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  1. Article ; Online: Ca

    Zhou, Jingsong

    Neuroscience letters

    2021  Volume 754, Page(s) 135899

    Abstract: The volitional movement of skeletal is controlled by the motor neuron at the site of neuromuscular junction (NMJ) where the retrograde signals are also passed back from muscle to the motor neuron. As the normal function of muscle largely depends on ... ...

    Abstract The volitional movement of skeletal is controlled by the motor neuron at the site of neuromuscular junction (NMJ) where the retrograde signals are also passed back from muscle to the motor neuron. As the normal function of muscle largely depends on mitochondria that determine the fate of a skeletal muscle myofiber, there must exist a fine-controlled functional coupling between NMJ and mitochondria in myofibers. This mini-review discusses recent publications that reveal how spatiotemporal profiles of intracellular free Ca
    MeSH term(s) Animals ; Calcium/metabolism ; Cations, Divalent/metabolism ; Humans ; Mitochondria/metabolism ; Motor Neurons/physiology ; Muscle Contraction/physiology ; Myofibrils/physiology ; Neuromuscular Junction/metabolism
    Chemical Substances Cations, Divalent ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2021-04-15
    Publishing country Ireland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 194929-9
    ISSN 1872-7972 ; 0304-3940
    ISSN (online) 1872-7972
    ISSN 0304-3940
    DOI 10.1016/j.neulet.2021.135899
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1166: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Crab-inspired compliant leg design method for adaptive locomotion of a multi-legged robot.

    Zhang, Jun / Liu, Qi / Zhou, Jingsong / Song, Aiguo

    Bioinspiration & biomimetics

    2022  Volume 17, Issue 2

    Abstract: Chinese mitten ... ...

    Abstract Chinese mitten crab
    MeSH term(s) Gait/physiology ; Leg/physiology ; Locomotion/physiology ; Lower Extremity ; Robotics/methods ; Walking/physiology
    Language English
    Publishing date 2022-01-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2235670-8
    ISSN 1748-3190 ; 1748-3182
    ISSN (online) 1748-3190
    ISSN 1748-3182
    DOI 10.1088/1748-3190/ac45e6
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  3. Article: Manipulation of plant height in garden asparagus (

    Zhou, Jingsong / He, Reqing / Liu, Xiaojing / Zhang, Bingbing / Chen, Guangyu / Wang, Dong / Zhu, Youlin

    Horticulture research

    2023  Volume 10, Issue 7, Page(s) uhad096

    Language English
    Publishing date 2023-05-10
    Publishing country England
    Document type Journal Article
    ISSN 2662-6810
    ISSN 2662-6810
    DOI 10.1093/hr/uhad096
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  4. Article ; Online: Distinct transcriptomic profile of satellite cells contributes to preservation of neuromuscular junctions in extraocular muscles of ALS mice.

    Li, Ang / Yi, Jianxun / Li, Xuejun / Dong, Li / Ostrow, Lyle W / Ma, Jianjie / Zhou, Jingsong

    eLife

    2024  Volume 12

    Abstract: Amyotrophic lateral sclerosis (ALS) is a fatal neuromuscular disorder characterized by progressive weakness of almost all skeletal muscles, whereas extraocular muscles (EOMs) are comparatively spared. While hindlimb and diaphragm muscles of end-stage ... ...

    Abstract Amyotrophic lateral sclerosis (ALS) is a fatal neuromuscular disorder characterized by progressive weakness of almost all skeletal muscles, whereas extraocular muscles (EOMs) are comparatively spared. While hindlimb and diaphragm muscles of end-stage SOD1G93A (G93A) mice (a familial ALS mouse model) exhibit severe denervation and depletion of Pax7
    MeSH term(s) Animals ; Neuromuscular Junction/metabolism ; Amyotrophic Lateral Sclerosis/genetics ; Amyotrophic Lateral Sclerosis/metabolism ; Mice ; Satellite Cells, Skeletal Muscle/metabolism ; Disease Models, Animal ; Transcriptome ; Mice, Transgenic ; Oculomotor Muscles/innervation ; Oculomotor Muscles/metabolism
    Language English
    Publishing date 2024-04-25
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.92644
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  5. Article: Distinct transcriptomic profile of satellite cells contributes to preservation of neuromuscular junctions in extraocular muscles of ALS mice.

    Li, Ang / Yi, Jianxun / Li, Xuejun / Dong, Li / Ostrow, Lyle W / Ma, Jianjie / Zhou, Jingsong

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Amyotrophic lateral sclerosis (ALS) is a fatal neuromuscular disorder characterized by progressive weakness of almost all skeletal muscles, whereas extraocular muscles (EOMs) are comparatively spared. While hindlimb and diaphragm muscles of end-stage ... ...

    Abstract Amyotrophic lateral sclerosis (ALS) is a fatal neuromuscular disorder characterized by progressive weakness of almost all skeletal muscles, whereas extraocular muscles (EOMs) are comparatively spared. While hindlimb and diaphragm muscles of end-stage SOD1G93A (G93A) mice (a familial ALS mouse model) exhibit severe denervation and depletion of Pax7
    Language English
    Publishing date 2024-04-08
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.02.12.528218
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Physiological Ca

    Li, Ang / Yi, Jianxun / Li, Xuejun / Zhou, Jingsong

    Frontiers in physiology

    2020  Volume 11, Page(s) 595800

    Abstract: Mitochondria are both the primary provider of ATP and the pivotal regulator of cell death, which are essential for physiological muscle activities. ... ...

    Abstract Mitochondria are both the primary provider of ATP and the pivotal regulator of cell death, which are essential for physiological muscle activities. Ca
    Language English
    Publishing date 2020-10-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2020.595800
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  7. Article ; Online: Butyrate Feeding Reverses CypD-Related Mitoflash Phenotypes in Mouse Myofibers.

    Li, Ang / Li, Xuejun / Yi, Jianxun / Ma, Jianjie / Zhou, Jingsong

    International journal of molecular sciences

    2021  Volume 22, Issue 14

    Abstract: Mitoflashes are spontaneous transients of the biosensor mt-cpYFP. In cardiomyocytes, mitoflashes are associated with the cyclophilin D (CypD) mediated opening of mitochondrial permeability transition pore (mPTP), while in skeletal muscle they are ... ...

    Abstract Mitoflashes are spontaneous transients of the biosensor mt-cpYFP. In cardiomyocytes, mitoflashes are associated with the cyclophilin D (CypD) mediated opening of mitochondrial permeability transition pore (mPTP), while in skeletal muscle they are considered hallmarks of mitochondrial respiration burst under physiological conditions. Here, we evaluated the potential association between mitoflashes and the mPTP opening at different CypD levels and phosphorylation status by generating three CypD derived fusion constructs with a red shifted, pH stable Ca
    MeSH term(s) Animals ; Butyrates/pharmacology ; Peptidyl-Prolyl Isomerase F/genetics ; Peptidyl-Prolyl Isomerase F/metabolism ; Female ; Humans ; Male ; Mice ; Mice, Transgenic ; Mitochondria/drug effects ; Mitochondria/metabolism ; Mitochondria/pathology ; Mitochondrial Permeability Transition Pore/metabolism ; Muscle Fibers, Skeletal/drug effects ; Muscle Fibers, Skeletal/metabolism ; Muscle Fibers, Skeletal/pathology ; Mutation ; Superoxide Dismutase-1/physiology
    Chemical Substances Butyrates ; Peptidyl-Prolyl Isomerase F ; Mitochondrial Permeability Transition Pore ; SOD1 protein, human ; Superoxide Dismutase-1 (EC 1.15.1.1)
    Language English
    Publishing date 2021-07-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22147412
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  8. Article ; Online: Butyrate Ameliorates Mitochondrial Respiratory Capacity of The Motor-Neuron-like Cell Line NSC34-G93A, a Cellular Model for ALS.

    Li, Xuejun / Dong, Li / Li, Ang / Yi, Jianxun / Brotto, Marco / Zhou, Jingsong

    Biomolecules

    2022  Volume 12, Issue 2

    Abstract: Mitochondrial defects in motor neurons are pathological hallmarks of ALS, a neuromuscular disease with no effective treatment. Studies have shown that butyrate, a natural gut-bacteria product, alleviates the disease progression of ALS mice overexpressing ...

    Abstract Mitochondrial defects in motor neurons are pathological hallmarks of ALS, a neuromuscular disease with no effective treatment. Studies have shown that butyrate, a natural gut-bacteria product, alleviates the disease progression of ALS mice overexpressing a human ALS-associated mutation, hSOD1
    MeSH term(s) Amyotrophic Lateral Sclerosis/metabolism ; Animals ; Butyrates/metabolism ; Butyrates/pharmacology ; Cell Line ; Disease Models, Animal ; Mice ; Mice, Transgenic ; Mitochondria/metabolism ; Motor Neurons/metabolism ; Motor Neurons/pathology ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/metabolism ; RNA, Messenger/metabolism ; Superoxide Dismutase/metabolism
    Chemical Substances Butyrates ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha ; RNA, Messenger ; Superoxide Dismutase (EC 1.15.1.1)
    Language English
    Publishing date 2022-02-19
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom12020333
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  9. Article ; Online: Synthesis of precisely functionalizable curved nanographenes via graphitization-induced regioselective chlorination in a mechanochemical Scholl Reaction.

    Stanojkovic, Jovana / William, Ronny / Zhang, Zhongbo / Fernández, Israel / Zhou, Jingsong / Webster, Richard D / Stuparu, Mihaiela C

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 803

    Abstract: While the synthesis of nanographenes has advanced greatly in the past few years, development of their atomically precise functionalization strategies remains rare. The ability to modify the carbon scaffold translates to controlling, adjusting, and ... ...

    Abstract While the synthesis of nanographenes has advanced greatly in the past few years, development of their atomically precise functionalization strategies remains rare. The ability to modify the carbon scaffold translates to controlling, adjusting, and adapting molecular properties. Towards this end, here, we show that mechanochemistry is capable of transforming graphitization precursors directly into chlorinated curved nanographenes through a Scholl reaction. The halogenation occurs in a regioselective, high-yielding, and general manner. Density Functional Theory (DFT) calculations suggest that graphitization activates specific edge-positions for chlorination. The chlorine atoms allow for precise chemical modification of the nanographenes through a Suzuki or a nucleophilic aromatic substitution reaction. The edge modification enables modulation of material properties. Among the molecules prepared, corannulene-coronene hybrids and laterally fully π-extended helicenes, heptabenzo[5]superhelicenes, are particularly noteworthy.
    Language English
    Publishing date 2023-02-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-36470-8
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  10. Article ; Online: Tetrakis(

    Fan, Jun / Koh, An-Ping / Zhou, Jingsong / Zhang, Zheng-Feng / Wu, Chi-Shiun / Webster, Richard D / Su, Ming-Der / So, Cheuk-Wai

    Journal of the American Chemical Society

    2023  Volume 145, Issue 21, Page(s) 11669–11677

    Abstract: The use of 1,3,4,5-tetramethylimidazol-2-ylidene (IMe) to coordinate with diatomic ... ...

    Abstract The use of 1,3,4,5-tetramethylimidazol-2-ylidene (IMe) to coordinate with diatomic B
    Language English
    Publishing date 2023-05-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.3c01801
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 4' 55/32: Show issues
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