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Article: Successful management of life-threatening aortoesophageal fistula: A case report and review of the literature.

Zhong, Xue-Qing / Li, Guo-Xiong

World journal of clinical cases

2022 Volume 10, Issue 12, Page(s) 3814–3821

Abstract: Background: Aortoesophageal fistula (AEF) is a rare but life-threatening cause of upper gastrointestinal bleeding. Only a handful of cases of successful management of AEF caused by esophageal cancer have been reported. The purpose of this study is to ... ...

Abstract	Background: Aortoesophageal fistula (AEF) is a rare but life-threatening cause of upper gastrointestinal bleeding. Only a handful of cases of successful management of AEF caused by esophageal cancer have been reported. The purpose of this study is to report a case of AEF managed by endovascular aortic repair and review the relevant literature. Case summary: A 66-year-old man with upper gastroenterology bleeding presented at the Emergency Department of our hospital complaining of chest pain, fever and hematemesis for 6 h. He had vomited 400 mL of bright-red blood and experienced severe chest pain 6 h prior. He had a past medical history of advanced esophageal cancer. He received chemoradiotherapy but stopped 8 mo prior because of intolerance. A chest contrast computed tomographic scan revealed communication between the esophagus and the descending aorta as well as a descending aortic pseudoaneurysm. According to the symptoms and imaging findings, AEF was our primary consideration. The patient underwent aortic angiography, which indicated AEF and descending aortic pseudoaneurysm. Emergency percutaneous thoracic endovascular aortic repair (TEVAR) of the descending aorta was performed, and bleeding was controlled after TEVAR. He received antibiotics and was discharged after treatment. However, he died 2 mo after the TEVAR due to cancer progression. Conclusion: Although AEF is a lethal condition, timely diagnosis and TEVAR may successfully control bleeding.
Language	English
Publishing date	2022-05-11
Publishing country	United States
Document type	Case Reports
ISSN	2307-8960
ISSN	2307-8960
DOI	10.12998/wjcc.v10.i12.3814
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A Novel Hollow Graphene/Polydimethylsiloxane Composite for Pressure Sensors with High Sensitivity and Superhydrophobicity.

Zhong, Xue / Jiao, Weicheng / Liu, Wenbo / Wang, Rongguo / He, Xiaodong

ACS applied materials & interfaces

2024

Abstract: Flexible pressure sensors have attracted great interest as they play an important role in various fields such as health monitoring and human-machine interactions. The design of the pressure sensors still faces challenges in achieving a high sensitivity ... ...

Abstract	Flexible pressure sensors have attracted great interest as they play an important role in various fields such as health monitoring and human-machine interactions. The design of the pressure sensors still faces challenges in achieving a high sensitivity for a wide sensing range, and the interference of water restricts the applications of the sensors. Herein, we developed a graphene-polydimethylsiloxane film combining a hierarchical surface with nanowrinkles on it and a hollow structure. The microstructure design of the composite can be facilely controlled to improve the sensing and hydrophobic performance by tailoring the microsphere building units. Attributed to the irregular surface and hollow structure of the sensing layer, the optimized sensor exhibits a superior sensitivity of 1085 kPa
Language	English
Publishing date	2024-05-08
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.4c01414
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Article: Regulation of bone metabolism mediated by β-adrenergic receptor and its clinical application.

Zhong, Xue-Ping / Xia, Wen-Fang

World journal of clinical cases

2021 Volume 9, Issue 30, Page(s) 8967–8973

Abstract: Recent studies have confirmed that β-adrenergic receptors (β-ARs) are expressed on the surface of osteoblasts and osteoclasts, and that the sympathetic nervous system can regulate bone metabolism by activating them. β-AR blockers (BBs) are commonly used ... ...

Abstract	Recent studies have confirmed that β-adrenergic receptors (β-ARs) are expressed on the surface of osteoblasts and osteoclasts, and that the sympathetic nervous system can regulate bone metabolism by activating them. β-AR blockers (BBs) are commonly used in the treatment of cardiovascular diseases in the elderly. It is important to investigate whether BBs have a beneficial effect on bone metabolism in the treatment of cardiovascular diseases, so as to expand their clinical application. This article reviews the effects of BB on bone metabolism and the progress of clinical research.
Language	English
Publishing date	2021-11-09
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2307-8960
ISSN	2307-8960
DOI	10.12998/wjcc.v9.i30.8967
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Thesis: Verbesserung des Patienten-Outcomes durch präoperative Gabe von Methylprednisolon vor bauchchirurgischen Eingriffen

Fu, Zhong Xue

eine prospektive klinische Doppelblindstudie

1997

Author's details	vorgelegt von Zhong Xue Fu
Language	German
Size	106 S. : graph. Darst.
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Köln, Univ., Diss., 1997
HBZ-ID	HT008017245
Database	Catalogue ZB MED Medicine, Health

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Shelf mark	Loan status	Location
97 D 3306	order for loan	Magazin

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Article: Paired-related homeobox 1 induces epithelial-mesenchymal transition in oesophageal squamous cancer.

Guo, Jin-Bao / Du, Ming / Wang, Bin / Zhong, Li / Fu, Zhong-Xue / Wei, Jin-Lai

World journal of gastrointestinal oncology

2024 Volume 15, Issue 12, Page(s) 2185–2196

Abstract: Background: It is unclear that paired-related homeobox 1 (PRRX1) induces epithelial-mesenchymal transition (EMT) in oesophageal cancer and the specific function of PRRX1 in oesophageal cancer metastasis.: Aim: To assess the signiﬁcance of PRRX1 ... ...

Abstract	Background: It is unclear that paired-related homeobox 1 (PRRX1) induces epithelial-mesenchymal transition (EMT) in oesophageal cancer and the specific function of PRRX1 in oesophageal cancer metastasis. Aim: To assess the signiﬁcance of PRRX1 expression and investigate the mechanism of EMT in oesophageal cancer metastasis. Methods: Detect the expression of PRRX1 by immunohistochemistry in oesophageal tumour tissues and adjacent normal oesophageal tissues; the PRRX1 short hairpin RNA (shRNA) or blank vector lentiviral gene delivery system was transfected into cells; cell proliferation assay, soft agar colony formation assays, cell invasion and migration assays and animal studies were used to observe cells biological characteristics Results: PRRX1 is expressed at high levels in oesophageal cancer specimens and is closely related to tumour metastasis in patients with oesophageal cancer. Regulation of PRRX1 expression might exert obvious effects on cell proliferation, especially the migration and invasion of oesophageal cancer cells. Moreover, silencing PRRX1 expression using a shRNA produced the opposite effects. In addition, when PRRX1 was overexpressed, inhibition of the Wnt/β-catenin pathway with XAV939 negated the effect of PRRX1 on EMT, whereas when PRRX1 was downregulated, activation of the Wnt/β-catenin pathway with LiCl impaired the effect on EMT. Conclusion: PRRX1 is upregulated in oesophageal cancer is closely correlated with cancer metastasis. Additionally, PRRX1 induces EMT in oesophageal cancer metastasis through activation of Wnt/β-catenin signalling.
Language	English
Publishing date	2024-01-04
Publishing country	China
Document type	Journal Article
ZDB-ID	2573696-6
ISSN	1948-5204
ISSN	1948-5204
DOI	10.4251/wjgo.v15.i12.2185
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Article ; Online: Realization of digital twin for dynamic control toward sample variation of ion exchange chromatography in antibody separation.

Shi, Ce / Chen, Xu-Jun / Zhong, Xue-Zhao / Yang, Yan / Lin, Dong-Qiang / Chen, Ran

Biotechnology and bioengineering

2024 Volume 121, Issue 5, Page(s) 1702–1715

Abstract: Digital twin (DT) is a virtual and digital representation of physical objects or processes. In this paper, this concept is applied to dynamic control of the collection window in the ion exchange chromatography (IEC) toward sample variations. A possible ... ...

Abstract	Digital twin (DT) is a virtual and digital representation of physical objects or processes. In this paper, this concept is applied to dynamic control of the collection window in the ion exchange chromatography (IEC) toward sample variations. A possible structure of a feedforward model-based control DT system was proposed. Initially, a precise IEC mechanistic model was established through experiments, model fitting, and validation. The average root mean square error (RMSE) of fitting and validation was 8.1% and 7.4%, respectively. Then a model-based gradient optimization was performed, resulting in a 70.0% yield with a remarkable 11.2% increase. Subsequently, the DT was established by systematically integrating the model, chromatography system, online high-performance liquid chromatography, and a server computer. The DT was validated under varying load conditions. The results demonstrated that the DT could offer an accurate control with acidic variants proportion and yield difference of less than 2% compared to the offline analysis. The embedding mechanistic model also showed a positive predictive performance with an average RMSE of 11.7% during the DT test under >10% sample variation. Practical scenario tests indicated that tightening the control target could further enhance the DT robustness, achieving over 98% success rate with an average yield of 72.7%. The results demonstrated that the constructed DT could accurately mimic real-world situations and perform an automated and flexible pooling in IEC. Additionally, a detailed methodology for applying DT was summarized.
MeSH term(s)	Chromatography, High Pressure Liquid/methods ; Antibodies, Monoclonal/chemistry ; Chromatography, Ion Exchange/methods
Chemical Substances	Antibodies, Monoclonal
Language	English
Publishing date	2024-01-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	280318-5
ISSN	1097-0290 ; 0006-3592
ISSN (online)	1097-0290
ISSN	0006-3592
DOI	10.1002/bit.28660
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Article ; Online: Calcium oscillation on homogeneous and heterogeneous networks of ryanodine receptor.

Gao, Zhong-Xue / Li, Tian-Tian / Jiang, Han-Yu / He, Jun

Physical review. E

2023 Volume 107, Issue 2-1, Page(s) 24402

Abstract: Calcium oscillation is an important calcium homeostasis, imbalance of which is the key mechanism of initiation and progression of many major diseases. The formation and maintenance of calcium homeostasis are closely related to the spatial distribution of ...

Abstract	Calcium oscillation is an important calcium homeostasis, imbalance of which is the key mechanism of initiation and progression of many major diseases. The formation and maintenance of calcium homeostasis are closely related to the spatial distribution of calcium channels on endoplasmic reticulum, whose complex structure was unveiled by recent observations with superresolution imaging techniques. In the current paper, a theoretical framework is established by abstracting the spatial distribution of the calcium channels as a nonlinear biological complex network with calcium channels as nodes and Ca^{2+} as edges. A dynamical model for a ryanodine receptor (RyR) is adopted to investigate the effect of spatial distribution on calcium oscillation. The mean-field model can be well reproduced from the complete graph and dense Erdös-Rényi network. The synchronization of RyRs is found important to generate a global calcium oscillation. Below a critical density of the Erdös-Rényi or BaraBási-Albert network, the amplitude and interspike interval decrease rapidly with the end of disappearance of oscillation due to the desynchronization. The clique graph with a cluster structure cannot produce a global oscillation due to the failure of synchronization between clusters. A more realistic geometric network is constructed in a two-dimensional plane based on the experimental information about the RyR arrangement of clusters and the frequency distribution of cluster sizes. Different from the clique graph, the global oscillation can be generated with reasonable parameters on the geometric network. The simulation also suggests that existence of small clusters and rogue RyRs plays an important role in the maintenance of global calcium oscillation through keeping synchronization between large clusters. Such results support the heterogeneous distribution of RyRs with different-size clusters, which is helpful to understand recent observations with superresolution nanoscale imaging techniques. The current theoretical framework can also be extent to investigate other phenomena in calcium signal transduction.
MeSH term(s)	Calcium Signaling/physiology ; Ryanodine Receptor Calcium Release Channel/metabolism ; Calcium/metabolism ; Computer Simulation ; Homeostasis
Chemical Substances	Ryanodine Receptor Calcium Release Channel ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2023-03-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2844562-4
ISSN	2470-0053 ; 2470-0045
ISSN (online)	2470-0053
ISSN	2470-0045
DOI	10.1103/PhysRevE.107.024402
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: New approach for the treatment of vertical root fracture of teeth: A case report and review of literature.

Zhong, Xue / Yan, Ping / Fan, Wei

World journal of clinical cases

2022 Volume 10, Issue 17, Page(s) 5816–5824

Abstract: Background: Vertical root fracture (VRF) is one of the most common reasons for tooth extraction, although various methods have been applied for saving teeth with VRF.: Case summary: This case report describes a woman who had a sinus tract on the ... ...

Abstract	Background: Vertical root fracture (VRF) is one of the most common reasons for tooth extraction, although various methods have been applied for saving teeth with VRF. Case summary: This case report describes a woman who had a sinus tract on the labial gingiva of the left maxillary central incisor for past two months. Periodontal probing revealed an 8-10 mm deep, narrow, isolated pocket on the palatal side of the tooth. Clinical and radiographic examination confirmed a longitudinal root fracture. A new approach using a combination of resin and iRoot BP Plus through intentional replantation was used for the treatment of the tooth. At one-year follow-up, the tooth remained asymptomatic with normal periodontal probing depth, and radiographic images showed almost normal bone and periodontal structures around the root. Conclusion: This new approach may be developed as an effective method for saving teeth with VRF.
Language	English
Publishing date	2022-08-01
Publishing country	United States
Document type	Case Reports
ISSN	2307-8960
ISSN	2307-8960
DOI	10.12998/wjcc.v10.i17.5816
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The Efficacy of Denosumab in Patients With Rheumatoid Arthritis: A Systematic Review and Pooled Analysis of Randomized or Matched Data.

Hu, Qiongwen / Zhong, Xue / Tian, Hua / Liao, Pu

Frontiers in immunology

2022 Volume 12, Page(s) 799575

Abstract: Objective: The purpose of this study was to evaluate the efficacy of denosumab treatment in patients with rheumatoid arthritis (RA).: Methods: The Medline, Embase and Cochrane Library databases were searched for relevant clinical studies. Studies ... ...

Abstract	Objective: The purpose of this study was to evaluate the efficacy of denosumab treatment in patients with rheumatoid arthritis (RA). Methods: The Medline, Embase and Cochrane Library databases were searched for relevant clinical studies. Studies that assessed the efficacy of denosumab in patients with RA were identified. The primary endpoints were the percent changes in bone mineral density (BMD), and the changes in modified total Sharp score (mTSS), modified Sharp erosion score and joint space narrowing (JSN) score. Pooled analyses were calculated using random-effect models. Results: After searching the literature and performing further detailed assessments, 10 studies with a total of 1758 patients were included in the quantitative analysis. Pooled analyses showed that denosumab treatment significantly increased the percent changes in lumbar spine BMD [mean difference (MD): 5.12, confidence intervals (CI): 4.15 to 6.09], total hip BMD (MD: 2.72, 95% CI: 1.80 to 3.64) and femoral neck BMD (MD: 2.20, 95% CI: 0.94 to 3.46) compared with controls. Moreover, denosumab treatment significantly decreased the changes in mTSS (MD: -0.63, 95% CI: -0.86 to -0.41) and modified Sharp erosion score (MD: -0.62, 95% CI: -0.88 to -0.35). Subgroup analysis indicated that denosumab was superior to bisphosphonates for the improvement of BMD and the mitigation of joint destruction. Conclusion: Denosumab treatment was associated with increased BMD and alleviated progression of joint destruction in RA patients, even when compared with bisphosphonates.
MeSH term(s)	Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/physiopathology ; Bone Density/drug effects ; Bone Density Conservation Agents/therapeutic use ; Denosumab/therapeutic use ; Female ; Humans ; Joints/drug effects ; Joints/pathology ; Joints/physiopathology ; Lumbar Vertebrae/drug effects ; Lumbar Vertebrae/pathology ; Lumbar Vertebrae/physiopathology ; Male ; Middle Aged ; Randomized Controlled Trials as Topic ; Treatment Outcome
Chemical Substances	Bone Density Conservation Agents ; Denosumab (4EQZ6YO2HI)
Language	English
Publishing date	2022-01-05
Publishing country	Switzerland
Document type	Meta-Analysis ; Systematic Review
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2021.799575
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Assessing Global Efforts in the Selection of Vertebrates as Umbrella Species for Conservation

Yang, Nan / Price, Megan / Xu, Yu / Zhu, Yun / Zhong, Xue / Cheng, Yuehong / Wang, Bin

Biology (Basel). 2023 Mar. 28, v. 12, no. 4

2023

Abstract: The umbrella-species strategy has been proposed as an attainable tool to achieve multi-species and community conservation with limited investment. There have been many umbrella-related studies since the concept’s inception; thus, a summary of global ... ...

Abstract	The umbrella-species strategy has been proposed as an attainable tool to achieve multi-species and community conservation with limited investment. There have been many umbrella-related studies since the concept’s inception; thus, a summary of global study efforts and recommended umbrella species is important for understanding advances in the field and facilitating conservation applications. Here, we collated 213 recommended umbrella species of terrestrial vertebrates from 242 scientific articles published during 1984–2021 and analyzed their geographic patterns, biological features, and conservation statuses to identify global trends in the selection of umbrella species. We found a considerable geographic bias: most studies and, consequently, recommended umbrella species are from the Northern Hemisphere. There is also a strong taxonomic bias, with grouses (order Galliformes) and large carnivores being the most popular umbrella species and amphibians and reptiles being largely overlooked. In addition, wide-ranging and non-threatened species were frequently recommended as umbrella species. Given the observed biases and trends, we caution that appropriate species need to be chosen for each location, and it is important to confirm that popular, wide-ranging species are effective umbrella species. Moreover, amphibians and reptiles should be investigated for their potential as umbrella species. The umbrella-species strategy has many strengths and, if applied appropriately, may be one of the best options in today’s conservation research and funding landscape.
Keywords	Galliformes ; amphibians ; carnivores ; conservation status ; fields ; grouse ; reptiles
Language	English
Dates of publication	2023-0328
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2661517-4
ISSN	2079-7737
ISSN	2079-7737
DOI	10.3390/biology12040509
Database	NAL-Catalogue (AGRICOLA)

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