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  1. Article: General features, management strategies, and outcomes of symptomatic spontaneous isolated celiac artery dissection.

    Zhou, Fushuo / Zheng, Zhi / Pan, Youmin

    Frontiers in surgery

    2022  Volume 9, Page(s) 972276

    Abstract: Objectives: Spontaneous isolated celiac artery dissection (SICAD) is a rare condition that has not been fully investigated and reported, and very little is known regarding its prognosis and management. Here, we aimed to provide more evidence on the ... ...

    Abstract Objectives: Spontaneous isolated celiac artery dissection (SICAD) is a rare condition that has not been fully investigated and reported, and very little is known regarding its prognosis and management. Here, we aimed to provide more evidence on the management strategy and outcome for symptomatic SICAD based on the experience of a single center.
    Methods: From January 2018 to December 2021, a total of consecutive 51 patients with symptomatic SICAD were retrospectively included in this study. These patients had been selectively treated with conservative treatment (
    Results: The mean age of the patients was 53.2 ± 9.6 years, 44 (86.3%) were male, and 36 (70.6%) had hypertension. The median length of stay was 10.0 days. The complete remission rate was 92.2% on discharge. The median follow-up time was 21.0 months. A secondary intervention was required for two patients during follow-up in the conservative group, wherein one underwent a stent placement three months after discharge because of progression of symptoms and extension of dissection, and the other required intervention one month after discharge because of symptomatic progression. No secondary intervention was required in the endovascular group. Occasional and mild relapse of symptoms occurred in two patients in both the conservative and endovascular groups, with no secondary intervention. The length of dissection (25.5 ± 11.8 mm vs. 19.1 ± 7.4 mm,
    Conclusion: Patients with symptomatic SICAD who were selectively treated with conservative treatment or endovascular treatment had satisfactory early and medium-term outcomes. Endovascular treatment showed significant advantages in the complete remodeling of the celiac artery and presented with a lower rate of secondary intervention. Moreover, it was found to be a safe and effective remedy for failed conservative treatment.
    Language English
    Publishing date 2022-10-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2773823-1
    ISSN 2296-875X
    ISSN 2296-875X
    DOI 10.3389/fsurg.2022.972276
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Management of Penetrating Injury to the Esophagus Into the Aorta by a Fishbone.

    Zhou, Fushuo / Zheng, Zhi / Pan, Youmin

    The American surgeon

    2022  Volume 89, Issue 6, Page(s) 2941–2942

    Abstract: A 66-year-old man was reported to have persistent chest pain for 4 hours after accidentally swallowing a fishbone. An isolated esophageal foreign body (EFB) was suspected in the community hospital. In our center, an emergency chest CT scan revealed an ... ...

    Abstract A 66-year-old man was reported to have persistent chest pain for 4 hours after accidentally swallowing a fishbone. An isolated esophageal foreign body (EFB) was suspected in the community hospital. In our center, an emergency chest CT scan revealed an EFB in the upper part of the esophagus of the patient which penetrated the left esophageal wall as well as the distal aortic arch. However, the experience of the treatment strategy for this lesion is still not enough available. Considering the surgical trauma and the risk associated with advanced age of the patient, the option for open surgery was waived. In addition, there was also a risk of sudden death due to aortic rupture that could occur after direct removal of the fishbone. Therefore, emergency thoracic endovascular aortic repair was performed and the fishbone was removed under an endoscope. The patient successfully pulled through without any discomfort, with no complications.
    MeSH term(s) Male ; Humans ; Aged ; Esophagus/surgery ; Esophagus/injuries ; Aorta/injuries ; Aorta, Thoracic/injuries ; Foreign Bodies/complications ; Foreign Bodies/diagnostic imaging ; Foreign Bodies/surgery ; Rupture/complications ; Wounds, Penetrating/surgery ; Wounds, Penetrating/complications
    Language English
    Publishing date 2022-04-20
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 202465-2
    ISSN 1555-9823 ; 0003-1348
    ISSN (online) 1555-9823
    ISSN 0003-1348
    DOI 10.1177/00031348221087906
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  3. Article ; Online: Pulmonary artery dissection secondary to pulmonary hypertension due to patent ductus arteriosus: echocardiography and computed tomography findings.

    Zhou, Fushuo / Zheng, Zhi / Pan, Youmin

    Acta cardiologica

    2022  Volume 78, Issue 4, Page(s) 478–479

    MeSH term(s) Humans ; Ductus Arteriosus, Patent/complications ; Ductus Arteriosus, Patent/diagnosis ; Hypertension, Pulmonary/etiology ; Hypertension, Pulmonary/complications ; Pulmonary Artery/diagnostic imaging ; Echocardiography ; Tomography, X-Ray Computed
    Language English
    Publishing date 2022-05-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 390197-x
    ISSN 1784-973X ; 0001-5385
    ISSN (online) 1784-973X
    ISSN 0001-5385
    DOI 10.1080/00015385.2022.2054496
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Deep learning-based diagnosis of aortic dissection using an electrocardiogram: Development, validation, and clinical implications of the AADE score.

    Zhou, Minghe / Lei, Lei / Chen, Wei / Luo, Qiushi / Li, Jin / Zhou, Fushuo / Yang, Xiaoyun / Pan, Youmin

    Kardiologia polska

    2024  Volume 82, Issue 1, Page(s) 63–71

    Abstract: Background: Aortic dissection (AD) is frequently associated with abnormalities in electrocardiographic findings. Advancements in medical technology present an opportunity to leverage these observations to improve patient diagnosis and care.: ... ...

    Abstract Background: Aortic dissection (AD) is frequently associated with abnormalities in electrocardiographic findings. Advancements in medical technology present an opportunity to leverage these observations to improve patient diagnosis and care.
    Objectives: This study aimed to develop a deep learning artificial intelligence (AI) model for AD detection using electrocardiograms (ECGs) and introduce the AI-Aortic-Dissection-ECG (AADE) score to provide clinicians with a measure to determine AD severity.
    Methods: From a cohort of 1878 patients, including 313 with AD, and 313 with chest pain (control group), we created training and validation subsets (7:3 ratio). A convolutional neural networks (CNN) model was trained for AD detection, with performance metrics like accuracy and F1 score (the harmonic mean of precision and recall) monitored. The AI-derived AADE score (0-1) was investigated against clinical parameters and ECG features over a median follow-up of 21.2 months.
    Results: The CNN model demonstrated robust performance with an accuracy of 0.93 and an F1 score of 0.93 for the AD group, and an accuracy of 0.871 with an F1 score of 0.867 for the chest pain group. The AADE score showed correlations with specific ECG patterns and demonstrated that higher scores aligned with increased mortality risk.
    Conclusions: Our CNN-based AI model offers a promising approach for AD detection using ECG. The AADE score, based on AI, can serve as a pivotal tool in refining clinical assessments and management strategies.
    MeSH term(s) Humans ; Deep Learning ; Artificial Intelligence ; Aortic Dissection/diagnosis ; Electrocardiography ; Chest Pain
    Language English
    Publishing date 2024-01-17
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 411492-9
    ISSN 1897-4279 ; 0022-9032
    ISSN (online) 1897-4279
    ISSN 0022-9032
    DOI 10.33963/v.phj.98880
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  5. Article: An elephant trunk stent graft strayed into the false lumen leading to a death during the Sun's operation: A case report.

    Zhou, Fushuo / Chai, Hong / Liu, Ruisheng / Song, Bing

    Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences

    2021  Volume 46, Issue 2, Page(s) 217–220

    Abstract: Type A aortic dissection (AD) is a critical and severe disease with high mortality. The Sun's operation is a standard surgical method for this kind of disease at present. For the procedure, an elephant trunk stent is inserted into the true lumen of the ... ...

    Title translation “
    Abstract Type A aortic dissection (AD) is a critical and severe disease with high mortality. The Sun's operation is a standard surgical method for this kind of disease at present. For the procedure, an elephant trunk stent is inserted into the true lumen of the descending aorta and the aortic arch is replaced. A patient was admitted to the First Hospital of Lanzhou University due to sudden chest and back pain for 6 days. Computed tomography angiography (CTA) showed type A AD. Ascending aorta replacement, Sun's operation, and ascending aorta to right femoral artery bypass grafting were performed. After surgery, the patient's condition was worsened. The digital subtraction angiography (DSA) showed the elephant trunk stent was inserted into the false lumen of AD, leading to the occlusion of the large blood vessel at the distal part of the abdominal aorta and below. Although we performed intima puncture and endovascular aortic repair, the patient was still dead.
    MeSH term(s) Aortic Dissection/diagnostic imaging ; Aortic Dissection/surgery ; Aorta, Abdominal ; Aorta, Thoracic/surgery ; Blood Vessel Prosthesis Implantation/adverse effects ; Humans ; Stents/adverse effects ; Treatment Outcome
    Language Chinese
    Publishing date 2021-02-27
    Publishing country China
    Document type Case Reports ; Journal Article
    ZDB-ID 2168533-2
    ISSN 1672-7347
    ISSN 1672-7347
    DOI 10.11817/j.issn.1672-7347.2021.190608
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  6. Article ; Online: Nuclear Paraspeckle Assembly Transcript 1 Enhances Hydrogen Peroxide-Induced Human Vascular Smooth Muscle Cell Injury by Regulating miR-30d-5p/A Disintegrin and Metalloprotease 10.

    Zhou, Fushuo / Zheng, Zhi / Zha, Zhengbiao / Xiong, Tianxin / Pan, Youmin

    Circulation journal : official journal of the Japanese Circulation Society

    2021  Volume 86, Issue 6, Page(s) 1007–1018

    Abstract: Background: Nuclear paraspeckle assembly transcript 1 (NEAT1) has been reported to be involved in the progression of many cancers; however, the role and mechanisms underlying NEAT1 in abdominal aortic aneurysm (AAA) remain unclear.Methods and Results: ... ...

    Abstract Background: Nuclear paraspeckle assembly transcript 1 (NEAT1) has been reported to be involved in the progression of many cancers; however, the role and mechanisms underlying NEAT1 in abdominal aortic aneurysm (AAA) remain unclear.Methods and Results: The expression of NEAT1, miR-30d-5p and A disintegrin and metalloprotease 10 (ADAM10) was measured by qRT-PCR and western blot. Functional experiments were conducted by using a CCK-8 assay, EDU assay, flow cytometry, western blot, ELISA, and commercial kits. The target relation was confirmed by dual-luciferase reporter assay and the RIP assay. It was then found that NEAT1 was upregulated in peripheral blood of AAA patients ~3.46-fold, smooth muscle cells (SMCs) isolated from AAA tissues ~2.6-fold and in a hydrogen peroxide (H
    Conclusions: NEAT1 promoted H
    MeSH term(s) Apoptosis ; Carrier Proteins ; Cell Proliferation ; Disintegrins/metabolism ; Disintegrins/pharmacology ; Humans ; Hydrogen Peroxide/metabolism ; Hydrogen Peroxide/pharmacology ; Metalloproteases/metabolism ; Metalloproteases/pharmacology ; MicroRNAs/metabolism ; Muscle, Smooth, Vascular/metabolism ; Myocytes, Smooth Muscle/metabolism ; Paraspeckles ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism
    Chemical Substances Carrier Proteins ; Disintegrins ; MicroRNAs ; NEAT1 long non-coding RNA, human ; RNA, Long Noncoding ; Hydrogen Peroxide (BBX060AN9V) ; Metalloproteases (EC 3.4.-)
    Language English
    Publishing date 2021-12-09
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2068090-9
    ISSN 1347-4820 ; 1346-9843
    ISSN (online) 1347-4820
    ISSN 1346-9843
    DOI 10.1253/circj.CJ-21-0042
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  7. Article ; Online: A mass in the pulmonary artery: the incremental value of cardiac magnetic resonance.

    Qi, Quan / Chen, Zixian / Zhou, Fushuo / Dong, Shuai / Song, Bing

    European heart journal. Cardiovascular Imaging

    2020  Volume 21, Issue 5, Page(s) 588

    MeSH term(s) Heart ; Humans ; Magnetic Resonance Imaging ; Magnetic Resonance Imaging, Cine ; Magnetic Resonance Spectroscopy ; Pulmonary Artery/diagnostic imaging
    Language English
    Publishing date 2020-01-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2638345-7
    ISSN 2047-2412 ; 2047-2404
    ISSN (online) 2047-2412
    ISSN 2047-2404
    DOI 10.1093/ehjci/jez291
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  8. Article: [Heparin-induced thrombocytopenia in patients 
undergoing cardiac surgery].

    Zhou, Fushuo / Huang, Lingjin / Wang, E / Lin, Guoqiang / Luo, Wanjun

    Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences

    2015  Volume 40, Issue 7, Page(s) 790–796

    Abstract: Objective: To investigate the incidence for heparin-induced thrombocytopenia (HIT) in patients undergoing cardiac surgery and to evaluate the risk factors for the generation of HIT-antibody.
: Methods: A total of 315 patients undergoing cardiac ... ...

    Abstract Objective: To investigate the incidence for heparin-induced thrombocytopenia (HIT) in patients undergoing cardiac surgery and to evaluate the risk factors for the generation of HIT-antibody.

    Methods: A total of 315 patients undergoing cardiac surgery in the Department of Cardiothoracic Surgery, Xiangya Hospital between December, 2013 and July, 2014 were enrolled for this study. Among them, 120, 154 and 41 were for surgery of congenital heart defect, valve and coronary artery bypass graft, respectively. There were 170 male patients and 69 patients were under 18 years old. Platelet counts, HIT-antibody and concentration of platelet factor 4 (PF4) were tested before and after the surgery. Diagnosis of HIT was based on "4Ts" (Pretest Clinical Scoring System). 

    Results: HIT was diagnosed in 11 patients (3.5%, 11/315). And thromboembolic events occurred in 2 of 11 patients with HIT. The positive ratio for HIT-antibody was 36.5% (115/315). The coronary artery disease patients had a higher incidence of HIT than that of either the valve disease or the congenital heart defect (17.1%, 7/41 versus 1.9%, 3/154 or 0.8%, 1/120; P<0.05). The congenital heart defect patients had a higher positive ratio for HIT-antibody than that of both the valve disease and the coronary artery disease. The valve disease patients had a higher positive ratio for HIT-antibody than that of the coronary artery disease (51.7%, 62/120 versus 30.5%, 47/154 versus 14.6%, 6/41; P<0.05). Major postoperative complications occurred more frequently in HIT patients (36.4%, 4/11 versus 10.5%, 32/304; P<0.05). Age was a risk factor for HIT (P=0.030, OR=1.083, 95% CI 1.008-1.163). Cardiopulmonary bypass (CPB) (P=0.037, OR=3.113, 95% CI 1.071-9.050) and age (P<0.001, OR=0.970, 95% CI 0.959-0.982) were risk factors for HIT-antibody.

    Conclusion: The incidence of HIT is low during cardiac surgery, but HIT is a highly risk factor for the major postoperative complications. More attentions should be paid to these severe complications and the risk factors for HIT.
    MeSH term(s) Antibodies/blood ; Cardiac Surgical Procedures ; Cardiopulmonary Bypass ; Coronary Artery Bypass ; Female ; Heparin/adverse effects ; Humans ; Incidence ; Male ; Platelet Count ; Platelet Factor 4/blood ; Postoperative Complications ; Risk Factors ; Thrombocytopenia/chemically induced
    Chemical Substances Antibodies ; Platelet Factor 4 (37270-94-3) ; Heparin (9005-49-6)
    Language Chinese
    Publishing date 2015-08-12
    Publishing country China
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2168533-2
    ISSN 1672-7347
    ISSN 1672-7347
    DOI 10.11817/j.issn.1672-7347.2015.07.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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