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  1. Article ; Online: Transcriptome analysis of the transition from primary to secondary growth of vertical stem in Eucalyptus grandis.

    Zhou, Fangping / Zhang, Haonan / Chen, Shanshan / Fan, Chunjie

    BMC plant biology

    2024  Volume 24, Issue 1, Page(s) 96

    Abstract: Eucalyptus was one of the most cultivated hardwood species worldwide, with rapid growth, good wood properties and a wide range of adaptability. Eucalyptus stem undergoes primary growth (longitudinal growth) followed by secondary growth (radial growth), ... ...

    Abstract Eucalyptus was one of the most cultivated hardwood species worldwide, with rapid growth, good wood properties and a wide range of adaptability. Eucalyptus stem undergoes primary growth (longitudinal growth) followed by secondary growth (radial growth), which produces biomass that is an important source of energy worldwide. In order to better understand the genetic regulation of secondary growth in Eucalyptus grandis, Transcriptome analyses in stem segments along a developmental gradient from the third internode to the eleventh internode of E. grandis that spanned primary to secondary growth were carried out. 5,149 genes that were differentially expressed during stem development were identified. Combining the trend analysis by the Mfuzz method and the module-trait correlation analysis by the Weighted Gene Co-expression Network Analysis method, a total of 70 differentially expressed genes (DEGs) selected from 868 DEGs with high connectivity were found to be closely correlated with secondary growth. Results revealed that the differential expression of these DEGs suggests that they may involve in the primary growth or secondary growth. AP1, YAB2 TFs and EXP genes are highly expressed in the IN3, whereas NAC, MYB TFs are likely to be important for secondary growth. These results will expand our understanding of the complex molecular and cellular events of secondary growth and provide a foundation for future studies on wood formation in Eucalyptus.
    MeSH term(s) Transcriptome ; Eucalyptus/genetics ; Eucalyptus/metabolism ; Plant Proteins/genetics ; Plant Proteins/metabolism ; Gene Expression Profiling ; Wood/metabolism ; Gene Expression Regulation, Plant
    Chemical Substances Plant Proteins
    Language English
    Publishing date 2024-02-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2059868-3
    ISSN 1471-2229 ; 1471-2229
    ISSN (online) 1471-2229
    ISSN 1471-2229
    DOI 10.1186/s12870-024-04731-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Exogenous applications of brassinosteroids promote secondary xylem differentiation in

    Zhou, Fangping / Hu, Bing / Li, Juan / Yan, Huifang / Liu, Qianyu / Zeng, Bingshan / Fan, Chunjie

    PeerJ

    2024  Volume 12, Page(s) e16250

    Abstract: Brassinosteroids (BRs) play many pivotal roles in plant growth and development, especially in cell elongation and vascular development. Although its biosynthetic and signal transduction pathway have been well characterized in model plants, their ... ...

    Abstract Brassinosteroids (BRs) play many pivotal roles in plant growth and development, especially in cell elongation and vascular development. Although its biosynthetic and signal transduction pathway have been well characterized in model plants, their biological roles in
    MeSH term(s) Eucalyptus ; Brassinosteroids/pharmacology ; Cell Differentiation ; Xylem ; Wood
    Chemical Substances Brassinosteroids
    Language English
    Publishing date 2024-01-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2703241-3
    ISSN 2167-8359 ; 2167-8359
    ISSN (online) 2167-8359
    ISSN 2167-8359
    DOI 10.7717/peerj.16250
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Agrobacterium

    Wang, Xiaoping / Chen, Shanshan / Zhang, Haonan / Luo, Ping / Zhou, Fangping / Zeng, Bingshan / Xu, Jianmin / Fan, Chunjie

    Frontiers in plant science

    2023  Volume 13, Page(s) 1011245

    Abstract: ... ...

    Abstract Eucalyptus
    Language English
    Publishing date 2023-01-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2022.1011245
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The Spin Modulation Stimulated Efficient Electrocatalytic Oxygen Evolution Reaction over LaCoO

    Zhou, Fangping / Zhao, Zhao / Xu, Ming / Wang, Ting / Yang, Huiru / Wang, Rong / Wang, Jiahui / Li, Haibo / Feng, Ming

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2022  Volume 28, Issue 14, Page(s) e202104157

    Abstract: Perovskite is a promising non-noble catalyst and has been widely investigated for the electrochemical oxygen evolution reaction (OER). However, there is still serious lack of valid approaches to further enhance their catalytic performance. Herein, we ... ...

    Abstract Perovskite is a promising non-noble catalyst and has been widely investigated for the electrochemical oxygen evolution reaction (OER). However, there is still serious lack of valid approaches to further enhance their catalytic performance. Herein, we propose a spin state modulation strategy to improve the OER electrocatalytic activity of typical perovskite material of LaCoO
    Language English
    Publishing date 2022-02-11
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.202104157
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Protective effect of sphingosine-1-phosphate for chronic intermittent hypoxia-induced endothelial cell injury.

    Yu, Fu-Chao / Yuan, Chu-Xiao / Tong, Jia-Yi / Zhang, Guang-Hao / Zhou, Fang-Ping / Yang, Fang

    Biochemical and biophysical research communications

    2018  Volume 498, Issue 4, Page(s) 1016–1021

    Abstract: Intermittent hypoxia (IH) induced by obstructive sleep apnea (OSA) is the key factor in oxidative stress and the concomitant inflammation of endothelial cells (ECs). In recent years, the lipid sphingosine-1-phosphate (S1P) has been reported to probably ... ...

    Abstract Intermittent hypoxia (IH) induced by obstructive sleep apnea (OSA) is the key factor in oxidative stress and the concomitant inflammation of endothelial cells (ECs). In recent years, the lipid sphingosine-1-phosphate (S1P) has been reported to probably play a central role in inflammatory diseases. However, its role in IH-induced endothelial injury remains uncertain. In this study, we investigated the IH-induced ECs inflammation and apoptosis, as well as the role of S1P in both. First, human umbilical vein endothelial cells (HUVECs) were treated with IH to explore the mechanism of S1P and S1P microbubbles (S1P-MBs) in HUVECs with altered function. The intracellular reactive oxygen species (ROS) significantly increased after IH treatment, which further resulted in the increased efficiency of cell apoptosis. Following the S1P and S1P-MBs treatments, the lower Bax protein and Cyt c protein levels in HUVECs indicated the protective effects of S1P for CIH-induced ECs injury. The reason may be that the enhanced expression levels of Gα
    MeSH term(s) Apoptosis ; Cytochromes c/metabolism ; Human Umbilical Vein Endothelial Cells/pathology ; Humans ; Hypoxia/pathology ; Inflammation/etiology ; Inflammation/metabolism ; Lysophospholipids ; Reactive Oxygen Species/metabolism ; Sphingosine/analogs & derivatives ; bcl-2-Associated X Protein/metabolism
    Chemical Substances Lysophospholipids ; Reactive Oxygen Species ; bcl-2-Associated X Protein ; sphingosine 1-phosphate (26993-30-6) ; Cytochromes c (9007-43-6) ; Sphingosine (NGZ37HRE42)
    Language English
    Publishing date 2018--15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 205723-2
    ISSN 1090-2104 ; 0006-291X ; 0006-291X
    ISSN (online) 1090-2104 ; 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2018.03.106
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Validation of the Palliative Prognostic Index, Performance Status-Based Palliative Prognostic Index and Chinese Prognostic Scale in a home palliative care setting for patients with advanced cancer in China.

    Zhou, Jun / Xu, Sitao / Cao, Ziye / Tang, Jing / Fang, Xiang / Qin, Ling / Zhou, Fangping / He, Yuzhen / Zhong, Xueren / Hu, Mingcai / Wang, Yan / Lu, Fengjuan / Bao, Yongzheng / Dai, Xiangheng / Wu, Qiang

    BMC palliative care

    2020  Volume 19, Issue 1, Page(s) 167

    Abstract: Background: The predictive value of the prognostic tool for patients with advanced cancer is uncertain in mainland China, especially in the home-based palliative care (HPC) setting. This study aimed to compare the accuracy of the Palliative Prognostic ... ...

    Abstract Background: The predictive value of the prognostic tool for patients with advanced cancer is uncertain in mainland China, especially in the home-based palliative care (HPC) setting. This study aimed to compare the accuracy of the Palliative Prognostic Index (PPI), the Performance Status-Based Palliative Prognostic Index (PS-PPI), and the Chinese Prognosis Scale (ChPS) for patients with advanced cancer in the HPC setting in mainland China.
    Methods: Patients with advanced cancer admitted to the hospice center of Yuebei People's Hospital between January 2014 and December 2018 were retrospectively calculated the scores according to the three prognostic tools. The Kaplan-Meier method was used to compare survival times among different risk groups. Receiver operating characteristic curve analysis was used to assess the predictive value. The accuracy of 21-, 42- and 90-day survival was compared among the three prognostic tools.
    Results: A total of 1863 patients were included. Survival time among the risk groups of all prognostic tools was significantly different from each other except for the PPI. The AUROC of the ChPS was significantly higher than that of the PPI and PS-PPI for 7-, 14, 21-, 42-, 90-, 120-, 150- and 180-day survival (P < 0.05). The AUROC of the PPI and PS-PPI were not significantly different from each other (P > 0.05).
    Conclusions: The ChPS is more suitable than the PPI and PS-PPI for advanced cancer patients in the HPC setting. More researches are needed to verify the predictive value of the ChPS, PPI, and PS-PPI in the HPC setting in the future.
    MeSH term(s) Aged ; Area Under Curve ; China ; Female ; Home Care Services/standards ; Home Care Services/trends ; Humans ; Male ; Middle Aged ; Neoplasms/complications ; Neoplasms/psychology ; Palliative Care/methods ; Prognosis ; ROC Curve ; Retrospective Studies ; Severity of Illness Index
    Language English
    Publishing date 2020-10-31
    Publishing country England
    Document type Journal Article ; Observational Study
    ZDB-ID 2091556-1
    ISSN 1472-684X ; 1472-684X
    ISSN (online) 1472-684X
    ISSN 1472-684X
    DOI 10.1186/s12904-020-00676-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Prolyl 4-Hydroxylase Domain Protein 3 Overexpression Improved Obstructive Sleep Apnea-Induced Cardiac Perivascular Fibrosis Partially by Suppressing Endothelial-to-Mesenchymal Transition.

    Zhang, Guang-Hao / Yu, Fu-Chao / Li, Yang / Wei, Qin / Song, Song-Song / Zhou, Fang-Ping / Tong, Jia-Yi

    Journal of the American Heart Association

    2017  Volume 6, Issue 10

    Abstract: Background: Intermittent hypoxia (IH) induced by obstructive sleep apnea is the key factor involved in cardiovascular fibrosis. Under persistent hypoxia condition, endothelial cells respond by endothelial-to-mesenchymal transition (EndMT), which is ... ...

    Abstract Background: Intermittent hypoxia (IH) induced by obstructive sleep apnea is the key factor involved in cardiovascular fibrosis. Under persistent hypoxia condition, endothelial cells respond by endothelial-to-mesenchymal transition (EndMT), which is associated with cardiovascular fibrosis. Prolyl 4-hydroxylase domain protein 3 (PHD3) is a cellular oxygen sensor and its expression increased in hypoxia. However, its role in obstructive sleep apnea-induced EndMT and cardiovascular fibrosis is still uncertain. We investigated the potential mechanism of obstructive sleep apnea-induced cardiac perivascular fibrosis and the role of PHD3 in it.
    Methods and results: In vivo, C56BL/6 mice were exposed to IH for 12 weeks. PHD3 expression was changed by lentivirus-mediated short-hairpin PHD3 and lentivirus carrying PHD3 cDNA. EndMT related protein levels, histological and functional parameters were detected after 12 weeks. In vitro, human umbilical vein endothelial cells were treated with IH/short-hairpin PHD3/lentivirus carrying PHD3 cDNA to explore the mechanism of PHD3 in altered function of human umbilical vein endothelial cells. We found that chronic intermittent hypoxia increase PHD3 expression and EndMT. In vivo, IH accelerate cardiac dysfunction and aggravate collagen deposition via the process of EndMT. And, when PHD3 were overexpressed, cardiac dysfunction and collagen excessive deposition were improved. In vitro, IH induced EndMT, which endow human umbilical vein endothelial cells spindle morphology and an enhanced ability to migration and collagen secretion. PHD3 overexpression in cultured human umbilical vein endothelial cells ameliorated IH-induced EndMT through inactivating hypoxia-inducible factor 1 alpha and small mothers against decapentaplegic 2 and 3.
    Conclusions: Obstructive sleep apnea-induced cardiac perivascular fibrosis is associated with EndMT, and PHD3 overexpression might be beneficial in the prevention of it by inhibiting EndMT. PHD3 overexpression might have therapeutic potential in the treatment of the disease.
    Language English
    Publishing date 2017-10-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2653953-6
    ISSN 2047-9980 ; 2047-9980
    ISSN (online) 2047-9980
    ISSN 2047-9980
    DOI 10.1161/JAHA.117.006680
    Database MEDical Literature Analysis and Retrieval System OnLINE

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