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Article ; Online: 2D Nano-Mica Sheets Assembled Membranes for High-Efficiency Oil/Water Separation

Yan Bao / Bin Wang / Conghui Du / Qiuhui Shi / Wenlong Xu / Zhining Wang

Nanomaterials, Vol 12, Iss 2895, p

2022 Volume 2895

Abstract: Oil-polluted water has become one of the most important environmental concerns nowadays due to the increasing industrial oily wastewater and frequent oil spill accidents. Herein, a novel two-dimensional (2D) nano-mica sheets assembled composite membrane ... ...

Abstract	Oil-polluted water has become one of the most important environmental concerns nowadays due to the increasing industrial oily wastewater and frequent oil spill accidents. Herein, a novel two-dimensional (2D) nano-mica sheets assembled composite membrane with underwater super-oleophobic properties was developed for effective oil/water separation. A 2D nano-mica sheet was synthesized by a facile solvent-assisted ultrasonic exfoliation and then the obtained 2D nano-mica sheets were co-deposited with dopamine on polyvinylidene fluoride substrate to prepare nano-mica composite membranes (NCM). The NCM is hydrophilic in air and super-oleophobic underwater (the water contact angle in the air is 37.6°, and the oil contact angle in water is 151.4°). Furthermore, the prepared NCM provided outstanding stability in different acid–base environments (pH = 1–11). Noteworthily, the oil removal rate is higher than 99.5% as the sodium dodecyl sulfate SDS-stabilized oil (soya-bean oil, mineral oil and pump oil) -in-water emulsions. Meanwhile, the NCM showed excellent reusability, as the oil removal efficiency kept at 99.0% after ten soya-bean oil-in-water or mineral oil-in-water emulsion filtration cycles. The present work paved a new way for developing a low-cost and environmentally friendly strategy for oily wastewater treatment and developed a high-increment utilization application field for natural minerals.
Keywords	oil/water separation ; emulsions ; nano-mica sheets ; 2D nanomaterial composite membranes ; super-oleophobicity ; Chemistry ; QD1-999
Language	English
Publishing date	2022-08-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Enhanced antifouling and antimicrobial thin film nanocomposite membranes with incorporation of Palygorskite/titanium dioxide hybrid material

Zhang, Tian / Baoyu Gao / Wenbo Wang / Yong Wang / Zhining Wang / Zhiqiang Li

Journal of colloid and interface science. 2019 Mar. 01, v. 537

2019

Abstract: Palygorskite (Pal) is a kind of low-cost and environment-friendly natural nanoclay material with tubular structure and excellent hydrophilicity. TiO2 nanoparticles, especially anatase phase, have prominent photocatalytic bactericidal and organic ... ...

Abstract	Palygorskite (Pal) is a kind of low-cost and environment-friendly natural nanoclay material with tubular structure and excellent hydrophilicity. TiO2 nanoparticles, especially anatase phase, have prominent photocatalytic bactericidal and organic pollutant decomposition activities. In this work, Pal and Pal/TiO2 nanocomposite were successfully embedded in the polyamide (PA) selective layer of the reverse osmosis (RO) membranes via interfacial polymerization. The tubular structure of Pal possesses a cross-sectional area of 0.37 × 0.63 nm2, which facilitates the selective transport of water molecules through PA layers. The water flux of Pal incorporated TFN membrane increases to approximately 40 l·m−2·h−1 at 16 bar, which is 1.6-fold higher than the reference TFC membrane. Meanwhile, the NaCl rejection is maintained at approximately 98%. Although the Pal/TiO2 incorporated TFN membrane exhibited slightly lower flux (1.4-fold higher than TFC), the embedded Pal/TiO2 contributed to the antifouling and photocatalytic bactericidal capacities and the salt rejection maintained at an acceptable level of 98%, which are greatly desired in the membrane desalination and water reclamation processes.
Keywords	desalination ; hydrophilicity ; nanoclays ; nanocomposites ; nanoparticles ; palygorskite ; photocatalysis ; pollutants ; polyamides ; polymerization ; reverse osmosis ; sodium chloride ; thin film composite membranes ; titanium dioxide ; water reuse
Language	English
Dates of publication	2019-0301
Size	p. 1-10.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	241597-5
ISSN	1095-7103 ; 0021-9797
ISSN (online)	1095-7103
ISSN	0021-9797
DOI	10.1016/j.jcis.2018.10.092
Database	NAL-Catalogue (AGRICOLA)

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Article: Cerium oxide doped nanocomposite membranes for reverse osmosis desalination

Wang, Yang / Baoyu Gao / Bo Jin / Qinyan Yue / Shuya Li / Zhining Wang

Chemosphere. 2019 Mar., v. 218

2019

Abstract: Cerium oxide (CeO2) nanoparticles (NPs) have indicated great potentials as nanofiller owing to its high surface area, antioxidant properties and low cost. In this paper, thin film nanocomposite (TFN) RO membranes were proposed to be prepared through ... ...

Abstract	Cerium oxide (CeO2) nanoparticles (NPs) have indicated great potentials as nanofiller owing to its high surface area, antioxidant properties and low cost. In this paper, thin film nanocomposite (TFN) RO membranes were proposed to be prepared through incorporation of hydrophilic CeO2 NPs in polyamide (PA) selective layers via interfacial polymerization (IP). EDX, XPS, SEM, AFM, contact angle and zeta potential were used to examine the property and morphology of the prepared membranes. CeO2 NPs were successfully embedded in the PA network, which endowed the TFN membranes with rougher surfaces and thinner PA layers. The TFN membranes were fabricated with different CeO2 NPs contents (0, 50, 100, 150, 200, 400 mg/L). With increasing CeO2 NPs loading amount, the hydrophilicity improved from 85.4° to 65.7° and the surface charge declined from −19.4 to −34.2 mV. These characteristics contributed to a 50% enhancement in water flux of TFN-CeO2100 membrane (containing 100 mg/L of CeO2 NPs) without compromise the NaCl rejection (98%). Moreover, CeO2 embedded membrane exhibited an enhanced fouling resistance property through preventing the adhesion of hydrophobic foultants. This study demonstrated the desirable applicability of CeO2 NPs in synthesizing novel TFN membranes for desalination application.
Keywords	adhesion ; antioxidant activity ; atomic force microscopy ; ceric oxide ; contact angle ; desalination ; energy-dispersive X-ray analysis ; fouling ; hydrophilicity ; hydrophobicity ; nanocomposites ; nanoparticles ; polyamides ; polymerization ; reverse osmosis ; sodium chloride ; surface area ; X-ray photoelectron spectroscopy ; zeta potential
Language	English
Dates of publication	2019-03
Size	p. 974-983.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2018.11.207
Database	NAL-Catalogue (AGRICOLA)

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Article: Electric field assisted layer-by-layer assembly of graphene oxide containing nanofiltration membrane

Wang, Tao / Jinren Lu / Lili Mao / Zhining Wang

Journal of membrane science. 2016 Oct. 01, v. 515

2016

Abstract: An external electric field (EF) was applied to assist the preparation of graphene oxide (GO) and polyethyleneimine (PEI) layer-by-layer films on hydrolyzed polyacrylonitrile (H-PAN) substrate. The property and structure of the resultant membranes were ... ...

Abstract	An external electric field (EF) was applied to assist the preparation of graphene oxide (GO) and polyethyleneimine (PEI) layer-by-layer films on hydrolyzed polyacrylonitrile (H-PAN) substrate. The property and structure of the resultant membranes were characterized by Fourier transform infrared (FTIR) spectroscopy, scanning electron microscope (SEM), atomic force microscopy (AFM), electrokinetic analyzer and water contact angle goniometer. The effect of assembly conditions (e.g. EF voltage, deposition time, GO concentration and number of PEI/GO bilayers) on nanofiltration (NF) performance of LbL membranes was systematically investigated. The optimized preparation conditions were 5V EF voltage, 3min deposition time, 0.025mg/ml GO, and 2 PEI/GO bilayers. The resultant EF assisted LbL membrane exhibited a flux of 65.6lm−2h−1 and a rejection of 80.9% to 0.5g/l MgCl2 at 0.40MPa. Salts rejection of LbL2.0 membrane followed the sequence of Na2SO4>MgSO4>MgCl2>NaCl, which indicated that the membrane surface was negatively charged with GO as the outmost layer. It was also demonstrated that the EF enabled denser and more ordered pack of PEI and GO layer, resulting in higher stability than the PEI/GO membrane prepared without EF. Our work not only offered an efficient approach for GO based membrane assembly and hereby provided a stable and high performance GO− containing NF membrane, but also paved a new way towards the design of nanomaterials contained membranes.
Keywords	artificial membranes ; atomic force microscopy ; contact angle ; electric field ; electric power ; Fourier transform infrared spectroscopy ; graphene oxide ; hydrolysis ; magnesium chloride ; magnesium sulfate ; nanofiltration ; nanomaterials ; polyacrylonitrile ; polyethyleneimine ; scanning electron microscopes ; scanning electron microscopy ; sodium chloride ; sodium sulfate
Language	English
Dates of publication	2016-1001
Size	p. 125-133.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	194516-6
ISSN	0376-7388
ISSN	0376-7388
DOI	10.1016/j.memsci.2016.05.053
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Bio-Inspired Aquaporinz Containing Double-Skinned Forward Osmosis Membrane Synthesized through Layer-by-Layer Assembly

Shuzheng Wang / Jin Cai / Wande Ding / Zhinan Xu / Zhining Wang

Membranes, Vol 5, Iss 3, Pp 369-

2015 Volume 384

Abstract: We demonstrated a novel AquaporinZ (AqpZ)-incorporated double-skinned forward osmosis (FO) membrane by layer-by-layer (LbL) assembly strategy. Positively charged poly(ethyleneimine) (PEI) and negatively charged poly(sodium 4-styrenesulfonate) (PSS) were ... ...

Abstract	We demonstrated a novel AquaporinZ (AqpZ)-incorporated double-skinned forward osmosis (FO) membrane by layer-by-layer (LbL) assembly strategy. Positively charged poly(ethyleneimine) (PEI) and negatively charged poly(sodium 4-styrenesulfonate) (PSS) were alternately deposited on both the top and bottom surfaces of a hydrolyzed polyacrylonitrile (H-PAN) substrate. Subsequently, an AqpZ-embedded 1,2-dioleloyl-sn-glycero-3-phosphocholine (DOPC)/1,2-dioleoyl-3-trimethylammonium- propane (chloride salt) (DOTAP) supported lipid bilayer (SLB) was formed on PSS-terminated (T-PSS) membrane via vesicle rupture method. The morphology and structure of the biomimetic membranes were characterized by in situ atomic force microscopy (AFM), scanning electron microscope (SEM), Fourier transform infrared spectrometer using the attenuated total reflection technique (ATR-FTIR), and contact angle. Moreover, the FO performance of the resultant membrane was measured by using 2 M MgCl2 solution as draw solution and deionized (DI) water as feed solution, respectively. The membrane with a protein-to-lipid weight ratio (P/L) of 1/50 exhibits 13.2 L/m2h water flux and 3.2 g/m2h reversed flux by using FO mode, as well as 15.6 L/m2h water flux and 3.4 L/m2h reversed flux for PRO mode (the draw solution is placed against the active layer). It was also shown that the SLB layer of the double-skinned FO membrane can increase the surface hydrophilicity and reduce the surface roughness, which leads to an improved anti-fouling performance against humic acid foulant. The current work introduced a new method of fabricating high performance biomimetic FO membrane by combining AqpZ and a double-skinned structure based on LbL assembly.
Keywords	Aquaporinz ; supported lipid bilayer ; layer-by-layer ; double-skinned ; biomimetic membrane ; forward osmosis ; Science (General) ; Q1-390 ; Science ; Q
Subject code	500
Language	English
Publishing date	2015-08-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Analysis of germline-driven ancestry-associated gene expression in cancers

Nyasha Chambwe / Rosalyn W. Sayaman / Donglei Hu / Scott Huntsman / Anab Kemal / Samantha Caesar-Johnson / Jean C. Zenklusen / Elad Ziv / Rameen Beroukhim / Andrew D. Cherniack / Jian Carrot-Zhang / Ashton C. Berger / Seunghun Han / Matthew Meyerson / Jeffrey S. Damrauer / Katherine A. Hoadley / Ina Felau / John A. Demchok / Michael K.A. Mensah /

STAR Protocols, Vol 3, Iss 3, Pp 101586- (2022)

2022

Abstract: Summary: Differential mRNA expression between ancestry groups can be explained by both genetic and environmental factors. We outline a computational workflow to determine the extent to which germline genetic variation explains cancer-specific molecular ... ...

Abstract	Summary: Differential mRNA expression between ancestry groups can be explained by both genetic and environmental factors. We outline a computational workflow to determine the extent to which germline genetic variation explains cancer-specific molecular differences across ancestry groups. Using multi-omics datasets from The Cancer Genome Atlas (TCGA), we enumerate ancestry-informative markers colocalized with cancer-type-specific expression quantitative trait loci (e-QTLs) at ancestry-associated genes. This approach is generalizable to other settings with paired germline genotyping and mRNA expression data for a multi-ethnic cohort.For complete details on the use and execution of this protocol, please refer to Carrot-Zhang et al. (2020), Robertson et al. (2021), and Sayaman et al. (2021). : Publisher’s note: Undertaking any experimental protocol requires adherence to local institutional guidelines for laboratory safety and ethics.
Keywords	Bioinformatics ; Sequence analysis ; Cancer ; Genomics ; RNAseq ; Gene Expression ; Science (General) ; Q1-390
Language	English
Publishing date	2022-09-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Analytical protocol to identify local ancestry-associated molecular features in cancer

Jian Carrot-Zhang / Seunghun Han / Wanding Zhou / Jeffrey S. Damrauer / Anab Kemal / Andrew D. Cherniack / Rameen Beroukhim / Ashton C. Berger / Matthew Meyerson / Katherine A. Hoadley / Ina Felau / Samantha Caesar-Johnson / John A. Demchok / Michael K.A. Mensah / Roy Tarnuzzer / Zhining Wang / Liming Yang / Jean C. Zenklusen / Nyasha Chambwe /

STAR Protocols, Vol 2, Iss 4, Pp 100766- (2021)

2021

Abstract: Summary: People of different ancestries vary in cancer risk and outcome, and their molecular differences may indicate sources of these variations. Determining the “local” ancestry composition at each genetic locus across ancestry-admixed populations can ... ...

Abstract	Summary: People of different ancestries vary in cancer risk and outcome, and their molecular differences may indicate sources of these variations. Determining the “local” ancestry composition at each genetic locus across ancestry-admixed populations can suggest causal associations. We present a protocol to identify local ancestry and detect the associated molecular changes, using data from the Cancer Genome Atlas. This workflow can be applied to cancer cohorts with matched tumor and normal data from admixed patients to examine germline contributions to cancer.For complete details on the use and execution of this protocol, please refer to Carrot-Zhang et al. (2020).
Keywords	Bioinformatics ; Cancer ; Genomics ; Science (General) ; Q1-390
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A double-blind randomized phase I clinical trial targeting ALVAC-HIV vaccine to human dendritic cells.

Michael A Eller / Bonnie M Slike / Josephine H Cox / Emil Lesho / Zhining Wang / Jeffrey R Currier / Janice M Darden / Victoria R Polonis / Maryanne T Vahey / Sheila Peel / Merlin L Robb / Nelson L Michael / Mary A Marovich

PLoS ONE, Vol 6, Iss 9, p e

2011 Volume 24254

Abstract: We conducted a novel pilot study comparing different delivery routes of ALVAC-HIV (vCP205), a canarypox vaccine containing HIV gene inserts: env, gag and pol. We explored the concept that direct ex vivo targeting of human dendritic cells (DC) would ... ...

Abstract	We conducted a novel pilot study comparing different delivery routes of ALVAC-HIV (vCP205), a canarypox vaccine containing HIV gene inserts: env, gag and pol. We explored the concept that direct ex vivo targeting of human dendritic cells (DC) would enhance the immune response compared to either conventional intramuscular or intradermal injections of the vaccine alone.Healthy HIV-1 uninfected volunteers were administered ALVAC-HIV or placebo by intramuscular injection (i.m.), intradermal injection (i.d.) or subcutaneous injection (s.q.) of autologous ex vivo transfected DC at months 0, 1, 3 and 6. All vaccine delivery routes were well tolerated. Binding antibodies were observed to both the ALVAC vector and HIV-1 gp160 proteins. Modest cellular responses were observed in 2/7 individuals in the DC arm and 1/8 in the i.m. arm as determined by IFN-γ ELISPOT. Proliferative responses were most frequent in the DC arm where 4/7 individuals had measurable responses to multiple HIV-1 antigens. Loading DC after maturation resulted in lower gene expression, but overall better responses to both HIV-1 and control antigens, and were associated with better IL-2, TNF-α and IFN-γ production.ALVAC-HIV delivered i.m., i.d. or s.q. with autologous ex vivo transfected DC proved to be safe. The DC arm was most immunogenic. Proliferative immune responses were readily detected with only modest cytotoxic CD8 T cell responses. Loading mature DC with the live viral vaccine induced stronger immune responses than loading immature DC, despite increased transgene expression with the latter approach. Volunteers who received the autologous vaccine loaded mature DC developed a broader and durable immune response compared to those vaccinated by conventional routes.ClinicalTrials.gov NCT00013572.
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2011-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Sequential waves of gene expression in patients with clinically defined dengue illnesses reveal subtle disease phases and predict disease severity.

Peifang Sun / Josefina García / Guillermo Comach / Maryanne T Vahey / Zhining Wang / Brett M Forshey / Amy C Morrison / Gloria Sierra / Isabel Bazan / Claudio Rocha / Stalin Vilcarromero / Patrick J Blair / Thomas W Scott / Daria E Camacho / Christian F Ockenhouse / Eric S Halsey / Tadeusz J Kochel

PLoS Neglected Tropical Diseases, Vol 7, Iss 7, p e

2013 Volume 2298

Abstract: BACKGROUND: Dengue virus (DENV) infection can range in severity from mild dengue fever (DF) to severe dengue hemorrhagic fever (DHF) or dengue shock syndrome (DSS). Changes in host gene expression, temporally through the progression of DENV infection, ... ...

Abstract	BACKGROUND: Dengue virus (DENV) infection can range in severity from mild dengue fever (DF) to severe dengue hemorrhagic fever (DHF) or dengue shock syndrome (DSS). Changes in host gene expression, temporally through the progression of DENV infection, especially during the early days, remains poorly characterized. Early diagnostic markers for DHF are also lacking. METHODOLOGY/PRINCIPAL FINDINGS: In this study, we investigated host gene expression in a cohort of DENV-infected subjects clinically diagnosed as DF (n = 51) and DHF (n = 13) from Maracay, Venezuela. Blood specimens were collected daily from these subjects from enrollment to early defervescence and at one convalescent time-point. Using convalescent expression levels as baseline, two distinct groups of genes were identified: the "early" group, which included genes associated with innate immunity, type I interferon, cytokine-mediated signaling, chemotaxis, and complement activity peaked at day 0-1 and declined on day 3-4; the second "late" group, comprised of genes associated with cell cycle, emerged from day 4 and peaked at day 5-6. The up-regulation of innate immune response genes coincided with the down-regulation of genes associated with viral replication during day 0-3. Furthermore, DHF patients had lower expression of genes associated with antigen processing and presentation, MHC class II receptor, NK and T cell activities, compared to that of DF patients. These results suggested that the innate and adaptive immunity during the early days of the disease are vital in suppressing DENV replication and in affecting outcome of disease severity. Gene signatures of DHF were identified as early as day 1. CONCLUSIONS/SIGNIFICANCE: Our study reveals a broad and dynamic picture of host responses in DENV infected subjects. Host response to DENV infection can now be understood as two distinct phases with unique transcriptional markers. The DHF signatures identified during day 1-3 may have applications in developing early molecular diagnostics for DHF.
Keywords	Arctic medicine. Tropical medicine ; RC955-962 ; Public aspects of medicine ; RA1-1270
Subject code	570
Language	English
Publishing date	2013-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images

Joel Saltz / Rajarsi Gupta / Le Hou / Tahsin Kurc / Pankaj Singh / Vu Nguyen / Dimitris Samaras / Kenneth R. Shroyer / Tianhao Zhao / Rebecca Batiste / John Van Arnam / Ilya Shmulevich / Arvind U.K. Rao / Alexander J. Lazar / Ashish Sharma / Vésteinn Thorsson / Samantha J. Caesar-Johnson / John A. Demchok / Ina Felau /

Melpomeni Kasapi / Martin L. Ferguson / Carolyn M. Hutter / Heidi J. Sofia / Roy Tarnuzzer / Zhining Wang / Liming Yang / Jean C. Zenklusen / Jiashan (Julia) Zhang / Sudha Chudamani / Jia Liu / Laxmi Lolla / Rashi Naresh / Todd Pihl / Qiang Sun / Yunhu Wan / Ye Wu / Juok Cho / Timothy DeFreitas / Scott Frazer / Nils Gehlenborg / Gad Getz / David I. Heiman / Jaegil Kim / Michael S. Lawrence / Pei Lin / Sam Meier / Michael S. Noble / Gordon Saksena / Doug Voet / Hailei Zhang

Cell Reports, Vol 23, Iss 1, Pp 181-193.e

2018 Volume 7

Abstract: Summary: Beyond sample curation and basic pathologic characterization, the digitized H&E-stained images of TCGA samples remain underutilized. To highlight this resource, we present mappings of tumor-infiltrating lymphocytes (TILs) based on H&E images ... ...

Abstract	Summary: Beyond sample curation and basic pathologic characterization, the digitized H&E-stained images of TCGA samples remain underutilized. To highlight this resource, we present mappings of tumor-infiltrating lymphocytes (TILs) based on H&E images from 13 TCGA tumor types. These TIL maps are derived through computational staining using a convolutional neural network trained to classify patches of images. Affinity propagation revealed local spatial structure in TIL patterns and correlation with overall survival. TIL map structural patterns were grouped using standard histopathological parameters. These patterns are enriched in particular T cell subpopulations derived from molecular measures. TIL densities and spatial structure were differentially enriched among tumor types, immune subtypes, and tumor molecular subtypes, implying that spatial infiltrate state could reflect particular tumor cell aberration states. Obtaining spatial lymphocytic patterns linked to the rich genomic characterization of TCGA samples demonstrates one use for the TCGA image archives with insights into the tumor-immune microenvironment. : Tumor-infiltrating lymphocytes (TILs) were identified from standard pathology cancer images by a deep-learning-derived “computational stain” developed by Saltz et al. They processed 5,202 digital images from 13 cancer types. Resulting TIL maps were correlated with TCGA molecular data, relating TIL content to survival, tumor subtypes, and immune profiles. Keywords: digital pathology, immuno-oncology, machine learning, lymphocytes, tumor microenvironment, deep learning, tumor-infiltrating lymphocytes, artificial intelligence, bioinformatics, computer vision
Keywords	Biology (General) ; QH301-705.5
Subject code	006
Language	English
Publishing date	2018-04-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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