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  1. Article: [Progress in early emergency treatment of pelvic fractures with severe hemodynamic instability].

    Zhou, Dong-Sheng

    Zhongguo gu shang = China journal of orthopaedics and traumatology

    2022  Volume 35, Issue 4, Page(s) 305–309

    MeSH term(s) Emergency Treatment ; Fractures, Bone/surgery ; Hemodynamics ; Humans ; Pelvic Bones/surgery
    Language Chinese
    Publishing date 2022-04-29
    Publishing country China
    Document type Journal Article
    ISSN 1003-0034
    ISSN 1003-0034
    DOI 10.12200/j.issn.1003-0034.2022.04.001
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  2. Article ; Online: Loss and recovery of ecological diversity associated with evolutionary rescue in abruptly and gradually deteriorating environments.

    Zhou, Dong-Hao / Zhang, Quan-Guo

    Evolution; international journal of organic evolution

    2024  Volume 78, Issue 4, Page(s) 768–777

    Abstract: Populations may survive environmental deterioration by evolutionary adaptation. However, such evolutionary rescue events may be associated with ecological costs, such as reduction in growth performance and loss of ecologically important genetic diversity. ...

    Abstract Populations may survive environmental deterioration by evolutionary adaptation. However, such evolutionary rescue events may be associated with ecological costs, such as reduction in growth performance and loss of ecologically important genetic diversity. Those negative ecological consequences may be mitigated by additional adaptive evolution. Both the ecological costs and the opportunities for additional evolution are contingent on the severity of environmental deterioration. Here, we hypothesize that populations evolutionarily rescued from faster, relative to slow, environmental deterioration suffer more severe long-term fitness decline and diversity loss. An experiment with the model adaptive radiation of bacterium Pseudomonas fluorescens exposed to abruptly or gradually increased antibiotic stress supported our hypothesis. The effect of additional adaptive evolution in recovering population size and ecological diversity was far from perfect. Cautions are therefore needed in predicting the role of rapid evolution for mitigating the impacts of environmental changes, in particular very fast environmental deterioration. We also found that bacterial populations rescued from gradually increased antibiotic stress evolved higher levels of antibiotic resistance, lending more support to aggressive chemotherapy in pathogen control.
    MeSH term(s) Anti-Bacterial Agents ; Biological Evolution
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2024-01-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2036375-8
    ISSN 1558-5646 ; 0014-3820
    ISSN (online) 1558-5646
    ISSN 0014-3820
    DOI 10.1093/evolut/qpad216
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  3. Article ; Online: Feeling Lonely, Engaging Online During the Outbreak of COVID-19: A Longitudinal Study of Chinese Older Adults.

    Xu, Yi / Zhou, Dong

    Innovation in aging

    2023  Volume 7, Issue 7, Page(s) igad090

    Abstract: Background and objectives: There is growing concern that the coronavirus disease 2019 (COVID-19) pandemic and associated social distancing policies may exacerbate mental health problems in older adults. Most studies primarily have focused on developed ... ...

    Abstract Background and objectives: There is growing concern that the coronavirus disease 2019 (COVID-19) pandemic and associated social distancing policies may exacerbate mental health problems in older adults. Most studies primarily have focused on developed countries, whereas the mental consequences of the pandemic in developing countries are less well known. This study evaluates the influences of the global pandemic in relation to loneliness and family contact among older Chinese adults and examines the roles of internet adoption in alleviating the emotional experience of loneliness.
    Research design and methods: We run individual fixed effects regression models using the 2018 and 2020 waves of the Chinese Family Panel Studies survey with 4,944 respondents aged 60 and above to capture the average within-person changes before and after the first outbreak of COVID-19 in China. We further examine the mediating effects of internet adoption on loneliness using structural equation modeling (SEM). Simultaneous SEM tested the effects of internet literacy and social network site use, and heterogeneous effects analyses were also conducted across subgroups.
    Results: Fixed effects estimates indicated increased loneliness and decreased family contact during the pandemic. Moreover, more older adults were found to use the internet in 2020. The fixed-effect estimations and structural equation models consistently found that older adults' use of the internet contributed to more social contacts and virtual meetings with their children, which have alleviated the emotional experience of loneliness.
    Discussion and implications: Digital inclusion of older adults to adopt the internet can be beneficial to improve mental well-being and alleviate loneliness during times of pandemic crisis. The targeted acceleration of digitalization to reduce the digital divide needs to be considered.
    Language English
    Publishing date 2023-08-22
    Publishing country England
    Document type Journal Article
    ISSN 2399-5300
    ISSN (online) 2399-5300
    DOI 10.1093/geroni/igad090
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  4. Article: The impact of COVID-19 on physical and mental health: A longitudinal study.

    Su, Yaqin Joyce / Zhou, Dong

    SSM - population health

    2023  Volume 24, Page(s) 101538

    Abstract: In this paper, we exploit variation in COVID-19 infections and deaths across Chinese cities to identify the health impacts of COVID-19 based on longitudinal data at the individual level. Our paper provides empirical evidence of the immediate impact of ... ...

    Abstract In this paper, we exploit variation in COVID-19 infections and deaths across Chinese cities to identify the health impacts of COVID-19 based on longitudinal data at the individual level. Our paper provides empirical evidence of the immediate impact of COVID-19 on both physical and mental health. Utilizing a difference-in-differences methodology and focusing on changes in within-individual health condition between pre-COVID-19 and the early stages of COVID-19, we find robust evidence that the COVID-19 pandemic has an adverse effect on self-perceived health condition, chronic illness, sleep, and depression. Our findings are robust to alternative constructions of cities' exposure to COVID-19, to the exclusion of Wuhan city, which was hit the hardest and had experienced the most stringent lockdowns. Furthermore, accounting for the impact of COVID-19 policies, our results indicate that the decline in physical health can be attributed to the shock of the pandemic, while emotional health is mainly affected by anti-contagion policies.
    Language English
    Publishing date 2023-10-14
    Publishing country England
    Document type Journal Article
    ISSN 2352-8273
    ISSN 2352-8273
    DOI 10.1016/j.ssmph.2023.101538
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  5. Article ; Online: Fast drug rotation reduces bacterial resistance evolution in a microcosm experiment.

    Zhou, Dong-Hao / Zhang, Quan-Guo

    Journal of evolutionary biology

    2023  Volume 36, Issue 4, Page(s) 641–649

    Abstract: Drug rotation (cycling), in which multiple drugs are administrated alternatively, has the potential for limiting resistance evolution in pathogens. The frequency of drug alternation could be a major factor to determine the effectiveness of drug rotation. ...

    Abstract Drug rotation (cycling), in which multiple drugs are administrated alternatively, has the potential for limiting resistance evolution in pathogens. The frequency of drug alternation could be a major factor to determine the effectiveness of drug rotation. Drug rotation practices often have low frequency of drug alternation, with an expectation of resistance reversion. Here we, based on evolutionary rescue and compensatory evolution theories, suggest that fast drug rotation can limit resistance evolution in the first place. This is because fast drug rotation would give little time for the evolutionarily rescued populations to recover in population size and genetic diversity, and thus decrease the chance of future evolutionary rescue under alternate environmental stresses. We experimentally tested this hypothesis using the bacterium Pseudomonas fluorescens and two antibiotics (chloramphenicol and rifampin). Increasing drug rotation frequency reduced the chance of evolutionary rescue, and most of the finally surviving bacterial populations were resistant to both drugs. Drug resistance incurred significant fitness costs, which did not differ among the drug treatment histories. A link between population sizes during the early stages of drug treatment and the end-point fates of populations (extinction vs survival) suggested that population size recovery and compensatory evolution before drug shift increase the chance of population survival. Our results therefore advocate fast drug rotation as a promising approach to reduce bacterial resistance evolution, which in particular could be a substitute for drug combination when the latter has safety risks.
    MeSH term(s) Rotation ; Bacteria ; Anti-Bacterial Agents/pharmacology ; Drug Resistance, Bacterial/genetics ; Mutation ; Evolution, Molecular
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-02-19
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1465318-7
    ISSN 1420-9101 ; 1010-061X
    ISSN (online) 1420-9101
    ISSN 1010-061X
    DOI 10.1111/jeb.14163
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  6. Article: Microscopic extrathyroidal extension does not affect the prognosis of patients with papillary thyroid carcinoma: A propensity score matching analysis.

    Jiang, Ke-Cheng / Zhou, Dong-Hui / Luo, Ding-Cun

    Heliyon

    2024  Volume 10, Issue 3, Page(s) e25280

    Abstract: Background: Extrathyroidal extension (ETE) in papillary thyroid carcinoma (PTC) can be divided into two categories based on different degrees of invasion: microscopic ETE (micro-ETE) and macroscopic ETE (macro-ETE). At present, there is a consensus that ...

    Abstract Background: Extrathyroidal extension (ETE) in papillary thyroid carcinoma (PTC) can be divided into two categories based on different degrees of invasion: microscopic ETE (micro-ETE) and macroscopic ETE (macro-ETE). At present, there is a consensus that macro-ETE significantly affects PTC prognosis, while the prognostic significance of micro-ETE remains controversial.
    Methods: The clinicopathological and follow-up data for PTC patients who underwent surgical treatment at the Hangzhou First People's Hospital between 2015 and 2018 were retrospectively analyzed. According to the degree of ETE, patients were divided into three groups: non-ETE, micro-ETE and macro-ETE. Cox regression analysis was performed to evaluate the effect of ETE on recurrence-free survival (RFS). The propensity score matching (PSM) method was used to reduce the interference of confounding factors, and Kaplan-Meier curves were utilized to compare the RFS.
    Results: Both micro- and macro-ETE were associated with some aggressive tumor features, including tumor size, multifocality, and lymph node metastasis. Univariate and multivariate Cox regression analyses showed that macro-ETE was an independent risk factor for recurrence, while micro-ETE was not associated with recurrence. The K-M curves showed that RFS for micro-ETE and non-ETE were not statistically different before and after PSM, while RFS for macro-ETE was significantly shorter than that for non-ETE.
    Conclusion: The presence of micro-ETE in PTC did not affect prognosis of patients, suggesting that its treatment should be consistent with the treatment for intrathyroidal tumors. The surgical method and the necessity for radioiodine therapy should be carefully evaluated to reduce overtreatment.
    Language English
    Publishing date 2024-01-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e25280
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  7. Article ; Online: Teamwork aids management and raises new issues in epilepsy.

    Zhou, Dong

    Nature reviews. Neurology

    2019  Volume 15, Issue 2, Page(s) 66–67

    MeSH term(s) Anticonvulsants/therapeutic use ; Biomedical Research/methods ; Biomedical Research/trends ; Disease Management ; Epilepsy/diagnosis ; Epilepsy/genetics ; Epilepsy/therapy ; Humans ; Patient Care Team/trends
    Chemical Substances Anticonvulsants
    Language English
    Publishing date 2019-01-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2491514-2
    ISSN 1759-4766 ; 1759-4758
    ISSN (online) 1759-4766
    ISSN 1759-4758
    DOI 10.1038/s41582-018-0130-8
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6257: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 88: Show issues

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  8. Article ; Online: Clinical characteristics and pregnancy outcome analysis of 20 cases of acute pancreatitis during pregnancy.

    Zhou, Dong / Sun, Guoqiang / Hu, Jing / Gan, Quan

    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

    2024  

    Abstract: Objective: This study investigated the clinical characteristics and pregnancy outcomes of acute pancreatitis during pregnancy (APIP).: Methods: A retrospective analysis was conducted on 20 cases of APIP admitted to Hubei Maternal and Child Health ... ...

    Abstract Objective: This study investigated the clinical characteristics and pregnancy outcomes of acute pancreatitis during pregnancy (APIP).
    Methods: A retrospective analysis was conducted on 20 cases of APIP admitted to Hubei Maternal and Child Health Hospital from January 2017 to September 2021. The etiology, clinical manifestations, and perinatal outcomes of APIP were analyzed using descriptive statistical analysis of the collected data.
    Results: The incidence of APIP in our hospital was 20 (0.02%) cases, all of which occurred in the late stage of pregnancy. Hypertriglyceridemic acute pancreatitis (HTG-AP) was the primary cause of APIP in 10 (50.0%) patients. A total of 11 (55.0%), seven (35.0%) and two (10.0%) patients had mild acute pancreatitis (MAP), moderately severe acute pancreatitis (MSAP) and severe acute pancreatitis (SAP), respectively. Pregnant women with HTG-AP had significantly elevated serum triglyceride levels, had higher prepregnancy body mass indices, were more prone to developing diabetes and were more likely to progress to SAP. With a multidisciplinary approach and individualized treatment plans, there were no maternal deaths, and fetal death only occurred in one (5.0%) case.
    Conclusion: HTG-AP is prone to advancing to more severe states, and it is becoming more common every year. Therefore, blood lipid management during pregnancy should be emphasized. Pregnant women with digestive symptoms or severe hyperlipidaemia should be screened for APIP in a timely manner and receive clinical intervention to improve maternal and fetal outcomes during the perinatal period.
    Language English
    Publishing date 2024-02-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80149-5
    ISSN 1879-3479 ; 0020-7292
    ISSN (online) 1879-3479
    ISSN 0020-7292
    DOI 10.1002/ijgo.15428
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 355: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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    Zs.MO 183: Show issues

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  9. Article: DPPX-Antibody-Associated Encephalitis Induced by Immune Checkpoint Inhibitor Treatment for Advanced Hepatocellular Carcinoma.

    Yang, Yi / Li, Sisi / Zhou, Dong / Li, Jinmei

    Journal of clinical neurology (Seoul, Korea)

    2024  Volume 20, Issue 2, Page(s) 214–216

    Language English
    Publishing date 2024-01-05
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2500489-X
    ISSN 2005-5013 ; 1738-6586
    ISSN (online) 2005-5013
    ISSN 1738-6586
    DOI 10.3988/jcn.2023.0381
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  10. Article ; Online: Numerical Analysis of Permeability Rebound and Recovery during Coalbed Methane Extraction and Its Implications for Enhanced Coalbed Methane Extraction through Injection of Superheated Water.

    Wang, Xing / Feng, Zengchao / Zhou, Dong / Zhang, Bichuan

    ACS omega

    2024  Volume 9, Issue 16, Page(s) 18099–18112

    Abstract: Permeability rebound and recovery are pivotal in determining the efficacy of coalbed methane (CBM) extraction and the impact of superheated water injection during thermally enhanced CBM extraction. Existing research predominantly focuses on the roles of ... ...

    Abstract Permeability rebound and recovery are pivotal in determining the efficacy of coalbed methane (CBM) extraction and the impact of superheated water injection during thermally enhanced CBM extraction. Existing research predominantly focuses on the roles of effective stress and methane desorption shrinkage, often neglecting the critical influence of the temperature. Therefore, our study introduces a mathematical model incorporating heat-fluid-solid coupling and a permeability evolution model considering temperature variations. The model was used to analyze the phenomenon of permeability rebound and recovery during CBM extraction and the effects of various factors on it. The results show that the permeability rebound and recovery time increase with initial gas pressure but decrease with initial diffusion coefficient and permeability. Initial coal seam temperature has little effect on the permeability rebound time, which increases the recovery time. The permeability rebound value rises with the initial diffusion coefficient but falls with the initial gas pressure and permeability, and the coal seam temperature has little impact on it. In addition, whether to consider the temperature on the permeability evolution is compared. The results reveal that temperature impact causes an elevation in permeability rebound, prolongs rebound and recovery time, and reduces postrecovery permeability ratio compared to the scenario without temperature influence. Inspired by the law of permeability evolution, this paper discusses the impact of injection pressure and temperature on the effectiveness of superheated water injection in the initial stage of enhanced CBM recovery engineering practice. The findings offer valuable insights into selecting optimal injection parameters tailored to various coal seams.
    Language English
    Publishing date 2024-04-12
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c10059
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