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Article: Identifying the link between serum VEGF and KL-6 concentrations: a correlation analysis for idiopathic pulmonary fibrosis interstitial lung disease progression.

Zhong, Bin / Luo, Shuixiang

2023 Volume 10, Page(s) 1282757

Abstract: Background: Idiopathic pulmonary fibrosis interstitial lung disease (IPF-ILD) is a progressive lung disease characterized by excessive collagen deposition and fibrotic changes in the lungs. Identifying reliable serum markers that correlate with disease ... ...

Abstract	Background: Idiopathic pulmonary fibrosis interstitial lung disease (IPF-ILD) is a progressive lung disease characterized by excessive collagen deposition and fibrotic changes in the lungs. Identifying reliable serum markers that correlate with disease progression is crucial for diagnosis and prognosis. Objective: This study aimed to explore the association between serum markers KL-6 and VEGF and IPF-ILD. Specifically, it assessed their correlation with PaO2, a measure of pulmonary gas function, to provide diagnostic and prognostic indicators. Methods: Patients with IPF-ILD were included, and their serum levels of KL-6 and VEGF were measured. Correlations with fibrotic damage and PaO2 were analyzed using statistical methods. Results: The analysis confirmed a positive correlation between the serum marker KL-6 and the degree of fibrotic damage in IPF-ILD. On the other hand, the serum marker VEGF was found to promote disease progression. In terms of correlation with PaO2, both KL-6 and VEGF demonstrated high sensitivity and specificity. Specifically, the correlation between KL-6 and PaO2 suggests that it can be used as a reliable indicator to assess the status of pulmonary oxygenation function in patients with ILD. The correlation between VEGF and PaO2 helps to understand its role in the progression of IPF-ILD and provides an important basis for predicting patient prognosis. Conclusion: This study confirmed the correlation between KL-6 and VEGF with IPF-ILD and their association with PaO2. KL-6 and VEGF demonstrated high specificity and sensitivity in diagnosing, monitoring, and predicting prognosis in IPF-ILD. These findings contribute to our understanding of the disease and have clinical implications for diagnosis and prognostication.
Language	English
Publishing date	2023-12-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2023.1282757
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Article ; Online: SliceLRF: A Local Reference Frame Sliced along the Height on the 3D Surface.

Zhong, Bin / Li, Dong

Sensors (Basel, Switzerland)

2023 Volume 23, Issue 7

Abstract: The local reference frame (LRF) plays a vital role in local 3D shape description and matching. Numerous LRF methods have been proposed in recent decades. However, few LRFs can achieve a balance between repeatability and robustness under exposure to a ... ...

Abstract	The local reference frame (LRF) plays a vital role in local 3D shape description and matching. Numerous LRF methods have been proposed in recent decades. However, few LRFs can achieve a balance between repeatability and robustness under exposure to a variety of nuisances, including Gaussian noise, mesh resolution variation, clutter, and occlusion. Additionally, most LRFs are heuristic and lack generalizability to different applications and data modalities. In this paper, we first define the degree of distinction to describe the distribution of 2D point clouds and explore the relationship between the relative deviation of the distinction degree and the LRF error through experiments. Based on Gaussian noise and a random sampling analysis, several factors that affect the relative deviation of the distinction degree and result in the LRF error are identified. A scoring criterion is proposed to evaluate the robustness of the point cloud distribution. On this basis, we propose an LRF method (SliceLRF) based on slicing along the Z-axis, which selects the most robust adjacent slices in the point cloud region by scoring criteria for X-axis estimation to improve the repeatability and robustness. SliceLRF is rigorously tested on four public benchmark datasets which have different applications and involve different data modalities. It is also compared with the state-of-the-art LRFs. The experimental results show that the SliceLRF has more comprehensive repeatability and robustness than the other LRFs under exposure to Gaussian noise and random sampling.
Language	English
Publishing date	2023-03-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s23073483
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Article ; Online: Bariatric Arterial Embolization for Overweight Patients: A New Exploration for Ideal Patients?

Zhong, Bin-Yan

Cardiovascular and interventional radiology

2019 Volume 42, Issue 7, Page(s) 1048–1049

MeSH term(s)	Bariatrics ; Embolization, Therapeutic ; Humans ; Overweight ; Stomach
Language	English
Publishing date	2019-03-27
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	603082-8
ISSN	1432-086X ; 0342-7196 ; 0174-1551
ISSN (online)	1432-086X
ISSN	0342-7196 ; 0174-1551
DOI	10.1007/s00270-019-02210-z
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Article ; Online: A Method to Develop the Driver-Adaptive Lane-Keeping Assistance System Based on Real Driver Preferences.

Chen, Jiachen / Chen, Hui / Lan, Xiaoming / Zhong, Bin / Ran, Wei

Sensors (Basel, Switzerland)

2024 Volume 24, Issue 5

Abstract: To satisfy the preference of each driver, the development of a Lane-Keeping Assistance (LKA) system that can adapt to individual drivers has become a research hotspot in recent years. However, existing studies have mostly relied on the assumption that ... ...

Abstract	To satisfy the preference of each driver, the development of a Lane-Keeping Assistance (LKA) system that can adapt to individual drivers has become a research hotspot in recent years. However, existing studies have mostly relied on the assumption that the LKA characteristic aligned with the driver's preference is consistent with this driver's naturalistic driving characteristic. Nevertheless, this assumption may not always hold true, causing limitations to the effectiveness of this method. This paper proposes a novel method for a Driver-Adaptive Lane-Keeping Assistance (DALKA) system based on drivers' real preferences. First, metrics are extracted from collected naturalistic driving data using action point theory to describe drivers' naturalistic driving characteristics. Then, the subjective and objective evaluation method is introduced to obtain the real preference of each test driver for the LKA system. Finally, machine learning methods are employed to train a model that relates naturalistic driving characteristics to the drivers' real preferences, and the model-predicted preferences are integrated into the DALKA system. The developed DALKA system is then subjectively evaluated by the drivers. The results show that our DALKA system, developed using this method, can enhance or maintain the subjective evaluations of the LKA system for most drivers.
Language	English
Publishing date	2024-03-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s24051666
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Article: Developing a fast and catalyst-free protocol to form C=N double bond with high functional group tolerance.

Zhong, Bin / Chen, Feng / Ge, Yushu / Liu, Dan

Royal Society open science

2023 Volume 10, Issue 10, Page(s) 231263

Abstract: The carbon-nitrogen double bond (C=N) is a fundamentally important functional group in organic chemistry. This is largely due to the fact that C=N acts as electrophilic synthon to give nitrogen-containing compounds. Here, we report the condensation of ... ...

Abstract	The carbon-nitrogen double bond (C=N) is a fundamentally important functional group in organic chemistry. This is largely due to the fact that C=N acts as electrophilic synthon to give nitrogen-containing compounds. Here, we report the condensation of primary amine or hydrazine with very electron-deficient aldehyde to form C=N bond in the absence of any catalysts (metals and acids). The protocol performs at room temperature and applies water as co-solvent. Two hundred examples are presented here. With its intrinsic advantages of wide substrate scopes, excellent efficiency (high yields and short reaction time), operational simplicity, mild condition (room temperature as reaction temperature, no catalysts, no additions, water as co-solvent and opening to air) and available starting materials, the protocol can be compatible with various drugs, prodrugs, dyes and pharmacophores containing primary amino group. In addition, we also successfully apply this protocol to rapidly synthesize the core scaffolds of bioactive molecules.
Language	English
Publishing date	2023-10-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2787755-3
ISSN	2054-5703
ISSN	2054-5703
DOI	10.1098/rsos.231263
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Article: Structural credit risk model driven by Lévy process under knight uncertainty.

Tang, Zhenyu / Zhong, Bin / Zhou, Liang / Shen, Chuanhe

Annals of operations research

2023 , Page(s) 1–14

Abstract: As per the projections of conventional credit risk structured model, the risky asset values tend to adhere to the geometric Brownian motion. On the contrary, the risky asset values remain a non-continuous and dynamic ones and jump based on the conditions. ...

Abstract	As per the projections of conventional credit risk structured model, the risky asset values tend to adhere to the geometric Brownian motion. On the contrary, the risky asset values remain a non-continuous and dynamic ones and jump based on the conditions. Is not possible to measure the real Knight Uncertainty risks in financial markets with the help of a single probability measure. In this background, the current research work analyzes a structural credit risk model that belongs to Levy market under Knight Uncertainty. With the help of Lévy-Laplace exponent, the authors developed a dynamic pricing model in this study and acquired the price intervals for default probability, stock value and the bond value of enterprise. To be specific, the study intended to establish explicit solutions for three value processes, discussed earlier, with an assumption that the jump process follows a log-normal distribution. At the end, the study also conducted numerical analysis to understand the crucial role played by Knight Uncertainty upon the pricing of default probability and the stock value of the enterprise.
Language	English
Publishing date	2023-05-03
Publishing country	United States
Document type	Journal Article
ISSN	0254-5330
ISSN	0254-5330
DOI	10.1007/s10479-023-05309-2
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Article ; Online: Global scientific trends in continuous renal replacement therapy from 2000 to 2023: A bibliometric and visual analysis.

Tao, ZhongBin / Feng, YanDong / Wang, Jie / Zhou, YongKang / Yang, JunQiang

Blood purification

2024

Abstract: Introduction: Continuous renal replacement therapy (CRRT) is one of the most widely used blood purification and organ support methods in the ICU. However, the development process, the current status, hotspots, and future trends of CRRT remain unclear.!## ...

Abstract	Introduction: Continuous renal replacement therapy (CRRT) is one of the most widely used blood purification and organ support methods in the ICU. However, the development process, the current status, hotspots, and future trends of CRRT remain unclear. Method: The WoSCC database was used to analyze CRRT research evolution and theme trends. VOSviewer was used to construct co-authorship, co-occurrence, co-citation, and network visualizations. Citespace is used to detect bursts for co-occurrence items. Several important subtopics were reviewed and discussed in more detail. Results: Global publications increased from 56 in 2000 to 398 in 2023, a 710.71% increase. Blood Purification published the most manuscripts, followed by International Journal of Artificial Organs. The United States, the San Bortolo Hospital, and Bellomo, R were the most productive and impactful institution, country, and author respectively. Based on co-occurrence cluster analysis, five clusters emerged: (1) Clinical applications and management of CRRT; (2) Sepsis and CRRT; (3) CRRT anticoagulant management; (4) CRRT and antibiotic pharmacokinetics and pharmacodynamics; and (5) Comparison of CRRT and intermittent hemodialysis. COVID-19, initiation, ECOMO, cefepime, guidelines, cardiogenic shock, biomarker and outcome were the latest high-frequency keywords or strongest bursts, indicating the emerging frontiers of CRRT. Conclusions: There has been widespread publication and citation of CRRT research in the past two decades. We provide an overview of current trends, global collaboration patterns, basic knowledge, research hotspots, and emerging frontiers.
Language	English
Publishing date	2024-02-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	605548-5
ISSN	1421-9735 ; 0253-5068
ISSN (online)	1421-9735
ISSN	0253-5068
DOI	10.1159/000536312
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Article ; Online: Molecular mechanisms of selenite reduction by Lactiplantibacillus plantarum BSe: An integrated genomic and transcriptomic analysis.

Zhong, Bin / Xu, Weijun / Gong, Ming / Xian, Wei / Xie, Hanyi / Wu, Zhenqiang

Journal of hazardous materials

2024 Volume 468, Page(s) 133850

Abstract: The reduction of selenite [Se(Ⅳ)] by microorganisms is a green and efficient detoxification strategy. We found that Se(Ⅳ) inhibited exopolysaccharide and protein secretion by Lactiplantibacillus plantarum BSe and compromised cell integrity. In this study, ...

Abstract	The reduction of selenite [Se(Ⅳ)] by microorganisms is a green and efficient detoxification strategy. We found that Se(Ⅳ) inhibited exopolysaccharide and protein secretion by Lactiplantibacillus plantarum BSe and compromised cell integrity. In this study, L. plantarum BSe reduced Se(Ⅳ) by increasing related enzyme activity and electron transfer. Genomic analysis demonstrated that L. plantarum BSe should be able to reduce Se(Ⅳ). Further transcriptome analysis showed that L. plantarum BSe enhanced its tolerance to Se(Ⅳ) by upregulating the expression of surface proteins and transporters, thus reducing the extracellular Se(Ⅳ) concentration through related enzymatic reactions and siderophore-mediated pathways. Lactiplantibacillus plantarum BSe was able to regulate the expression of related genes involved in quorum sensing and a two-component system and then select appropriate strategies for Se(Ⅳ) transformation in response to varying environmental Se(Ⅳ) concentrations. In addition, azo reductase was linked to the reduction of Se(Ⅳ) for the first time. The present study established a multipath model for the reduction of Se(Ⅳ) by L. plantarum, providing new insights into the biological reduction of Se(Ⅳ) and the biogeochemical cycle of selenium.
MeSH term(s)	Selenious Acid/metabolism ; Oxidation-Reduction ; Genomics ; Selenium/metabolism ; Electron Transport
Chemical Substances	Selenious Acid (F6A27P4Q4R) ; Selenium (H6241UJ22B)
Language	English
Publishing date	2024-02-20
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1491302-1
ISSN	1873-3336 ; 0304-3894
ISSN (online)	1873-3336
ISSN	0304-3894
DOI	10.1016/j.jhazmat.2024.133850
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Article ; Online: Phillyrin improves myocardial remodeling in salt-sensitive hypertensive mice by reducing endothelin1 signaling.

Luo, Qingman / Liu, Qiao / Tang, Kecheng / Zhong, Bin / Yang, Shengqian / Li, Xiaohui

The Journal of pharmacy and pharmacology

2024

Abstract: Objectives: Prolonged exposure to chronic hypertension places the heart under excessive strain, resulting in myocardial remodeling. Phillyrin, derived from the natural plant Forsythia suspensa, has been found to possess cardioprotective properties. The ... ...

Abstract	Objectives: Prolonged exposure to chronic hypertension places the heart under excessive strain, resulting in myocardial remodeling. Phillyrin, derived from the natural plant Forsythia suspensa, has been found to possess cardioprotective properties. The objective of this study is to investigate the role and mechanism of phillyrin in hypertension-induced myocardial remodeling in mice. Methods: We constructed a mouse model of salt-sensitive hypertension. The mice were treated with varying doses of phillyrin, and their blood pressure, cardiac function, cardiac hypertrophy, fibrosis, inflammation, and other conditions were assessed. Key findings: Our research findings demonstrated that phillyrin has the potential to lower blood pressure, enhance cardiac function, and mitigate cardiac hypertrophy, fibrosis, and inflammatory responses in deoxycorticosterone acetate-salt hypertension mice. In hypertensive mice, there was an elevated expression of endothelin1 (ET-1) in heart tissue, which can be reduced by phillyrin. Additionally, phillyrin effectively reduced the hypertrophy of H9c2 cells induced by ET-1 stimulation. Conclusions: Our research highlights the therapeutic capabilities of phillyrin in the treatment of myocardial remodeling through the reduction of ET-1 signaling. These results contribute to the advancement of novel applications for phillyrin and establish a solid conceptual basis for future investigations in this area.
Language	English
Publishing date	2024-03-06
Publishing country	England
Document type	Journal Article
ZDB-ID	3107-0
ISSN	2042-7158 ; 0022-3573 ; 0373-1022
ISSN (online)	2042-7158
ISSN	0022-3573 ; 0373-1022
DOI	10.1093/jpp/rgae018
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Article ; Online: Enhancing synthesis of ethyl lactate in rice baijiu fermentation by adding recovered granular cells.

Du, Shoujie / Yao, Liucui / Zhong, Bin / Qin, Junwei / He, Songgui / Liu, Youqiang / Wu, Zhenqiang

Journal of bioscience and bioengineering

2024 Volume 137, Issue 5, Page(s) 388–395

Abstract: Ethyl lactate is the most abundant ester in semi-solid rice baijiu fermentation, affecting the flavor of baijiu to a great extent. The present study aimed to investigate the spatial distribution and formation contributor of ethyl lactate by removing the ... ...

Abstract	Ethyl lactate is the most abundant ester in semi-solid rice baijiu fermentation, affecting the flavor of baijiu to a great extent. The present study aimed to investigate the spatial distribution and formation contributor of ethyl lactate by removing the microorganisms and extracellular enzymes from the upper, middle, and lower fermentation broth during the later fermentation stage. The removal of suspended substances by centrifugation did not affect the ethyl lactate content in the top and middle fermentation broth containing free cells, enzymes, and starch particles. After day 5 of fermentation, only the lower fermentation broth containing granular cells attached to the starch could continue to accumulate lactic acid, thereby increasing the ethyl lactate content. The results showed that the chemical reactions were the main contributor to the increased ethyl lactate content at the anaphase of fermentation rather than enzymatic catalysis or microbial metabolism. Sequencing of granular cells revealed the main lactic acid producers at different fermentation stages. Lactobacillus helveticus showed the highest abundance of 94.45-95.40% on day 5, which decreased to 29.58-30.20% on day 15, while Lactobacillus acetotolerans showed the highest abundance of 47.93-49.72% at day 15. Additionally, the granular cells were recovered and used for supplementary inoculation in the next batch, which significantly increased the ethyl lactate content. This study provided a novel strategy for improving the ethyl lactate content in semi-solid baijiu fermentation.
MeSH term(s)	Fermentation ; Oryza/metabolism ; Lactic Acid/metabolism ; Lactobacillus helveticus ; Starch/metabolism ; Lactates
Chemical Substances	ethyl lactate (F3P750VW8I) ; Lactic Acid (33X04XA5AT) ; Starch (9005-25-8) ; Lactates
Language	English
Publishing date	2024-03-08
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1465387-4
ISSN	1347-4421 ; 1389-1723
ISSN (online)	1347-4421
ISSN	1389-1723
DOI	10.1016/j.jbiosc.2024.02.002
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