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Article ; Online: The Effect and Potential Mechanism of microRNA-124 on the Biological Behavior of Colon Cancer Cells.

Zhou, Gang

Annals of clinical and laboratory science

2021 Volume 51, Issue 5, Page(s) 646–653

Abstract: Objective: We aimed to investigate the expression of microRNA-124 (miR-124) in colon cancer and its biological function in colon cancer cells as well as its underlying mechanism.: Methods: Mimic miR-124 and unrelated sequence were transfected into ... ...

Abstract	Objective: We aimed to investigate the expression of microRNA-124 (miR-124) in colon cancer and its biological function in colon cancer cells as well as its underlying mechanism. Methods: Mimic miR-124 and unrelated sequence were transfected into colon cancer HT29 cells, and a blank control group was established with untreated HT29 cells. The expression of miR-124 in each group was detected by qRT-PCR. CCK-8 assay, cell scratch assay, Transwell assay, and flow cytometry were used to detect the effects of miR-124 on cell growth, invasion, migration, and apoptosis in HT29 cells. The expression of TET protein family and related protein was evaluated by Western blot. Results: miR-124 expression was significantly downregulated in colon cancer HT29 cells ( Conclusion: The expression of miR-124 inhibited cell proliferation, suppressed tumor cell migration and invasion, and enhanced apoptosis by its regulation of the expression of TET1, TET2, vimentin, and MMP-2 in colon cancer HT29 cells.
MeSH term(s)	Actins/genetics ; Actins/metabolism ; Apoptosis/genetics ; Cell Movement/genetics ; Cell Proliferation/genetics ; Colonic Neoplasms/genetics ; Colonic Neoplasms/metabolism ; Colonic Neoplasms/pathology ; Gene Expression Regulation, Neoplastic ; HT29 Cells ; Humans ; Matrix Metalloproteinase 2/genetics ; Matrix Metalloproteinase 2/metabolism ; MicroRNAs/genetics ; Vimentin/genetics ; Vimentin/metabolism
Chemical Substances	Actins ; MIRN124 microRNA, human ; MicroRNAs ; VIM protein, human ; Vimentin ; MMP2 protein, human (EC 3.4.24.24) ; Matrix Metalloproteinase 2 (EC 3.4.24.24)
Language	English
Publishing date	2021-10-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	193092-8
ISSN	1550-8080 ; 0091-7370 ; 0095-8905
ISSN (online)	1550-8080
ISSN	0091-7370 ; 0095-8905
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Zs.A 942: Show issues

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Article: Helicobacter pylori

Zhou, Gang

Gastroenterology research and practice

2020 Volume 2020, Page(s) 7510872

Abstract: Purpose: To investigate the recurrence rate of : Methods: Outpatients who were eradicated of : Results: In total, 400 patients (225 males and 175 females) were included in this study. Of them, the recurrence rate of : Conclusions: The overall ... ...

Abstract	Purpose: To investigate the recurrence rate of Methods: Outpatients who were eradicated of Results: In total, 400 patients (225 males and 175 females) were included in this study. Of them, the recurrence rate of Conclusions: The overall recurrence rate after
Language	English
Publishing date	2020-04-06
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	2435460-0
ISSN	1687-630X ; 1687-6121
ISSN (online)	1687-630X
ISSN	1687-6121
DOI	10.1155/2020/7510872
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Article ; Online: Prognostic value of elevated plasma angiotensin-converting enzyme 2 in cardiometabolic diseases: A review.

Zhou, Gang / Liu, Jingchen

Medicine

2023 Volume 102, Issue 10, Page(s) e33251

Abstract: Angiotensin-converting enzyme 2, as an internal anti regulator of the renin-angiotensin hormone cascade reaction, plays a protective role in vasodilation, inhibition of fibrosis, and initiation of anti-inflammatory and antioxidative stress by degrading ... ...

Abstract	Angiotensin-converting enzyme 2, as an internal anti regulator of the renin-angiotensin hormone cascade reaction, plays a protective role in vasodilation, inhibition of fibrosis, and initiation of anti-inflammatory and antioxidative stress by degrading angiotensin II and generating angiotensin (1-7). Multiple studies have shown that plasma angiotensin-converting enzyme 2 activity is low in healthy populations without significant cardiometabolic disease, and elevated plasma angiotensin-converting enzyme 2 levels can be used as a novel biomarker of abnormal myocardial structure and/or adverse events in cardiometabolic diseases. This article aims to elaborate the determinants of plasma angiotensin-converting enzyme 2 concentration, the relevance between angiotensin-converting enzyme 2 and cardiometabolic disease risk markers, and its relative importance compared with known cardiovascular disease risk factors. Confronted with the known cardiovascular risk factors, plasma angiotensin-converting enzyme 2 (ACE2) concentration uniformly emerged as a firm predictor of abnormal myocardial structure and/or adverse events in cardiometabolic diseases and may improve the risk prediction of cardiometabolic diseases when combined with other conventional risk factors. Cardiovascular disease is the leading cause of death worldwide, while the renin-angiotensin system is the main hormone cascade system involved in the pathophysiology of cardiovascular disease. A multi-ancestry global cohort study from the general population by Narula et al revealed that plasma ACE2 concentration was strongly associated with cardiometabolic disease and might be an easily measurable indicator of renin-angiotensin system disorder. The association between this atypical hormone disorder marker and cardiometabolic disease is isolated from conventional cardiac risk factors and brain natriuretic peptide, suggesting that a clearer comprehending of the changes in plasma ACE2 concentration and activity may help us to improve the risk prediction of cardiometabolic disease, guide early diagnosis and feasible therapies, and develop and test new therapeutic targets.
MeSH term(s)	Humans ; Prognosis ; Angiotensin-Converting Enzyme 2 ; Peptidyl-Dipeptidase A ; Cardiovascular Diseases ; Cohort Studies ; Renin-Angiotensin System/physiology ; Angiotensin II
Chemical Substances	Angiotensin-Converting Enzyme 2 (EC 3.4.17.23) ; Peptidyl-Dipeptidase A (EC 3.4.15.1) ; Angiotensin II (11128-99-7)
Language	English
Publishing date	2023-03-09
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000033251
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Article ; Online: Metal/graphene heterobilayers as hydrogen evolution reaction cathodes: a first-principles study.

Zhou, Gang

Physical chemistry chemical physics : PCCP

2019 Volume 21, Issue 8, Page(s) 4594–4599

Abstract: From the study of precious metal/graphene heterobilayers instead of commercial Pt/C catalysts, we propose a strategy for improving the performance/cost ratio of metals in electrocatalysis. Results from the Rh/graphene bilayer show that the Rh atoms that ... ...

Abstract	From the study of precious metal/graphene heterobilayers instead of commercial Pt/C catalysts, we propose a strategy for improving the performance/cost ratio of metals in electrocatalysis. Results from the Rh/graphene bilayer show that the Rh atoms that directly interact with graphene occupy most of the area of the supported metal sheet, and they exhibit better hydrogen evolution reaction (HER) activity than Rh and even than Pt. The interlayer charge transfer, rather than the intralayer charge transfer, leads to the downshift of the d-states of these Rh atoms in energy and weakens the H-Rh binding. This allows the HER process to be almost thermo-neutral. Support interactions determine whether the interlayer charge transfer or the intralayer charge transfer is dominant in the bilayer and surface corrugations on the two sheets. A different structure-activity relationship is present in two-dimensional systems. This study on the corrugation-sensitive HER activity and the activation mechanism of Rh/graphene heterobilayers is also helpful for the design of more ultrathin precious or non-precious metal/graphene heterostructures used as electrodes in water electrolysis.
Language	English
Publishing date	2019-02-11
Publishing country	England
Document type	Journal Article
ZDB-ID	1476244-4
ISSN	1463-9084 ; 1463-9076
ISSN (online)	1463-9084
ISSN	1463-9076
DOI	10.1039/c8cp07725h
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Article ; Online: Effects of a graphene substrate on the structure and properties of atomically thin metal sheets.

Zhou, Gang

Physical chemistry chemical physics : PCCP

2019 Volume 22, Issue 2, Page(s) 667–673

Abstract: The production and use of atomically thin metal sheets are desirable but challenging. Here, density functional theory calculations indicate that the introduction of graphene as a support can play an unexpected role in the stability and function of Rh ... ...

Abstract	The production and use of atomically thin metal sheets are desirable but challenging. Here, density functional theory calculations indicate that the introduction of graphene as a support can play an unexpected role in the stability and function of Rh monolayer, as a representative of single-layer metal nanosheets. The graphene stabilizes the otherwise unstable Rh monolayer by the substrate interaction that not only impedes the out-of-plane movement of the Rh atoms but also decreases the surface energy. The Rh/graphene bilayer has good mechanical properties, comparable to those of emerging 2D graphene-based materials. The interfacial stress from the substrate interaction causes surface corrugations to form on the bilayer, exhibiting a degree of consistency in the direction and the area. Discrete magnetic units, compatible with the substrate interaction, are present in the corrugated Rh sheet. The visible magnetic anisotropy and spin-splitting of polarized carrier states of the corrugated Rh sheet dominate the spin-dependent transport in the bilayer film, which can be used as a building block for ultrathin electronic/spintronic devices.
Language	English
Publishing date	2019-12-12
Publishing country	England
Document type	Journal Article
ZDB-ID	1476244-4
ISSN	1463-9084 ; 1463-9076
ISSN (online)	1463-9084
ISSN	1463-9076
DOI	10.1039/c9cp05466a
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Article ; Online: Optical coherence tomography: Promising imaging technique for the diagnosis of oral mucosal diseases.

Chen, Xu-Ya / Zhou, Gang / Zhang, Jing

Oral diseases

2024

Abstract: Objective: This review aims to summarize the latest application of optical coherence tomography (OCT) in oral mucosal diseases, promoting an accurate and earlier diagnosis of such disorders, which are difficult to be differentiated.: Subjective and ... ...

Abstract	Objective: This review aims to summarize the latest application of optical coherence tomography (OCT) in oral mucosal diseases, promoting an accurate and earlier diagnosis of such disorders, which are difficult to be differentiated. Subjective and methods: References on the application of OCT in oral mucosal diseases were mainly obtained from PubMed, Embase, Web of Science and Scopus databases, using the keywords: "optical coherence tomography and 'oral mucosa/oral cancers/oral potentially malignant diseases/oral lichen planus/oral leukoplakia/oral erythroplakia/discoid lupus erythematosus/oral autoimmune bullous diseases/oral ulcers/erythema multiforme/oral mucositis'". Results: It is found that OCT is showing a promising application potential in the early detection, diagnosis, differential diagnosis, monitoring of oral cancer and oral dysplastic lesions, as well as the delineation of tumor margins. OCT is also playing an increasingly important role in the diagnosis of oral potentially malignant disorders, oral mucosal bullous diseases, oral ulcerative diseases, erythema multiforme, and the early detection of oral mucositis. Conclusion: Optical coherence tomography, as a novel optical technique featured by real-time, noninvasive, dynamic and high-resolution imaging, is of great use to serve as an adjunct tool for the diagnosis, differential diagnosis, monitoring and therapy evaluation of oral mucosal diseases.
Language	English
Publishing date	2024-01-08
Publishing country	Denmark
Document type	Journal Article ; Review
ZDB-ID	1290529-x
ISSN	1601-0825 ; 1354-523X
ISSN (online)	1601-0825
ISSN	1354-523X
DOI	10.1111/odi.14851
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Zs.A 4427: Show issues

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Article ; Online: Divergent Synthesis of Fluoroalkyl Ketones through Controlling the Reactivity of Organoboronate Complexes.

Zhou, Gang / Guo, Zhuanzhuan / Liu, Shanshan / Shen, Xiao

Journal of the American Chemical Society

2024 Volume 146, Issue 6, Page(s) 4026–4035

Abstract: Herein, we report a divergent synthesis of fluoroalkyl ketones through visible-light-induced reactions between readily available organoboronic esters and fluoroalkyl acylsilanes. Selective control of the reactivity of ... ...

Abstract	Herein, we report a divergent synthesis of fluoroalkyl ketones through visible-light-induced reactions between readily available organoboronic esters and fluoroalkyl acylsilanes. Selective control of the reactivity of the
Language	English
Publishing date	2024-02-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/jacs.3c12150
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Z 7.3: Show issues

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Article ; Online: CASC19: An Oncogenic Long Non-coding RNA in Different Cancers.

Wu, Yinxin / Mou, Jie / Zhou, Gang / Yuan, Chengfu

Current pharmaceutical design

2024

Abstract: A 324 bp lncRNA called CASC19 is found on chromosome 8q24.21. Recent research works have revealed that CASC19 is involved in the prognosis of tumors and related to the regulation of the radiation tolerance mechanisms during tumor radiotherapy (RT). This ... ...

Abstract	A 324 bp lncRNA called CASC19 is found on chromosome 8q24.21. Recent research works have revealed that CASC19 is involved in the prognosis of tumors and related to the regulation of the radiation tolerance mechanisms during tumor radiotherapy (RT). This review sheds light on the changes and roles that CASC19 plays in many tumors and diseases, such as nasopharyngeal carcinoma (NPC), cervical cancer, colorectal cancer (CRC), non-small cell lung cancer (NSCLC), clear cell renal cell carcinoma (ccRCC), gastric cancer (GC), pancreatic cancer (PC), hepatocellular carcinoma (HCC), glioma, and osteoarthritis (OA). CASC19 provides a new strategy for targeted therapy, and the regulatory networks of CASC19 expression levels play a key role in the occurrence and development of tumors and diseases. In addition, the expression level of CASC19 has predictive roles in the prognosis of some tumors and diseases, which has major implications for clinical diagnoses and treatments. CASC19 is also unique in that it is a key gene affecting the efficacy of RT in many tumors, and its expression level plays a decisive role in improving the success rate of treatments. Further research is required to determine the precise process by which CASC19 causes changes in diseased cells in some tumors and diseases.
Language	English
Publishing date	2024-03-27
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	1304236-1
ISSN	1873-4286 ; 1381-6128
ISSN (online)	1873-4286
ISSN	1381-6128
DOI	10.2174/0113816128300061240319034243
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Zs.A 4714: Show issues

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Article ; Online: Melatonin improves salivary gland damage and hypofunction in pSS by inhibiting IL-6/STAT3 signaling through its receptor-dependent manner.

Liu, Yi / Wang, Fang / Cheng, Bo / Zhou, Gang

Molecular immunology

2024 Volume 169, Page(s) 10–27

Abstract: Objective: Primary Sjogren's syndrome (pSS) is an autoimmune disease of the exocrine glands with no specific or efficient treatments. Melatonin, a natural hormone, is revealed to show multiple biological functions, both receptor-dependent and ... ...

Abstract	Objective: Primary Sjogren's syndrome (pSS) is an autoimmune disease of the exocrine glands with no specific or efficient treatments. Melatonin, a natural hormone, is revealed to show multiple biological functions, both receptor-dependent and independent effects, including anti-apoptotic, antioxidant, and anti-inflammatory activities. However, the potential mechanism by which melatonin protects salivary glands (SGs) of pSS from damage needs to be clarified. The purpose of current study was to explore the role and receptor-related mechanisms of melatonin in pSS-induced glandular damage. Methods and results: NOD/Ltj mice were used to spontaneously mimic pSS-induced glandular hypofunction in vivo and primary human salivary gland epithelial (HSGE) cells were stimulated by interferon-γ (IFN-γ) to mimic pSS-induced inflammation in SGs cells in vitro. Melatonin-treated mice exhibited a significant reduction in SG injury of NOD/Ltj mice, which was accompanied by an increase in salivary flow rate, a decrease in inflammatory infiltration within the gland, and a suppression of oxidative stress indicators as well as cell apoptosis. Notably, both melatonin membrane receptors and nuclear receptors played an important role in the anti-apoptotic effects of melatonin on the SGs of NOD/Ltj mice. Furthermore, melatonin blocked the IL-6/STAT3 pathway through receptor-dependent manners in IFN-γ-stimulated HSGE cells. However, it was evident that the anti-oxidative and anti-apoptotic properties of melatonin on IFN-γ-stimulated HSGE cells were diminished by IL-6 treatment. Conclusion: Melatonin had the potential to mitigate inflammation, oxidative stress, and apoptosis in SGs of pSS by inhibiting the IL-6/STAT3 pathway through receptor-dependent mechanisms. This intervention effectively prevented glandular damage and preserved functional integrity.
MeSH term(s)	Humans ; Mice ; Animals ; Interleukin-6/metabolism ; Melatonin/pharmacology ; Melatonin/metabolism ; Sjogren's Syndrome/drug therapy ; Mice, Inbred NOD ; Salivary Glands ; Inflammation ; Interferon-gamma/metabolism ; STAT3 Transcription Factor/metabolism
Chemical Substances	Interleukin-6 ; Melatonin (JL5DK93RCL) ; Interferon-gamma (82115-62-6) ; STAT3 protein, human ; STAT3 Transcription Factor
Language	English
Publishing date	2024-03-10
Publishing country	England
Document type	Journal Article
ZDB-ID	424427-8
ISSN	1872-9142 ; 0161-5890
ISSN (online)	1872-9142
ISSN	0161-5890
DOI	10.1016/j.molimm.2024.02.012
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Zs.A 166: Show issues

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Article ; Online: Implications of innate lymphoid cells in oral diseases.

Hu, Si-Ting / Zhou, Gang / Zhang, Jing

International immunopharmacology

2024 Volume 133, Page(s) 112122

Abstract: Innate lymphoid cells (ILCs), as newly discovered antigen-independent innate immune cells, respond promptly to stimuli by secreting effector cytokines to exert effector functions similar to those of T cells. ILCs predominantly reside at mucosal sites and ...

Abstract	Innate lymphoid cells (ILCs), as newly discovered antigen-independent innate immune cells, respond promptly to stimuli by secreting effector cytokines to exert effector functions similar to those of T cells. ILCs predominantly reside at mucosal sites and play critical roles in defending against infections, maintaining mucosal homeostasis, regulating inflammatory and immune responses, and participating in tumorigenesis. Recently, there has been a growing interest in the role of ILCs in oral diseases. This review outlines the classifications and the major characteristics of ILCs, and then comprehensively expatiates the research on ILCs in oral cancer, primary Sjogren's syndrome, periodontal diseases, oral lichen planus, oral candidiasis, Behcet's disease, and pemphigus vulgaris, aiming at summarising the implications of ILCs in oral diseases and providing new ideas for further research.
Language	English
Publishing date	2024-04-24
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2043785-7
ISSN	1878-1705 ; 1567-5769
ISSN (online)	1878-1705
ISSN	1567-5769
DOI	10.1016/j.intimp.2024.112122
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