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Article: Porous ZnCl

Zhao, Hongxia / Zhong, Haihong / Jiang, Yu / Li, Huiyu / Tang, Pinggui / Li, Dianqing / Feng, Yongjun

2022 Volume 15, Issue 3

Abstract: It is of great interest and importance to resource utilization of waste biomass to produce porous carbon for environmental treatments. Pore structure and properties of the obtained carbon mainly relate to carbonization conditions and biomass types. In ... ...

Abstract	It is of great interest and importance to resource utilization of waste biomass to produce porous carbon for environmental treatments. Pore structure and properties of the obtained carbon mainly relate to carbonization conditions and biomass types. In this work, a series of porous, biomass-activated carbons (AC) were prepared using shaddock peel, with ZnCl
Language	English
Publishing date	2022-01-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma15030895
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The clinical value of bedside ultrasound in predicting the severity of coronavirus disease-19 (COVID-19).

Xian, Jianzhong / Pei, Xiaofeng / Lu, Wuzhu / Zhong, Haihong / Lin, Yuhong / Jin, Hongjun / Su, Zhongzhen

Annals of translational medicine

2021 Volume 9, Issue 4, Page(s) 336

Abstract: Background: To summarise the ultrasound manifestations of coronavirus disease-19 (COVID-19) patients with lung lesions and explore the clinical value of bedside ultrasound in the identification of patients at risk of progression to severe disease.: ... ...

Abstract	Background: To summarise the ultrasound manifestations of coronavirus disease-19 (COVID-19) patients with lung lesions and explore the clinical value of bedside ultrasound in the identification of patients at risk of progression to severe disease. Methods: This retrospective study enrolled 31 patients with COVID-19 who were admitted to our hospital from January 18 to February 5, 2020. Lung ultrasounds were performed in all cases to evaluate the ultrasound manifestations of the patient's lung lesions and to determine the lung ultrasound scores (LUS). The Cox proportional hazards regression model was used for the multifactor analysis of 7 candidate parameters, including the LUS and the oxygenation index (PaO Results: Lung ultrasound images of COVID-19 patients mainly reflected the presence of interstitial pulmonary lesions (90.3%, 28/31). The lung lesions were primarily distributed in the subpleural and peripheral pulmonary zones. Multivariate analyses identified the oxygenation index, the LUS, and the lymphocyte count as factors related to the progression to severe-critical disease in COVID-19 patients (P<0.05). With a cut-off value of 9.5, the area under the ROC curve was 0.910. The LUS showed a sensitivity and specificity of 81.3% and 93.0%, respectively (P≤0.001), with an overall accuracy of 75%. Conclusions: The lung ultrasound findings in COVID-19 patients were mainly and specifically manifested as interstitial lesions involving the peripheral zones of the lung. In addition, ultrasound imaging could predict the likelihood of COVID-19 patients progressing to severe disease, thereby allowing for early intervention. Thus, lung ultrasounds have great clinical value in monitoring and evaluating COVID-19 patients.
Language	English
Publishing date	2021-01-06
Publishing country	China
Document type	Journal Article
ZDB-ID	2893931-1
ISSN	2305-5847 ; 2305-5839
ISSN (online)	2305-5847
ISSN	2305-5839
DOI	10.21037/atm-20-7944
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Article ; Online: Cobalt-Based Multicomponent Oxygen Reduction Reaction Electrocatalysts Generated by Melamine Thermal Pyrolysis with High Performance in an Alkaline Hydrogen/Oxygen Microfuel Cell.

Zhong, Haihong / Estudillo-Wong, Luis Alberto / Gao, Yuan / Feng, Yongjun / Alonso-Vante, Nicolas

ACS applied materials & interfaces

2020 Volume 12, Issue 19, Page(s) 21605–21615

Abstract: A series of cobalt-based multicomponent electrocatalysts (Co-Cat-T) for the oxygen reduction reaction (ORR) were synthesized by thermal pyrolysis of activated carbon-supported cobalt and melamine mixture from 500 to 800 °C. Their corresponding ... ...

Abstract	A series of cobalt-based multicomponent electrocatalysts (Co-Cat-T) for the oxygen reduction reaction (ORR) were synthesized by thermal pyrolysis of activated carbon-supported cobalt and melamine mixture from 500 to 800 °C. Their corresponding electrocatalytic performance was systematically investigated toward ORR in an alkaline electrolyte. The electrocatalyst chemical composition and structure evolution (e.g., microstrain, crystallite size, and cell volume) were confirmed by X-ray diffraction Rietveld analyses. The material generated at 550 °C (Co-Cat-T550) showed the largest cell volume of the C
Language	English
Publishing date	2020-04-29
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.0c02884
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Article ; Online: Redundant Signaling as the Predominant Mechanism for Resistance to Antibodies Targeting the Type-I Insulin-Like Growth Factor Receptor in Cells Derived from Childhood Sarcoma.

Shackleford, Terry J / Hariharan, Seethalakshmi / Vaseva, Angelina V / Alagoa, Karina / Espinoza, Maricruz / Bid, Hemant K / Li, Fuyang / Zhong, Haihong / Phelps, Doris A / Roberts, Ryan D / Cam, Hakan / London, Cheryl A / Guttridge, Denis C / Chen, Yidong / Rao, Manjeet / Shiio, Yuzuru / Houghton, Peter J

Molecular cancer therapeutics

2023 Volume 22, Issue 4, Page(s) 539–550

Abstract: Antibodies targeting insulin-like growth factor 1 receptor (IGF-1R) induce objective responses in only 5% to 15% of children with sarcoma. Understanding the mechanisms of resistance may identify combination therapies that optimize efficacy of IGF-1R- ... ...

Abstract	Antibodies targeting insulin-like growth factor 1 receptor (IGF-1R) induce objective responses in only 5% to 15% of children with sarcoma. Understanding the mechanisms of resistance may identify combination therapies that optimize efficacy of IGF-1R-targeted antibodies. Sensitivity to the IGF-1R-targeting antibody TZ-1 was determined in rhabdomyosarcoma and Ewing sarcoma cell lines. Acquired resistance to TZ-1 was developed and characterized in sensitive Rh41 cells. The BRD4 inhibitor, JQ1, was evaluated as an agent to prevent acquired TZ-1 resistance in Rh41 cells. The phosphorylation status of receptor tyrosine kinases (RTK) was assessed. Sensitivity to TZ-1 in vivo was determined in Rh41 parental and TZ-1-resistant xenografts. Of 20 sarcoma cell lines, only Rh41 was sensitive to TZ-1. Cells intrinsically resistant to TZ-1 expressed multiple (>10) activated RTKs or a relatively less complex set of activated RTKs (∼5). TZ-1 decreased the phosphorylation of IGF-1R but had little effect on other phosphorylated RTKs in all resistant lines. TZ-1 rapidly induced activation of RTKs in Rh41 that was partially abrogated by knockdown of SOX18 and JQ1. Rh41/TZ-1 cells selected for acquired resistance to TZ-1 constitutively expressed multiple activated RTKs. TZ-1 treatment caused complete regressions in Rh41 xenografts and was significantly less effective against the Rh41/TZ-1 xenograft. Intrinsic resistance is a consequence of redundant signaling in pediatric sarcoma cell lines. Acquired resistance in Rh41 cells is associated with rapid induction of multiple RTKs, indicating a dynamic response to IGF-1R blockade and rapid development of resistance. The TZ-1 antibody had greater antitumor activity against Rh41 xenografts compared with other IGF-1R-targeted antibodies tested against this model.
MeSH term(s)	Child ; Humans ; Nuclear Proteins ; Transcription Factors ; Receptor, IGF Type 1 ; Sarcoma/drug therapy ; Receptors, Somatomedin ; Antibodies, Monoclonal/pharmacology ; Cell Line, Tumor ; Cell Cycle Proteins ; SOXF Transcription Factors
Chemical Substances	Nuclear Proteins ; Transcription Factors ; Receptor, IGF Type 1 (EC 2.7.10.1) ; Receptors, Somatomedin ; Antibodies, Monoclonal ; BRD4 protein, human ; Cell Cycle Proteins ; SOX18 protein, human ; SOXF Transcription Factors
Language	English
Publishing date	2023-01-24
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	2063563-1
ISSN	1538-8514 ; 1535-7163
ISSN (online)	1538-8514
ISSN	1535-7163
DOI	10.1158/1535-7163.MCT-20-0625
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Article ; Online: Design and Synthesis of Cobalt-Based Electrocatalysts for Oxygen Reduction Reaction.

Zhong, Haihong / Gong, Xiaoman / Zhang, Shuwei / Tang, Pinggui / Li, Dianqing / Feng, Yongjun

Chemical record (New York, N.Y.)

2017 Volume 18, Issue 7-8, Page(s) 840–848

Abstract: Oxygen reduction reaction (ORR) is the crucial step of various renewable energy conversion and storage technologies such as fuel cells and air-batteries. Cobalt-based electrocatalysts including oxides/chalcogenides and Co- ... ...

Abstract	Oxygen reduction reaction (ORR) is the crucial step of various renewable energy conversion and storage technologies such as fuel cells and air-batteries. Cobalt-based electrocatalysts including oxides/chalcogenides and Co-N
Language	English
Publishing date	2017-12-29
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2044646-9
ISSN	1528-0691 ; 1527-8999
ISSN (online)	1528-0691
ISSN	1527-8999
DOI	10.1002/tcr.201700081
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Article ; Online: Correction: Upregulation of annexin A1 protein expression in the intratumoral vasculature of human non-small-cell lung carcinoma and rodent tumor models.

Allen, Kevin L / Cann, Jennifer / Zhao, Weiguang / Peterson, Norman / Lazzaro, Michelle / Zhong, Haihong / Wu, Herren / Dall'Acqua, William F / Borrok, M Jack / Damschroder, Melissa M / Tsui, Ping / Li, Qing

PloS one

2021 Volume 16, Issue 5, Page(s) e0252060

Abstract: This corrects the article DOI: 10.1371/journal.pone.0234268.]. ...

Abstract	[This corrects the article DOI: 10.1371/journal.pone.0234268.].
Language	English
Publishing date	2021-05-17
Publishing country	United States
Document type	Published Erratum
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0252060
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Article: Electrocatalytic Cobalt Nanoparticles Interacting with Nitrogen-Doped Carbon Nanotube in Situ Generated from a MetalâOrganic Framework for the Oxygen Reduction Reaction

Zhong, Haihong / Alonso-Vante Nicolas / Feng Yongjun / He Shi / Li Dianqing / Luo Yun / Tang Pinggui

ACS Applied Materials & Interfaces. 2017 Jan. 25, v. 9, no. 3

2017

Abstract: A metal organic framework (MOF), synthesized from cobalt salt, melamine (mela), and 1,4-dicarboxybezene (BDC), was used as precursor to prepare Co/CoNâ/N-CNT/C electrocatalyst via heat treatment at different temperature (700â900 Â°C) under nitrogen ... ...

Abstract	A metal organic framework (MOF), synthesized from cobalt salt, melamine (mela), and 1,4-dicarboxybezene (BDC), was used as precursor to prepare Co/CoNâ/N-CNT/C electrocatalyst via heat treatment at different temperature (700â900 Â°C) under nitrogen atmosphere. Crystallites size and microstrain in the 800 Â°C heat-treated sample (MOFs-800) were the lowest, whereas the stacking fault value was the highest among the rest of the homemade samples, as attested to by the WilliamsonâHall analysis, hence assessing that the structural or/and surface modification of Co nanoparticles (NPs), found in MOFs-800, was different from that in other samples. CNTs in MOFs-800, interacting with Co NPs, were formed on the surface of the support, keeping the hexagonal shape of the initial MOF. Among the three homemade samples, the MOF-800 sample, with the best electrocatalytic performance toward oxygen reduction reaction (ORR) in 0.1 M KOH solution, showed the highest density of CNTs skin on the support, the lowest ID/IG ratio, and the largest N atomic content in form of pyridinic-N, CoNâ, pyrrolic-N, graphitic-N, and oxidized-N species. Based on the binding energy shift toward lower energies, a strong interaction between the active site and the support was identified for MOFs-800 sample. The number of electron transfer was 3.8 on MOFs-800, close to the value of 4.0 determined on the Pt/C benchmark, thus implying a fast and efficient multielectron reduction of molecular oxygen on CoNâ active sites. In addition, the chronoamperometric response within 24â¯000 s showed a more stable current density at 0.69 V/RHE on MOFs-800 as compared with that of Pt/C.
Keywords	carbon nanotubes ; cobalt ; coordination polymers ; crystallites ; electron transfer ; energy ; heat treatment ; melamine ; nanoparticles ; nitrogen ; oxygen ; potassium hydroxide ; temperature
Language	English
Dates of publication	2017-0125
Size	p. 2541-2549.
Publishing place	American Chemical Society
Document type	Article
ISSN	1944-8252
DOI	10.1021%2Facsami.6b14942
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Upregulation of annexin A1 protein expression in the intratumoral vasculature of human non-small-cell lung carcinoma and rodent tumor models.

PloS one

2020 Volume 15, Issue 6, Page(s) e0234268

Abstract: Annexin A1 (anxA1) is an immunomodulatory protein that has been proposed as a tumor vascular target for antitumor biologic agents, yet to date the vascular expression of anxA1 in specific tumor indications has not been systematically assessed. Attempts ... ...

Abstract	Annexin A1 (anxA1) is an immunomodulatory protein that has been proposed as a tumor vascular target for antitumor biologic agents, yet to date the vascular expression of anxA1 in specific tumor indications has not been systematically assessed. Attempts to evaluate vascular anxA1 expression by immunohistochemistry are complicated by a lack of available antibodies that are both specific for anxA1 and bind the N-terminal-truncated form of anxA1 that has previously been identified in tumor vasculature. To study the vascular expression pattern of anxA1 in non-small-cell lung carcinoma (NSCLC), we isolated an antibody capable of binding N-terminal-truncated anxA127-346 and employed it in immunohistochemical studies of human lung specimens. Lung tumor specimens evaluated with this antibody revealed vascular (endothelial) anxA1 expression in five of eight tumor samples studied, but no vascular anxA1 expression was observed in normal lung tissue. Tumor microarray analysis further demonstrated positive vascular staining for anxA1 in 30 of 80 NSCLC samples, and positive staining of neoplastic cells was observed in 54 of 80 samples. No correlation was observed between vascular and parenchymal anxA1 expression. Two rodent tumor models, B16-F10 and Py230, were determined to have upregulated anxA1 expression in the intratumoral vasculature. These data validate anxA1 as a potential vascular anti-tumor target in a subset of human lung tumors and identify rodent models which demonstrate anxA1 expression in tumor vasculature.
MeSH term(s)	Animals ; Annexin A1/metabolism ; Carcinoma, Non-Small-Cell Lung/blood supply ; Carcinoma, Non-Small-Cell Lung/metabolism ; Cell Line, Tumor ; Disease Models, Animal ; Female ; Humans ; Lung Neoplasms/blood supply ; Lung Neoplasms/metabolism ; Mice ; Up-Regulation
Chemical Substances	Annexin A1
Language	English
Publishing date	2020-06-04
Publishing country	United States
Document type	Journal Article
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0234268
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Article ; Online: Boosting oxygen reduction activity and enhancing stability through structural transformation of layered lithium manganese oxide.

Zhong, Xuepeng / Oubla, M'hamed / Wang, Xiao / Huang, Yangyang / Zeng, Huiyan / Wang, Shaofei / Liu, Kun / Zhou, Jian / He, Lunhua / Zhong, Haihong / Alonso-Vante, Nicolas / Wang, Chin-Wei / Wu, Wen-Bin / Lin, Hong-Ji / Chen, Chien-Te / Hu, Zhiwei / Huang, Yunhui / Ma, Jiwei

Nature communications

2021 Volume 12, Issue 1, Page(s) 3136

Abstract: Structural degradation in manganese oxides leads to unstable electrocatalytic activity during long-term cycles. Herein, we overcome this obstacle by using proton exchange on well-defined layered ... ...

Abstract	Structural degradation in manganese oxides leads to unstable electrocatalytic activity during long-term cycles. Herein, we overcome this obstacle by using proton exchange on well-defined layered Li
Language	English
Publishing date	2021-05-25
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-021-23430-3
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Article ; Online: Efficient Preparation of Site-Specific Antibody-Drug Conjugates Using Cysteine Insertion.

Dimasi, Nazzareno / Fleming, Ryan / Zhong, Haihong / Bezabeh, Binyam / Kinneer, Krista / Christie, Ronald J / Fazenbaker, Christine / Wu, Herren / Gao, Changshou

Molecular pharmaceutics

2017 Volume 14, Issue 5, Page(s) 1501–1516

Abstract: Antibody-drug conjugates (ADCs) are a class of biopharmaceuticals that combine the specificity of antibodies with the high-potency of cytotoxic drugs. Engineering cysteine residues in the antibodies using mutagenesis is a common method to prepare site- ... ...

Abstract	Antibody-drug conjugates (ADCs) are a class of biopharmaceuticals that combine the specificity of antibodies with the high-potency of cytotoxic drugs. Engineering cysteine residues in the antibodies using mutagenesis is a common method to prepare site-specific ADCs. With this approach, solvent accessible amino acids in the antibody have been selected for substitution with cysteine for conjugating maleimide-bearing cytotoxic drugs, resulting in homogeneous and stable site-specific ADCs. Here we describe a cysteine engineering approach based on the insertion of cysteines before and after selected sites in the antibody, which can be used for site-specific preparation of ADCs. Cysteine-inserted antibodies have expression level and monomeric content similar to the native antibodies. Conjugation to a pyrrolobenzodiazepine dimer (SG3249) resulted in comparable efficiency of site-specific conjugation between cysteine-inserted and cysteine-substituted antibodies. Cysteine-inserted ADCs were shown to have biophysical properties, FcRn, and antigen binding affinity similar to the cysteine-substituted ADCs. These ADCs were comparable for serum stability to the ADCs prepared using cysteine-mutagenesis and had selective and potent cytotoxicity against human prostate cancer cells. Two of the cysteine-inserted variants abolish binding of the resulting ADCs to FcγRs in vitro, thereby potentially preventing non-target mediated uptake of the ADCs by cells of the innate immune system that express FcγRs, which may result in mitigating off-target toxicities. A selected cysteine-inserted ADC demonstrated potent dose-dependent anti-tumor activity in a xenograph tumor mouse model of human breast adenocarcinoma expressing the oncofetal antigen 5T4.
MeSH term(s)	Animals ; Antibodies, Monoclonal/chemistry ; Antibodies, Monoclonal/therapeutic use ; Antibodies, Monoclonal, Humanized/chemistry ; Antibodies, Monoclonal, Humanized/therapeutic use ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/therapeutic use ; Cell Line, Tumor ; Cysteine/chemistry ; Female ; Humans ; Immunoconjugates/chemistry ; Immunoconjugates/therapeutic use ; Mammary Neoplasms, Experimental/drug therapy ; Mice ; Mice, Nude ; Trastuzumab/chemistry ; Trastuzumab/therapeutic use ; Xenograft Model Antitumor Assays
Chemical Substances	Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized ; Antineoplastic Agents ; Immunoconjugates ; Cysteine (K848JZ4886) ; Trastuzumab (P188ANX8CK)
Language	English
Publishing date	2017-03-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2138405-8
ISSN	1543-8392 ; 1543-8384
ISSN (online)	1543-8392
ISSN	1543-8384
DOI	10.1021/acs.molpharmaceut.6b00995
Database	MEDical Literature Analysis and Retrieval System OnLINE

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