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  1. Article ; Online: Re-treating bleeding hereditary haemorrhagic telangiectasia with bevacizumab.

    Ho, Gwo Yaw / Zhong, Edward / Chern, Boris

    The Medical journal of Australia

    2013  Volume 199, Issue 10, Page(s) 658

    MeSH term(s) Aged ; Angiogenesis Inhibitors/therapeutic use ; Antibodies, Monoclonal, Humanized/therapeutic use ; Bevacizumab ; Humans ; Male ; Recurrence ; Telangiectasia, Hereditary Hemorrhagic/diagnosis ; Telangiectasia, Hereditary Hemorrhagic/drug therapy
    Chemical Substances Angiogenesis Inhibitors ; Antibodies, Monoclonal, Humanized ; Bevacizumab (2S9ZZM9Q9V)
    Language English
    Publishing date 2013-05-01
    Publishing country Australia
    Document type Case Reports ; Letter
    ZDB-ID 186082-3
    ISSN 1326-5377 ; 0025-729X
    ISSN (online) 1326-5377
    ISSN 0025-729X
    DOI 10.5694/mja13.10260
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.398: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Book ; Online: Complex mortgages

    Amromin, Gene / Huang, Jennifer / Sialm, Clemens / Zhong, Edward

    (Working papers / Federal Reserve Bank of Chicago ; 2010-17)

    2010  

    Abstract: Complex mortgages became a popular borrowing instrument during the bullish housing market of the early 2000s but vanished rapidly during the subsequent downturn. These non-traditional loans (interest only, negative amortization, and teaser mortgages) ... ...

    Author's details Gene Amromin; Jennifer Huang; Clemens Sialm; Edward Zhong
    Series title Working papers / Federal Reserve Bank of Chicago ; 2010-17
    Abstract Complex mortgages became a popular borrowing instrument during the bullish housing market of the early 2000s but vanished rapidly during the subsequent downturn. These non-traditional loans (interest only, negative amortization, and teaser mortgages) enable households to postpone loan repayment compared to traditional mortgages and hence relax borrowing constraints. At the same time, they increase household leverage and heighten dependence on mortgage refinancing to escape changes in contract terms. We document that complex mortgages were chosen by prime borrowers with high income levels seeking to purchase expensive houses relative to their incomes. Borrowers with complex mortgages experience substantially higher ex post default rates than borrowers with traditional mortgages with similar characteristics.
    Keywords Finanzmarkt ; Kreditmarkt ; Hypothek ; Liquiditätsbeschränkung ; USA
    Language English
    Size Online-Ressource (PDF-Datei: 43, 6 S., 458,42 KB), graph. Darst., Kt.
    Publisher Federal Reserve Bank of Chicago
    Publishing place Chicago, Ill
    Document type Book ; Online
    Note IMD-Felder maschinell generiert
    Database ECONomics Information System

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  3. Article ; Online: Noninvasive vagus nerve stimulation alters neural response and physiological autonomic tone to noxious thermal challenge.

    Lerman, Imanuel / Davis, Bryan / Huang, Mingxiong / Huang, Charles / Sorkin, Linda / Proudfoot, James / Zhong, Edward / Kimball, Donald / Rao, Ramesh / Simon, Bruce / Spadoni, Andrea / Strigo, Irina / Baker, Dewleen G / Simmons, Alan N

    PloS one

    2019  Volume 14, Issue 2, Page(s) e0201212

    Abstract: The mechanisms by which noninvasive vagal nerve stimulation (nVNS) affect central and peripheral neural circuits that subserve pain and autonomic physiology are not clear, and thus remain an area of intense investigation. Effects of nVNS vs sham ... ...

    Abstract The mechanisms by which noninvasive vagal nerve stimulation (nVNS) affect central and peripheral neural circuits that subserve pain and autonomic physiology are not clear, and thus remain an area of intense investigation. Effects of nVNS vs sham stimulation on subject responses to five noxious thermal stimuli (applied to left lower extremity), were measured in 30 healthy subjects (n = 15 sham and n = 15 nVNS), with fMRI and physiological galvanic skin response (GSR). With repeated noxious thermal stimuli a group × time analysis showed a significantly (p < .001) decreased response with nVNS in bilateral primary and secondary somatosensory cortices (SI and SII), left dorsoposterior insular cortex, bilateral paracentral lobule, bilateral medial dorsal thalamus, right anterior cingulate cortex, and right orbitofrontal cortex. A group × time × GSR analysis showed a significantly decreased response in the nVNS group (p < .0005) bilaterally in SI, lower and mid medullary brainstem, and inferior occipital cortex. Finally, nVNS treatment showed decreased activity in pronociceptive brainstem nuclei (e.g. the reticular nucleus and rostral ventromedial medulla) and key autonomic integration nuclei (e.g. the rostroventrolateral medulla, nucleus ambiguous, and dorsal motor nucleus of the vagus nerve). In aggregate, noninvasive vagal nerve stimulation reduced the physiological response to noxious thermal stimuli and impacted neural circuits important for pain processing and autonomic output.
    MeSH term(s) Adolescent ; Adult ; Brain/diagnostic imaging ; Brain/physiopathology ; Brain Mapping ; Female ; Galvanic Skin Response/physiology ; Hot Temperature/adverse effects ; Humans ; Lower Extremity ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Neural Pathways/diagnostic imaging ; Neural Pathways/physiopathology ; Pain/diagnostic imaging ; Pain/physiopathology ; Pain Management/methods ; Pain Perception/physiology ; Pilot Projects ; Vagus Nerve Stimulation ; Young Adult
    Language English
    Publishing date 2019-02-13
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, U.S. Gov't, Non-P.H.S.
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0201212
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Chlamydial induction of hydrosalpinx in 11 strains of mice reveals multiple host mechanisms for preventing upper genital tract pathology.

    Chen, Jianlin / Zhang, Hongbo / Zhou, Zhou / Yang, Zhangsheng / Ding, Yiling / Zhou, Zhiguang / Zhong, Edward / Arulanandam, Bernard / Baseman, Joel / Zhong, Guangming

    PloS one

    2014  Volume 9, Issue 4, Page(s) e95076

    Abstract: The female lower genital tract is constantly exposed to microbial infection, some of which can ascend to and cause pathology such as hydrosalpinx in the upper genital tract, which can affect fertility. To understand host mechanisms for preventing upper ... ...

    Abstract The female lower genital tract is constantly exposed to microbial infection, some of which can ascend to and cause pathology such as hydrosalpinx in the upper genital tract, which can affect fertility. To understand host mechanisms for preventing upper genital tract pathology, we screened 11 inbred strains of mice for hydrosalpinx induction by C. muridarum. When examined on days 60 to 80 after intravaginal infection, the 11 strains fell into 3 groups based on their hydrosalpinx severity: CBA/J and SJL/J mice were highly susceptible with a hydrosalpinx score of 5 or greater; Balb/c, C57BL/6J, C57BL/10J, C3H/HeJ and C3H/HeN were susceptible with a score between 1 and <5; NOD/ShiLtJ, DBA/1J, DBA/2J and A/J were resistant with a score of <1. The diverse range of mouse susceptibility to hydrosalpinx induction may reflect the varied clinical outcomes of C. trachomatis-infected women. When the 11 strains were infected via an intrauterine inoculation to bypass the requirement for ascension, higher incidence and more severe hydrosalpinges were induced in most mice, indicating that the interaction between chlamydial ascension and host control of ascension is critical for determining susceptibility to hydrosalpinx development in many mice. However, a few mouse strains resisted significant exacerbation of hydrosalpinx by intrauterine infection, indicating that these mice have evolved ascension-independent mechanisms for preventing upper genital tract pathology. Together, the above observations have demonstrated that different strains of mice can prevent upper genital tract pathology by using different mechanisms.
    MeSH term(s) Animals ; Chlamydia Infections/microbiology ; Chlamydia muridarum ; Cytokines/metabolism ; Disease Models, Animal ; Female ; H-2 Antigens/genetics ; Haplotypes ; Host-Pathogen Interactions ; Mice ; Reproductive Tract Infections/genetics ; Reproductive Tract Infections/metabolism ; Reproductive Tract Infections/microbiology ; Reproductive Tract Infections/pathology
    Chemical Substances Cytokines ; H-2 Antigens
    Language English
    Publishing date 2014-04-15
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0095076
    Database MEDical Literature Analysis and Retrieval System OnLINE

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