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  1. Article: [The role of the retinoid-related orphan receptor α in the regulation of lipid metabolism].

    Lin, Jia-Chen / Sun, Yan-Sha / Zhou, Bo-Ya

    Sheng li ke xue jin zhan [Progress in physiology

    2015  Volume 46, Issue 4, Page(s) 281–286

    MeSH term(s) Lipid Metabolism ; Nuclear Receptor Subfamily 1, Group F, Member 1
    Chemical Substances Nuclear Receptor Subfamily 1, Group F, Member 1
    Language Chinese
    Publishing date 2015-08
    Publishing country China
    Document type Journal Article
    ZDB-ID 259864-4
    ISSN 0559-7765
    ISSN 0559-7765
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3363: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Nintedanib inhibits keloid fibroblast functions by blocking the phosphorylation of multiple kinases and enhancing receptor internalization.

    Zhou, Bo-Ya / Wang, Wen-Bo / Wu, Xiao-Li / Zhang, Wen-Jie / Zhou, Guang-Dong / Gao, Zhen / Liu, Wei

    Acta pharmacologica Sinica

    2020  Volume 41, Issue 9, Page(s) 1234–1245

    Abstract: Keloid is a benign skin tumor characterized by its cell hyperproliferative activity, invasion into normal skin, uncontrolled growth, overproduction and deposition of extracellular matrices and high recurrence rate after various therapies. Nintedanib is a ...

    Abstract Keloid is a benign skin tumor characterized by its cell hyperproliferative activity, invasion into normal skin, uncontrolled growth, overproduction and deposition of extracellular matrices and high recurrence rate after various therapies. Nintedanib is a receptor tyrosine kinase inhibitor targeting VEGF, PDGF, FGF, and TGF-β receptors with proved efficacy in anti-angiogenesis and in treating various types of cancers. In this study, we investigated the effects of nintedanib on keloid fibroblasts in both in vitro and ex vivo models. Keloid fibroblasts were prepared from 54 keloid scar samples in active stages collected from 49 patients. We found that nintedanib (1-4 μM) dose-dependently suppressed cell proliferation, induced G
    MeSH term(s) Adolescent ; Adult ; Aged ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Child ; Collagen/metabolism ; Dose-Response Relationship, Drug ; Female ; Fibroblasts/drug effects ; G1 Phase Cell Cycle Checkpoints/drug effects ; Gene Expression Regulation/drug effects ; Humans ; Indoles/pharmacology ; Keloid/pathology ; MAP Kinase Signaling System/drug effects ; Male ; Middle Aged ; Phosphorylation/drug effects ; Protein Kinase Inhibitors/pharmacology ; Protein Kinases/metabolism ; Receptors, Growth Factor/metabolism ; Young Adult
    Chemical Substances Indoles ; Protein Kinase Inhibitors ; Receptors, Growth Factor ; Collagen (9007-34-5) ; Protein Kinases (EC 2.7.-) ; nintedanib (G6HRD2P839)
    Keywords covid19
    Language English
    Publishing date 2020-04-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1360774-1
    ISSN 1745-7254 ; 0253-9756 ; 1671-4083
    ISSN (online) 1745-7254
    ISSN 0253-9756 ; 1671-4083
    DOI 10.1038/s41401-020-0381-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1904: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Rational Use and Pharmaceutical Care of Coronavirus Disease 2019 during Pregnancy/ 妊娠期合并新型冠状病毒肺炎药物合理使用与药学监护

    Li, Yi-Fan / Yuan, Si-Si / Zhou, Bo-Ya / Gai, Di / Wang, Yue / Feng, Xin

    Chin. Pharm. J. (China)

    Abstract: Since December 2019, a new type of coronavirus pneumonia (coronavirus disease 2019,COVID-19) has been emerging and has attracted widespread attention. Because of its characteristics of rapid spread, wide spread, long incubation period and high infection ... ...

    Abstract Since December 2019, a new type of coronavirus pneumonia (coronavirus disease 2019,COVID-19) has been emerging and has attracted widespread attention. Because of its characteristics of rapid spread, wide spread, long incubation period and high infection rate, a few pregnant women are infected. In order to better cooperate with the clinical pharmaceutical care, the pregnancy pharmaceutical care points of antiviral drugs mentioned in COVID-19 diagnosis and treatment guidelines are specially sorted out. It aims to provide clinicians and pharmacists with a quick understanding of the characteristics, usage and dosage and precautions of recommended antiviral drugs at present, so as to ensure the safety and rational use of drugs and improve the treatment effect of patients with new crown pneumonia.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #706045
    Database COVID19

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  4. Article: A Novel Network Pharmacology Strategy to Decode Mechanism of Lang Chuang Wan in Treating Systemic Lupus Erythematosus.

    Gao, Yao / Wang, Ke-Xin / Wang, Peng / Li, Xiao / Chen, Jing-Jing / Zhou, Bo-Ya / Tian, Jun-Sheng / Guan, Dao-Gang / Qin, Xue-Mei / Lu, Ai-Ping

    Frontiers in pharmacology

    2020  Volume 11, Page(s) 512877

    Abstract: Complex disease is a cascade process which is associated with functional abnormalities in multiple proteins and protein-protein interaction (PPI) networks. One drug one target has not been able to perfectly intervene complex diseases. Increasing ... ...

    Abstract Complex disease is a cascade process which is associated with functional abnormalities in multiple proteins and protein-protein interaction (PPI) networks. One drug one target has not been able to perfectly intervene complex diseases. Increasing evidences show that Chinese herb formula usually treats complex diseases in the form of multi-components and multi-targets. The key step to elucidate the underlying mechanism of formula in traditional Chinese medicine (TCM) is to optimize and capture the important components in the formula. At present, there are several formula optimization models based on network pharmacology has been proposed. Most of these models focus on the 2D/3D similarity of chemical structure of drug components and ignore the functional optimization space based on relationship between pathogenetic genes and drug targets. How to select the key group of effective components (KGEC) from the formula of TCM based on the optimal space which link pathogenic genes and drug targets is a bottleneck problem in network pharmacology. To address this issue, we designed a novel network pharmacological model, which takes Lang Chuang Wan (LCW) treatment of systemic lupus erythematosus (SLE) as the case. We used the weighted gene regulatory network and active components targets network to construct disease-targets-components network, after filtering through the network attribute degree, the optimization space and effective proteins were obtained. And then the KGEC was selected by using contribution index (CI) model based on knapsack algorithm. The results show that the enriched pathways of effective proteins we selected can cover 96% of the pathogenetic genes enriched pathways. After reverse analysis of effective proteins and optimization with CI index model, KGEC with 82 components were obtained, and 105 enriched pathways of KGEC targets were consistent with enriched pathways of pathogenic genes (80.15%). Finally, the key components in KGEC of LCW were evaluated by
    Language English
    Publishing date 2020-10-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2020.512877
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Uncovering the Complexity Mechanism of Different Formulas Treatment for Rheumatoid Arthritis Based on a Novel Network Pharmacology Model.

    Wang, Ke-Xin / Gao, Yao / Lu, Cheng / Li, Yao / Zhou, Bo-Ya / Qin, Xue-Mei / Du, Guan-Hua / Gao, Li / Guan, Dao-Gang / Lu, Ai-Ping

    Frontiers in pharmacology

    2020  Volume 11, Page(s) 1035

    Abstract: Traditional Chinese medicine (TCM) with the characteristics of "multi-component-multi-target-multi-pathway" has obvious advantages in the prevention and treatment of complex diseases, especially in the aspects of "treating the same disease with different ...

    Abstract Traditional Chinese medicine (TCM) with the characteristics of "multi-component-multi-target-multi-pathway" has obvious advantages in the prevention and treatment of complex diseases, especially in the aspects of "treating the same disease with different treatments". However, there are still some problems such as unclear substance basis and molecular mechanism of the effectiveness of formula. Network pharmacology is a new strategy based on system biology and poly-pharmacology, which could observe the intervention of drugs on disease networks at systematical and comprehensive level, and especially suitable for study of complex TCM systems. Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease, causing articular and extra articular dysfunctions among patients, it could lead to irreversible joint damage or disability if left untreated. TCM formulas, Danggui-Sini-decoction (DSD), Guizhi-Fuzi-decoction (GFD), and Huangqi-Guizhi-Wuwu-Decoction (HGWD), et al., have been found successful in controlling RA in clinical applications. Here, a network pharmacology-based approach was established. With this model, key gene network motif with significant (KNMS) of three formulas were predicted, and the molecular mechanism of different formula in the treatment of rheumatoid arthritis (RA) was inferred based on these KNMSs. The results show that the KNMSs predicted by the model kept a high consistency with the corresponding C-T network in coverage of RA pathogenic genes, coverage of functional pathways and cumulative contribution of key nodes, which confirmed the reliability and accuracy of our proposed KNMS prediction strategy. All validated KNMSs of each RA therapy-related formula were employed to decode the mechanisms of different formulas treat the same disease. Finally, the key components in KNMSs of each formula were evaluated by
    Language English
    Publishing date 2020-07-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2020.01035
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: [Effects of stereoscopic cultivation on photosynthetic characteristics and growth of Tulipa edulis].

    Sun, Yuan / Guo, Qiao-Sheng / Zhu, Zai-Biao / Lin, Jian-Luo / Zhou, Bo-Ya / Zhao, Min-Jie

    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

    2016  Volume 41, Issue 11, Page(s) 2030–2035

    Abstract: The effect of stereoscopic cultivation on the growth, photosynthetic characteristics and yield of Tulipa edulis was studied to explore the feasibility of stereoscopic cultivation on efficient cultivation of T.edulis. Total leaf area and photosynthetic ... ...

    Abstract The effect of stereoscopic cultivation on the growth, photosynthetic characteristics and yield of Tulipa edulis was studied to explore the feasibility of stereoscopic cultivation on efficient cultivation of T.edulis. Total leaf area and photosynthetic parameters of T.edulis under stereoscopic cultivation (the upper, middle and the lower layers ) and the control were measured using LI-3100 leaf area meter and LI-6400XT photosynthesis system in the growing peak period of T.edulis.Plant biomass and biomass allocation were also determined.In addition, the bulb regeneration and yield of T.edulis were measured in the harvesting time.The results indicated that in the middle layer of stereoscopic cultivation, leaf biomass proportion was the highest, but total bulb fresh and dry weight and output growth (fresh weight) were the lowest among the treatments.And total bulb fresh weight in the middle of stereoscopic cultivation reduced significantly, by 22.84%, compared with the control.Light intensity in the lower layer of stereoscopic cultivation was moderate, in which T.edulis net photosynthetic rate and water use efficiency were higher than those of the other layers of stereoscopic cultivation, and bulb biomass proportion was the highest in all the treatments.No significant difference was detected in the total bulb fresh weight, dry weight and output growth (fresh weight) between the middle layer of stereoscopic cultivation and the control.In general, there was no significant difference in the growth status of T.edulis between stereoscopic cultivation and the control.Stereoscopic cultivation increased the yield of T.edulis by 161.66% in fresh weight and 141.35% in dry weight compared with the control in the condition of the same land area, respectively.In conclusion, stereoscopic cultivation can improve space utilization, increase the production, and achieve the high density cultivation of T.edulis.
    Language Chinese
    Publishing date 2016-06
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 1004649-5
    ISSN 1001-5302 ; 0254-0029
    ISSN 1001-5302 ; 0254-0029
    DOI 10.4268/cjcmm20161110
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3056: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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