LIVIVO - Search results -

Search results

Result 1 - 10 of total 88

Search options

Article ; Online: Chrysin 7-O-β-D-glucuronide is not a potential inhibitor against SARS-CoV-2 main protease.

Zhang, Rui / Zhou, Jiahao / Yan, Haohao / Liu, Xiaoping / Chen, Yunyu

International journal of antimicrobial agents

2024 Volume 63, Issue 5, Page(s) 107136

Language	English
Publishing date	2024-03-08
Publishing country	Netherlands
Document type	Letter
ZDB-ID	1093977-5
ISSN	1872-7913 ; 0924-8579
ISSN (online)	1872-7913
ISSN	0924-8579
DOI	10.1016/j.ijantimicag.2024.107136
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3368: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 500: Show issues

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Long Non-Coding RNA as a Potential Biomarker for Canine Tumors.

Zhang, Yan / Wu, Meijin / Zhou, Jiahao / Diao, Hongxiu

Veterinary sciences

2023 Volume 10, Issue 11

Abstract: Cancer is the leading cause of death in both humans and companion animals. Long non-coding RNA (lncRNA) plays a crucial role in the progression of various types of cancers in humans, involving tumor proliferation, metastasis, angiogenesis, and signaling ... ...

Abstract	Cancer is the leading cause of death in both humans and companion animals. Long non-coding RNA (lncRNA) plays a crucial role in the progression of various types of cancers in humans, involving tumor proliferation, metastasis, angiogenesis, and signaling pathways, and acts as a potential biomarker for diagnosis and targeted treatment. However, research on lncRNAs related to canine tumors is in an early stage. Dogs have long been considered a promising natural model for human disease. This article summarizes the molecular function of lncRNAs as novel biomarkers in various types of canine tumors, providing new insights into canine tumor diagnosis and treatment. Further research on the function and mechanism of lncRNAs is needed, which will benefit both human and veterinary medicine.
Language	English
Publishing date	2023-10-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2768971-2
ISSN	2306-7381 ; 2306-7381
ISSN (online)	2306-7381
ISSN	2306-7381
DOI	10.3390/vetsci10110637
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Spinal Interferon Regulatory Factor 8 and Brain-derived Neurotrophic Factor in the Prefrontal Cortex are Involved in Pain-induced Depression Relief via Ultrasound-guided Pulsed Radiofrequency in a Rat Spared Nerve Injury Model.

Lyu, Chao / Zhou, Jiahao / Wu, Qiaolin / Fang, Xiangyu

Pain physician

2023 Volume 26, Issue 2, Page(s) 187–196

Abstract: Background: Pain-depression comorbidity has become a great burden to individuals and society. Nevertheless, the mechanisms underlying comorbid diseases have still not been fully revealed. Ultrasound-guided pulsed radiofrequency (PRF) on peripheral ... ...

Abstract	Background: Pain-depression comorbidity has become a great burden to individuals and society. Nevertheless, the mechanisms underlying comorbid diseases have still not been fully revealed. Ultrasound-guided pulsed radiofrequency (PRF) on peripheral nerves, which produces remarkable analgesia via high-frequency electromagnetic energy, has become a main, minimally invasive treatment for chronic neuropathic pain. Objectives: The aim of this study was to explore the effect of ultrasound-guided PRF on the sciatic nerve of spared nerve injury (SNI) rats to relieve pain-induced depression. Study design: Experimental trial in rats. Setting: The research took place in the Laboratory of The First Affiliated Hospital of Wenzhou Medical University. Methods: Sixty male Wistar rats were randomly divided into a sham group, an SNI group, an SNI + free-PRF group, and an SNI + PRF group. Ultrasound-guided PRF was applied to the sciatic nerve on day 7 after SNI. The basal paw mechanical withdrawal threshold (PMWT) was evaluated as a measure for pain-related behavior, and a sucrose preference test was performed as a measure for depression-related behavior. The expression levels of spinal interferon regulatory factor 8 (IRF8) and of brain-derived neurotrophic factor (BDNF) in the prefrontal cortex (PFC) were also studied on days 21 and 42. Results: The results showed that the PMWT was significantly decreased in rats following SNI operation; the decreased levels of PMWT were reversed in the SNI + PRF group after the application of PRF on the sciatic nerve on day 7. There were no statistically significant differences among the groups in the sucrose preference rate on day 21 after SNI operation. The sucrose preference rate on day 42 was higher in the SNI + PRF group than in the SNI + free-PRF group. Western blot and reverse transcription polymerase chain reaction also demonstrated that ultrasound-guided PRF on the sciatic nerve downregulated overexpression of spinal IRF8 and increased the levels of BDNF in the PFC. Limitations: This study was performed using only an SNI rat model which cannot represent all rodent neuropathic pain models. Only the short-term effectiveness of ultrasound-guided PRF on the sciatic nerve of SNI rats was investigated. The BDNF changes of other important brain areas were not taken into consideration in this study. Conclusions: These findings suggest that ultrasound-guided PRF on sciatic nerve could alleviate pain-induced depression. The mechanisms of this treatment may be involved in the downregulated spinal IRF8 and the increased BDNF in PFC.
MeSH term(s)	Rats ; Male ; Animals ; Rats, Sprague-Dawley ; Rats, Wistar ; Pain Management ; Brain-Derived Neurotrophic Factor/metabolism ; Depression/therapy ; Pulsed Radiofrequency Treatment/methods ; Neuralgia/therapy ; Neuralgia/metabolism ; Interferon Regulatory Factors ; Sciatic Nerve/injuries ; Prefrontal Cortex/metabolism ; Ultrasonography, Interventional ; Disease Models, Animal
Chemical Substances	interferon regulatory factor-8 ; Brain-Derived Neurotrophic Factor ; Interferon Regulatory Factors
Language	English
Publishing date	2023-03-29
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2146393-1
ISSN	2150-1149 ; 1533-3159
ISSN (online)	2150-1149
ISSN	1533-3159
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5930: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Evaluation of natural products from virtual screenings as SARS-CoV-2 main protease inhibitors using combinational experiments.

Zhou, Jiahao / Zhang, Rui / Yan, Haohao / Liu, Xiaoping / Shang, Chao / Chen, Yunyu

Natural product research

2024 , Page(s) 1–4

Abstract: Recently, andrographolide, kaempferol, maslinic acid, rutin, and schaftoside have been identified as potent SARS-CoV-2 main protease (Mpro) ... ...

Abstract	Recently, andrographolide, kaempferol, maslinic acid, rutin, and schaftoside have been identified as potent SARS-CoV-2 main protease (Mpro) inhibitors
Language	English
Publishing date	2024-01-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2185747-7
ISSN	1478-6427 ; 1478-6419
ISSN (online)	1478-6427
ISSN	1478-6419
DOI	10.1080/14786419.2023.2301466
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Improved fluorescence-based assay for rapid screening and evaluation of SARS-CoV-2 main protease inhibitors.

Zhang, Rui / Yan, Haohao / Zhou, Jiahao / Yan, Gangan / Liu, Xiaoping / Shang, Chao / Chen, Yunyu

Journal of medical virology

2024 Volume 96, Issue 3, Page(s) e29498

Abstract: The outbreak of coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a global threat to human health. In parallel with vaccines, efficacious antivirals are urgently needed. SARS-CoV-2 ... ...

Abstract	The outbreak of coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a global threat to human health. In parallel with vaccines, efficacious antivirals are urgently needed. SARS-CoV-2 main protease (Mpro) is an attractive drug target for antiviral development owing to its key roles in virus replication and host immune evasion. Due to the limitations of currently available methods, the development of novel high-throughput screening assays is of the highest importance for the discovery of Mpro inhibitors. In this study, we first developed an improved fluorescence-based assay for rapid screening of Mpro inhibitors from an anti-infection compound library using a versatile dimerization-dependent red fluorescent protein (ddRFP) biosensor. Utilizing this assay, we identified MG-101 as a competitive Mpro inhibitor in vitro. Moreover, our results revealed that ensitrelvir is a potent Mpro inhibitor, but baicalein, chloroquine, ebselen, echinatin, and silibinin are not. Therefore, this robust ddRFP assay provides a faithful avenue for rapid screening and evaluation of Mpro inhibitors to fight against COVID-19.
MeSH term(s)	Humans ; COVID-19 ; SARS-CoV-2 ; Protease Inhibitors/pharmacology ; Antiviral Agents/pharmacology ; Coronavirus 3C Proteases
Chemical Substances	3C-like proteinase, SARS-CoV-2 (EC 3.4.22.-) ; Protease Inhibitors ; Antiviral Agents ; Coronavirus 3C Proteases (EC 3.4.22.28)
Language	English
Publishing date	2024-03-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.29498
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1320: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Manidipine is not a potential inhibitor against SARS-CoV-2 main protease.

Zhang, Rui / Zhou, Jiahao / Yan, Haohao / Liu, Xiaoping / Shang, Chao / Chen, Yunyu

Antimicrobial agents and chemotherapy

2024 Volume 68, Issue 3, Page(s) e0129723

MeSH term(s)	Humans ; COVID-19 ; SARS-CoV-2 ; Coronavirus 3C Proteases ; Protease Inhibitors/pharmacology ; Molecular Docking Simulation ; Dihydropyridines ; Nitrobenzenes ; Piperazines
Chemical Substances	3C-like proteinase, SARS-CoV-2 (EC 3.4.22.-) ; manidipine (6O4754US88) ; Coronavirus 3C Proteases (EC 3.4.22.28) ; Protease Inhibitors ; Dihydropyridines ; Nitrobenzenes ; Piperazines
Language	English
Publishing date	2024-01-31
Publishing country	United States
Document type	Letter
ZDB-ID	217602-6
ISSN	1098-6596 ; 0066-4804
ISSN (online)	1098-6596
ISSN	0066-4804
DOI	10.1128/aac.01297-23
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 809: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Einzelsignatur: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Multi-Functional Actuators Made with Biomass-Based Graphene-Polymer Films for Intelligent Gesture Recognition and Multi-Mode Self-Powered Sensing.

Weng, Mingcen / Zhou, Jiahao / Zhou, Peidi / Shang, Ruzhi / You, Minghua / Shen, Guozhen / Chen, Huamin

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

2024 , Page(s) e2309846

Abstract: Multi-functional actuation systems involve the mechanical integration of multiple actuation and sensor devices with external energy sources. The intricate combination makes it difficult to meet the requirements of lightweight. Hence, polypyrrole@graphene- ...

Abstract	Multi-functional actuation systems involve the mechanical integration of multiple actuation and sensor devices with external energy sources. The intricate combination makes it difficult to meet the requirements of lightweight. Hence, polypyrrole@graphene-bacterial cellulose (PPy@G-BC) films are proposed to construct multi-responsive and bilayer actuators integrated with multi-mode self-powered sensing function. The PPy@G-BC film not only exhibits good photo-thermoelectric (PTE) properties but also possesses good hydrophilicity and high Young's modulus. Thus, the PPy@G-BC films are used as active layers in multi-responsive bilayer actuators integrated with self-powered sensing functions. Here, two types of multi-functional actuators integrated with self-powered sensing functions is designed. One is a light-driven actuator that realizes the self-powered temperature sensing function through the PTE effect. Assisted by a machine learning algorithm, the self-powered bionic hand can realize intelligent gesture recognition with an accuracy rate of 96.8%. The other is humidity-driven actuators integrated a zinc-air battery, which can realize self-powered humidity sensing. Based on the above advantages, these two multi-functional actuators are ingeniously integrated into a single device, which can simultaneously perform self-powered temperature/humidity sensing while grasping objects. The highly integrated design enables the efficient utilization of environmental energy sources and complementary synergistic monitoring of multiple physical properties without increasing system complexity.
Language	English
Publishing date	2024-03-26
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2808093-2
ISSN	2198-3844 ; 2198-3844
ISSN (online)	2198-3844
ISSN	2198-3844
DOI	10.1002/advs.202309846
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Total neoadjuvant therapy for locally advanced rectal cancer: a three-group propensity score matched study.

Zhou, Jiahao / Huang, Jun / Zhou, Zikai / Deng, Xiangbing / Wu, Qingbin / Wang, Ziqiang

International journal of colorectal disease

2024 Volume 39, Issue 1, Page(s) 38

Abstract: Purpose: Total neoadjuvant therapy (TNT) has emerged as a therapeutic approach for locally advanced rectal cancer (LARC). However, the optimal chemotherapy cycles within TNT remain uncertain. This study aimed to evaluate and compare the prognostic ... ...

Abstract	Purpose: Total neoadjuvant therapy (TNT) has emerged as a therapeutic approach for locally advanced rectal cancer (LARC). However, the optimal chemotherapy cycles within TNT remain uncertain. This study aimed to evaluate and compare the prognostic efficacy of varying cycles of chemotherapy during TNT for LARC. Methods: Patients diagnosed with LARC (T3-4N0M0/T1-4N1-2M0), who underwent TNT or chemoradiotherapy followed by total mesorectal excision (TME) between 2015 and 2020, were retrospective included. Patients were categorized into three groups based on their neoadjuvant strategy: CRT (long-course chemoradiotherapy), STNT (long-course CRT with one to three cycles of chemotherapy), and LTNT (long-course CRT with four or more cycles of chemotherapy). Propensity score matching (PSM) based on gender, age, body mass index, tumor distance from the anal verge, clinical T stage, clinical N stage, and mesorectal fascia status was employed to reduce confounding bias. Primary endpoints were disease-free survival (DFS) and metastasis-free survival (MFS). Results: The study comprised 372 patients, with 73 patients in each group after PSM. Compared with CRT, both STNT and LTNT demonstrated improved DFS (5-year rate: 59.7% vs. 77.8% vs. 76.5%, p = 0.027) and MFS (5-year rate: 65.1% vs. 81.3% vs. 81.4%, p = 0.030). There was no difference in DFS or MFS between STNT and LTNT. These favorable outcomes were consistent among subgroups defined by tumor distance from the anal verge ≥ 5 cm, clinical T3 stage, clinical N positive status, or involved mesorectal fascia. Conclusion: Compared to CRT, both STNT and LTNT demonstrated improved DFS and MFS outcomes. Notably, survival outcomes were similar between STNT and LTNT, suggesting that chemotherapy cycles in TNT may not significantly impact survival.
MeSH term(s)	Humans ; Neoadjuvant Therapy ; Treatment Outcome ; Retrospective Studies ; Propensity Score ; Neoplasm Staging ; Rectal Neoplasms/pathology ; Disease-Free Survival ; Chemoradiotherapy ; Neoplasms, Second Primary/pathology ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use
Language	English
Publishing date	2024-03-16
Publishing country	Germany
Document type	Journal Article
ZDB-ID	84975-3
ISSN	1432-1262 ; 0179-1958
ISSN (online)	1432-1262
ISSN	0179-1958
DOI	10.1007/s00384-024-04610-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2121: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Nomogram predicting overall prognosis for invasive micropapillary carcinoma of the breast: a SEER-based population study.

Liu, Jianpeng / Xi, Wei / Zhou, Jiahao / Gao, Wei / Wu, Qiaolin

BMJ open

2023 Volume 13, Issue 8, Page(s) e072632

Abstract: Objectives: The prognosis of invasive micropapillary carcinoma (IMPC) of the breast is determined by many clinicopathological factors. This study aims to identify prognostic factors and develop reliable nomogram to predict the overall survival (OS) in ... ...

Abstract	Objectives: The prognosis of invasive micropapillary carcinoma (IMPC) of the breast is determined by many clinicopathological factors. This study aims to identify prognostic factors and develop reliable nomogram to predict the overall survival (OS) in patients with IMPC. Design: Log-rank test and Cox proportional hazards analysis were used to identify variables and construct a nomogram based on the training cohort. C-index and calibration curves were performed to evaluate the performance of the model in the training cohort and validation cohorts. Setting: We collected the patient data from the Surveillance, Epidemiology and End Results (SEER) database. This database holds data related to the cancer incidence from 18 population-based cancer registries in the USA. Participants: The SEER database was used to screen 754 eligible patients as the study cohort. The whole cohort was randomly divided into a training cohort (n=377) and a validation cohort (n=377). Results: Age at diagnosis, hormone receptors, number of positive regional lymph nodes and clinical stage were independent prognostic factors for patients with IMPC. The calibration curves presented excellent consistency between the actual and nomogram-predict survival probabilities in the training and validation cohorts. The C-index values of the nomogram were 0.794 and 0.774 for OS in the training and validation cohorts, respectively. Conclusions: The novel nomogram provides new insights of the risk of each prognostic factor and can assist doctors in predicting the 1-year, 3-year and 5-year OS in patients with IMPC.
MeSH term(s)	Humans ; Nomograms ; Prognosis ; Carcinoma ; Risk Factors
Language	English
Publishing date	2023-08-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2023-072632
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Invalidation of geraniin as a potential inhibitor against SARS-CoV-2 main protease.

Zhang, Rui / Yan, Haohao / Zhou, Jiahao / Liu, Xiaoping / Chen, Yunyu

Natural product research

2023 , Page(s) 1–4

Abstract: Recently, geraniin has been identified as a potent antiviral agent targeting SARS-CoV-2 main protease (Mpro). Considering the potential of geraniin in COVID-19 treatment, a stringent validation for its Mpro inhibition is necessary. Herein, we rigorously ... ...

Abstract	Recently, geraniin has been identified as a potent antiviral agent targeting SARS-CoV-2 main protease (Mpro). Considering the potential of geraniin in COVID-19 treatment, a stringent validation for its Mpro inhibition is necessary. Herein, we rigorously evaluated the
Language	English
Publishing date	2023-08-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2185747-7
ISSN	1478-6427 ; 1478-6419
ISSN (online)	1478-6427
ISSN	1478-6419
DOI	10.1080/14786419.2023.2241973
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito