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Article: [Differences in chemical components in processing of dried ginger-steamed, sand-fried, and rice swill water-bleached Aconiti Lateralis Radix Praeparata pieces in "Jianchang" faction based on UPLC-MS/MS].

Zhou, Ying / Zhong, Ling-Yun / Luo, Hong-Bing / Zhong, Si-Min / Liu, Bin / Deng, Qi / Xu, Fu-Yu

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

2024 Volume 48, Issue 23, Page(s) 6387–6395

Abstract: This study compared the changes in chemical components during the processing of different types of Aconiti Lateralis Radix Praeparata(ALRP) in "Jianchang" faction, i.e., dried ginger-steamed ALRP pieces(Yin-FP), sand-fried ALRP pieces(Yang-FP), and rice ... ...

Abstract	This study compared the changes in chemical components during the processing of different types of Aconiti Lateralis Radix Praeparata(ALRP) in "Jianchang" faction, i.e., dried ginger-steamed ALRP pieces(Yin-FP), sand-fried ALRP pieces(Yang-FP), and rice swill water-bleached ALRP pieces(DFP), and provided a scientific basis for the mechanism in toxicity reduction and efficacy enhancement from a compositional perspective. Samples were collected during the processing of the three types of ALRP pieces, yielding raw ALRP pieces, water-bleached Yin-FP, ginger juice-moistened Yin-FP, steamed Yin-FP, water-bleached Yang-FP, sand-fried Yang-FP, water-bleached DFP, rice swill water-bleached DFP, and roasted DFP. Aconitine, mesaconitine, hypaconitine, benzoylaconine, benzoylmesaconine, benzoylhypaconine, aconine, mesaconine, hypaconine, salsolinol, fuziline, and higenamine in the extracts were determined by UPLC-MS/MS, and then content analysis and cluster heatmap analysis were performed on 11 sets of samples. During the processing of the three types of ALRP pieces, bleaching significantly reduced the content of 12 alkaloids; steaming, stir-frying, and roasting significantly reduced the content of diester-type alkaloids(aconitine, mesaconitine, and hypaconitine) and significantly increased the content of monoester-type alkaloids(benzoylaconine, benzoylmesaconine, and benzoylhypaconine) and aminoalcohol-type alkaloids(aconine, mesaconine, and hypaconine). During the processing of Yin-FP, the diester-type alkaloids continuously decreased, while the monoester-type and aminoalcohol-type alkaloids showed an initial decrease followed by an increase. During the processing of Yin-FP, Yang-FP, and DFP, the diester-type alkaloids continuously decreased, while the monoester-type and aminoalcohol-type alkaloids showed an initial decrease followed by an increase. Steamed Yin-FP showed a higher increase in content than fried Yang-FP and roasted DFP. Comprehensive analysis of content differences in toxic and therapeutic components in three ALRP pieces suggests that the distinctive processing methods in "Jianchang" faction can indeed achieve detoxification and efficacy enhancement on ALRP. This study provides references for understanding the mechanisms of action of the three processing methods.
MeSH term(s)	Aconitine/analysis ; Tandem Mass Spectrometry ; Zingiber officinale ; Oryza ; Sand ; Liquid Chromatography-Mass Spectrometry ; Chromatography, Liquid ; Drugs, Chinese Herbal/chemistry ; Chromatography, High Pressure Liquid/methods ; Alkaloids/analysis ; Steam
Chemical Substances	mesaconitine (621OT356HL) ; hypaconitine (5207313N6E) ; benzoylmesaconine (PXJ8W3681R) ; benzoylhypaconine ; benzoylaconine (369U7A6HXD) ; aconine (GNS9EEX31X) ; Aconitine (X8YN71D5WC) ; Sand ; Drugs, Chinese Herbal ; Alkaloids ; Steam
Language	Chinese
Publishing date	2024-01-09
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	1004649-5
ISSN	1001-5302 ; 0254-0029
ISSN	1001-5302 ; 0254-0029
DOI	10.19540/j.cnki.cjcmm.20230908.301
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: [Study progress on Pinelliae Rhizoma processed by replication method].

Cui, Mei-Na / Zhong, Ling-Yun / Zhang, Da-Yong / Yang, Ming

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

2020 Volume 45, Issue 6, Page(s) 1304–1310

Abstract: In the clinical practice of traditional Chinese medicine, Pinelliae Rhizoma is a commonly used traditional Chinese medicinal material, with a very important medicinal value, but its raw products have certain toxicity. According to the basic theory of ... ...

Abstract	In the clinical practice of traditional Chinese medicine, Pinelliae Rhizoma is a commonly used traditional Chinese medicinal material, with a very important medicinal value, but its raw products have certain toxicity. According to the basic theory of traditional Chinese medicine, after Pinelliae Rhizoma is processed, its toxic and side effects can be reduced, there by ensuring its medication safety in clinic. Based on the processing characteristics of Pinelliae Rhizoma replication method, this article discusses the changes before and after processing of Pinelliae Rhizoma with multiple materials and multiple processes. This method does not have a unified process. One or more materials are added, and various processes, such as dipping, soaking, bleaching, or steaming, cooking or combined methods are adopted. Then, Pinelliae Rhizoma is repeatedly processed to meet the specified quality requirements. By different processing methods, the efficacy changes accordingly, and Pinelliae Rhizoma can be used for the treatment of different diseases. The article starts in the two directions of multi-materials and multi-processes, and summarizes the effects of multi-materials or multi-processes on the chemical composition and efficacy, as well as the processing mechanism of reducing toxicity and increasing efficiency, in the expectation of reducing the toxicity and enhancing the efficacy of Pinelliae Rhizoma. The medicinal scope provides a reference and theoretical basis for further studies on the processing mechanism. An in-depth study is conducted to make Pinelliae Rhizoma more safe and effective in clinic application, and ensure its clinical efficacy. It will provide reference for future studies on quality control, active ingredients and new drug development of the processing of pinellia slices. It has laid a scientific foundation for exploring the best processing techno-logy, and provided a theoretical basis for solving the production problems of processed Pinelliae Rhizoma products, so as to improve the production efficiency and the quality of medicines.
MeSH term(s)	Drugs, Chinese Herbal/chemistry ; Medicine, Chinese Traditional ; Pinellia/chemistry ; Rhizome/chemistry ; Technology, Pharmaceutical
Chemical Substances	Drugs, Chinese Herbal
Language	Chinese
Publishing date	2020-04-13
Publishing country	China
Document type	Journal Article
ZDB-ID	1004649-5
ISSN	1001-5302 ; 0254-0029
ISSN	1001-5302 ; 0254-0029
DOI	10.19540/j.cnki.cjcmm.20200207.305
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: [Modern researches on effect of processing of Chinese herb medicine on Chinese medical properties].

Zhong, Ling-Yun / Cui, Mei-Na / Yang, Ming / Gong, Qian-Feng

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

2020 Volume 44, Issue 23, Page(s) 5109–5113

Abstract: The processing of Chinese herb medicine( PCHM) is the premise and necessity of treating diseases in traditional Chinese medicine( TCM). After processing,Chinese herbal medicine can achieve the effects of correcting odor,inducing channel tropism,changing ... ...

Abstract	The processing of Chinese herb medicine( PCHM) is the premise and necessity of treating diseases in traditional Chinese medicine( TCM). After processing,Chinese herbal medicine can achieve the effects of correcting odor,inducing channel tropism,changing drug properties and reducing toxicity. As the most important part of TCM theory system,Chinese medicine property,involving four odors and five flavors,ascending and descending,channel tropism,toxicity and side effects. In recent years,with the development of modern science and technology,many researches on the changes of properties of Chinese herb medicines by PCHM have been reported. In this paper,the researches in four aspects of processing method,chemical composition,medicinal effect and biological effect on properties changes by PCHM were reviewed,so as to discuss the modern research ideas and technologies,and explain the importance of the increase of clinical efficacy of TCM through property changes by PCHM. In the end,the future research ideas and cutting-edge technologies were discussed to make the studies on property changes by PCHM more systematic and deeper.
MeSH term(s)	Drug-Related Side Effects and Adverse Reactions ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/toxicity ; Medicine, Chinese Traditional ; Odorants ; Taste ; Technology, Pharmaceutical
Chemical Substances	Drugs, Chinese Herbal
Language	Chinese
Publishing date	2020-04-01
Publishing country	China
Document type	Journal Article ; Review
ZDB-ID	1004649-5
ISSN	1001-5302 ; 0254-0029
ISSN	1001-5302 ; 0254-0029
DOI	10.19540/j.cnki.cjcmm.20190916.301
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Components and Pharmacodynamical Mechanism of Yinfupian Based on Liquid Chromatography-Mass Spectrometry and Proteomics Analyses.

Tong, Heng-Li / Chen, Hao / Gong, Fei-Peng / Zhong, Ling-Yun / Zhu, Jing / Yang, Song-Hong

Frontiers in pharmacology

2021 Volume 12, Page(s) 680640

Abstract: Objective: ...

Abstract	Objective:
Language	English
Publishing date	2021-06-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2021.680640
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Article: [Effect of processing method on chemical constituents of Rehmanniae Radix: based on UHPLC-LTQ-Orbitrap MS].

Lu, Xing-Mei / Zhong, Ling-Yun / Wang, Shuo / Deng, Yan-Wen / Liu, Hong / Chen, Ming-Xia / Huang, Yi / Tong, Heng-Li

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

2022 Volume 48, Issue 2, Page(s) 399–414

Abstract: This study aims to explore the chemical composition of Rehmanniae Radix braised with mild fire and compare the effect of processing method on the chemical composition of Rehmanniae Radix. To be specific, ultra-high performance liquid chromatography with ... ...

Abstract	This study aims to explore the chemical composition of Rehmanniae Radix braised with mild fire and compare the effect of processing method on the chemical composition of Rehmanniae Radix. To be specific, ultra-high performance liquid chromatography with linear ion trap-orbitrap mass spectrometry(UHPLC-LTQ-Orbitrap MS) was used to screen the chemical constituents of Rehmanniae Radix. The chemical constituents were identified based on the relative molecular weight and fragment ions, literature information, and Human Metabolome Database(HMDB). The ion peak area ratio of each component before and after processing was used as the index for the variation. SIMCA was employed to establish principal component analysis(PCA) and orthogonal partial least squares discriminant analysis(OPLS-DA) models of different processed products. According to the PCA plot, OPLS-DA plot, and VIP value, the differential components before and after the processing were screened out. The changes of the content of differential components with the processing method were analyzed. A total of 66 chemical components were identified: 57 of raw Rehmanniae Radix, 55 of steamed Rehmanniae Radix, 55 of wine-stewed Rehmanniae Radix, 51 of repeatedly steamed and sundried Rehmanniae Radix Praeparata, 62 of traditional bran-braised Rehmanniae Radix, and 63 of electric pot-braised Rehmanniae Radix. Among them, the 9 flavonoids of braised Rehmanniae Radix were from Citri Reticulatae Pericarpium. PCA suggested significant differences in the chemical composition of Rehmanniae Radix Praeparata prepared with different processing methods. OPLS-DA screened out 32 chemical components with VIP value >1 as the main differential components. Among the differential components, 9 were unique to braised Rehmanniae Radix(traditional bran-braised, electric pot-braised) and the degradation rate of the rest in braised(traditional bran-braised, electric pot-braised) or repeatedly steamed and sundried Rehmanniae Radix was higher than that in the steamed or wine-stewed products. The results indicated the chemical species and component content of Rehmanniae Radix changed significantly after the processing. The 32 components, such as rehmapicrogenin, martynoside, jionoside D, aeginetic acid, hesperidin, and naringin, were the most important compounds to distinguish different processed products of Rehmanniae Radix. The flavonoids introduced by Citri Reticulatae Pericarpium as excipient may be the important material basis for the effectiveness of braised Rehmanniae Radix compared with other processed products.
MeSH term(s)	Humans ; Chromatography, High Pressure Liquid ; Drugs, Chinese Herbal/chemistry ; Plant Extracts/chemistry ; Rehmannia/chemistry ; Flavonoids/analysis
Chemical Substances	rehmannia root (1BEM3U6LQQ) ; Drugs, Chinese Herbal ; Plant Extracts ; Flavonoids
Language	Chinese
Publishing date	2022-04-06
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	1004649-5
ISSN	1001-5302 ; 0254-0029
ISSN	1001-5302 ; 0254-0029
DOI	10.19540/j.cnki.cjcmm.20220816.301
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: [Water migration and kinetics of Arecae Semen during moistening process].

Qi, Feng-Mei / Rao, Xiao-Yong / Han, Tong-Tong / Zhong, Ling-Yun / Luo, Xiao-Jian / He, Yan / Shen, Rui-Lin

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

2022 Volume 47, Issue 7, Page(s) 1871–1880

Abstract: In this study, low-field nuclear magnetic resonance(LF-NMR) and magnetic resonance imaging(MRI) were employed to analyze the water distribution, status, and migration in the moistening process of Arecae Semen. Peleg model was adopted to study the water ... ...

Abstract	In this study, low-field nuclear magnetic resonance(LF-NMR) and magnetic resonance imaging(MRI) were employed to analyze the water distribution, status, and migration in the moistening process of Arecae Semen. Peleg model was adopted to study the water absorption kinetics of Arecae Semen moistened at different water temperatures(10, 30, and 50 ℃). The Arecae Semen samples soaked at different water temperatures all contained four water states: binding water T_(21), non-flowing water T_(22), free water T_(23), and unbound water T_(24). Non-flowing water had the largest increase in peak area during the moistening process, followed by free water. The peak areas of non-flowing water, free water, and total water were correlated with the water content(P<0.01). Therefore, LF-NMR can quickly and non-destructively predict the water content of Arecae Semen during moistening. The peak area of non-flowing water and the content of free water were correlated with the content of arecoline in the soaking solution(P<0.01), which indicated that the faster flow of non-flowing water and more free water corresponded to more arecoline dissolved. The MRI images showed that the water migration pathway varied at different soaking temperatures, and the moistening degree obtained by this means was consistent with that obtained based on traditional experience. The rate constant K_1 fitted by Peleg model decreased with the increase in water temperature, while the capacity constant K_2 showed an opposite trend. The Arrhenius equation fitting of K_1 with temperature showed that the activation energy of Arecae Semen in the moistening process was 32.98 kJ·mol~(-1). LF-NMR/MRI can be used to analyze the water status and content and determine the end moisturing point of Arecae Semen. Peleg model can accurately describe the water absorption properties of Arecae Semen in the moistening process. The findings of this study can guide the moistening optimization and mechanism research of other seed Chinese medicinal materials.
MeSH term(s)	Areca ; Arecoline/analysis ; Drugs, Chinese Herbal/analysis ; Kinetics ; Seeds/chemistry ; Water/analysis
Chemical Substances	Drugs, Chinese Herbal ; Water (059QF0KO0R) ; Arecoline (4ALN5933BH)
Language	Chinese
Publishing date	2022-05-09
Publishing country	China
Document type	Journal Article
ZDB-ID	1004649-5
ISSN	1001-5302 ; 0254-0029
ISSN	1001-5302 ; 0254-0029
DOI	10.19540/j.cnki.cjcmm.20211123.301
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: [Optimization of processing technology of braised Rehmanniae Radix based on multiple indexes and response surface technology and correlation between components and color].

Xie, Yang / Zhong, Ling-Yun / Xue, Xiao / Wang, Zhuo / Song, Jin-Ju / Li, Jia-Qing / Zhang, Qing / Wang, Yi-Bin / Zeng, Yan

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

2022 Volume 47, Issue 18, Page(s) 4927–4937

Abstract: This study aims to explore the key factors influencing the processing of braised Rehmanniae Radix, optimize the processing, and determine the correlation between the components in different processed products and chroma values, which is expected to add ... ...

Abstract	This study aims to explore the key factors influencing the processing of braised Rehmanniae Radix, optimize the processing, and determine the correlation between the components in different processed products and chroma values, which is expected to add quantitative indexes for the processing of braised Rehmanniae Radix and better control the processing. The weights of the indexes catalpol, rehmannioside D, verbascoside, isoacteoside, 5-hydroxymethylfurfural, reducing sugar, and appearance were calculated based on analytic hierarchy process(AHP) in combination with coefficient of variation, and the overall desirability(OD) was obtained. Box-Behnken design was used to explore the optimal amount of water added, time for soaking with rice wine, and steaming time in the processing of braised Rehmanniae Radix. Colorimeter was employed to determine the chroma of 17 samples and raw samples, and SPSS, Prism, and other software to investigate the correlation between the components in braised Rehmanniae Radix and the chroma values. The results showed that each factor influenced the processing, and the influence followed the order of steaming time>amount of water added>time for soaking with rice wine. The optimal processing process is as below: A total of 100 g medicinal material was added with 7 times of water, followed by soaking with rice wine for 5 h and steaming in a pot for 6 h. The correlation analysis suggested the extremely significantly positive correlation between L~* and content of catalpol, between a~* and 5-hydroxymethylfurfural content, and between b~* and catalpol content, and the extremely significantly negative correlation between L~* and the content of 5-hydroxymethylfurfural and reducing sugar, and between b~* and the content of 5-hydroxymethylfural and reducing sugar. In this experiment, response surface methodology was used to optimize the processing technology of braised Rehmanniae Radix and the optimized process was rational and feasible. The content of chemical components in braised Rehmanniae Radix was significantly correlated with the chroma. This study provided a new method for the quality evaluation of braised Rehmanniae Radix.
MeSH term(s)	Drugs, Chinese Herbal/chemistry ; Furaldehyde/analogs & derivatives ; Iridoid Glucosides ; Plant Extracts ; Rehmannia/chemistry ; Sugars ; Technology ; Water
Chemical Substances	5-hydroxymethylfurfural (70ETD81LF0) ; catalpol (2415-24-9) ; Drugs, Chinese Herbal ; Furaldehyde (DJ1HGI319P) ; Iridoid Glucosides ; Plant Extracts ; rehmannia root (1BEM3U6LQQ) ; Sugars ; Water (059QF0KO0R)
Language	Chinese
Publishing date	2022-09-23
Publishing country	China
Document type	Journal Article
ZDB-ID	1004649-5
ISSN	1001-5302 ; 0254-0029
ISSN	1001-5302 ; 0254-0029
DOI	10.19540/j.cnki.cjcmm.20220128.306
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Pharmacological effects of different ginger juices on the concurrent symptoms in animal models of functional dyspepsia: A comparative study.

Zhong, Ling-Yun / Tong, Heng-Li / Zhu, Jing / Lv, Mu

Food science & nutrition

2019 Volume 7, Issue 7, Page(s) 2205–2213

Abstract: Objective: Patients with gastrointestinal disorders commonly suffer from poor treatment outcomes and adverse effects of traditional pharmacological therapy. Herbal medicine is a favorable alternative due to the low risk of side effects. This study was ... ...

Abstract	Objective: Patients with gastrointestinal disorders commonly suffer from poor treatment outcomes and adverse effects of traditional pharmacological therapy. Herbal medicine is a favorable alternative due to the low risk of side effects. This study was performed to explore the antiemetic effects and the improvement effect on gastrointestinal function of components of three ginger juice excipients. Methods: The compositions were analyzed by liquid chromatograph mass spectrometer (LC-MS), especially the gingerols of dried ginger juice (DGJ), fresh ginger juice (FGJ), and fresh ginger boiled juice (FGBJ). Furthermore, the respective gastrointestinal effects on rat models with functional dyspepsia (FD) were compared. Results: The 6-keto-PGF Conclusion: Ginger juice should be recommended for the medicinal materials used in the treatment of concurrent symptoms of FD.
Language	English
Publishing date	2019-06-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2703010-6
ISSN	2048-7177
ISSN	2048-7177
DOI	10.1002/fsn3.990
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Rhizoma Atractylodis Macrocephalae-Assessing the influence of herbal processing methods and improved effects on functional dyspepsia.

Yang, Song-Hong / Zhu, Jing / Wu, Wen-Ting / Li, Jun-Mao / Tong, Heng-Li / Huang, Yi / Gong, Qian-Feng / Gong, Fei-Peng / Zhong, Ling-Yun

Frontiers in pharmacology

2023 Volume 14, Page(s) 1236656

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2023-08-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1236656
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Article: [Pharmacodynamics and intestinal flora research on different processed products of Puerariae Lobatae Radix and Puerariae Thomsonii Radix].

Zhong, Ling-Yun / Deng, Xiao-Yan / Huang, Yi / Liao, Jing-Jing / Zhu, Wei-Feng / Yu, Huan / Zhou, Shi-Cheng / Chen, Rui-Lin

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

2021 Volume 46, Issue 17, Page(s) 4403–4409

Abstract: This study aims to explore the pharmacodynamic differences of Puerariae Lobatae Radix(PLR), Puerariae Thomsonii Radix(PTR) and their different processed products and the influences of these medical materials on the diversity of intestinal flora. The ... ...

Abstract	This study aims to explore the pharmacodynamic differences of Puerariae Lobatae Radix(PLR), Puerariae Thomsonii Radix(PTR) and their different processed products and the influences of these medical materials on the diversity of intestinal flora. The Sennae Folium-induced diarrhea model, streptozotocin(STZ)-induced diabetes model and L-nitro-arginine methyl ester(L-NAME)-induced hypertension model were used to compare the pharmacodynamic differences in anti-diarrhea, blood glucose reduction and blood pressure lowering among raw, roasted and vinegar-processed PLR and PTR. The effects of raw and processed PLR and PTR on intestinal flora diversity of rats were evaluated by 16 S rDNA high-throughput sequencing. The roasted PLR and PTR performed better in anti-diarrhea, especially the former. PLR and its processed products all presented the efficacy of reducing blood glucose, and the vinegar-processed PLR was the most outstanding. The raw PTR was not that effective in reducing blood glucose, whereas its efficacy was improved after roasting and vinegar processing. Both PLR and PTR were capable of lowering blood pressure to a certain extent, and PLR is superior to PTR in this aspect. Further, the vinegar-processed PLR showed the best effect. The diversity of intestinal flora was different among rats to which different products of PLR and PTR were administered. The roasted PLR led to the highest abundance of Lactobacillus, which was closely related to its best antidiarrheal effect. The highest abilities of vinegar-processed PLR to lower blood glucose and blood pressure were associated with the high abundance of Blautia and Prevotella_9. This study lays a foundation for elucidating the processing mechanisms of PLR and PTR and provides a basis for their further development and application.
MeSH term(s)	Animals ; Drugs, Chinese Herbal ; Gastrointestinal Microbiome ; Plant Roots ; Pueraria ; Rats
Chemical Substances	Drugs, Chinese Herbal
Language	Chinese
Publishing date	2021-09-27
Publishing country	China
Document type	Journal Article
ZDB-ID	1004649-5
ISSN	1001-5302 ; 0254-0029
ISSN	1001-5302 ; 0254-0029
DOI	10.19540/j.cnki.cjcmm.20210205.302
Database	MEDical Literature Analysis and Retrieval System OnLINE

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