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  1. Article: Identifying the link between serum VEGF and KL-6 concentrations: a correlation analysis for idiopathic pulmonary fibrosis interstitial lung disease progression.

    Zhong, Bin / Luo, Shuixiang

    Frontiers in medicine

    2023  Volume 10, Page(s) 1282757

    Abstract: Background: Idiopathic pulmonary fibrosis interstitial lung disease (IPF-ILD) is a progressive lung disease characterized by excessive collagen deposition and fibrotic changes in the lungs. Identifying reliable serum markers that correlate with disease ... ...

    Abstract Background: Idiopathic pulmonary fibrosis interstitial lung disease (IPF-ILD) is a progressive lung disease characterized by excessive collagen deposition and fibrotic changes in the lungs. Identifying reliable serum markers that correlate with disease progression is crucial for diagnosis and prognosis.
    Objective: This study aimed to explore the association between serum markers KL-6 and VEGF and IPF-ILD. Specifically, it assessed their correlation with PaO2, a measure of pulmonary gas function, to provide diagnostic and prognostic indicators.
    Methods: Patients with IPF-ILD were included, and their serum levels of KL-6 and VEGF were measured. Correlations with fibrotic damage and PaO2 were analyzed using statistical methods.
    Results: The analysis confirmed a positive correlation between the serum marker KL-6 and the degree of fibrotic damage in IPF-ILD. On the other hand, the serum marker VEGF was found to promote disease progression. In terms of correlation with PaO2, both KL-6 and VEGF demonstrated high sensitivity and specificity. Specifically, the correlation between KL-6 and PaO2 suggests that it can be used as a reliable indicator to assess the status of pulmonary oxygenation function in patients with ILD. The correlation between VEGF and PaO2 helps to understand its role in the progression of IPF-ILD and provides an important basis for predicting patient prognosis.
    Conclusion: This study confirmed the correlation between KL-6 and VEGF with IPF-ILD and their association with PaO2. KL-6 and VEGF demonstrated high specificity and sensitivity in diagnosing, monitoring, and predicting prognosis in IPF-ILD. These findings contribute to our understanding of the disease and have clinical implications for diagnosis and prognostication.
    Language English
    Publishing date 2023-12-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2023.1282757
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Making "Joy Pie" to Stay Joyful: Self-Care Interventions Alleviate College Students' Mental Health Challenges.

    Zhong, Bu / Xie, Lola

    International journal of environmental research and public health

    2023  Volume 20, Issue 5

    Abstract: As more college students are facing mental health challenges, it is imperative to explore innovative ways of improving their mental health, including developing self-care interventions that help mitigate their stressors. Based on the Response Styles ... ...

    Abstract As more college students are facing mental health challenges, it is imperative to explore innovative ways of improving their mental health, including developing self-care interventions that help mitigate their stressors. Based on the Response Styles Theory and self-care conceptions, this study creates the "Joy Pie" project that consists of five self-care strategies, aiming to regulate negative emotions and increase self-care efficacy. Using an experimental design and two-wave data collected from a representative sample of Beijing college students (
    MeSH term(s) Humans ; COVID-19 ; Mental Health ; Pandemics ; Self Care ; Students
    Language English
    Publishing date 2023-02-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph20053823
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  3. Article ; Online: A stretchable cardiac ultrasound imager: a milestone in wearable bioimaging.

    Zhong, Bowen / Wang, Lili

    Science bulletin

    2023  Volume 68, Issue 9, Page(s) 868–870

    MeSH term(s) Wearable Electronic Devices ; Electrodes
    Language English
    Publishing date 2023-04-05
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2816140-3
    ISSN 2095-9281 ; 2095-9273
    ISSN (online) 2095-9281
    ISSN 2095-9273
    DOI 10.1016/j.scib.2023.04.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: SliceLRF: A Local Reference Frame Sliced along the Height on the 3D Surface.

    Zhong, Bin / Li, Dong

    Sensors (Basel, Switzerland)

    2023  Volume 23, Issue 7

    Abstract: The local reference frame (LRF) plays a vital role in local 3D shape description and matching. Numerous LRF methods have been proposed in recent decades. However, few LRFs can achieve a balance between repeatability and robustness under exposure to a ... ...

    Abstract The local reference frame (LRF) plays a vital role in local 3D shape description and matching. Numerous LRF methods have been proposed in recent decades. However, few LRFs can achieve a balance between repeatability and robustness under exposure to a variety of nuisances, including Gaussian noise, mesh resolution variation, clutter, and occlusion. Additionally, most LRFs are heuristic and lack generalizability to different applications and data modalities. In this paper, we first define the degree of distinction to describe the distribution of 2D point clouds and explore the relationship between the relative deviation of the distinction degree and the LRF error through experiments. Based on Gaussian noise and a random sampling analysis, several factors that affect the relative deviation of the distinction degree and result in the LRF error are identified. A scoring criterion is proposed to evaluate the robustness of the point cloud distribution. On this basis, we propose an LRF method (SliceLRF) based on slicing along the Z-axis, which selects the most robust adjacent slices in the point cloud region by scoring criteria for X-axis estimation to improve the repeatability and robustness. SliceLRF is rigorously tested on four public benchmark datasets which have different applications and involve different data modalities. It is also compared with the state-of-the-art LRFs. The experimental results show that the SliceLRF has more comprehensive repeatability and robustness than the other LRFs under exposure to Gaussian noise and random sampling.
    Language English
    Publishing date 2023-03-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s23073483
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Cell segmentation in fluorescence microscopy images based on multi-scale histogram thresholding.

    Fang, Yating / Zhong, Baojiang

    Mathematical biosciences and engineering : MBE

    2023  Volume 20, Issue 9, Page(s) 16259–16278

    Abstract: Cell segmentation from fluorescent microscopy images plays an important role in various applications, such as disease mechanism assessment and drug discovery research. Exiting segmentation methods often adopt image binarization as the first step, through ...

    Abstract Cell segmentation from fluorescent microscopy images plays an important role in various applications, such as disease mechanism assessment and drug discovery research. Exiting segmentation methods often adopt image binarization as the first step, through which the foreground cell is separated from the background so that the subsequent processing steps can be greatly facilitated. To pursue this goal, a histogram thresholding can be performed on the input image, which first applies a Gaussian smoothing to suppress the jaggedness of the histogram curve and then exploits Rosin's method to determine a threshold for conducting image binarization. However, an inappropriate amount of smoothing could lead to the inaccurate segmentation of cells. To address this crucial problem, a multi-scale histogram thresholding (MHT) technique is proposed in the present paper, where the scale refers to the standard deviation of the Gaussian that determines the amount of smoothing. To be specific, the image histogram is smoothed at three chosen scales first, and then the smoothed histogram curves are fused to conduct image binarization via thresholding. To further improve the segmentation accuracy and overcome the difficulty of extracting overlapping cells, our proposed MHT technique is incorporated into a multi-scale cell segmentation framework, in which a region-based ellipse fitting technique is adopted to identify overlapping cells. Extensive experimental results obtained on benchmark datasets show that the new method can deliver superior performance compared to the current state-of-the-arts.
    Language English
    Publishing date 2023-08-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2265126-3
    ISSN 1551-0018 ; 1551-0018
    ISSN (online) 1551-0018
    ISSN 1551-0018
    DOI 10.3934/mbe.2023726
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Effects of reverse engineering pedagogy on students' learning performance in STEM education: The bridge-design project as an example.

    Zhong, Baichang / Liu, Xiaofan / Li, Xinwei

    Heliyon

    2024  Volume 10, Issue 2, Page(s) e24278

    Abstract: In K-12 STEM education, engineering design is emphasized, as demonstrated by the bridge-design project. Due to the iterative nature of engineering design, engineering practice is frequently complicated and requires pedagogical guidance. As an emerging ... ...

    Abstract In K-12 STEM education, engineering design is emphasized, as demonstrated by the bridge-design project. Due to the iterative nature of engineering design, engineering practice is frequently complicated and requires pedagogical guidance. As an emerging pedagogy in STEM education, REP (Reverse Engineering Pedagogy) is showing, but not enough, some benefits in several cases. This paper aims to explore the effects of REP in a bridge-design course. A comparison experiment, REP versus PBL (Project-Based Learning), was conducted by randomly forming two groups of fourth-grade students from a primary school in China. Results indicated that REP was more advantageous than PBL in terms of decreasing students' cognitive load, boosting their scientific knowledge level and engineering design skills. However, REP and PBL have the same effect on the students' learning attitude and engagement. The key findings, possible reasons, and suggestions for practice are also discussed.
    Language English
    Publishing date 2024-01-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e24278
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Conference proceedings ; Online: Estimation of terrestrial water storage changes from the combination of GNSS and GRACE/GFO in the Yangtze River Basin of China

    Li, X. / Zhong, B. / Jiancheng, L.

    XXVIII General Assembly of the International Union of Geodesy and Geophysics (IUGG)

    2023  

    Abstract: In terms of inferring the terrestrial water storage (TWS) changes, the Global Navigation Satellite System (GNSS) and Gravity Recovery and Climate Experiment (GRACE) and GRACE Follow-On (GFO) observations have complementary advantages in spatio-temporal ... ...

    Abstract In terms of inferring the terrestrial water storage (TWS) changes, the Global Navigation Satellite System (GNSS) and Gravity Recovery and Climate Experiment (GRACE) and GRACE Follow-On (GFO) observations have complementary advantages in spatio-temporal resolution, spatial coverage and spectrum sensitivity. We present a joint inversion strategy to infer TWS changes by simultaneously inverting GNSS vertical displacements and GRACE/GFO mass concentration (mascon) solutions in the Yangtze River Basin of China, for the period of January 2011 to December 2020. The GRACE/GFO-derived empirical covariance function is used as the regularization constraint matrix, and no external constraint information has been introduced to the joint inversion model. The performance of the joint inversion strategy is validated through the closed-loop simulation and external hydrological and meteorological data. The closed‐loop simulation study shows that the joint inversion results have higher accuracy and reliability than those of GNSS- or GRACE/GFO-only estimates and present more spatial detail than the traditional Laplacian matrix-based joint solutions. The estimated results of measured data demonstrate that the spatio-temporal distribution of TWS changes derived from GNSS and GRACE/GFO are generally in good agreement, but evident differences in the local scope can be observed due to the respective features of the two technologies. The joint inversion results can fully utilize the complementary advantages of GNSS and GRACE/GFO observations, which presents better agreements with hydrological and meteorological data compared to the GNSS- and GRACE/GFO-only estimates. Additionally, the joint solutions-based scale factors can be well used for signal attenuation and leakage correction of GRACE/GFO results.
    Subject code 550
    Language English
    Publishing country de
    Document type Conference proceedings ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Preserving credibility of open access journals.

    Zhong, Baichang / Liu, Xiaofan

    Science (New York, N.Y.)

    2022  Volume 378, Issue 6617, Page(s) 257

    Language English
    Publishing date 2022-10-20
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.ade8966
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  9. Article ; Online: Regulation and function of the cGAS-MITA/STING axis in health and disease.

    Zhang, Zhi-Dong / Zhong, Bo

    Cell insight

    2022  Volume 1, Issue 1, Page(s) 100001

    Abstract: The innate immune systems detect pathogens via pattern-recognition receptors including nucleic acid sensors and non-nucleic acid sensors. Cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase (cGAS, also known as MB21D1) is a cytosolic ... ...

    Abstract The innate immune systems detect pathogens via pattern-recognition receptors including nucleic acid sensors and non-nucleic acid sensors. Cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase (cGAS, also known as MB21D1) is a cytosolic DNA sensor that recognizes double-stranded DNA (dsDNA) and catalyzes the synthesis of 2',3'-cGAMP. Subsequently, 2',3'-cGAMP binds to the adaptor protein mediator of IRF3 activation (MITA, also known as STING, MPYS, ERIS, and TMEM173) to activate downstream signaling cascades. The cGAS-MITA/STING signaling critically mediates immune responses against DNA viruses, retroviruses, bacteria, and protozoan parasites. In addition, recent discoveries have extended our understanding of the roles of the cGAS-MITA/STING pathway in autoimmune diseases and cancers. Here, we summarize the identification and activation of cGAS and MITA/STING, present the updated functions and regulatory mechanisms of cGAS-MITA/STING signaling and provide a comprehensive understanding of the cGAS-MITA/STING axis in autoimmune diseases and cancers.
    Language English
    Publishing date 2022-01-05
    Publishing country Netherlands
    Document type Journal Article ; Review
    ISSN 2772-8927
    ISSN (online) 2772-8927
    DOI 10.1016/j.cellin.2021.100001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: MITA/STING-mediated antiviral immunity and autoimmunity: the evolution, mechanism, and intervention.

    Zhong, Bo / Shu, Hong-Bing

    Current opinion in immunology

    2022  Volume 78, Page(s) 102248

    Abstract: Mediator of IRF3 activation (MITA, also known as stimulator of interferon genes (STING) and endoplasmic reticulum interferon stimulator (ERIS)) is an ER-associated protein that senses cellular and bacterium-derived cyclic dinucleotide (CDN), leading to ... ...

    Abstract Mediator of IRF3 activation (MITA, also known as stimulator of interferon genes (STING) and endoplasmic reticulum interferon stimulator (ERIS)) is an ER-associated protein that senses cellular and bacterium-derived cyclic dinucleotide (CDN), leading to induction of type-I interferons (IFNs) and innate immune responses against viruses and bacteria. Recently, it has become clear that sensing of CDN and induction of autophagy are two evolutionarily conserved functions of MITA, predating its role in mediating type-I IFN induction. Studies have shown that MITA-mediated signaling promotes a number of autoimmune disorders caused by gene mutations in human. Here, we summarize the most recent progress on MITA-mediated signaling in a view of evolution and highlight the roles of MITA in human inflammatory disorders caused by gene mutations and in genetically modified mouse models. We also briefly introduce the chemicals targeting MITA and discuss their potential in treatment of MITA-mediated inflammatory diseases. Finally, we propose several key questions that should be addressed for targeting MITA for treatment of related autoimmune diseases.
    MeSH term(s) Animals ; Humans ; Mice ; Autoimmune Diseases/immunology ; Autoimmune Diseases/metabolism ; Autoimmunity ; Immunity, Innate ; Interferon Type I ; Membrane Proteins/immunology ; Membrane Proteins/metabolism ; Virus Diseases/immunology ; Virus Diseases/metabolism
    Chemical Substances Interferon Type I ; Membrane Proteins ; STING1 protein, human
    Language English
    Publishing date 2022-09-30
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1035767-1
    ISSN 1879-0372 ; 0952-7915
    ISSN (online) 1879-0372
    ISSN 0952-7915
    DOI 10.1016/j.coi.2022.102248
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