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Article ; Online: Analytical model for monochromator performance characterizations under thermal load.

Qu, Zhengxian / Ma, Yanbao / Zhou, Guanqun / Wu, Juhao

2020 Volume 28, Issue 20, Page(s) 30075–30084

Abstract: Non-uniform thermal load causes performance degradation of crystal X-ray optics. With the development of high-brightness X-ray free-electron lasers, the thermal load on X-ray optics becomes even more severe. To mitigate the thermal load, a quantitative ... ...

Abstract	Non-uniform thermal load causes performance degradation of crystal X-ray optics. With the development of high-brightness X-ray free-electron lasers, the thermal load on X-ray optics becomes even more severe. To mitigate the thermal load, a quantitative understanding of thermal effects on the optical performance is necessary. We derived an analytical model for monochromator performance under a non-uniform thermal load. This analytical model quantitatively describes the distortion of the rocking curve and attributes different contributions to different factors of thermal load. It provides not only monochromator design insights and considerations, but also a quick estimation of the rocking curve distortion due to thermal load for practical situations such as pump-probe experiments.
Language	English
Publishing date	2020-10-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	1491859-6
ISSN	1094-4087 ; 1094-4087
ISSN (online)	1094-4087
ISSN	1094-4087
DOI	10.1364/OE.394958
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Article ; Online: Dynamic pulse-to-pulse thermal load effects in pulse-train-mode self-seeded X-ray free-electron laser.

Qu, Zhengxian / Ma, Yanbao / Zhou, Guanqun / Wu, Juhao

Journal of synchrotron radiation

2020 Volume 27, Issue Pt 6, Page(s) 1725–1729

Abstract: Thermal load has been a haunting factor that undermines the brightness and coherence of the self-seeded X-ray free-electron laser. Different from uniformly pulsed mode, in pulse train mode a thermal quasi-steady state of the crystal monochromator may not ...

Abstract	Thermal load has been a haunting factor that undermines the brightness and coherence of the self-seeded X-ray free-electron laser. Different from uniformly pulsed mode, in pulse train mode a thermal quasi-steady state of the crystal monochromator may not be reached. This leads to a dynamic thermal distortion of the spectral transmission curves and seed quality degradation. In this paper, the pulse-to-pulse thermal load effects on the spectral transmission curves and seed quality are shown, and some instructive information for the tuning process is provided.
Language	English
Publishing date	2020-10-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2021413-3
ISSN	1600-5775 ; 0909-0495
ISSN (online)	1600-5775
ISSN	0909-0495
DOI	10.1107/S1600577520011935
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Article ; Online: New mounting mechanism for cryogenically cooled thin crystal x-ray optics in high brightness high repetition rate free-electron laser applications.

Qu, Zhengxian / Borzenets, Valery / Zhou, Guanqun / Ma, Yanbao / Wu, Juhao

The Review of scientific instruments

2021 Volume 92, Issue 8, Page(s) 83904

Abstract: We present a new mounting design for thin crystal optics with cryogenic cooling compatibility. We design a crystal geometry with two symmetric strain-relief cuts to mitigate the distortion from mounting. We propose to sputter gold onto the crystal and ... ...

Abstract	We present a new mounting design for thin crystal optics with cryogenic cooling compatibility. We design a crystal geometry with two symmetric strain-relief cuts to mitigate the distortion from mounting. We propose to sputter gold onto the crystal and the holder to ensure excellent thermal contact and sufficient mechanical bonding. The system is analyzed and verified by finite element analysis to have an acceptable level of strain due to mounting. The thermal performance of this mounting scheme is validated in an example cryogenic cooling system and the results indicate a tolerance of power density up to ∼1 kW/mm
Language	English
Publishing date	2021-09-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	209865-9
ISSN	1089-7623 ; 0034-6748
ISSN (online)	1089-7623
ISSN	0034-6748
DOI	10.1063/5.0052764
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Article ; Online: Radiotherapy alone versus concurrent chemoradiotherapy in patients with stage II and T3N0 nasopharyngeal carcinoma with adverse features: A propensity score-matched cohort study.

Zhang, Wei-Wei / Lin, Jia-Yi / Wang, Gao-Yuan / Huang, Cheng-Long / Tang, Ling-Long / Mao, Yan-Ping / Zhou, Guan-Qun / Liu, Li-Zhi / Tian, Li / Li, Ji-Bin / Ma, Jun / Guo, Rui

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

2024 Volume 194, Page(s) 110189

Abstract: Background and purpose: Whether concurrent chemoradiotherapy would provide survival benefits in patients with stage II and T3N0 NPC with adverse factors remains unclear in IMRT era. We aimed to assess the value of concurrent chemotherapy compared to ... ...

Abstract	Background and purpose: Whether concurrent chemoradiotherapy would provide survival benefits in patients with stage II and T3N0 NPC with adverse factors remains unclear in IMRT era. We aimed to assess the value of concurrent chemotherapy compared to IMRT alone in stage II and T3N0 NPC with adverse features. Materials and methods: 287 patients with stage II and T3N0 NPC with adverse factors were retrospectively analyzed, including 98 patients who received IMRT alone (IMRT alone group) and 189 patients who received cisplatin-based concurrent chemotherapy (CCRT group). The possible prognostic factors were balanced using propensity score matching (PSM). Kaplan-Meier analysis was used to evaluate the survival rates, and log-rank tests were employed to compare differences between groups. Results: The median follow-up duration was 90.8 months (interquartile range = 75.6-114.7 months). The IMRT alone and the CCRT group were well matched; however, for all survival-related endpoints, there were no significant differences between them (5-year failure-free survival: 84.3% vs. 82.7%, P value = 0.68; 5-year overall survival: 87.3% vs. 90.6%, P value = 0.11; 5-year distant metastasis-free survival: 92.8% vs. 92.5%, P value = 0.97; 5-year locoregional relapse-free survival: 93.4% vs. 89.9%, P value = 0.30). The incidence of acute toxicities in the IMRT alone group was significantly lower than that in the CCRT group. Conclusion: For patients with stage II and T3N0 NPC with adverse features treated using IMRT, no improvement in survival was gained by adding concurrent chemotherapy; however, the occurrence of acute toxicities increased significantly. For those combined with non-single adverse factors, the comprehensive treatment strategy needs further exploration.
MeSH term(s)	Humans ; Male ; Female ; Chemoradiotherapy/adverse effects ; Nasopharyngeal Neoplasms/therapy ; Nasopharyngeal Neoplasms/pathology ; Nasopharyngeal Neoplasms/mortality ; Propensity Score ; Middle Aged ; Nasopharyngeal Carcinoma/therapy ; Nasopharyngeal Carcinoma/mortality ; Nasopharyngeal Carcinoma/pathology ; Neoplasm Staging ; Retrospective Studies ; Adult ; Radiotherapy, Intensity-Modulated/adverse effects ; Cisplatin/therapeutic use ; Cisplatin/administration & dosage ; Cohort Studies ; Survival Rate ; Carcinoma/therapy ; Carcinoma/pathology ; Carcinoma/mortality ; Aged
Chemical Substances	Cisplatin (Q20Q21Q62J)
Language	English
Publishing date	2024-03-01
Publishing country	Ireland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Comparative Study
ZDB-ID	605646-5
ISSN	1879-0887 ; 0167-8140
ISSN (online)	1879-0887
ISSN	0167-8140
DOI	10.1016/j.radonc.2024.110189
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Article ; Online: KLF5 regulates actin remodeling to enhance the metastasis of nasopharyngeal carcinoma.

Yang, Zhenyu / Peng, Yanfu / Wang, Yaqin / Yang, Panyang / Huang, Zhuohui / Quan, Tingqiu / Xu, Xudong / Sun, Peng / Sun, Ying / Lv, Jiawei / Wei, Denghui / Zhou, Guan-Qun

Oncogene

2024

Abstract: Transcription factors (TFs) engage in various cellular essential processes including differentiation, growth and migration. However, the master TF involved in distant metastasis of nasopharyngeal carcinoma (NPC) remains largely unclear. Here we show that ...

Abstract	Transcription factors (TFs) engage in various cellular essential processes including differentiation, growth and migration. However, the master TF involved in distant metastasis of nasopharyngeal carcinoma (NPC) remains largely unclear. Here we show that KLF5 regulates actin remodeling to enhance NPC metastasis. We analyzed the msVIPER algorithm-generated transcriptional regulatory networks and identified KLF5 as a master TF of metastatic NPC linked to poor clinical outcomes. KLF5 regulates actin remodeling and lamellipodia formation to promote the metastasis of NPC cells in vitro and in vivo. Mechanistically, KLF5 preferentially occupies distal enhancer regions of ACTN4 to activate its transcription, whereby decoding the informative DNA sequences. ACTN4, extensively localized within actin cytoskeleton, facilitates dense and branched actin networks and lamellipodia formation at the cell leading edge, empowering cells to migrate faster. Collectively, our findings reveal that KLF5 controls robust transcription program of ACTN4 to modulate actin remodeling and augment cell motility which enhances NPC metastasis, and provide new potential biomarkers and therapeutic interventions for NPC.
Language	English
Publishing date	2024-04-22
Publishing country	England
Document type	Journal Article
ZDB-ID	639046-8
ISSN	1476-5594 ; 0950-9232
ISSN (online)	1476-5594
ISSN	0950-9232
DOI	10.1038/s41388-024-03033-0
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Article ; Online: An Immune-Related Gene Prognostic Index for Head and Neck Squamous Cell Carcinoma.

Chen, Yue / Li, Zhi-Yong / Zhou, Guan-Qun / Sun, Ying

Clinical cancer research : an official journal of the American Association for Cancer Research

2020 Volume 27, Issue 1, Page(s) 330–341

Abstract: Purpose: To construct an immune-related gene prognostic index (IRGPI) for head and neck squamous cell carcinoma (HNSCC) and clarify the molecular and immune characteristics and the benefit of immune checkpoint inhibitor (ICI) therapy in IRGPI-defined ... ...

Abstract	Purpose: To construct an immune-related gene prognostic index (IRGPI) for head and neck squamous cell carcinoma (HNSCC) and clarify the molecular and immune characteristics and the benefit of immune checkpoint inhibitor (ICI) therapy in IRGPI-defined subgroups of HNSCC. Experimental design: On the basis of The Cancer Genome Atlas HNSCC immune dataset ( Results: The IRGPI was constructed on the basis of Conclusions: IRGPI is a promising biomarker to distinguish the prognosis, the molecular and immune characteristics, and the immune benefit from ICI therapy in HNSCC.
MeSH term(s)	Aged ; Biomarkers, Tumor/genetics ; Datasets as Topic ; Drug Resistance, Neoplasm/genetics ; Female ; Follow-Up Studies ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic/immunology ; Gene Regulatory Networks/immunology ; Head and Neck Neoplasms/drug therapy ; Head and Neck Neoplasms/genetics ; Head and Neck Neoplasms/immunology ; Head and Neck Neoplasms/mortality ; Humans ; Immune Checkpoint Inhibitors/pharmacology ; Immune Checkpoint Inhibitors/therapeutic use ; Male ; Middle Aged ; Mutation ; Prognosis ; Risk Assessment/methods ; Risk Assessment/statistics & numerical data ; Squamous Cell Carcinoma of Head and Neck/drug therapy ; Squamous Cell Carcinoma of Head and Neck/genetics ; Squamous Cell Carcinoma of Head and Neck/immunology ; Squamous Cell Carcinoma of Head and Neck/mortality ; Treatment Outcome
Chemical Substances	Biomarkers, Tumor ; Immune Checkpoint Inhibitors
Language	English
Publishing date	2020-10-23
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1225457-5
ISSN	1557-3265 ; 1078-0432
ISSN (online)	1557-3265
ISSN	1078-0432
DOI	10.1158/1078-0432.CCR-20-2166
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Article ; Online: Physical performance and risk of hip fracture in community-dwelling elderly people in China: A 4-year longitudinal cohort study.

Zhong, Bi-Xia / Zhong, Hai-Li / Zhou, Guan-Qun / Xu, Wen-Qi / Lu, Ying / Zhao, Qian

Maturitas

2021 Volume 146, Page(s) 26–33

Abstract: Background: This study aims to evaluate the association between the risk of hip fracture and score on the Short Physical Performance Battery (SPPB) and handgrip strength in community-dwelling elderly people in China.: Methods: A total of 5,958 ... ...

Abstract	Background: This study aims to evaluate the association between the risk of hip fracture and score on the Short Physical Performance Battery (SPPB) and handgrip strength in community-dwelling elderly people in China. Methods: A total of 5,958 community-dwelling Chinese people aged 60 years or more from the China Health and Retirement Longitudinal Study (CHARLS) were surveyed in 2011 (baseline) and followed through to 2016. Score on the SPPB (which comprises tests of balance, walking speed, and repeated chair stands) and handgrip strength were determined at baseline. Binary logistic regression models were used to estimate the risk ratio (RR) and 95 % CI. Result: During an average of approximately 4 years of follow-up, 180 (3.0 %) participants experienced incident hip fracture. After multivariate adjustment, the overall SPPB score and repeated chair stands alone distinguished a gradient of hip fracture risks. The risk of hip fracture was 1.65-fold higher in poor SPPB performers (score 0-6) than in good SPPB performers (score 10-12). Participants unable to complete repeated chair stands, and those who took ≥16.7 s or 13.7-16.6 s to complete them, had a higher risk than those who took ≤ 11.1 s to complete them, with RRs of 2.45, 2.12, and 1.93, respectively. Participants unable to complete the balance tests had a higher hip fracture risk than those with scores of 4, with an RR of 2.16. Walking speed and handgrip strength were not associated with increased hip fracture risk. Conclusion: Among community-dwelling elderly Chinese people, overall SPPB score, as well as performance on repeated chair stands and balance tests within the SPPB, were significantly and independently associated with increased hip fracture risk. These indicators could be used to predict hip fracture in clinical settings.
MeSH term(s)	Aged ; China/epidemiology ; Female ; Hand Strength ; Hip Fractures/epidemiology ; Humans ; Independent Living/statistics & numerical data ; Longitudinal Studies ; Male ; Middle Aged ; Physical Functional Performance ; Postural Balance ; Walking
Language	English
Publishing date	2021-01-22
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	80460-5
ISSN	1873-4111 ; 0378-5122
ISSN (online)	1873-4111
ISSN	0378-5122
DOI	10.1016/j.maturitas.2021.01.003
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Article: Variational deep embedding-based active learning for the diagnosis of pneumonia.

Huang, Jian / Ding, Wen / Zhang, Jiarun / Li, Zhao / Shu, Ting / Kuosmanen, Pekka / Zhou, Guanqun / Zhou, Chuan / Yu, Gang

Frontiers in neurorobotics

2022 Volume 16, Page(s) 1059739

Abstract: Machine learning works similar to the way humans train their brains. In general, previous experiences prepared the brain by firing specific nerve cells in the brain and increasing the weight of the links between them. Machine learning also completes the ... ...

Abstract	Machine learning works similar to the way humans train their brains. In general, previous experiences prepared the brain by firing specific nerve cells in the brain and increasing the weight of the links between them. Machine learning also completes the classification task by constantly changing the weights in the model through training on the training set. It can conduct a much more significant amount of training and achieve higher recognition accuracy in specific fields than the human brain. In this paper, we proposed an active learning framework called variational deep embedding-based active learning (VaDEAL) as a human-centric computing method to improve the accuracy of diagnosing pneumonia. Because active learning (AL) realizes label-efficient learning by labeling the most valuable queries, we propose a new AL strategy that incorporates clustering to improve the sampling quality. Our framework consists of a VaDE module, a task learner, and a sampling calculator. First, the VaDE performs unsupervised reduction and clustering of dimension over the entire data set. The end-to-end task learner obtains the embedding representations of the VaDE-processed sample while training the target classifier of the model. The sampling calculator will calculate the representativeness of the samples by VaDE, the uncertainty of the samples through task learning, and ensure the overall diversity of the samples by calculating the similarity constraints between the current and previous samples. With our novel design, the combination of uncertainty, representativeness, and diversity scores allows us to select the most informative samples for labeling, thus improving overall performance. With extensive experiments and evaluations performed on a large dataset, we demonstrate that our proposed method is superior to the state-of-the-art methods and has the highest accuracy in the diagnosis of pneumonia.
Language	English
Publishing date	2022-11-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2453002-5
ISSN	1662-5218
ISSN	1662-5218
DOI	10.3389/fnbot.2022.1059739
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Article ; Online: Cisplatin-based concurrent chemoradiotherapy improved the survival of locoregionally advanced nasopharyngeal carcinoma after induction chemotherapy by reducing early treatment failure.

Yang, Xing-Li / Zhang, Lu-Lu / Kou, Jia / Zhou, Guan-Qun / Wu, Chen-Fei / Sun, Ying / Lin, Li

BMC cancer

2022 Volume 22, Issue 1, Page(s) 1230

Abstract: Purpose: The aims of this study focusing on Locoregionally advanced nasopharyngeal carcinoma (LANPC) were mainly two-fold: on the one hand, to establish a cut-off value to differentiate early and late failure based on prognosis after recurrence or ... ...

Abstract	Purpose: The aims of this study focusing on Locoregionally advanced nasopharyngeal carcinoma (LANPC) were mainly two-fold: on the one hand, to establish a cut-off value to differentiate early and late failure based on prognosis after recurrence or metastasis; and on the other hand, to investigate the duration of concurrent cisplatin benefit over follow-up time. The results of our study have the potential to guide clinical practice and follow-up. Methods: In total, 3123 patients with stage III-IVa NPC receiving Induction chemotherapy followed by concurrent cisplatin or not were analysed. The cut-off value of treatment failure was calculated using the minimum P-value approach. Random survival forest (RSF) model was to simulate the cumulative probabilities of treatment failure (locoregional recurrence and /or distant metastasis) over-time, as well as the monthly time-specific, event-occurring probabilities, for patients at different treatment groups. Results: Based on subsequent prognosis, early locoregional failure (ELRF) should be defined as recurrence within 14 months (P = 1.47 × 10 - 3), and early distant failure (EDF) should be defined as recurrence within 20 months (P = 1.95 × 10 - 4). A cumulative cisplatin dose (CCD) > 200 mg/m Conclusion: Locoregional failure that developed within 14 months and/or distant failure within 20 months had poorer subsequent survival. Concurrent chemotherapy provides a significant FFS benefit, primarily by reducing EDF, translating into a long-term OS benefit.
MeSH term(s)	Humans ; Induction Chemotherapy ; Nasopharyngeal Carcinoma/drug therapy ; Nasopharyngeal Carcinoma/radiotherapy ; Cisplatin/therapeutic use ; Chemoradiotherapy ; Treatment Failure ; Nasopharyngeal Neoplasms/drug therapy ; Nasopharyngeal Neoplasms/radiotherapy
Chemical Substances	Cisplatin (Q20Q21Q62J)
Language	English
Publishing date	2022-11-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2041352-X
ISSN	1471-2407 ; 1471-2407
ISSN (online)	1471-2407
ISSN	1471-2407
DOI	10.1186/s12885-022-10237-8
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Article ; Online: Prediction on X-ray output of free electron laser based on artificial neural networks.

Li, Kenan / Zhou, Guanqun / Liu, Yanwei / Wu, Juhao / Lin, Ming-Fu / Cheng, Xinxin / Lutman, Alberto A / Seaberg, Matthew / Smith, Howard / Kakhandiki, Pranav A / Sakdinawat, Anne

Nature communications

2023 Volume 14, Issue 1, Page(s) 7183

Abstract: Knowledge of x-ray free electron lasers' (XFELs) pulse characteristics delivered to a sample is crucial for ensuring high-quality x-rays for scientific experiments. XFELs' self-amplified spontaneous emission process causes spatial and spectral variations ...

Abstract	Knowledge of x-ray free electron lasers' (XFELs) pulse characteristics delivered to a sample is crucial for ensuring high-quality x-rays for scientific experiments. XFELs' self-amplified spontaneous emission process causes spatial and spectral variations in x-ray pulses entering a sample, which leads to measurement uncertainties for experiments relying on multiple XFEL pulses. Accurate in-situ measurements of x-ray wavefront and energy spectrum incident upon a sample poses challenges. Here we address this by developing a virtual diagnostics framework using an artificial neural network (ANN) to predict x-ray photon beam properties from electron beam properties. We recorded XFEL electron parameters while adjusting the accelerator's configurations and measured the resulting x-ray wavefront and energy spectrum shot-to-shot. Training the ANN with this data enables effective prediction of single-shot or average x-ray beam output based on XFEL undulator and electron parameters. This demonstrates the potential of utilizing ANNs for virtual diagnostics linking XFEL electron and photon beam properties.
Language	English
Publishing date	2023-11-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-42573-z
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