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Article ; Online: The development of aesthetic experience through virtual and augmented reality.

Zhou, Cong / Li, JianQi

2024 Volume 14, Issue 1, Page(s) 4290

Abstract: Emerging technological innovations offer the potential for experiential engagement through virtual scenarios, yet the viability of this approach for educational purposes remains significantly underexplored. This study aims to assess the feasibility of ... ...

Abstract	Emerging technological innovations offer the potential for experiential engagement through virtual scenarios, yet the viability of this approach for educational purposes remains significantly underexplored. This study aims to assess the feasibility of Augmented Reality (AR) and Virtual Reality (VR) technologies in providing users with aesthetic experiences when visiting digital exhibitions. A total of 190 students participated in this investigation. The control group visited traditional exhibits at the Palace Museum in Beijing. This group underwent a survey to evaluate their acquired aesthetic experience. In contrast, the experimental group, comprising 96 students, engaged with VR/AR scenarios at the Palace Museum in Beijing. Accordingly, students in the experimental group were also surveyed to evaluate both their aesthetic experiences and, additionally, their user experiences. The survey results unveiled significant distinctions in aesthetic experiences between students in the control and experimental groups. Moreover, there were notable correlations between individual variables related to user and aesthetic experiences within the experimental group. Furthermore, the study revealed disparities in both user and aesthetic experiences among male and female students. The findings have implications for aesthetic education teachers and officials in the context of developing sound strategies for providing aesthetic experiences to their students. This information is also of interest to employees of museums, exhibitions, and other cultural facilities, who are interested in holding or hold digital exhibitions.
MeSH term(s)	Humans ; Male ; Female ; Augmented Reality ; Virtual Reality ; Students ; Educational Status ; Museums
Language	English
Publishing date	2024-02-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-53840-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Multiple masks of a Shigella podophage.

Jiang, Yong-Liang / Zhou, Cong-Zhao

Structure (London, England : 1993)

2024 Volume 32, Issue 1, Page(s) 1–2

Abstract: In this issue of Structure, Subramanian et al. present the cryo-EM structure of Shigella podophage HRP29, which possesses a T7-like tail complex surrounded by six P22/Sf6-like tailspikes and two unique decoration proteins. These colorful masks of HRP29 ... ...

Abstract	In this issue of Structure, Subramanian et al. present the cryo-EM structure of Shigella podophage HRP29, which possesses a T7-like tail complex surrounded by six P22/Sf6-like tailspikes and two unique decoration proteins. These colorful masks of HRP29 record the frequent events of horizontal gene transfer during evolution.
MeSH term(s)	Shigella/virology ; Bacteriophages/ultrastructure
Language	English
Publishing date	2024-01-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	1213087-4
ISSN	1878-4186 ; 0969-2126
ISSN (online)	1878-4186
ISSN	0969-2126
DOI	10.1016/j.str.2023.12.002
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Article ; Online: Low-cost structured light imaging of regional volume changes for use in assessing mechanical ventilation.

Zhou, Cong / Chase, J Geoffrey

Computer methods and programs in biomedicine

2022 Volume 226, Page(s) 107176

Abstract: Background: Optimal setting of mechanical ventilators is critical for improving outcomes. Accurate, predictive lung mechanics models are effective in optimizing MV settings, but only at a global level as they cannot estimate regional lung volume ... ...

Abstract	Background: Optimal setting of mechanical ventilators is critical for improving outcomes. Accurate, predictive lung mechanics models are effective in optimizing MV settings, but only at a global level as they cannot estimate regional lung volume ventilation to assess the potential of local distension or under-ventilation. This study presents a low-cost structured light system for non-contact high resolution chest motion measurement to estimate regional lung volume changes. Methods: The system consists of a structured light projector and two cameras. A new pattern is designed to extract motion from sub-regions of the chest surface, and an efficient feature is proposed to provide a fast and accurate correspondence matching between two views. Reconstruction of 3D surface points is based on the matched points and stereo method. Asymmetric distribution of tidal volume into left and right lungs is estimated based on reconstructed regional chest expansion. A proof-of-concept experiment using a dummy model and two test lungs connected to a ventilator to provide differential chest expansion is conducted under tidal volumes of 400 ml, 500 ml and 600 ml, with results compared to the widely-used SURF and ORB methods. Results: Compared to the SURF and ORB methods, the proposed method is more computationally efficient with ∼40% less computational time cost, and higher accuracy for dense point correspondence. Finally, the proposed method estimated the region lung volumes with the maximum error of 8 ml under 600 ml tidal volume, indicating a good accuracy. Conclusions: Surface reconstruction results in a proof-of-concept experiment with differential chest expansion show good performance for the proposed pattern and method in extracting the key information for regional chest expansion. The proposed method is generalizable, with potential for use in other applications.
MeSH term(s)	Respiration, Artificial/methods ; Tidal Volume ; Ventilators, Mechanical ; Lung/diagnostic imaging ; Respiration
Language	English
Publishing date	2022-10-06
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	632564-6
ISSN	1872-7565 ; 0169-2607
ISSN (online)	1872-7565
ISSN	0169-2607
DOI	10.1016/j.cmpb.2022.107176
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Article ; Online: Effects of hypo-osmotic stress on osmoregulation, antioxidant response, and energy metabolism in sea cucumber Holothuria moebii under desalination environment.

Jiang, Junyang / Tang, Yanna / Cao, Zhaozhao / Zhou, Cong / Yu, Zonghe

Environmental research

2024 Volume 252, Issue Pt 1, Page(s) 118800

Abstract: With global climate changing, hypo-salinity events are increasing in frequency and duration because of continuous rainfall and freshwater inflow, which causes reduced cytosolic osmolarity and cellular stress responses in aquatic animals. Sea cucumbers ... ...

Abstract	With global climate changing, hypo-salinity events are increasing in frequency and duration because of continuous rainfall and freshwater inflow, which causes reduced cytosolic osmolarity and cellular stress responses in aquatic animals. Sea cucumbers are considered stenohaline because they lack osmoregulatory organs and are vulnerable to salinity fluctuations. In this study, we performed multiple biochemical assays, de novo transcriptomics, and widely targeted metabolomics to comprehensively explore the osmoregulatory mechanisms and physiological responses of sea cucumber Holothuria moebii to hypo-osmotic stress, which is a representative specie that is frequently exposed to hypo-saline intertidal zones. Our results found that H. moebii contracted their ambulacral feet and oral tentacles, and the coelomic fluid ion concentrations were reduced to be consistent with the environment. The microvilli of intestines and respiratory trees underwent degeneration, and the cytoplasm exhibited swelling and vacuolation. Moreover, the Na
Language	English
Publishing date	2024-03-28
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2024.118800
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Article: Screening for thalassemia carriers among the Han population of childbearing age in Southwestern of China.

Du, Yepei / Zhou, Cong / Wang, Jing / Yang, Yanting / Liu, Hui

Frontiers in genetics

2024 Volume 15, Page(s) 1356068

Abstract: Purpose: Thalassemia is a severe hereditary blood disorder that poses a significant threat to human health and leads to mortality and disability. It is one of the most prevalent monogenic diseases worldwide. The aim of this study was to analyze the ... ...

Abstract	Purpose: Thalassemia is a severe hereditary blood disorder that poses a significant threat to human health and leads to mortality and disability. It is one of the most prevalent monogenic diseases worldwide. The aim of this study was to analyze the molecular epidemiological data of individuals of childbearing age from the Han ethnic group with thalassemia in Southwest China and to explore the application of next-generation sequencing (NGS) technology in screening thalassemia carriers. Methods: The participants were Han males and females of childbearing age who sought medical advice at the West China Second University Hospital, Sichuan University from June 2022 to June 2023. We detected α- and β-thalassemia mutations using full-length capture of the thalassemia genes and NGS technology. Results: In a cohort of 1,093 participants, 130 thalassemia carriers were identified, with an overall detection rate of 11.89% (130/1,093). Among these, 0.91% (10/1,093) had mutations that could not be detected using traditional PCR techniques. The proportions of carriers with α-, β-, and α-complexed β-thalassemia gene mutations were 7.68% (84/1,093), 3.93% (43/1,093), and 0.27% (3/1,093), respectively. We identified a novel HBA2 c.166del variant that has not been previously reported. Conclusion: Using NGS technology, we found that the mutation-carrying rate of thalassemia genes was 11.89% in the Han population of childbearing age in Southwest China. Compared with the results of traditional PCR techniques, NGS detected an additional 0.91% (10/1,093) rare genetic variants. NGS technology should be utilized as the primary screening method for thalassemia carriers among Han nationality people of childbearing age in Southwest China.
Language	English
Publishing date	2024-04-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606823-0
ISSN	1664-8021
ISSN	1664-8021
DOI	10.3389/fgene.2024.1356068
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Article: Preserving multi-dimensional information: A hypersphere method for parameter space analysis.

Davey, Nicolas A C / Chase, J Geoffrey / Zhou, Cong / Murphy, Liam

Heliyon

2024 Volume 10, Issue 7, Page(s) e28822

Abstract: Background: Physiological modelling often involves models described by large numbers of variables and significant volumes of clinical data. Mathematical interpretation of such models frequently necessitates analysing data points in high-dimensional ... ...

Abstract	Background: Physiological modelling often involves models described by large numbers of variables and significant volumes of clinical data. Mathematical interpretation of such models frequently necessitates analysing data points in high-dimensional spaces. Existing algorithms for analysing high-dimensional points either lose important dimensionality or do not describe the full position of points. Hence, there is a need for an algorithm which preserves this information. Methods: The most-distant uncovered point (MDUP) hypersphere method is a binary classification approach which defines a collection of equidistant N-dimensional points as the union of hyperspheres. The method iteratively generates hyperspheres at the most distant point in the interest region not yet contained within any hypersphere, until the entire region of interest is defined by the union of all generated hyperspheres. This method is tested on a 7-dimensional space with up to 35.8 million points representing feasible and infeasible spaces of model parameters for a clinically validated cardiovascular system model. Results: For different numbers of input points, the MDUP hypersphere method tends to generate large spheres away from the boundary of feasible and infeasible points, but generates the greatest number of relatively much smaller spheres around the boundary of the region of interest to fill this space. Runtime scales quadratically, in part because the current MDUP implementation is not parallelised. Conclusions: The MDUP hypersphere method can define points in a space of any dimension using only a collection of centre points and associated radii, making the results easily interpretable. It can identify large continuous regions, and in many cases capture the general structure of a region in only a relative few hyperspheres. The MDUP method also shows promise for initialising optimisation algorithm starting conditions within pre-defined feasible regions of model parameter spaces, which could improve model identifiability and the quality of optimisation results.
Language	English
Publishing date	2024-03-30
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e28822
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Article ; Online: Lithospheric Velocity Structure Beneath the Northern Margin of the South China Sea

Zhang, Meng / Sun, Daoyuan / Shi, Kexu / Zhou, Cong

Journal of Geophysical Research: Solid Earth. 2023 July, v. 128, no. 7 p.e2023JB026384-

2023

Abstract: Imaging the lithospheric structure beneath the South China Sea (SCS) not only provides crucial constraints on the tectonic history of southeastern Asia, but also provides an important sample for understanding the evolution of the oceanic lithosphere. ... ...

Abstract	Imaging the lithospheric structure beneath the South China Sea (SCS) not only provides crucial constraints on the tectonic history of southeastern Asia, but also provides an important sample for understanding the evolution of the oceanic lithosphere. However, due to the lack of seismic sampling, the lithospheric structures beneath the SCS are not well resolved. Here, with China National Seismic Network, we observe the “Lid signal” generated by earthquakes below the lithosphere, which propagates through the fast mantle Lid and acts as the first arrival. The Lid signal provides robust constraints on the structure of the lithosphere. Through modeling the Lid signals of events occurred at different depths, we find that the thickness of the lithosphere beneath the northern margin of the SCS is ∼65 km. Across the lithosphere‐asthenosphere boundary, the SH velocity decreases by 6% ∼ 8% within 60 km. Such a large velocity contrast may be due to the presence of melt in the asthenosphere. We also detect another velocity jump at a depth of ∼250 km in both SH and P wave data, which correlates with the depth of the X‐discontinuity. A comparison between the lithospheric structure beneath the SCS basin and other oceanic plates further suggests a hot asthenosphere beneath the SCS, which could be related to the existence of the Hainan Plume nearby.
Keywords	basins ; evolution ; geophysics ; research ; tectonics ; China ; South China Sea
Language	English
Dates of publication	2023-07
Publishing place	John Wiley & Sons, Ltd
Document type	Article ; Online
Note	JOURNAL ARTICLE
ISSN	2169-9313
DOI	10.1029/2023JB026384
Database	NAL-Catalogue (AGRICOLA)

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Book ; Online: Vibrational Anharmonicity Assisted Phase Transitions in Perovskite Oxides under Terahertz Irradiation

Zhou, Cong / Zhou, Jian

2023

Abstract: Despite extensive research interests in perovskite oxides, low energy consumption, non-destructive and maneuverable methods for phase transition in perovskite oxides are still the under its exploration, and the underlying mechanisms remain ambiguous. ... ...

Abstract	Despite extensive research interests in perovskite oxides, low energy consumption, non-destructive and maneuverable methods for phase transition in perovskite oxides are still the under its exploration, and the underlying mechanisms remain ambiguous. Here, optical susceptibility including electronic and anharmonic phononic contributions is used to evaluate Gibbs free energy variations of $\mathrm{PbTiO}_3$ and $\mathrm{BaTiO}_3$ under terahertz irradiation. This corresponds to an off-resonant light-controlled phase transition, rather than the resonant approaches that excites hot carriers over electronic band or infrared-active vibrations in the phonon band. We show that intermediate terahertz light can trigger polarization change between ferroelectric orientation variants of $\mathrm{PbTiO}_3$ at room temperature 300 K. Furthermore, the phase transition from low symmetric ferroelectric phase to high symmetric paraelectric structure in $\mathrm{PbTiO}_3$ can be driven by changing the direction and intensity of the incident light under the same conditions. Similar results are observed in $\mathrm{BaTiO}_3$. In detail, phonon spectrum and optical susceptibility are obviously modified and show temperature dependence, in which we show the significant effects of anharmonic vibration. In order to show its nonlinear optical nature, we perform an alternating electric field dressed ab initio molecular dynamics simulation, which maps the Raman-active phonon excitation under off-resonant terahertz irradiation. Comment: 20 pages, 6 figures, 2 tables, under peer review
Keywords	Condensed Matter - Materials Science
Subject code	535
Publishing date	2023-06-14
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Time to break mental illness-related stigma and discrimination in China.

Zhou, Cong / Xu, Yinghong

Asian journal of psychiatry

2021 Volume 66, Page(s) 102881

MeSH term(s)	China ; Humans ; Mental Disorders ; Social Discrimination ; Social Stigma
Language	English
Publishing date	2021-10-02
Publishing country	Netherlands
Document type	Letter
ZDB-ID	2456678-0
ISSN	1876-2026 ; 1876-2018
ISSN (online)	1876-2026
ISSN	1876-2018
DOI	10.1016/j.ajp.2021.102881
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Article ; Online: Discovery of Potential Neonicotinoid Insecticides by an Artificial Intelligence Generative Model and Structure-Based Virtual Screening.

Kong, Yijin / Zhou, Cong / Tan, Du / Xu, Xiaoyong / Li, Zhong / Cheng, Jiagao

Journal of agricultural and food chemistry

2024 Volume 72, Issue 10, Page(s) 5145–5152

Abstract: The identification of neonicotinoid insecticides bearing novel scaffolds is of great importance for pesticide discovery. Here, artificial intelligence-based tools and virtual screening strategy were integrated to discover potential leads of neonicotinoid ...

Abstract	The identification of neonicotinoid insecticides bearing novel scaffolds is of great importance for pesticide discovery. Here, artificial intelligence-based tools and virtual screening strategy were integrated to discover potential leads of neonicotinoid insecticides. A deep generative model was successfully constructed using a recurrent neural network combined with transfer learning. The model evaluation showed that the pretrained model could accurately grasp the SMILES grammar of drug-like molecules and generate potential neonicotinoid compounds after transfer learning. The generated molecules were evaluated by hierarchical virtual screening, hits were subjected to a similarity search, and the most similar structures were purchased for the bioassay. Compounds
MeSH term(s)	Animals ; Insecticides/chemistry ; Artificial Intelligence ; Neonicotinoids/chemistry ; Aphids/metabolism
Chemical Substances	Insecticides ; Neonicotinoids
Language	English
Publishing date	2024-02-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	241619-0
ISSN	1520-5118 ; 0021-8561
ISSN (online)	1520-5118
ISSN	0021-8561
DOI	10.1021/acs.jafc.3c06895
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