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  1. Article: Animal models of inflammatory bowel disease: category and evaluation indexes.

    Wen, Changlin / Chen, Dan / Zhong, Rao / Peng, Xi

    Gastroenterology report

    2024  Volume 12, Page(s) goae021

    Abstract: Inflammatory bowel disease (IBD) research often relies on animal models to study the etiology, pathophysiology, and management of IBD. Among these models, rats and mice are frequently employed due to their practicality and genetic manipulability. However, ...

    Abstract Inflammatory bowel disease (IBD) research often relies on animal models to study the etiology, pathophysiology, and management of IBD. Among these models, rats and mice are frequently employed due to their practicality and genetic manipulability. However, for studies aiming to closely mimic human pathology, non-human primates such as monkeys and dogs offer valuable physiological parallels. Guinea pigs, while less commonly used, present unique advantages for investigating the intricate interplay between neurological and immunological factors in IBD. Additionally, New Zealand rabbits excel in endoscopic biopsy techniques, providing insights into mucosal inflammation and healing processes. Pigs, with their physiological similarities to humans, serve as ideal models for exploring the complex relationships between nutrition, metabolism, and immunity in IBD. Beyond mammals, non-mammalian organisms including zebrafish,
    Language English
    Publishing date 2024-04-16
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2710871-5
    ISSN 2052-0034
    ISSN 2052-0034
    DOI 10.1093/gastro/goae021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Dietary Zinc Ameliorates TNBS-Induced Colitis in Mice Associated with Regulation of Th1/Th2/Th17 Balance and NF-κB/NLRP3 Signaling Pathway.

    Wen, Changlin / Wang, Jiayu / Sun, Zhenhua / Zhong, Rao / Li, Mengjie / Shen, Xuemei / Ye, Qiaobo / Qin, Kaihua / Peng, Xi

    Biological trace element research

    2023  Volume 202, Issue 2, Page(s) 659–670

    Abstract: Inflammatory bowel diseases (IBDs), including Crohn's disease and ulcerative colitis, are chronic relapsing inflammatory gastrointestinal tract diseases of uncertain origin, which are frequently associated with zinc deficiency. Animal models have a ... ...

    Abstract Inflammatory bowel diseases (IBDs), including Crohn's disease and ulcerative colitis, are chronic relapsing inflammatory gastrointestinal tract diseases of uncertain origin, which are frequently associated with zinc deficiency. Animal models have a considerable value in elucidating the process of IBD. In this study, 50 male C57BL/6 J mice were randomly assigned to five groups: control group (Con), 2,4,6-trinitrobenzenesulfonic acid (TNBS) group, and three zinc supplementation groups, namely 160 ppm group, 400 ppm group, and 1000 ppm group. The results showed that supplementation of dietary zinc with zinc oxide could effectively relieve the severity of ulcerative colitis induced by TNBS in mice. We demonstrate that the protective mechanism involves the immunomodulation of dietary zinc by increasing CD3
    MeSH term(s) Mice ; Male ; Animals ; NF-kappa B/metabolism ; Colitis, Ulcerative ; NLR Family, Pyrin Domain-Containing 3 Protein ; Th17 Cells/metabolism ; Zinc Oxide/pharmacology ; Mice, Inbred C57BL ; Colitis/chemically induced ; Colitis/drug therapy ; Colitis/prevention & control ; Inflammatory Bowel Diseases ; Signal Transduction ; Zinc/adverse effects ; Disease Models, Animal
    Chemical Substances NF-kappa B ; NLR Family, Pyrin Domain-Containing 3 Protein ; Zinc Oxide (SOI2LOH54Z) ; Zinc (J41CSQ7QDS)
    Language English
    Publishing date 2023-05-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 445336-0
    ISSN 1559-0720 ; 0163-4984
    ISSN (online) 1559-0720
    ISSN 0163-4984
    DOI 10.1007/s12011-023-03715-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2323: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Adult midgut malrotation: multi-detector computed tomography (MDCT) findings of 14 cases.

    Yang, Bin / Chen, Wen-Hui / Zhang, Xiao-Feng / Luo, Zhong-Rao

    Japanese journal of radiology

    2013  Volume 31, Issue 5, Page(s) 328–335

    Abstract: Purpose: To describe MDCT findings in adult patients of midgut malrotation and to correlate the types of adult midgut malrotation with its complications.: Materials and methods: CT scans were performed on 14 adult patients with midgut malrotation. ... ...

    Abstract Purpose: To describe MDCT findings in adult patients of midgut malrotation and to correlate the types of adult midgut malrotation with its complications.
    Materials and methods: CT scans were performed on 14 adult patients with midgut malrotation. The images were reviewed retrospectively by one radiologist. Abnormal intestinal location, mesenteric vascular arrangement, extraintestinal anomalies and complications were evaluated and correlated with patterns of adult midgut malrotation.
    Results: The 14 cases of adult midgut malrotation revealed the following CT findings: intestinal malposition (n = 14), abnormally oriented mesenteric vessels (n = 8), extraintestinal anomalies (n = 14). These cases were classified into six types: complete nonrotation (n = 3), nonrotated duodenum and partially rotated colon (n = 6), isolated nonrotation of the duodenum (n = 2), partial rotation of the duodenum and colon (n = 1), partially rotated duodenum (n = 1) and isolated colonic partial rotation (n = 1). Four of these patients had accompanying complications, including volvulus (n = 2), right paraduodenal hernia (n = 1) and gastroduodenal intussusception (n = 1), respectively.
    Conclusion: Imaging features of adult midgut malrotation are characteristic. Adult midgut malrotation has various manifestations, and types of midgut malrotation may be closely related to their complications.
    MeSH term(s) Abnormalities, Multiple/diagnostic imaging ; Adult ; Aged ; Duodenum/abnormalities ; Duodenum/diagnostic imaging ; Female ; Hernia/diagnostic imaging ; Humans ; Intestines/abnormalities ; Intestines/diagnostic imaging ; Intussusception/diagnostic imaging ; Male ; Middle Aged ; Multidetector Computed Tomography ; Retrospective Studies ; Rotation
    Language English
    Publishing date 2013-03-09
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2488907-6
    ISSN 1867-108X ; 1867-1071
    ISSN (online) 1867-108X
    ISSN 1867-1071
    DOI 10.1007/s11604-013-0194-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2249: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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