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  1. Article ; Online: Wave Aberration Correction for an Unobscured Off-Axis Three-Mirror Astronomical Telescope Using an Aberration Field Compensation Mechanism

    Jinxin Wang / Xu He / Xiaohui Zhang / Mingze Ma / Zhirui Cao

    Applied Sciences, Vol 12, Iss 10716, p

    2022  Volume 10716

    Abstract: Studying how to use the coupling characteristics of net aberration fields induced by different perturbation parameters to realize the wave aberration compensation correction of perturbed telescopes is of great significance for the development of active ... ...

    Abstract Studying how to use the coupling characteristics of net aberration fields induced by different perturbation parameters to realize the wave aberration compensation correction of perturbed telescopes is of great significance for the development of active optics. Based on nodal aberration theory, this paper studies the wave aberration compensation correction method of an unobscured off-axis three-mirror telescope. Specifically, first of all, it theoretically analyzes the coupling effects and compensation relationships of net aberration fields induced by different perturbation parameters of the telescope. Furthermore, it establishes wave aberration correction models with the secondary mirror as the compensator and the third mirror as the compensator for the telescope, respectively. In the end, it verifies the two compensation correction models by simulations. The results show that the tolerance of the secondary mirror compensation correction mode (SMCM) to the perturbation parameter threshold is significantly better than that of the third mirror compensation correction model (TMCM). When the introduced perturbation parameter threshold is small, the correction accuracy of the two models for the wave aberrations is equivalent, and both reach the order of <math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msup><mrow><mn>10</mn></mrow><mrow><mo>−</mo><mn>3</mn></mrow></msup></mrow></semantics></math> λ (RMS, λ = 632.8 nm). When the perturbation parameter threshold is increased, the correction accuracy of SMCM can still be maintained at the order of <math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msup><mrow><mn>10</mn></mrow><mrow><mo>−</mo><mn>3</mn></mrow></msup></mrow></semantics></math> λ but the correction accuracy of TMCM would ...
    Keywords astronomical telescope ; active optics ; nodal aberration theory ; aberration compensation ; misalignments ; figure errors ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
    Subject code 539
    Language English
    Publishing date 2022-10-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: The gut virome

    Zhirui Cao / Naoki Sugimura / Elke Burgermeister / Matthias P. Ebert / Tao Zuo / Ping Lan

    EBioMedicine, Vol 81, Iss , Pp 104113- (2022)

    A new microbiome component in health and disease

    2022  

    Abstract: Summary: The human gastrointestinal tract harbours an abundance of viruses, collectively known as the gut virome. The gut virome is highly heterogeneous across populations and is linked to geography, ethnicity, diet, lifestyle, and urbanisation. The ... ...

    Abstract Summary: The human gastrointestinal tract harbours an abundance of viruses, collectively known as the gut virome. The gut virome is highly heterogeneous across populations and is linked to geography, ethnicity, diet, lifestyle, and urbanisation. The currently known function of the gut virome varies greatly across human populations, and much remains unknown. We review current literature on the human gut virome, and the intricate trans-kingdom interplay among gut viruses, bacteria, and the mammalian host underlying health and diseases. We summarise evidence on the use of the gut virome as diagnostic markers and a therapeutic target. We shed light on novel avenues of microbiome-inspired diagnosis and therapies. We also review pre-clinical and clinical studies on gut virome-rectification-based therapies, including faecal microbiota transplantation, faecal virome transplantation, and refined phage therapy. Our review suggests that future research effort should focus on unravelling the mechanisms exerted by gut viruses/phages in human pathophysiology, and on developing phage-prompted precision therapies.
    Keywords Gut virome ; Microbiome ; Virus ; Phage ; Faecal virome transplantation ; Phage therapy ; Medicine ; R ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2022-07-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Novel Molecular Subtypes Associated With 5mC Methylation and Their Role in Hepatocellular Carcinoma Immunotherapy

    Zhuomao Mo / Zhirui Cao / Shaoju Luo / Yan Chen / Shijun Zhang

    Frontiers in Molecular Biosciences, Vol

    2020  Volume 7

    Abstract: Background5-methylcytosine (5mC) has been reported in the prognosis of a variety of cancers, however, its role in hepatocellular carcinoma (HCC) has not been investigated yet. This study aimed at identifying the molecular subtypes associated with 5mC and ...

    Abstract Background5-methylcytosine (5mC) has been reported in the prognosis of a variety of cancers, however, its role in hepatocellular carcinoma (HCC) has not been investigated yet. This study aimed at identifying the molecular subtypes associated with 5mC and establishing a relevant score to predict its prognosis in HCC.MethodsSomatic gene mutation data and gene expression data were retrieved from The Cancer Genome Atlas database. Molecular subtypes were identified by unsupervised clustering based on the expression of 5mC regulators, and the molecular features of each subtype were investigated by survival, mutation, gene set variation, and immune cell infiltration analyses. Next, we performed a differentially expressed analysis based on the new subtypes and selected the overlapping genes for further analysis. We undertook univariate Cox analysis to analyze these genes and constructed a prognostic model by lasso regression analysis. Meanwhile, survival and gene set enrichment analyses were used to explore the prognosis and the relevant pathways, respectively. The LIRI cohort from the International Cancer Genome Consortium database was used as a reference to validate the 5mC subtypes and 5mC score.ResultsTwenty-one types of 5mC regulators were employed in this study, and three 5mC-associated molecular subtypes were identified. These three subtypes presented significant differences in prognosis, immune cell infiltration, immune checkpoint inhibitors, signaling pathways, and mutational features. Compared with cluster 3, cluster 2 exhibited significantly increased expression of PD-L1, TIM3, Galectin9, CTLA4, and CD80, while PD-L1, TIM3, and CD80 were higher in cluster 2 than in cluster 1. Furthermore, a 5mC-related score, composed of seven genes (SGPP2, SALL4, B3GNT7, ROR1, MYBL2, SLC7A1, and CAND2), was proven to be significantly associated with prognosis. The established subtypes and scores were thus successfully verified by the validated cohort.ConclusionTo the best of our knowledge, this is the first study to identify ...
    Keywords hepatocellular carcinoma ; molecular subtype ; score ; immunotherapy ; 5mC methylation ; Biology (General) ; QH301-705.5
    Subject code 616
    Language English
    Publishing date 2020-10-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: An Integrative Analysis Reveals the Potential Mechanism between Herbal Medicine Yinchen and Immunoregulation in Hepatocellular Carcinoma

    Zhuomao Mo / Zhirui Cao / Ling Yu / Yongdan Wang / Pan Li / Youwu Lin / Shijun Zhang

    BioMed Research International, Vol

    2020  Volume 2020

    Abstract: Aims. Abundant evidences in traditional Chinese medicine (TCM) supported the therapeutic value of herbal medicine Yinchen in hepatocellular carcinoma (HCC), but the underlying mechanism remains to be investigated. Main Methods. The intersection of immune ...

    Abstract Aims. Abundant evidences in traditional Chinese medicine (TCM) supported the therapeutic value of herbal medicine Yinchen in hepatocellular carcinoma (HCC), but the underlying mechanism remains to be investigated. Main Methods. The intersection of immune gene set, module genes, HCC-associated genes, and target genes of Yinchen was employed for further analyses. The module genes were identified by weighted gene coexpression network analysis, and the other three gene sets were obtained from public databases. Subsequently, we further explored the clinical value and immunoregulation of the hub gene of intersection. The relevant pathways related to hub gene expression were investigated by gene set enrichment analysis. Finally, the interaction of active compounds and target genes was validated by molecular docking. Key Findings. Thirteen active compounds and 90 target genes of Yinchen were included. After constructing the network among Yinchen, target genes, and HCC, BIRC5 was identified as the hub gene. Significant difference was found between the high-expressed group and the low-expressed group in survival and stage. Different immune subtypes also presented significant difference in BIRC5 expression. Moreover, NK cell and T cell (CD4+ effector memory and CD4+ memory resting) were negatively correlated with BIRC5 expression, while CTLA4 and LAG3 were positively correlated. The results of molecular docking further validated a good binding activity of quercetin-BIRC5 interaction. Significance. In summary, our research identified for the first time a novel underlying association among herbal medicine Yinchen, BIRC5, immunotherapy, and HCC. We speculated that Yinchen may target the immune checkpoints (CTLA4 and LAG3) and activate the immune cells by suppressing BIRC5.
    Keywords Medicine ; R
    Subject code 570
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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