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  1. Article: Predicting the macrovascular contribution to resting-state fMRI functional connectivity at 3 Tesla: A model-informed approach.

    Zhong, Xiaole Z / Polimeni, Jonathan R / Chen, J Jean

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Macrovascular biases have been a long-standing challenge for fMRI, limiting its ability to detect spatially specific neural activity. Recent experimental studies, including our own (Huck et al., 2023; Zhong et al., 2023), found substantial resting-state ... ...

    Abstract Macrovascular biases have been a long-standing challenge for fMRI, limiting its ability to detect spatially specific neural activity. Recent experimental studies, including our own (Huck et al., 2023; Zhong et al., 2023), found substantial resting-state macrovascular BOLD fMRI contributions from large veins and arteries, extending into the perivascular tissue at 3 T and 7 T. The objective of this study is to demonstrate the feasibility of predicting, using a biophysical model, the experimental resting-state BOLD fluctuation amplitude (RSFA) and associated functional connectivity (FC) values at 3 Tesla. We investigated the feasibility of both 2D and 3D infinite-cylinder models as well as macrovascular anatomical networks (mVANs) derived from angiograms. Our results demonstrate that: 1) with the availability of mVANs, it is feasible to model macrovascular BOLD FC using both the mVAN-based model and 3D infinite-cylinder models, though the former performed better; 2) biophysical modelling can accurately predict the BOLD pairwise correlation near to large veins (with R
    Language English
    Publishing date 2024-02-16
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.02.13.580143
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Resting-state functional magnetic resonance imaging signal variations in aging: The role of neural activity.

    Zhong, Xiaole Z / Chen, J Jean

    Human brain mapping

    2022  Volume 43, Issue 9, Page(s) 2880–2897

    Abstract: Resting-state functional magnetic resonance imaging (rs-fMRI) has been extensively used to study brain aging, but the age effect on the frequency content of the rs-fMRI signal has scarcely been examined. Moreover, the neuronal implications of such age ... ...

    Abstract Resting-state functional magnetic resonance imaging (rs-fMRI) has been extensively used to study brain aging, but the age effect on the frequency content of the rs-fMRI signal has scarcely been examined. Moreover, the neuronal implications of such age effects and age-sex interaction remain unclear. In this study, we examined the effects of age and sex on the rs-fMRI signal frequency using the Leipzig mind-brain-body data set. Over a frequency band of up to 0.3 Hz, we found that the rs-fMRI fluctuation frequency is higher in the older adults, although the fluctuation amplitude is lower. The rs-fMRI signal frequency is also higher in men than in women. Both age and sex effects on fMRI frequency vary with the frequency band examined but are not found in the frequency of physiological-noise components. This higher rs-fMRI frequency in older adults is not mediated by the electroencephalograph (EEG)-frequency increase but a likely link between fMRI signal frequency and EEG entropy, which vary with age and sex. Additionally, in different rs-fMRI frequency bands, the fMRI-EEG amplitude ratio is higher in young adults. This is the first study to investigate the neuronal contribution to age and sex effects in the frequency dimension of the rs-fMRI signal and may lead to the development of new, frequency-based rs-fMRI metrics. Our study demonstrates that Fourier analysis of the fMRI signal can reveal novel information about aging. Furthermore, fMRI and EEG signals reflect different aspects of age- and sex-related brain differences, but the signal frequency and complexity, instead of amplitude, may hold their link.
    MeSH term(s) Aged ; Aging/physiology ; Brain/physiology ; Brain Mapping/methods ; Electroencephalography ; Female ; Humans ; Magnetic Resonance Imaging/methods ; Male ; Young Adult
    Language English
    Publishing date 2022-03-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1197207-5
    ISSN 1097-0193 ; 1065-9471
    ISSN (online) 1097-0193
    ISSN 1065-9471
    DOI 10.1002/hbm.25823
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Generating dynamic carbon-dioxide traces from respiration-belt recordings: Feasibility using neural networks and application in functional magnetic resonance imaging.

    Agrawal, Vismay / Zhong, Xiaole Z / Chen, J Jean

    Frontiers in neuroimaging

    2023  Volume 2, Page(s) 1119539

    Abstract: Introduction: In the context of functional magnetic resonance imaging (fMRI), carbon dioxide (CO: Methods: In this proof-of-concept study, we propose a deep-learning (DL) approach to reconstruct CO2 and PETCO2 data from respiration waveforms in the ... ...

    Abstract Introduction: In the context of functional magnetic resonance imaging (fMRI), carbon dioxide (CO
    Methods: In this proof-of-concept study, we propose a deep-learning (DL) approach to reconstruct CO2 and PETCO2 data from respiration waveforms in the resting state.
    Results: We demonstrate that the one-to-one mapping between respiration and CO
    Discussion: Our results demonstrate that dynamic CO
    Language English
    Publishing date 2023-02-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 3123824-5
    ISSN 2813-1193 ; 2813-1193
    ISSN (online) 2813-1193
    ISSN 2813-1193
    DOI 10.3389/fnimg.2023.1119539
    Database MEDical Literature Analysis and Retrieval System OnLINE

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