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Article: Short sleep duration associated with increased risk for new-onset cardiovascular diseases in individuals with metabolic syndromes: Evidence from the China Health and Retirement Longitudinal Study.

Sun, Jiaxin / Chen, Yizhou / Sun, Yazhou / Yang, Bo / Zhou, Jining

2022 Volume 9, Page(s) 1010941

Abstract: To explore the impact and risk of short sleep duration (sleep duration < 6 h/night) on new-onset cardiovascular and cerebrovascular diseases (CVDs) in people with metabolic syndromes (Mets), this study used the 2011 baseline and 2015 follow-up data from ... ...

Abstract	To explore the impact and risk of short sleep duration (sleep duration < 6 h/night) on new-onset cardiovascular and cerebrovascular diseases (CVDs) in people with metabolic syndromes (Mets), this study used the 2011 baseline and 2015 follow-up data from the China Longitudinal Study of Health and Retirement (CHARLS) to conduct a prospective study of people aged ≥ 45 years in China. A total of 5,530 individuals without pre-existing CVDs in baseline were included. Mets were defined according to the harmonized criteria. We applied the Logistic Regression (LR), the Deep Neural Networks (DNN), and the Adaptive Boosting (AdaBoost), to evaluate the association between Mets components, short sleep, and the risk of new-onset CVDs, and the importance of multiple variates for new-onset CVDs. During the 4-year follow-up period, 512 individuals developed CVDs, and short sleep increased the risk of CVD in individuals with Mets. The odds ratio for prevalent CVD in Mets with short sleep group was 3.73 (95%CI 2.95-4.71;
Language	English
Publishing date	2022-11-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2022.1010941
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Article: Lysine demethylase 3A is a positive regulator of cardiac myofibroblast transdifferentiation that increases Smad3 phosphorylation following transforming growth factor beta1 stimulation

Liu, Xiaopei / Zhou, Jining / Zhang, Bofang / Liu, Gen / Hu, Qi / Chen, Jing

Molecular biology reports. 2022 Apr., v. 49, no. 4

2022

Abstract: BACKGROUND: The epigenetic modifier molecule lysine demethylase 3A (KDM3A) has been shown to help ameliorate cardiovascular diseases, but its effect on cardiac fibroblasts (CFs) remains unclear. METHODS AND RESULTS: We designed gain- and loss-of-function ...

Abstract	BACKGROUND: The epigenetic modifier molecule lysine demethylase 3A (KDM3A) has been shown to help ameliorate cardiovascular diseases, but its effect on cardiac fibroblasts (CFs) remains unclear. METHODS AND RESULTS: We designed gain- and loss-of-function experiments to investigate the biological functions of KDM3A in CFs. Moreover, we used SIS3-HCl (a specific inhibitor of p-Smad3) to explore the underlying mechanism. Cell viability and migration were verified by CCK-8 and cell migration experiments, respectively, and the degree of fibrosis was measured by Western blot analysis. Our data revealed that KDM3A enhanced the proliferation and migration of CFs and increased the fibroblast-to-myofibroblast transition while enabling the Smad3 phosphorylation response to transforming growth factor beta1 (TGFβ1) stimulation. However, these effects were abolished by SIS3-HCl. Furthermore, KDM3A inhibition obviously protected against cardiac myofibroblast transdifferentiation under TGFβ1 stimulation. CONCLUSIONS: KDM3A may act as a novel regulator of cardiac myofibroblast transdifferentiation through its ability to modulate the phosphorylation of Smad3 following TGFβ1 stimulation.
Keywords	Western blotting ; cell movement ; cell viability ; epigenetics ; fibroblasts ; fibrosis ; loss-of-function mutation ; lysine ; molecular biology ; phosphorylation
Language	English
Dates of publication	2022-04
Size	p. 3177-3185.
Publishing place	Springer Netherlands
Document type	Article
ZDB-ID	186544-4
ISSN	1573-4978 ; 0301-4851
ISSN (online)	1573-4978
ISSN	0301-4851
DOI	10.1007/s11033-022-07150-5
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Article ; Online: Lysine demethylase 3A is a positive regulator of cardiac myofibroblast transdifferentiation that increases Smad3 phosphorylation following transforming growth factor beta1 stimulation.

Liu, Xiaopei / Zhou, Jining / Zhang, Bofang / Liu, Gen / Hu, Qi / Chen, Jing

Molecular biology reports

2022 Volume 49, Issue 4, Page(s) 3177–3185

Abstract: Background: The epigenetic modifier molecule lysine demethylase 3A (KDM3A) has been shown to help ameliorate cardiovascular diseases, but its effect on cardiac fibroblasts (CFs) remains unclear.: Methods and results: We designed gain- and loss-of- ... ...

Abstract	Background: The epigenetic modifier molecule lysine demethylase 3A (KDM3A) has been shown to help ameliorate cardiovascular diseases, but its effect on cardiac fibroblasts (CFs) remains unclear. Methods and results: We designed gain- and loss-of-function experiments to investigate the biological functions of KDM3A in CFs. Moreover, we used SIS3-HCl (a specific inhibitor of p-Smad3) to explore the underlying mechanism. Cell viability and migration were verified by CCK-8 and cell migration experiments, respectively, and the degree of fibrosis was measured by Western blot analysis. Our data revealed that KDM3A enhanced the proliferation and migration of CFs and increased the fibroblast-to-myofibroblast transition while enabling the Smad3 phosphorylation response to transforming growth factor beta1 (TGFβ1) stimulation. However, these effects were abolished by SIS3-HCl. Furthermore, KDM3A inhibition obviously protected against cardiac myofibroblast transdifferentiation under TGFβ1 stimulation. Conclusions: KDM3A may act as a novel regulator of cardiac myofibroblast transdifferentiation through its ability to modulate the phosphorylation of Smad3 following TGFβ1 stimulation.
MeSH term(s)	Cell Transdifferentiation ; Fibroblasts/metabolism ; Lysine/metabolism ; Myofibroblasts/metabolism ; Phosphorylation ; Smad3 Protein/metabolism ; Transforming Growth Factor beta/metabolism ; Transforming Growth Factor beta1/metabolism ; Transforming Growth Factor beta1/pharmacology
Chemical Substances	Smad3 Protein ; Transforming Growth Factor beta ; Transforming Growth Factor beta1 ; Lysine (K3Z4F929H6)
Language	English
Publishing date	2022-02-03
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	186544-4
ISSN	1573-4978 ; 0301-4851
ISSN (online)	1573-4978
ISSN	0301-4851
DOI	10.1007/s11033-022-07150-5
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Article ; Online: Activation of sigma-1 receptor ameliorates sepsis-induced myocardial injury by mediating the Nrf2/HO1 signaling pathway to attenuate mitochondrial oxidative stress.

Li, Zixuan / Zhou, Jining / Cui, Shengyu / Hu, Shan / Li, Bin / Liu, Xin / Zhang, Cui / Zou, Ying / Hu, Yiqian / Yu, Yi / Shen, Bo / Yang, Bo

International immunopharmacology

2023 Volume 127, Page(s) 111382

Abstract: Background: Sepsis is a condition that triggers the release of large amounts of reactive oxygen species and inflammatory factors in the body, leading to myocardial injury and cardiovascular dysfunction - an important contributor to the high mortality ... ...

Abstract	Background: Sepsis is a condition that triggers the release of large amounts of reactive oxygen species and inflammatory factors in the body, leading to myocardial injury and cardiovascular dysfunction - an important contributor to the high mortality rate associated with sepsis. Although it has been demonstrated that the sigma-1 receptor (S1R) is essential for preventing oxidative stress, its effectiveness in treating sepsis is yet unknown. Aim: This study aimed to investigate the role and mechanisms of S1R activation in sepsis-induced myocardial injury. Methods: A model of sepsis-induced myocardial injury was constructed by performing cecum ligation and puncture(CLP) surgery on rats. Flv or BD1047 were intraperitoneally injected into rats for one consecutive week before performing CLP, and then intraperitoneally injected into the rats again 1 h after the surgery.The effects of Flv and BD1047 were detected by HE staining, immunofluorescence staining, IHC staining, echocardiography measurements,TUNEL, oxidative stress detection, TEM, flow cytometry and western blot. We further validated the mechanism in vitro using neonatal rat cardiomyocites and H9C2 cells. Results: S1R protein level was reduced in the hearts of septic rats, whereas administration of Flv, an S1R activator, ameliorated myocardial injury, mitochondrial oxidative stress, and pathological manifestations of sepsis. On the other hand, administration of the S1R inhibitor BD1047 exacerbated the mitochondrial oxidative stress, and apoptosis, as well as symptoms and pathological manifestations of sepsis. In addition, we found that up-regulation of S1R activated the Nrf2/HO1 signaling pathway and promoted nuclear translocation of Nrf2, which activated downstream proteins to generate antioxidant factors, such as HO1, in turn alleviating oxidative stress and countering myocardial damage. Conclusion: By scavenging ROS accumulation and reducing mitochondrial oxidative stress via the Nrf2/HO1 signaling pathway, activation of S1R improves cardiac function, mitigates death of cardiomyocytes, and attenuates sepsis-induced myocardial injury.
MeSH term(s)	Rats ; Animals ; NF-E2-Related Factor 2/metabolism ; Sigma-1 Receptor ; Signal Transduction ; Myocytes, Cardiac/metabolism ; Oxidative Stress ; Heart Injuries ; Sepsis/complications ; Sepsis/drug therapy ; Sepsis/metabolism ; Ethylenediamines
Chemical Substances	N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin (1S3X75QGDO) ; NF-E2-Related Factor 2 ; Sigma-1 Receptor ; Ethylenediamines
Language	English
Publishing date	2023-12-22
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2043785-7
ISSN	1878-1705 ; 1567-5769
ISSN (online)	1878-1705
ISSN	1567-5769
DOI	10.1016/j.intimp.2023.111382
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Article ; Online: MiR-128-3p inhibits vascular smooth muscle cell proliferation and migration by repressing FOXO4/MMP9 signaling pathway.

Qu, Chuan / Liu, Xin / Guo, Yan / Fo, Yuhong / Chen, Xiuhuan / Zhou, Jining / Yang, Bo

Molecular medicine (Cambridge, Mass.)

2020 Volume 26, Issue 1, Page(s) 116

Abstract: Background: MicroRNAs (miRNAs) have been identified as important participants in the development of atherosclerosis (AS). The present study explored the role of miR-128-3p in the dysfunction of vascular smooth muscle cells (VSMCs) and the underlying ... ...

Abstract	Background: MicroRNAs (miRNAs) have been identified as important participants in the development of atherosclerosis (AS). The present study explored the role of miR-128-3p in the dysfunction of vascular smooth muscle cells (VSMCs) and the underlying mechanism. Methods: Human VSMCs and ApoE knockout (ApoE Results: MiR-128-3p was found to be decreased in AS patient serum, ox-LDL-treated VSMCs, AS mice serum and VSMCs of AS mice. Transfection of miR-128-3p mimics suppressed the proliferation and migration of VSMCs, accompanied by the promoted apoptosis and the decreased levels of inflammatory cytokines. Further experiments confirmed the interaction between miR-128-3p and FOXO4. Augmentation of FOXO4 or MMP9 reversed the effects of miR-128-3p. Besides, miR-128-3p inhibited triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) but increased high-density lipoprotein cholesterol (HDL-C) in the serum of AS mice. Conclusion: MiR-128-3p repressed the proliferation and migration of VSMCs through inhibiting the expressions of FOXO4 and MMP9.
MeSH term(s)	3' Untranslated Regions ; Aged ; Aged, 80 and over ; Animals ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; Cell Movement/drug effects ; Cell Proliferation ; Female ; Forkhead Transcription Factors/genetics ; Forkhead Transcription Factors/metabolism ; Gene Expression Regulation ; Humans ; Male ; Matrix Metalloproteinase 9/genetics ; Matrix Metalloproteinase 9/metabolism ; Mice ; MicroRNAs/genetics ; Middle Aged ; Muscle, Smooth, Vascular/metabolism ; Myocytes, Smooth Muscle/metabolism
Chemical Substances	3' Untranslated Regions ; Cell Cycle Proteins ; FOXO4 protein, human ; Forkhead Transcription Factors ; MIRN128 microRNA, human ; MicroRNAs ; MMP9 protein, human (EC 3.4.24.35) ; Matrix Metalloproteinase 9 (EC 3.4.24.35)
Language	English
Publishing date	2020-11-25
Publishing country	England
Document type	Journal Article
ZDB-ID	1283676-x
ISSN	1528-3658 ; 1076-1551
ISSN (online)	1528-3658
ISSN	1076-1551
DOI	10.1186/s10020-020-00242-7
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Article ; Online: The Tp-e/QT ratio as a predictor of nocturnal premature ventricular contraction events in patients with obstructive sleep apnea.

Yan, Hui / Liu, Huafen / Wang, Guipeng / Xing, Shifeng / Huang, Bing / Xing, Hongyun / Guo, Yankai / Zhang, Pengke / Hu, Limei / Zhou, Jining / Cao, Guiqiu

Sleep & breathing = Schlaf & Atmung

2022 Volume 27, Issue 2, Page(s) 469–476

Abstract: Background: Obstructive sleep apnea (OSA) is significantly associated with a higher risk of ventricular arrhythmia (VA). QT, the Tp-e/QT ratio, and QT dispersion (QTd) are used to evaluate myocardial repolarization and are highly correlated with VA. The ...

Abstract	Background: Obstructive sleep apnea (OSA) is significantly associated with a higher risk of ventricular arrhythmia (VA). QT, the Tp-e/QT ratio, and QT dispersion (QTd) are used to evaluate myocardial repolarization and are highly correlated with VA. The aim was to evaluate the predictive value of the Tp-e/QT ratio and other electrocardiogram (ECG) parameters for nocturnal premature ventricular contractions (PVCs) in patients with OSA. Methods: We retrospectively analyzed data from patients with OSA and conducted a 1:1 matched cohort study. Patients diagnosed with OSA who met our criteria for the PVC group, and sex- and age-matched patients with OSA who met our criteria for the control group were enrolled in the study. The Tp-e, Tp-e/QT ratio, corrected QT interval (QTc), corrected Tp-e interval (Tp-ec), and QTd were measured, calculated and analyzed. Results: Patients in the PVC group (n = 31) showed a greater Tp-e, Tp-ec, QTc, Tp-e/QT ratio, and QTd than patients in the control group (n = 31). In the univariate binary logistic regression analysis, higher Tp-ec (OR: 1.025; P = 0.042), QTc (OR: 1.014; P = 0.036), Tp-e/QT ratio (OR: 1.675; P < 0.001), and QTd (OR: 1.052; P = 0.012) values were all significantly associated with nocturnal PVCs. In multivariate analysis and receiver operating characteristic analysis, a higher Tp-e/QT ratio (OR: 2.168; 95% CI: 0.762-0.952; P < 0.001) was an independent predictor of nocturnal PVCs. Conclusions: The QTc, Tp-e/QT ratio, and QTd in patients with OSA with nocturnal PVCs were significantly increased compared with those in patients without nocturnal PVCs. A prolonged Tp-e/QT ratio was an independent predictor of nocturnal PVCs in patients with OSA.
MeSH term(s)	Humans ; Ventricular Premature Complexes/diagnosis ; Retrospective Studies ; Cohort Studies ; Electrocardiography ; Sleep Apnea, Obstructive/diagnosis
Language	English
Publishing date	2022-04-30
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1500381-4
ISSN	1522-1709 ; 1520-9512
ISSN (online)	1522-1709
ISSN	1520-9512
DOI	10.1007/s11325-022-02626-x
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Zs.A 5658: Show issues

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Article ; Online: Copper(II)-catalyzed enantioselective hydrosilylation of halo-substituted alkyl aryl and heteroaryl ketones: asymmetric synthesis of (R)-fluoxetine and (S)-duloxetine.

Zhou, Ji-Ning / Fang, Qiang / Hu, Yi-Hu / Yang, Li-Yao / Wu, Fei-Fei / Xie, Lin-Jie / Wu, Jing / Li, Shijun

Organic & biomolecular chemistry

2014 Volume 12, Issue 6, Page(s) 1009–1017

Abstract: A set of reaction conditions has been established to facilitate the non-precious copper-catalyzed enantioselective hydrosilylation of a number of structurally diverse β-, γ- or ε-halo-substituted alkyl aryl ketones and α-, β- or γ-halo-substituted alkyl ... ...

Abstract	A set of reaction conditions has been established to facilitate the non-precious copper-catalyzed enantioselective hydrosilylation of a number of structurally diverse β-, γ- or ε-halo-substituted alkyl aryl ketones and α-, β- or γ-halo-substituted alkyl heteroaryl ketones under air to afford a broad spectrum of halo alcohols in high yields and good to excellent enantioselectivities (up to 99% ee). The developed procedure has been successfully applied to the asymmetric synthesis of antidepressant drugs (R)-fluoxetine and (S)-duloxetine, which highlighted its synthetic utility.
MeSH term(s)	Catalysis ; Copper/chemistry ; Duloxetine Hydrochloride ; Fluoxetine/chemical synthesis ; Fluoxetine/chemistry ; Ketones/chemistry ; Molecular Conformation ; Organometallic Compounds/chemistry ; Stereoisomerism ; Thiophenes/chemical synthesis ; Thiophenes/chemistry
Chemical Substances	Ketones ; Organometallic Compounds ; Thiophenes ; Fluoxetine (01K63SUP8D) ; Copper (789U1901C5) ; Duloxetine Hydrochloride (9044SC542W)
Language	English
Publishing date	2014-02-14
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2097583-1
ISSN	1477-0539 ; 1477-0520
ISSN (online)	1477-0539
ISSN	1477-0520
DOI	10.1039/c3ob42214c
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Article: Potential of intensity-modulated radiotherapy to escalate doses to head-and-neck cancers: what is the maximal dose?

Zhou, Jining / Fei, Dingyu / Wu, Qiuwen

International journal of radiation oncology, biology, physics

2003 Volume 57, Issue 3, Page(s) 673–682

Abstract: Purpose: To investigate the potential of intensity-modulated radiotherapy (IMRT) to escalate doses to head-and-neck cancer and find the maximal dose that could be prescribed to the target volume with IMRT while doses to critical organs were maintained ... ...

Abstract	Purpose: To investigate the potential of intensity-modulated radiotherapy (IMRT) to escalate doses to head-and-neck cancer and find the maximal dose that could be prescribed to the target volume with IMRT while doses to critical organs were maintained at their currently acceptable levels. The secondary goal was to search for limits in current IMRT technology. Methods and materials: For a group of 12 head-and-neck cancer patients with different tumor locations and shapes, we performed IMRT planning using a simultaneous integrated boost strategy, that is, the gross tumor volume (GTV), clinical target volume (CTV), and electively treated nodes were treated simultaneously at different dose levels. The critical structures involved in the treatment field that needed to be spared included the brainstem, spinal cord, and parotid glands, depending on the disease site. Nine coplanar 6-MV photon beams were used for planning with the IMRT system developed at our institution, and dose-volume criteria were used for optimization. By varying the optimization parameters, we gradually increased the dose to the GTV while keeping the dose to the critical structures at less than the acceptable tolerance level. The criteria for accepting the plan included the following: (1) the prescription dose to the GTV had to cover 99% of the volume, and the dose homogeneity of the GTV needed to be <10%; (2) the prescription to the CTV (which was set either at 60 Gy or 10 Gy less than that of the GTV) had to cover 95% of the volume, and the same amount of normal tissue outside the CTV received the CTV prescription dose as in the current acceptable plan; (3) the prescription to the electively treated lymph nodes needed to cover 90% of the volume; and (4) the maximal dose to the brainstem and spinal cord had to be <55 Gy and 45 Gy, respectively. For parotid glands, the dose needed to be as low as possible without compromising the target doses. The deliverable plans as determined by the actual multileaf collimator leaf sequences were used for the final evaluation. To verify that the acceptable plans were deliverable, the experimental measurements of planar dose distribution were performed in phantom with film. Results: The maximal dose to the GTV varied from 86 to 176 Gy if the CTV dose increased with the GTV dose. It was reduced to 76-82 Gy if the CTV dose was kept at 60 Gy. The competing criteria usually are the requirements of the tolerance doses to the critical organs and target dose homogeneity, not the target prescription dose. Using more beams only increased the dose marginally. The results could change significantly if a different set of criteria for the plan evaluation were used. Dosimetric measurements confirmed that such a high dose and dose gradient could be delivered accurately with dynamic multileaf collimators. Statistical analyses showed no significant correlations between the maximal doses and the number of GTVs and volume of GTVs and CTVs. Conclusion: Doses to head-and-neck cancers with simultaneous integrated boost IMRT can be escalated to a greater level than currently prescribed clinically. The limit of IMRT in head-and-neck cancer has not been reached at the current prescription level of 70 Gy. Such high total and fractionated doses should be carefully evaluated before being prescribed clinically.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Algorithms ; Carcinoma, Squamous Cell/diagnostic imaging ; Carcinoma, Squamous Cell/radiotherapy ; Female ; Head and Neck Neoplasms/diagnostic imaging ; Head and Neck Neoplasms/radiotherapy ; Humans ; Male ; Middle Aged ; Radiotherapy Dosage ; Radiotherapy, Conformal/methods ; Tomography, X-Ray Computed
Language	English
Publishing date	2003-11-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	197614-x
ISSN	1879-355X ; 0360-3016
ISSN (online)	1879-355X
ISSN	0360-3016
DOI	10.1016/s0360-3016(03)00626-6
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Article: [Value of QT hysteresis during treadmill exercise test for diagnosing coronary heart disease].

Bao, Ming-wei / Zhang, Yi-jie / Tan, Tuan-tuan / Zhou, Ji-ning / Yang, Jian-xue / Wang, Fang / Ha, Fei

Zhonghua xin xue guan bing za zhi

2012 Volume 40, Issue 7, Page(s) 589–592

Abstract: Objective: To investigate the value of QT hysteresis index during treadmill exercise test (TET) in diagnosing coronary heart disease (CHD).: Methods: One hundred consecutive patients suspected for CHD were referred for TET and selective coronary ... ...

Abstract	Objective: To investigate the value of QT hysteresis index during treadmill exercise test (TET) in diagnosing coronary heart disease (CHD). Methods: One hundred consecutive patients suspected for CHD were referred for TET and selective coronary angiography (CAG). Patients were divided into positive [n = 55, age (56.0 ± 7.9) years] and negative [n = 45, age (53.2 ± 6.7) years] group based on their CAG results. For each TET recording, 50 points were selected for the RR, QTp, and QTe interval measurements. QTp and QTe interval was plotted against corresponding RR interval. QT/RR curve was constructed by connect all point, QT hysteresis index was calculated for each patient. Results: The QTp [(22.4 ± 10.3) ms vs. (6.7 ± 4.6) ms, P < 0.001] and QTe [(27.1 ± 11.1) ms vs. (7.6 ± 4.6) ms, P < 0.001] hysteresis index of patients in positive group were significantly higher than those in negative group. The sensitivity of QTp and QTe hysteresis index for diagnosing CHD was 89.1% (49/55) and 94.5% (52/55), respectively, and the specificity was 82.2% (37/45) and 80.0% (36/45), respectively. If the patient fulfilled both the classical TET and QT hysteresis criteria, the sensitivity for diagnosing CHD increased to 94.3% (33/35, QTp) and 94.6% (35/37, QTe), and the specificity were both 100% (26/26, 26/26). Moreover, QTp (r = -0.399, P < 0.001) and QTe (r = -0.547, P < 0.001) hysteresis index highly correlated to Duke treadmill score. Conclusion: QT hysteresis index is useful parameter for CHD diagnosis and which could improve the diagnostic value of TET for CHD in combination with the classical TET criteria for diagnosis of CHD.
MeSH term(s)	Adult ; Aged ; Coronary Disease/diagnosis ; Coronary Disease/physiopathology ; Electrocardiography/methods ; Exercise Test ; Female ; Heart Rate ; Humans ; Male ; Middle Aged ; Sensitivity and Specificity
Language	Chinese
Publishing date	2012-07
Publishing country	China
Document type	English Abstract ; Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	603425-1
ISSN	0253-3758
ISSN	0253-3758
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Article ; Online: Nickel(II)-dipyridylphosphine-catalyzed enantioselective hydrosilylation of ketones in air.

Wu, Fei-Fei / Zhou, Ji-Ning / Fang, Qiang / Hu, Yi-Hu / Li, Shijun / Zhang, Xi-Chang / Chan, Albert S C / Wu, Jing

Chemistry, an Asian journal

2012 Volume 7, Issue 11, Page(s) 2527–2530

Abstract: Out of thin air: Catalytic amounts of nickel(II) salt and non-racemic dipyridylphosphine ligand, as well as the stoichiometric hydride source PhSiH(3), formed an effective catalyst system for the Ni(II)-catalyzed asymmetric hydrosilylation of a diverse ... ...

Abstract	Out of thin air: Catalytic amounts of nickel(II) salt and non-racemic dipyridylphosphine ligand, as well as the stoichiometric hydride source PhSiH(3), formed an effective catalyst system for the Ni(II)-catalyzed asymmetric hydrosilylation of a diverse range of electron-deficient aryl alkyl ketones with enantioselectivities up to 90% ee. The practical potential of the protocol was evinced by its good air-stability.
MeSH term(s)	Air ; Catalysis ; Electrons ; Ketones/chemistry ; Nickel/chemistry ; Phosphines/chemistry ; Stereoisomerism
Chemical Substances	Ketones ; Phosphines ; Nickel (7OV03QG267) ; phosphine (FW6947296I)
Language	English
Publishing date	2012-11
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1861-471X
ISSN (online)	1861-471X
DOI	10.1002/asia.201200512
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