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  1. Book ; Thesis: Sulforaphane inhibits upregulation of the eIF4F translation initiation complex in human colorectal cancer via the PI3K/AKT/mTOR/4E-BP1 signaling pathway

    Zhou, Dachen

    2016  

    Author's details vorgelegt von Dachen Zhou
    Language English
    Size iv, 72 Blätter, Illustrationen, Diagramme
    Publishing place Heidelberg
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Ruprecht-Karls-Universität Heidelberg, 2017
    HBZ-ID HT019394929
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2017 E 1251 order for loan Magazin

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  2. Article ; Online: Mobility and interlinkage: the transformation and new approaches for anthropological research.

    Zhou, Daming

    International journal of anthropology and ethnology

    2022  Volume 6, Issue 1, Page(s) 13

    Abstract: Mobility and interlinkage have become the most important characteristics of our time. The mobility and interlinkage of people, material and information constitute the way and rules of the operation of today's world. Internet links, cloud computing, ... ...

    Abstract Mobility and interlinkage have become the most important characteristics of our time. The mobility and interlinkage of people, material and information constitute the way and rules of the operation of today's world. Internet links, cloud computing, complex database and human computation have changed the way people relate to the world, thus the anthropology for understanding and interpretation of human cultures have changed correspondingly. Cultures in the state of mobility and interlinkage, such as spatial changes, the evolution of interpersonal relationships and the new cultural order, have become a new subject.
    Language English
    Publishing date 2022-08-29
    Publishing country China
    Document type Journal Article
    ZDB-ID 2918110-0
    ISSN 2366-1003 ; 2366-1003
    ISSN (online) 2366-1003
    ISSN 2366-1003
    DOI 10.1186/s41257-022-00072-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: [Precision nutritional therapy in gastrointestinal tumor].

    Zhou, D / Wang, S J / Wang, X Y

    Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery

    2024  Volume 27, Issue 3, Page(s) 225–230

    Abstract: Apart from individual genetic background, unhealthy lifestyle and diet, etc., nutrition also plays an important role in the occurrence and progression of gastrointestinal tumors. Although some patients with gastrointestinal tumors can be satisfied with ... ...

    Abstract Apart from individual genetic background, unhealthy lifestyle and diet, etc., nutrition also plays an important role in the occurrence and progression of gastrointestinal tumors. Although some patients with gastrointestinal tumors can be satisfied with the traditional nutritional support, it is apparently inadequate for the systemic management of all patients. Precision nutrition support, also known as personalized nutrition support, refers to safe and efficient individualized nutrition intervention based on the investigation of individual genetic background, life characteristics, metabolic indicators, intestinal microbial characteristics, and physiological status factors through big data analysis for the prevention and treatment of chronic diseases. This review focuses on the relationship between nutrition and gastrointestinal tumors and discusses the progress of precision nutrition support therapy in the gastrointestinal tumors. Based on this, we hope to achieve effective personalized intervention protocols, and improve the clinical outcome and the overall oncology care of gastrointestinal tumors.
    MeSH term(s) Humans ; Nutritional Support ; Nutritional Status ; Chronic Disease ; Gastrointestinal Neoplasms
    Language Chinese
    Publishing date 2024-03-27
    Publishing country China
    Document type Review ; English Abstract ; Journal Article
    ISSN 1671-0274
    ISSN 1671-0274
    DOI 10.3760/cma.j.cn441530-20231212-00212
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Recent advances in cancer-associated fibroblast: Biomarkers, signaling pathways, and therapeutic opportunities.

    Zhou, Donger / Zheng, Lei

    Chinese medical journal

    2024  Volume 137, Issue 6, Page(s) 638–650

    Abstract: Abstract: Anti-cancer therapies usually focus on tumor cells, but non-tumor stromal components in the tumor microenvironment also play vital roles in tumor initiation and progression, which may be the prognostic factors and potential therapeutic targets. ...

    Abstract Abstract: Anti-cancer therapies usually focus on tumor cells, but non-tumor stromal components in the tumor microenvironment also play vital roles in tumor initiation and progression, which may be the prognostic factors and potential therapeutic targets. Cancer-associated fibroblasts (CAFs) are the essential component in the tumor environment, exhibiting high heterogeneity in their cell origin and phenotype with diverse functions that influence tumor angiogenesis, immune systems, and metabolism. Single-cell RNA sequencing and genetically engineered mouse models have increased our understanding of CAF diversity, and many subtypes have been defined. However, the precise functions of these subtypes need to be studied and validated. Studies of signaling pathways and epigenetic changes in CAFs facilitate understanding of the phenotypes of CAFs and the crosstalk between tumor cells and CAFs to provide potential therapeutic targets. Some clinical trials, including phase III trials targeting CAFs, have been performed recently. However, few of these trials have generated promising results, which indicates that the complexity of CAFs in the tumor microenvironment remains largely unknown, and in-depth investigations of CAFs should be performed. This review summarizes the research on CAFs, focusing on the heterogeneity of their phenotypes and functions, specific signaling pathways, and the therapeutic strategies involving CAFs. Additionally, we briefly discuss the current technologies commonly used in CAF studies and describe the challenges and future perspectives of CAF research.
    MeSH term(s) Animals ; Mice ; Cancer-Associated Fibroblasts ; Biomarkers ; Phenotype ; Cell Transformation, Neoplastic ; Epigenesis, Genetic ; Tumor Microenvironment
    Chemical Substances Biomarkers
    Language English
    Publishing date 2024-02-29
    Publishing country China
    Document type Review ; Journal Article
    ZDB-ID 127089-8
    ISSN 2542-5641 ; 0366-6999 ; 1002-0187
    ISSN (online) 2542-5641
    ISSN 0366-6999 ; 1002-0187
    DOI 10.1097/CM9.0000000000003031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1207: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Ua VI Zs.425: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: [Update on the role of CMR in the evaluation of heart failure: interpretation of the "2022 AHA/ACC/HFSA Guideline for the management of heart failure"].

    Zhou, D / Zhao, S H / Lu, M J

    Zhonghua xin xue guan bing za zhi

    2023  Volume 51, Issue 5, Page(s) 528–534

    MeSH term(s) Humans ; United States ; Heart Failure/therapy ; Cardiology
    Language Chinese
    Publishing date 2023-05-17
    Publishing country China
    Document type Journal Article
    ZDB-ID 603425-1
    ISSN 0253-3758
    ISSN 0253-3758
    DOI 10.3760/cma.j.cn112148-20220627-00495
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2276: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Effects of tetracycline on the relationship between the microbial community and oxidative stress in earthworms based on canonical correlation analysis.

    Zhou, Dongxing

    Environmental toxicology and pharmacology

    2020  Volume 76, Page(s) 103342

    Abstract: In this study, Eisenia fetida was taken as the test organism and tetracycline was taken as the stress compound. The artificial soil test was conducted to study the utilization intensity of different carbon sources (the Biolog-microplate supplied) by ... ...

    Abstract In this study, Eisenia fetida was taken as the test organism and tetracycline was taken as the stress compound. The artificial soil test was conducted to study the utilization intensity of different carbon sources (the Biolog-microplate supplied) by microorganisms under different stress times and stress concentrations. The changes in the in vivo key enzymes activities of earthworms and oxidative stress indicators, such as malondialdehyde (MDA), were explored. The canonical correlation analysis method was the first used to establish a analysis-model to explore the relationship between the functional diversity of microbial community and the oxidative stress in earthworms in vivo under different stress times and concentrations. Research shows: 1) after tetracycline stress, in the earthworm, the CAT, POD, SOD, GPX were related to the microbes that use carbohydrate carbon sources; the GST and AChE were related to the microbes that use polymer carbon sources; the MDA was related to the microbes that use carbon sources: amino acid, carboxylic acid and phenolic acid. 2) Under low concentrations of tetracycline stress, there was no significant relationship between the functional diversity of the microbial communities and the effects of oxidative stress at this concentration. The high concentration of tetracycline can be utilized to screen probiotics that alleviate the effects of oxidative stress. 3) The utilization of carbon sources by microbial community in the earthworm after stress can be used as biomarker of ecotoxicology. It provides a basic theoretical for adding beneficial carbon sources to combat oxidative damage in vivo.
    MeSH term(s) Animals ; Bacteria/drug effects ; Oligochaeta/drug effects ; Oligochaeta/microbiology ; Oxidative Stress/drug effects ; Soil Microbiology ; Tetracycline/toxicity
    Chemical Substances Tetracycline (F8VB5M810T)
    Language English
    Publishing date 2020-02-01
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1318302-3
    ISSN 1872-7077 ; 1382-6689
    ISSN (online) 1872-7077
    ISSN 1382-6689
    DOI 10.1016/j.etap.2020.103342
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4490: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Book ; Thesis: New methods to analyze clonotypic T cells in multiple sclerosis

    Zhou, Dun

    2007  

    Author's details vorgelegt von Dun Zhou
    Language English
    Size S. 315-321
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Düsseldorf, Univ., Diss., 2009
    Note Ursprünglich als Zeitschriftenaufsätze erschienen
    HBZ-ID HT016064418
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2011 E 2288 order for loan Magazin

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  8. Article ; Online: Gut microbiota and tumor-associated macrophages: potential in tumor diagnosis and treatment.

    Zhou, Dongqin / Li, Yongsheng

    Gut microbes

    2023  Volume 15, Issue 2, Page(s) 2276314

    Abstract: Avoiding immune destruction and polymorphic microbiomes are two key hallmarks of cancer. The tumor microenvironment (TME) is essential for the development of solid tumors, and the function of tumor-associated macrophages (TAMs) in the TME is closely ... ...

    Abstract Avoiding immune destruction and polymorphic microbiomes are two key hallmarks of cancer. The tumor microenvironment (TME) is essential for the development of solid tumors, and the function of tumor-associated macrophages (TAMs) in the TME is closely linked to tumor prognosis. Therefore, research on TAMs could improve the progression and control of certain tumor patients. Additionally, the intestinal flora plays a crucial role in metabolizing substances and maintaining a symbiotic relationship with the host through a complex network of interactions. Recent experimental and clinical studies have suggested a potential link between gut microbiome and TME, particularly in regulating TAMs. Understanding this association could improve the efficacy of tumor immunotherapy. This review highlights the regulatory role of intestinal flora on TAMs, with a focus on gut microbiota and their metabolites. The implications of this association for tumor diagnosis and treatment are also discussed, providing a promising avenue for future clinical treatment strategies.
    MeSH term(s) Humans ; Gastrointestinal Microbiome ; Tumor-Associated Macrophages ; Immunotherapy ; Microbiota ; Neoplasms/diagnosis ; Neoplasms/therapy ; Tumor Microenvironment
    Language English
    Publishing date 2023-11-09
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2575755-6
    ISSN 1949-0984 ; 1949-0984
    ISSN (online) 1949-0984
    ISSN 1949-0984
    DOI 10.1080/19490976.2023.2276314
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Advances in Graphene-Polymer Nanocomposite Foams for Electromagnetic Interference Shielding.

    Sun, Jiaotong / Zhou, Dan

    Polymers

    2023  Volume 15, Issue 15

    Abstract: With the continuous advancement of wireless communication technology, the use of electromagnetic radiation has led to issues such as electromagnetic interference and pollution. To address the problem of electromagnetic radiation, there is a growing need ... ...

    Abstract With the continuous advancement of wireless communication technology, the use of electromagnetic radiation has led to issues such as electromagnetic interference and pollution. To address the problem of electromagnetic radiation, there is a growing need for high-performance electromagnetic shielding materials. Graphene, a unique carbon nanomaterial with a two-dimensional structure and exceptional electrical and mechanical properties, offers advantages such as flexibility, light weight, good chemical stability, and high electromagnetic shielding efficiency. Consequently, it has emerged as an ideal filler in electromagnetic shielding composites, garnering significant attention. In order to meet the requirements of high efficiency and low weight for electromagnetic shielding materials, researchers have explored the use of graphene-polymer nanocomposite foams with a cellular structure. This mini-review provides an overview of the common methods used to prepare graphene-polymer nanocomposite foams and highlights the electromagnetic shielding effectiveness of some representative nanocomposite foams. Additionally, the future prospects for the development of graphene-polymer nanocomposite foams as electromagnetic shielding materials are discussed.
    Language English
    Publishing date 2023-07-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym15153235
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Feeling Lonely, Engaging Online During the Outbreak of COVID-19: A Longitudinal Study of Chinese Older Adults.

    Xu, Yi / Zhou, Dong

    Innovation in aging

    2023  Volume 7, Issue 7, Page(s) igad090

    Abstract: Background and objectives: There is growing concern that the coronavirus disease 2019 (COVID-19) pandemic and associated social distancing policies may exacerbate mental health problems in older adults. Most studies primarily have focused on developed ... ...

    Abstract Background and objectives: There is growing concern that the coronavirus disease 2019 (COVID-19) pandemic and associated social distancing policies may exacerbate mental health problems in older adults. Most studies primarily have focused on developed countries, whereas the mental consequences of the pandemic in developing countries are less well known. This study evaluates the influences of the global pandemic in relation to loneliness and family contact among older Chinese adults and examines the roles of internet adoption in alleviating the emotional experience of loneliness.
    Research design and methods: We run individual fixed effects regression models using the 2018 and 2020 waves of the Chinese Family Panel Studies survey with 4,944 respondents aged 60 and above to capture the average within-person changes before and after the first outbreak of COVID-19 in China. We further examine the mediating effects of internet adoption on loneliness using structural equation modeling (SEM). Simultaneous SEM tested the effects of internet literacy and social network site use, and heterogeneous effects analyses were also conducted across subgroups.
    Results: Fixed effects estimates indicated increased loneliness and decreased family contact during the pandemic. Moreover, more older adults were found to use the internet in 2020. The fixed-effect estimations and structural equation models consistently found that older adults' use of the internet contributed to more social contacts and virtual meetings with their children, which have alleviated the emotional experience of loneliness.
    Discussion and implications: Digital inclusion of older adults to adopt the internet can be beneficial to improve mental well-being and alleviate loneliness during times of pandemic crisis. The targeted acceleration of digitalization to reduce the digital divide needs to be considered.
    Language English
    Publishing date 2023-08-22
    Publishing country England
    Document type Journal Article
    ISSN 2399-5300
    ISSN (online) 2399-5300
    DOI 10.1093/geroni/igad090
    Database MEDical Literature Analysis and Retrieval System OnLINE

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