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Article: [Perioperative management of subglottic foreign body in children].

Zhou, C L / Xia, Z F

Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery

2018 Volume 31, Issue 20, Page(s) 1603–1605

Language	Chinese
Publishing date	2018-06-19
Publishing country	China
Document type	Journal Article
ISSN	1001-1781
ISSN	1001-1781
DOI	10.13201/j.issn.1001-1781.2017.20.014
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Article: [Analysis of the efficacy of azacitidine combined with homoharringtonine and cytarabine in induction and salvage therapy of acute myeloid leukemia].

Hou, J X / Liu, K Q / Hu, Y M / Wei, S N / Zhang, G J / Zhou, C L / Lin, D / Wang, Y / Wei, H / Li, S Z / Wang, J X / Mi, Y C

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi

2023 Volume 43, Issue 9, Page(s) 778–780

MeSH term(s)	Humans ; Homoharringtonine/therapeutic use ; Cytarabine/therapeutic use ; Azacitidine/therapeutic use ; Salvage Therapy ; Leukemia, Myeloid, Acute/drug therapy ; Remission Induction ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Treatment Outcome
Chemical Substances	Homoharringtonine (6FG8041S5B) ; Cytarabine (04079A1RDZ) ; Azacitidine (M801H13NRU)
Language	Chinese
Publishing date	2023-01-28
Publishing country	China
Document type	Journal Article
ZDB-ID	2997162-7
ISSN	0253-2727 ; 0253-2727
ISSN (online)	0253-2727
ISSN	0253-2727
DOI	10.3760/cma.j.issn.0253-2727.2022.09.011
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Article: [Transplantation of bilateral superficial inferior epigastric artery perforator flap for breast reconstruction in a patient with unilateral breast cancer].

Song, D J / Li, Z / Zhou, Y X / Zhang, P / Zhou, C L / Lyu, Y Y / Tang, L / Yi, Z H / Luo, Zhenhua

Zhonghua shao shang yu chuang mian xiu fu za zhi

2022 Volume 38, Issue 10, Page(s) 964–967

Abstract: On May 14, 2020, a 37 year old female patient with unilateral breast cancer was admitted to Hunan Cancer Hospital. She underwent modified radical mastectomy for right breast cancer and free transplantation of bilateral superficial inferior epigastric ... ...

Abstract	On May 14, 2020, a 37 year old female patient with unilateral breast cancer was admitted to Hunan Cancer Hospital. She underwent modified radical mastectomy for right breast cancer and free transplantation of bilateral superficial inferior epigastric artery perforator flap (weighed 305 g) for breast reconstruction. During the operation, the right inferior epigastric vascular pedicle was anastomosed with the proximal end of the right internal mammary vessel, and the left inferior epigastric vascular pedicle was anastomosed with the distal end of the right internal mammary vessel; the blood flow of the flap was good; the wound in the donor site of the abdominal flap was closed directly. The operation lasted for 9 hours. In the first 48 hours post operation, the flap showed mild elevation in perfusion over drainage, but no obvious edema or blister was observed, flap temperature was consistent with the surrounding skin, and the drainage volume out of drainage tube was only 40 mL. The blood supply of the flap was completely restored to normal 3 days post operation, the flap survived well, the donor site incision had no obvious tension, and the healing was smooth. After 2 months of follow-up, the donor site incision of abdomen healed completely, only linear scar was left, and the reconstructed breast had a natural appearance; the patient planned to perform further nipple reconstruction and contralateral breast mastopexy. This case suggests that autologous breast reconstruction can be performed using bilateral superficial inferior epigastric artery perforator flaps under certain circumstances to minimize donor site injury to the greatest extent.
MeSH term(s)	Female ; Humans ; Adult ; Epigastric Arteries/surgery ; Perforator Flap/blood supply ; Breast Neoplasms/surgery ; Mastectomy ; Unilateral Breast Neoplasms/surgery ; Mammaplasty
Language	Chinese
Publishing date	2022-09-28
Publishing country	China
Document type	Case Reports ; English Abstract ; Journal Article
ISSN	2097-1109
ISSN	2097-1109
DOI	10.3760/cma.j.cn501225-20220306-00047
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Article: [Application of tracheotomy in the treatment of severe cases of COVID-19].

Deng, Z F / Zhu, T / Ding, Y J / Zhou, C L / Kang, Y / Qu, J N / Hua, Q Q / Xu, Y

Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery

2020 Volume 55, Page(s) E009

Abstract: Objective: ...

Abstract	Objective:
Keywords	covid19
Language	Chinese
Publishing date	2020-04-15
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	2195655-8
ISSN	1673-0860
ISSN	1673-0860
DOI	10.3760/cma.j.issn.1673-0860.2020.0009
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Zs.A 3733: Show issues

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Article ; Online: Overexpression of miRNA-433-5p protects acute spinal cord injury through activating MAPK1.

Zhou, C-L / Li, F / Wu, X-W / Cong, C-L / Liu, X-D / Tian, J / Zheng, W-Z / Yan, J-L

European review for medical and pharmacological sciences

2020 Volume 24, Issue 6, Page(s) 2829–2835

Abstract: Objective: The aim of this study was to clarify the role of microRNA-433-5p (miRNA-433-5p) in influencing pathological lesions following acute spinal cord injury (SCI) by targeting mitogen-activated protein kinase 1 (MAPK1).: Patients and methods: ... ...

Abstract	Objective: The aim of this study was to clarify the role of microRNA-433-5p (miRNA-433-5p) in influencing pathological lesions following acute spinal cord injury (SCI) by targeting mitogen-activated protein kinase 1 (MAPK1). Patients and methods: SCI model was successfully established in mice by performing hitting injury procedures. Serum levels of miRNA-433-5p and MAPK1 in SCI patients and mice were determined. Grip strengths of both forelimbs in SCI mice and controls were determined. Dual-Luciferase reporter gene assay was applied to verify the binding relation between miRNA-433-5p and MAPK1. After overexpression of miRNA-433-5p and MAPK1 in vivo, the grip strength changes in SCI mice were assessed. Furthermore, the protein level of inflammatory factor iNOS in 293T cells influenced by miRNA-433-5p and MAPK1 was detected by Western blot. Results: MiRNA-433-5p was significantly downregulated in the serum of SCI patients and mice, whereas MAPK1 was up-regulated. Grip strengths of SCI mice were significantly lower than those of controls at different postoperative time points. However, this could be markedly reversed by the in vivo overexpression of miRNA-433-5p. Western blot indicated that the protein level of iNOS was remarkably downregulated in 293T cells overexpressing miRNA-433-5p. MAPK1 was confirmed as the target of miRNA-433-5p, whose expression level was negatively regulated by miRNA-433-5p. Importantly, MAPK1 partially reversed the protective role of miRNA-433-5p in grip strength of SCI mice and inflammatory response at post-SCI. Conclusions: Overexpression of miRNA-433-5p protects SCI-induced motor dysfunction and inflammatory response by targeting MAPK1.
MeSH term(s)	Acute Disease ; Animals ; Disease Models, Animal ; Female ; Humans ; Male ; Mice ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Mitogen-Activated Protein Kinase 1/metabolism ; Spinal Cord Injuries/metabolism ; Spinal Cord Injuries/pathology
Chemical Substances	MIRN433 microRNA, human ; MicroRNAs ; Mirn433 microRNA, mouse ; MAPK1 protein, human (EC 2.7.11.24) ; Mapk1 protein, mouse (EC 2.7.11.24) ; Mitogen-Activated Protein Kinase 1 (EC 2.7.11.24)
Language	English
Publishing date	2020-05-18
Publishing country	Italy
Document type	Journal Article
ZDB-ID	605550-3
ISSN	2284-0729 ; 1128-3602 ; 0392-291X
ISSN (online)	2284-0729
ISSN	1128-3602 ; 0392-291X
DOI	10.26355/eurrev_202003_20644
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Zs.A 1887: Show issues

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Article: [Application of tracheotomy in the treatment of severe cases of COVID-19].

Deng, Z F / Zhu, T / Ding, Y J / Zhou, C L / Kang, Y / Qu, J N / Hua, Q Q / Xu, Y

Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery

2020 Volume 55, Issue 6, Page(s) 576–579

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	COVID-19 ; Coronavirus Infections/surgery ; Humans ; Pandemics ; Pneumonia, Viral/surgery ; Retrospective Studies ; Severity of Illness Index ; Tracheotomy ; Treatment Outcome
Keywords	covid19
Language	Chinese
Publishing date	2020-08-25
Publishing country	China
Document type	Journal Article
ZDB-ID	2195655-8
ISSN	1673-0860
ISSN	1673-0860
DOI	10.3760/cma.j.cn115330-20200305-00162
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Zs.A 3733: Show issues

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Article: [The role of CTLA-4 in the pathogenesis of chronic tonsillitis].

Zhou, C L / Liu, Y H / Da, H T / Ang, Q Q / Sha, Q

Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery

2018 Volume 31, Issue 13, Page(s) 977–980

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	CTLA-4 Antigen/metabolism ; Chronic Disease ; Humans ; Hypertrophy ; Inflammation ; Palatine Tonsil ; Tonsillectomy ; Tonsillitis/immunology
Chemical Substances	CTLA-4 Antigen
Language	Chinese
Publishing date	2018-09-11
Publishing country	China
Document type	Journal Article
ISSN	1001-1781
ISSN	1001-1781
DOI	10.13201/j.issn.1001-1781.2017.13.001
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Article ; Online: Galantamine protects against lipopolysaccharide-induced acute lung injury in rats.

Li, G / Zhou, C L / Zhou, Q S / Zou, H D

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas

2016 Volume 49, Issue 2, Page(s) e5008

Abstract: Lipopolysaccharide (LPS)-induced endotoxemia triggers the secretion of proinflammatory cytokines and can cause acute lung injury (ALI). The high mobility group box 1 (HMGB1) protein plays an important role as a late mediator of sepsis and ALI. ... ...

Abstract	Lipopolysaccharide (LPS)-induced endotoxemia triggers the secretion of proinflammatory cytokines and can cause acute lung injury (ALI). The high mobility group box 1 (HMGB1) protein plays an important role as a late mediator of sepsis and ALI. Galantamine (GAL) is a central acetylcholinesterase inhibitor that inhibits the expression of HMGB1. This study evaluated the effects of GAL by measuring levels of inflammatory mediators and observing histopathological features associated with LPS-induced ALI. Sixty 8-10 week old male Sprague-Dawley rats (200-240 g) were randomized into three groups as follows: control group, LPS group (7.5 mg/kg LPS), and LPS+GAL group (5 mg/kg GAL before LPS administration). Histopathological examination of lung specimens obtained 12 h after LPS administration was performed to analyze changes in wet-to-dry (W/D) weight ratio, myeloperoxidase (MPO) activity, and HMGB1 expression level. Additionally, plasma concentrations of tumor necrosis factor-α, interleukin-6, and HMGB1 were measured using an enzyme-linked immunosorbent assay at 0 (baseline), 3, 6, 9, and 12 h after LPS administration. Mortality in the three groups was recorded at 72 h. LPS-induced ALI was characterized by distortion of pulmonary architecture and elevation of MPO activity, W/D weight ratio, and levels of pro-inflammatory cytokines, including tumor necrosis factor-α, interleukin-6, and HMGB1. Pretreatment with GAL significantly reduced the LPS-induced lung pathological changes, W/D weight ratio, levels of pro-inflammatory cytokines and MPO activity (ANOVA). Moreover, GAL treatment significantly decreased the mortality rate (ANOVA). In conclusion, we demonstrated that GAL exerted a protective effect on LPS-induced ALI in rats.
MeSH term(s)	Acute Lung Injury/chemically induced ; Acute Lung Injury/drug therapy ; Acute Lung Injury/mortality ; Acute Lung Injury/pathology ; Analysis of Variance ; Animals ; Cholinesterase Inhibitors/therapeutic use ; Enzyme-Linked Immunosorbent Assay ; Galantamine/therapeutic use ; HMGB1 Protein/antagonists & inhibitors ; HMGB1 Protein/metabolism ; Interleukin-6/blood ; Lipopolysaccharides ; Lung/drug effects ; Lung/metabolism ; Lung/pathology ; Male ; Mortality ; Organ Size ; Peroxidase/metabolism ; Protective Agents/therapeutic use ; Random Allocation ; Rats, Sprague-Dawley ; Tumor Necrosis Factor-alpha/blood
Chemical Substances	Cholinesterase Inhibitors ; HMGB1 Protein ; Interleukin-6 ; Lipopolysaccharides ; Protective Agents ; Tumor Necrosis Factor-alpha ; Galantamine (0D3Q044KCA) ; Peroxidase (EC 1.11.1.7)
Language	English
Publishing date	2016-02
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	786234-9
ISSN	1414-431X ; 0100-879X
ISSN (online)	1414-431X
ISSN	0100-879X
DOI	10.1590/1414-431X20155008
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Zs.B 1359: Show issues

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Article ; Online: Point-prevalence survey of healthcare-associated infections in Beijing, China: a survey and analysis in 2014.

Liu, J Y / Wu, Y H / Cai, M / Zhou, C L

The Journal of hospital infection

2016 Volume 93, Issue 3, Page(s) 271–279

Abstract: Background: Point-prevalence studies can identify priorities for infection control.: Aim: In May 2014, the Beijing Nosocomial Infection Control and Quality Improvement Centre organized a point-prevalence survey in 124 acute care hospitals in Beijing ... ...

Abstract	Background: Point-prevalence studies can identify priorities for infection control. Aim: In May 2014, the Beijing Nosocomial Infection Control and Quality Improvement Centre organized a point-prevalence survey in 124 acute care hospitals in Beijing province. By analysing the survey results and factors affecting the point prevalence of healthcare-associated infections (HCAIs) in secondary and tertiary acute care hospitals in a certain area of China, this study provides evidence and reference to monitor HCAIs in a wide variety of hospitals. Methods: An epidemiological cross-sectional survey conducted by infection control practitioners was used to assess the point-prevalence rate of HCAIs by reviewing cases and performing bedside surveys. Findings: In total, 124 hospitals and 61,990 patients were surveyed, and 1389 (2.2%) HCAIs were diagnosed in 1294 (2.1%) patients. Respiratory tract infections were the most common HCAIs (54.4%, 51.7-56.9%), followed by urinary tract infections (15.0%, 13.2-16.9%), gastrointestinal tract infections (7.7%, 6.3-9.1%), surgical site infections (6.3%, 5.1-7.6%) and bloodstream infections (5.5%, 4.3-6.8%). In this survey, the top three pathogens were Pseudomonas aeruginosa, Acinetobacter baumannii and Escherichia coli. Rates of central vein catheter insertion, urethral catheterization and mechanical ventilation were 9.9%, 12.4% and 3.8%, respectively. Overall, 23.7% of the patients underwent surgery on or before the date of the survey. HCAIs were present in 14.5% of intensive care unit patients, 2.3% of medical patients and 2% of surgical patients. Diarrhoea was found in 0.8% of the assessed cases; however, tests for Clostridium difficile are not routinely available in China. Conclusion: In areas with limited personnel and resources, regular investigation of the point prevalence of HCAIs can be performed in lieu of comprehensive monitoring to elucidate risk factors and disease burdens of HCAIs.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Bacteria/classification ; Bacteria/isolation & purification ; Beijing/epidemiology ; Child ; Child, Preschool ; Cross Infection/epidemiology ; Cross Infection/microbiology ; Cross-Sectional Studies ; Epidemiological Monitoring ; Female ; Fungi/classification ; Fungi/isolation & purification ; Hospitals ; Humans ; Infant ; Infant, Newborn ; Male ; Middle Aged ; Prevalence ; Young Adult
Language	English
Publishing date	2016-07
Publishing country	England
Document type	Journal Article
ZDB-ID	779366-2
ISSN	1532-2939 ; 0195-6701
ISSN (online)	1532-2939
ISSN	0195-6701
DOI	10.1016/j.jhin.2016.03.019
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Zs.A 1586: Show issues

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Article: [Comparison of the efficacy of IA and HAD induction regimens in the treatment of patients with newly diagnosed acute myeloid leukemia: a single-center study].

Zhang, C X / Qiu, S W / Gong, B F / Gong, X Y / Li, Y / Liu, Y T / Fang, Q Y / Zhang, G J / Liu, K Q / Zhou, C L / Wei, S N / Lin, D / Liu, B C / Wang, Y / Mi, Y C / Wei, H / Wang, J X

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi

2022 Volume 43, Issue 5, Page(s) 383–387

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Adolescent ; Adult ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Cytarabine/therapeutic use ; Daunorubicin/therapeutic use ; Female ; Homoharringtonine/therapeutic use ; Humans ; Induction Chemotherapy ; Leukemia, Myeloid, Acute/drug therapy ; Leukemia, Myeloid, Acute/genetics ; Male ; Middle Aged ; Nuclear Proteins ; Prognosis ; Remission Induction ; Retrospective Studies ; Young Adult
Chemical Substances	Nuclear Proteins ; Cytarabine (04079A1RDZ) ; Homoharringtonine (6FG8041S5B) ; Daunorubicin (ZS7284E0ZP)
Language	Chinese
Publishing date	2022-06-08
Publishing country	China
Document type	Comparative Study ; Journal Article
ZDB-ID	2997162-7
ISSN	0253-2727 ; 0253-2727
ISSN (online)	0253-2727
ISSN	0253-2727
DOI	10.3760/cma.j.issn.0253-2727.2022.05.006
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