ... ...

Abstract	Drought and vegetation conditions within the Damqu River Basin, part of the Yangtze River Source Region (YRSR), are assessed here using the standardized precipitation index (SPI), the standardized precipitation evapotranspiration index (SPEI), the normalized difference vegetation index (NDVI), and the leaf area index (LAI). We utilized Sen's method, least squares regression method, linear regression and Pearson's correlation analysis to study variations in drought and vegetation indices and the drought effect on vegetation between 1988 and 2015. Results reveal that droughts occurred at a 25% frequency over this period; SPI and SPEI analyses show that 1994, 1999, 2005, and 2010 were change points and that the basin was characterized by varying drought and humidity trends. Subsequent to 2010, both SPI and SPEI decreased within the basin, while 1995, 2000, 2004, and 2010 were change points for NDVI and LAI while the watershed exhibited variable trends in vegetation reduction and increase. The NDVI-annual values of 63.36% regions and the LAI-summer values of 68.39% areas within the basin were decreased during 1988-2015 and 2000-2015, respectively. Subsequent to 2010, both NDVI and LAI decreased within the basin and significant positive correlations at inter-annual and inter-summer time scales were seen in both drought and vegetation indices; drought has exerted a lag effect on vegetation as shown by significant positive correlations between annual SPI/SPEI values and following year NDVI/LAI values.
Keywords	Medicine ; R ; Science ; Q
Subject code	910 ; 550
Language	English
Publishing date	2018-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Investigation on depth-dependent properties and benthic effluxes of dissolved organic matter (DOM) in pore water from plateau lake sediments

Shuaidong Li / Lingfeng Lu / Yongfang Wu / Zhilong Zhao / Changchun Huang / Tao Huang / Hao Yang / Xiaohua Ma / Quanliang Jiang

Ecological Indicators, Vol 125, Iss , Pp 107500- (2021)

2021

Abstract: Dissolved organic matter (DOM) in sediment pore water plays a key role in lake water quality, complexation of the contaminants, biogeochemical cycles, and even climate. To better understand the vertical dynamics and characteristics of DOM among pore ... ...

Abstract	Dissolved organic matter (DOM) in sediment pore water plays a key role in lake water quality, complexation of the contaminants, biogeochemical cycles, and even climate. To better understand the vertical dynamics and characteristics of DOM among pore water profiles, we investigated concentrations, chemical structures, and benthic fluxes of DOM in plateau lake sediments via stoichiometric analysis, ultraviolet–visible (UV–vis) absorption, three-dimensional fluorescence matrix spectroscopy (EEMs), and parallel factor model (PARAFAC). The results revealed that dissolved organic carbon (DOC), concurrent with chromophoric DOM (CDOM) and fluorescent DOM (FDOM), tended to accumulate in the anaerobic deeper layers. These trends also demonstrated a good agreement with the ammonium nitrogen (NH4+-N) concentration, implying that the pathway of DOM dynamics was closely related to the redox state. The EEMs-PARAFAC model revealed that DOM in pore water mostly consisted of two terrestrial humic-like components (average contribution:> 60%) followed by microbial and tryptophan-like components, respectively. Terrestrial humic-like components were relatively stable, and their abundance was positively correlated with the FDOM level (p < 0.05). The changes of aromatic, molecular weight, and humification degree of DOM were possibly driven by microbial activities at different depths. Moreover, benthic flux estimations indicated that DOM and the total dissolved nitrogen (TDN) in inland sediments were potential sources for the overlying water and possibly affected the quality and ecological safety of lake water bodies.
Keywords	Pore water ; Dissolved organic matter ; UV–vis absorption spectroscopy ; Three-dimensional fluorescence matrix spectroscopy ; Depth ; Ecology ; QH540-549.5
Subject code	550
Language	English
Publishing date	2021-06-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Assessment of Changes in the Value of Ecosystem Services in the Koshi River Basin, Central High Himalayas Based on Land Cover Changes and the CA-Markov Model

Zhilong, Zhao / Gao Jungang / Wu Xue / Zhang Yili

Journal of resources and ecology. 2017 Jan., v. 8, no. 1

2017

Abstract: Climate warming and economic developments have created pressures on the ecological systems that human populations rely on, and this process has contributed to the degradation of ecosystems and the loss of ecosystem services. In this study, Landsat ... ...

Abstract	Climate warming and economic developments have created pressures on the ecological systems that human populations rely on, and this process has contributed to the degradation of ecosystems and the loss of ecosystem services. In this study, Landsat satellite data were chosen as the data source and the Koshi River Basin (KB) in the central high Himalayas as the study area. Changes in land cover and changes in the value of ecosystem services between 1990 and 2010 were analyzed and the land cover pattern of the KB in 2030 and 2050 was modeled using the CA-Markov model. Changes in land cover and in the value of ecosystem services in the KB for the period 2010–2050 were then analyzed. The value of ecosystem services in the KB was found to decrease by 2.05×108 USD y−1 between 1990 and 2010. Among these results, the services value of forest, snow/glacier and barren area decreased, while that of cropland increased. From 1990 to 2050, forest showed the largest reduction in ecosystem services value, as much as 11.87×108 USD y−1, while cropland showed the greatest increase, by 3.05×108 USD y−1. Deforestation and reclamation in Nepal contributed to a reduction in the value of ecosystem services in the KB. Barren areas that were transformed into water bodies brought about an increase in ecosystem services value in the lower reaches of the Koshi River. In general, this process is likely to be related to increasing human activity in the KB.
Keywords	cropland ; deforestation ; ecological value ; ecosystem services ; ecosystems ; forests ; glaciers ; global warming ; human population ; humans ; land cover ; Landsat ; models ; remote sensing ; rivers ; snow ; surface water ; watersheds ; Himalayan region ; Nepal
Language	English
Dates of publication	2017-01
Size	p. 67-76.
Publishing place	Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences
Document type	Article
ZDB-ID	2630108-8
ISSN	1674-764X
ISSN	1674-764X
DOI	10.5814/j.issn.1674-764x.2017.01.009
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: A Novel Space-Borne High-Resolution SAR System with the Non-Uniform Hybrid Sampling Technology for Space Targets Imaging

Zhenghuan Xia / Shichao Jin / Fuzhan Yue / Jian Yang / Qingjun Zhang / Zhilong Zhao / Chuang Zhang / Wenning Gao / Tao Zhang / Yao Zhang / Xin Liu / Tao Peng

Applied Sciences, Vol 12, Iss 4848, p

2022 Volume 4848

Abstract: In order to reduce the complexity of the receiving system for wideband signals, a novel space-borne high-resolution synthetic aperture radar (SAR) system with the non-uniform hybrid sampling technology is proposed in this paper. The non-uniform hybrid ... ...

Abstract	In order to reduce the complexity of the receiving system for wideband signals, a novel space-borne high-resolution synthetic aperture radar (SAR) system with the non-uniform hybrid sampling technology is proposed in this paper. The non-uniform hybrid sampling technology is firstly applied in the SAR imaging system for the detection of space targets. The non-uniform hybrid sampling technology is able to optimize the transmitted and receiving timing of SAR signals, reducing the requirement of the sampling rate of the analog-to-digital converter (ADC) for the reception of the wideband echoes from space targets. Meanwhile, according to the oversampling requirement of SAR imaging in the azimuth direction, a theoretical model of non-uniform hybrid sampling parameters and relative velocity between the SAR system and the space targets is established. A series of simulation experiments with different targets and different non-uniform hybrid parameters are performed, and an X-band SAR imaging experimental system is constructed to verify the effectiveness of the proposed non-uniform hybrid sampling technology. The experimental results show that the imaging resolution is better than 8 cm. When the non-uniform hybrid sampling interval is 15 us, the imaging quality is consistent with imaging results of the Nyquist real-time sampling, and it is easier to implement in the high-resolution imaging for space targets.
Keywords	space-borne SAR imaging ; wideband SAR ; non-uniform hybrid sampling ; high-resolution SAR imaging ; space targets ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
Subject code	600
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Feature Extraction for Moving Targets Based on the Statistical Characteristics of Echo Amplitude with the L-Band Fully Polarimetric Radar

Chuang Zhang / Yaxin Mu / Zhenghuan Xia / Shichao Jin / Fuzhan Yue / Xin Liu / Lanqing Zhang / Zhixin Tian / Zongqiang Liu / Yao Zhang / Wenning Gao / Tao Zhang / Zhilong Zhao / Ying Zhang

Remote Sensing, Vol 15, Iss 1, p

2022 Volume 80

Abstract: Non-imaging radar can achieve the detection and localization of moving targets, but it faces difficulties in the classification of targets. Aiming for the application of moving target classification by low/medium resolution non-imaging radar, this paper ... ...

Abstract	Non-imaging radar can achieve the detection and localization of moving targets, but it faces difficulties in the classification of targets. Aiming for the application of moving target classification by low/medium resolution non-imaging radar, this paper proposes a novel feature extraction method, based on the statistical characteristics of echo amplitude with the L-band fully polarimetric radar. A feature plane, composed of the 3rd-order central moment (skewness) and 4th-order central moment (kurtosis) as the statistical characteristics of the echo envelope, is established. In addition, two types of moving targets, pedestrians and non-motorized vehicles, are able to be effectively distinguished according to whether the echo signals of different polarizations have overlapping areas in the feature plane. The L-band fully polarimetric radar has been developed and field experiments have been conducted. The experimental results verify that the kurtosis and skewness of the fully polarimetric echo amplitude of the pedestrians are very close, and there is an overlapping area in the feature plane, while the statistical characteristics of the fully polarimetric echo signal of non-motor vehicles are different, and there is no overlapping area in the feature plane. This proposed feature extraction method has the advantage of being simple and robust, compared to the traditional imaging approach.
Keywords	L-band fully polarimetric radar ; statistical characteristics ; central moment ; target feature extraction ; Science ; Q
Subject code	621
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Targets Research of Non-small Cell Lung Cancer Targeted Therapy

Hongsheng XUE / Shaohua ZHOU / Wanpeng LU / Zhilong ZHAO

Chinese Journal of Lung Cancer, Vol 16, Iss 2, Pp 107-

2013 Volume 113

Keywords	Lung neoplasms ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Oncology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Language	Chinese
Publishing date	2013-02-01T00:00:00Z
Publisher	Chinese Anti-Cancer Association; Chinese Antituberculosis Association
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Eutrophication and lakes dynamic conditions control the endogenous and terrestrial POC observed by remote sensing

Zhilong Zhao / Changchun Huang / Lize Meng / Lingfeng Lu / Yongfang Wu / Rong Fan / Shuaidong Li / Zhengwei Sui / Tao Huang / Chulong Huang / Hao Yang / Limin Zhang

Ecological Indicators, Vol 129, Iss , Pp 107907- (2021)

Modeling and application

2021

Abstract: The sources of particulate organic carbon (POC) determine its conversion, thereby playing an important role in the carbon cycle of lakes. Accurate estimation of the sources and dynamic characteristics of POC is important for understanding the migration ... ...

Abstract	The sources of particulate organic carbon (POC) determine its conversion, thereby playing an important role in the carbon cycle of lakes. Accurate estimation of the sources and dynamic characteristics of POC is important for understanding the migration and transformation of organic carbon. However, the synchronous observation of POC sources with large areas through remote sensing is still challenging because of the complex composition of POC and the optical conditions of inland lakes. In this study, a three-band (1/ Rrs (689)–1/ Rrs (717)) × Rrs (697)) empirical algorithm of POC sources was constructed based on remote sensing reflectance (Rrs(λ)) and the proportion of endogenous POC estimated from the field-measured stable isotope (δ13CPOC) values. The validation and calibration results of the three-band algorithm showed robust performance, with MAPE and RMSE of estimated values and measured values of 10% and 0.07, respectively. The three-band algorithm had good simulation results for the Ocean and Land Color Instrument (OLCI), Moderate Imaging Spectroradiometer (MODIS), Geostationary Ocean Color Imager (GOCI), and Medium Resolution Imaging Spectrometer (MERIS) spectra. The POC sources estimated by the three-band algorithm suggest that the endogenous POC of Taihu Lake in August showed a decreasing trend from 2006 to 2019. The variation in terrestrial POC was slow and stable for both annual and monthly variations. The analysis of POC sources with total phosphorus (TP), total nitrogen (TN), water temperature, and wind speed indicated that terrestrial POC was closely related to wind speed (r = 0.33, P < 0.001), while endogenous POC was significantly associated with TP (r = 0.6, P < 0.001), TN (r = 0.56, P < 0.001), and water temperature (r = 0.49, P < 0.001). The use of remote sensing algorithms to evaluate POC from different sources is convenient and effective; furthermore, it helps to better understand the carbon cycle in lacustrine ecosystems.
Keywords	POC source ; Carbon cycle ; Stable isotope ; Remote sensing ; Ecology ; QH540-549.5
Subject code	551
Language	English
Publishing date	2021-10-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: CRISPR knock out CTLA-4 enhances the anti-tumor activity of cytotoxic T lymphocytes

Shi, Long / Fei Gao / Jianhui Cai / Jinsheng Han / Tongyu Meng / Wei Zhang / Zhilong Zhao

Gene. 2017 Dec. 15, v. 636

2017

Abstract: T cell-mediated anti-tumor immunity plays a pivotal role in cancer immune surveillance. Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) is a protein receptor mainly expressed in activated T cells and regulatory T cells. CTLA-4 competes with CD28 for ...

Abstract	T cell-mediated anti-tumor immunity plays a pivotal role in cancer immune surveillance. Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) is a protein receptor mainly expressed in activated T cells and regulatory T cells. CTLA-4 competes with CD28 for ligand binding and generates inhibitory signals to attenuate T cell activation. The blockade of CTLA-4 mediated immune inhibitory checkpoint has been associated with enhanced anti-tumor immunity. In this study, we use CRISPR-Cas9 system to knock out (KO) CTLA-4 from cytotoxic T lymphocytes (CTLs) and evaluate its effect on the anti-tumor activity of the CTLs. CTLA-4 KO CTLs robustly enhanced tumor cell death by 40% compared to the control and facilitated apoptosis and caspase activities in tumor cells. The knockout of CTLA-4 also increased TNF-α and IFN-γ secretion of the CTLs by approximately 2-fold. The effectiveness of CTLA-4 KO in enhancing anti-tumor activity of the CTLs was verified in vivo using mouse xenograft model. The xenografted mice treated with CTLA-4 KO CTLs demonstrated repressed tumor growth and prolonged survival compared to the control group. Our data suggest that CRISPR targeting CTLA-4 immune checkpoint could significantly improve the anti-tumor activity of CTLs.
Keywords	antineoplastic activity ; apoptosis ; caspases ; cytotoxic T-lymphocytes ; cytotoxicity ; enzyme activity ; genetic engineering ; immunity ; interferon-gamma ; ligands ; mice ; models ; monitoring ; neoplasm cells ; neoplasms ; secretion ; tumor necrosis factor-alpha
Language	English
Dates of publication	2017-1215
Size	p. 36-41.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	391792-7
ISSN	1879-0038 ; 0378-1119
ISSN (online)	1879-0038
ISSN	0378-1119
DOI	10.1016/j.gene.2017.09.010
Database	NAL-Catalogue (AGRICOLA)

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