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  1. Article: Analysis of child mortality under 5 years old in Liuyang City from 2013 to 2020.

    Zhou, Huihuang / Zhang, Manman / Chen, Shaoru / Yang, Ying / Wang, Jianwu

    Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences

    2022  Volume 47, Issue 3, Page(s) 352–357

    Abstract: Objectives: To provide reference basis for reducing the mortality for children under 5 years old and promote the healthy development, the mortality for children under 5 years old and the main causes for death in Liuyang City from 2013 to 2020 are ... ...

    Title translation 浏阳市2013至2020年5岁以下儿童死亡状况分析.
    Abstract Objectives: To provide reference basis for reducing the mortality for children under 5 years old and promote the healthy development, the mortality for children under 5 years old and the main causes for death in Liuyang City from 2013 to 2020 are analyzed.
    Methods: The data of 725 cases of death for children under 5 years old in Liuyang City from 2013 to 2020 were collected.The causes and difference of death among the children were analyzed retrospectively by descriptive statistic methods.
    Results: There were a total of 144 516 live births in Liuyang City from 2013 to 2020. The mortality for children under 5 years old was 5.01‰, for infants was 3.39‰, and for newborns was 1.63‰. The male child mortality was 5.28‰, and the female child mortality rate was 4.72‰, with significant difference (
    Conclusions: The mortality for children under 5 years old in Liuyang City is gradually reduced in the past 5 years. The main causes for death are premature birth and low birth weight, congenital heart disease and pneumonia. We should develop healthy education, improve the rate of prenatal diagnosis, promote the construction of obstetrics and paediatrics, and fundamentally reduce the mortality for children under 5 years old.
    MeSH term(s) Cause of Death ; Child ; Child Mortality ; Child, Preschool ; Female ; Heart Defects, Congenital ; Humans ; Infant ; Infant Mortality ; Infant, Newborn ; Male ; Pneumonia/epidemiology ; Pregnancy ; Premature Birth ; Retrospective Studies
    Language Chinese
    Publishing date 2022-05-09
    Publishing country China
    Document type Journal Article
    ZDB-ID 2168533-2
    ISSN 1672-7347
    ISSN 1672-7347
    DOI 10.11817/j.issn.1672-7347.2022.210151
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Effects of vaginal seeding on gut microbiota, body mass index, and allergy risks in infants born through cesarean delivery: a randomized clinical trial.

    Liu, Yang / Li, Hong-Tian / Zhou, Shu-Jin / Zhou, Hui-Huang / Xiong, Ying / Yang, Jing / Zhou, Yu-Bo / Chen, Dun-Jin / Liu, Jian-Meng

    American journal of obstetrics & gynecology MFM

    2022  Volume 5, Issue 1, Page(s) 100793

    Abstract: Background: Vaginal seeding-exposure of neonates to maternal vaginal fluids-has been proposed to improve the microbiota of infants born through cesarean delivery, but its impacts on the infants' subsequent health outcomes remain unclear.: Objective: ... ...

    Abstract Background: Vaginal seeding-exposure of neonates to maternal vaginal fluids-has been proposed to improve the microbiota of infants born through cesarean delivery, but its impacts on the infants' subsequent health outcomes remain unclear.
    Objective: This study aimed to examine the impacts of vaginal seeding on gut microbiota, growth, and allergy risks in infants born through cesarean delivery.
    Study design: This randomized controlled trial was conducted at Liuyang Maternal and Child Health Care Hospital in Hunan, China. We estimated that a minimum sample size of 106 was needed by assuming a standardized effect size of 0.6 for the primary outcomes, with a statistical power of 80%, a 2-sided type I error of 0.05, and an expected loss to follow-up rate of 15%. Finally, 120 singleton term pregnant women scheduled for cesarean delivery were enrolled from November 2018 to September 2019. Infant follow-up was completed in September 2021. The participants were randomized in a 1:1 ratio to the vaginal seeding group (n=60; infants were swabbed immediately after birth using gauze preincubated in maternal vagina) or the control group (n=60; routine standard care). The first set of primary outcomes was infant body mass index and body mass index z-scores at 6, 12, 18, and 24 months of age. The other primary outcome was the total allergy risk score at 18 months for 20 common allergens (each scored from 0-6 points). Characteristics of gut microbiota, overweight/obesity, and allergic diseases and symptoms were included as secondary outcomes. The main analyses were performed according to the modified intention-to-treat principle.
    Results: Of 120 infants, 117 were included in the analyses. Infant body mass index and body mass index z-scores did not significantly differ between the 2 groups at any of the 4 time points, with the largest difference in point estimates occurring at 6 months: the mean (standard deviation) body mass index was 17.5 (1.4) kg/m
    Conclusion: For infants born through cesarean delivery, vaginal seeding has no significant impacts on the gut microbiota, growth, or allergy risks during the first 2 years of life.
    MeSH term(s) Infant, Newborn ; Child ; Humans ; Infant ; Female ; Pregnancy ; Body Mass Index ; Gastrointestinal Microbiome ; Overweight ; Vagina ; Obesity ; Hypersensitivity/diagnosis ; Hypersensitivity/epidemiology ; Hypersensitivity/etiology
    Language English
    Publishing date 2022-11-02
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2589-9333
    ISSN (online) 2589-9333
    DOI 10.1016/j.ajogmf.2022.100793
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: MFGM components promote gut Bifidobacterium growth in infant and in vitro

    Zhao, Junying / Yi, Wei / Liu, Bin / Dai, Yaohua / Jiang, Tiemin / Chen, Shuxing / Wang, Jianwu / Feng, Baowen / Qiao, Weicang / Liu, Yanpin / Zhou, Huihuang / He, Jianying / Hou, Juncai / Chen, Lijun

    European journal of nutrition. 2022 Feb., v. 61, no. 1

    2022  

    Abstract: PURPOSE: Infant gut microbiota which plays an important role in long-term health is mainly shaped by early life nutrition. However, the effect of nutrients on infants gut microbiota is less researched. Here, we present a study aiming to investigate in ... ...

    Abstract PURPOSE: Infant gut microbiota which plays an important role in long-term health is mainly shaped by early life nutrition. However, the effect of nutrients on infants gut microbiota is less researched. Here, we present a study aiming to investigate in vitro a modified formula that is supplemented with milk fat globule membrane (MFGM) that were missing in common formulas when compared with human milk and to assess the impact of feeding scheme on microbiota and metabolism. METHODS: A total of 44 infants including 16 from breast milk feeding, 13 from common formula feeding and 15 from modified formula feeding were analyzed, and A cross-sectional sampling of fecal and urine was done at 1 month-of-age. Stool microbiota composition was characterized using high-throughput DNA sequencing, and urinary metabolome was profiled by nuclear magnetic resonance (NMR). In vitro growth experiment of Bifidobacterium with key components from MFGM was performed and analyzed by both DNA and RNA. RESULTS: Stool samples from the infants who were breastfed had a higher relative abundance of Bifidobacterium and a lower relative abundance of Escherichia than the formula-fed infants. The stool microbiome shifts were associated with urine metabolites changes. Three substances including lactadherin, sialic acid and phospholipid, key components of MFGM were significantly positively correlated to Bifidobacterium of stool samples from infants, and stimulated the growth rate of Bifidobacterium significantly by provided energy in vitro growth experiment with RNA analysis. CONCLUSIONS: These findings suggest that the key components from MFGM could improve infants’ health by modulating the gut microbiome, and possibly supporting the growth of Bifidobacterium. REGISTRATION: Clinicaltrials.gov NCT02658500 (registered on January 20, 2016).
    Keywords Bifidobacterium ; DNA ; RNA ; bottle feeding ; breast feeding ; breast milk ; digestive system ; energy ; intestinal microorganisms ; lactadherin ; metabolism ; metabolites ; metabolome ; microbiome ; milk fat ; nuclear magnetic resonance spectroscopy ; phospholipids ; sialic acid ; urine
    Language English
    Dates of publication 2022-02
    Size p. 277-288.
    Publishing place Springer Berlin Heidelberg
    Document type Article
    ZDB-ID 1466536-0
    ISSN 1436-6215 ; 1436-6207
    ISSN (online) 1436-6215
    ISSN 1436-6207
    DOI 10.1007/s00394-021-02638-5
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 2281: Show issues

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  4. Article ; Online: MFGM components promote gut Bifidobacterium growth in infant and in vitro.

    Zhao, Junying / Yi, Wei / Liu, Bin / Dai, Yaohua / Jiang, Tiemin / Chen, Shuxing / Wang, Jianwu / Feng, Baowen / Qiao, Weicang / Liu, Yanpin / Zhou, Huihuang / He, Jianying / Hou, Juncai / Chen, Lijun

    European journal of nutrition

    2021  Volume 61, Issue 1, Page(s) 277–288

    Abstract: Purpose: Infant gut microbiota which plays an important role in long-term health is mainly shaped by early life nutrition. However, the effect of nutrients on infants gut microbiota is less researched. Here, we present a study aiming to investigate in ... ...

    Abstract Purpose: Infant gut microbiota which plays an important role in long-term health is mainly shaped by early life nutrition. However, the effect of nutrients on infants gut microbiota is less researched. Here, we present a study aiming to investigate in vitro a modified formula that is supplemented with milk fat globule membrane (MFGM) that were missing in common formulas when compared with human milk and to assess the impact of feeding scheme on microbiota and metabolism.
    Methods: A total of 44 infants including 16 from breast milk feeding, 13 from common formula feeding and 15 from modified formula feeding were analyzed, and A cross-sectional sampling of fecal and urine was done at 1 month-of-age. Stool microbiota composition was characterized using high-throughput DNA sequencing, and urinary metabolome was profiled by nuclear magnetic resonance (NMR). In vitro growth experiment of Bifidobacterium with key components from MFGM was performed and analyzed by both DNA and RNA.
    Results: Stool samples from the infants who were breastfed had a higher relative abundance of Bifidobacterium and a lower relative abundance of Escherichia than the formula-fed infants. The stool microbiome shifts were associated with urine metabolites changes. Three substances including lactadherin, sialic acid and phospholipid, key components of MFGM were significantly positively correlated to Bifidobacterium of stool samples from infants, and stimulated the growth rate of Bifidobacterium significantly by provided energy in vitro growth experiment with RNA analysis.
    Conclusions: These findings suggest that the key components from MFGM could improve infants' health by modulating the gut microbiome, and possibly supporting the growth of Bifidobacterium.
    Registration: Clinicaltrials.gov NCT02658500 (registered on January 20, 2016).
    MeSH term(s) Bifidobacterium ; Breast Feeding ; Cross-Sectional Studies ; Feces ; Female ; Gastrointestinal Microbiome ; Humans ; Infant ; Infant Formula ; Milk, Human
    Language English
    Publishing date 2021-07-29
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1466536-0
    ISSN 1436-6215 ; 1436-6207
    ISSN (online) 1436-6215
    ISSN 1436-6207
    DOI 10.1007/s00394-021-02638-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    Ue I Zs.262: Show issues Location:
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