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  1. Article ; Online: Effective Attenuation of Arteriosclerosis Following Lymphatic-Targeted Delivery of Hyaluronic Acid-Decorated Rapamycin Liposomes.

    Liu, Xiaojia / Lin, Caiyan / Zhong, Wenfei / Yuan, Zhongwen / Yan, Pengke / Guan, Shixia

    International journal of nanomedicine

    2023  Volume 18, Page(s) 4403–4419

    Abstract: Background: The activation of lymphatic vessel function is the crux to resolving atherosclerosis (AS), a chronic inflammatory disease. Rapamycin (RAPA) recently has attracted considerable attention as a potent drug to induce atherosclerotic plaque ... ...

    Abstract Background: The activation of lymphatic vessel function is the crux to resolving atherosclerosis (AS), a chronic inflammatory disease. Rapamycin (RAPA) recently has attracted considerable attention as a potent drug to induce atherosclerotic plaque attenuation. The objective of this work was to develop a ligand-decorated, RAPA-loaded liposome for lymphatic-targeted delivery of drugs to improve abnormal lymphatic structure and function, resulting in highly effective regression of atherosclerotic plaques.
    Methods: Hyaluronic acid-decorated, RAPA-loaded liposomes (HA-RL) were fabricated by emulsion-solvent evaporation. The average size, zeta potential, entrapment efficiency were characterized, and the stability and drug release in vitro were investigated. Furthermore, the in vitro and in vivo lymphatic targeting ability were evaluated on lymphatic endothelial cells and LDLR
    Results: HA-RL had a size of 100 nm, over 90% drug encapsulation efficiency, the storage stability was distinguished, demonstrating a slow release from the lipid nano-carriers. The mean retention time (MRT) and elimination half-life (t
    Conclusion: HA-RL exhibited the most appreciable lymphatic targeting ability and best atherosclerotic plaques attenuation efficiency, opening a new paradigm and promising perspective for the treatment of arteriosclerosis.
    MeSH term(s) Mice ; Animals ; Liposomes/chemistry ; Hyaluronic Acid/chemistry ; Sirolimus/pharmacology ; Plaque, Atherosclerotic/drug therapy ; Endothelial Cells ; Drug Delivery Systems/methods ; Atherosclerosis/drug therapy
    Chemical Substances Liposomes ; Hyaluronic Acid (9004-61-9) ; Sirolimus (W36ZG6FT64)
    Language English
    Publishing date 2023-08-02
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2364941-0
    ISSN 1178-2013 ; 1176-9114
    ISSN (online) 1178-2013
    ISSN 1176-9114
    DOI 10.2147/IJN.S410653
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Effective prediction of potential ferroptosis critical genes in clinical colorectal cancer.

    Huang, Hongliang / Dai, Yuexiang / Duan, Yingying / Yuan, Zhongwen / Li, Yanxuan / Zhang, Maomao / Zhu, Wenting / Yu, Hang / Zhong, Wenfei / Feng, Senling

    Frontiers in oncology

    2022  Volume 12, Page(s) 1033044

    Abstract: Background: Colon cancer is common worldwide, with high morbidity and poor prognosis. Ferroptosis is a novel form of cell death driven by the accumulation of iron-dependent lipid peroxides, which differs from other programmed cell death mechanisms. ... ...

    Abstract Background: Colon cancer is common worldwide, with high morbidity and poor prognosis. Ferroptosis is a novel form of cell death driven by the accumulation of iron-dependent lipid peroxides, which differs from other programmed cell death mechanisms. Programmed cell death is a cancer hallmark, and ferroptosis is known to participate in various cancers, including colon cancer. Novel ferroptosis markers and targeted colon cancer therapies are urgently needed. To this end, we performed a preliminary exploration of ferroptosis-related genes in colon cancer to enable new treatment strategies.
    Methods: Ferroptosis-related genes in colon cancer were obtained by data mining and screening for differentially expressed genes (DEGs) using bioinformatics analysis tools. We normalized the data across four independent datasets and a ferroptosis-specific database. Identified genes were validated by immunohistochemical analysis of pathological and healthy clinical samples.
    Results: We identified DEGs in colon cancer that are involved in ferroptosis. Among these, five core genes were found:
    Conclusions: The preliminary exploration of the five core genes revealed that they are differentially expressed in colon cancer, playing an essential role in ferroptosis. This study provides a foundation for subsequent research on ferroptosis in colon cancer.
    Language English
    Publishing date 2022-10-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2022.1033044
    Database MEDical Literature Analysis and Retrieval System OnLINE

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