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Article ; Online: Effects of different wall-breaking methods on the nutrient release of Ganoderma lucidum spore powder during in vitro digestion.

Qi, Yaoyao / Zhong, Shun / Pan, Feng / Zhou, Junfu / Wang, Zhiyu / Deng, Zeyuan / Li, Hongyan

Journal of the science of food and agriculture

2024

Abstract: Background: The hard double-walled structure of Ganoderma lucidum spore powder (GLSP) is difficult for the human body to digest, so it is very important to break the wall of GLSP. In this study, the wall of GLSP was broken by mechanical milling at room ... ...

Abstract	Background: The hard double-walled structure of Ganoderma lucidum spore powder (GLSP) is difficult for the human body to digest, so it is very important to break the wall of GLSP. In this study, the wall of GLSP was broken by mechanical milling at room temperature (MM-R) and ultra-fine grinding at low temperature (UFG-L), respectively. Results: Compared with MM-R, UFG-L could better retain the sporangium powder's morphological and structural integrity. During in vitro digestion, compared with unbroken GLSP, the released amounts of polysaccharides and triterpenes from broken GLSP were significantly increased, and they increased with the increase of specific surface area. The bioaccessibility of polysaccharide and triterpene from unbroken GLSP after the intestinal stage were 29.52% and 5.37%, respectively. The bioaccessibility of polysaccharides and triterpene from broken GLSP by MM-R after the intestinal phase were 39.73-72.45% and 16.44-24.97%, while those by UFG-L were 44.53-104.18% and 12.96-32.90%, respectively. Conclusion: The active ingredients of broken GLSP showed better digestion and absorption abilities than unbroken GLSP. Moreover, the specific surface area of GLSP by UFG-L was lower than that by MM-R, and the bioaccessibility of GLSP by UFG-L was higher than that by MM-R. © 2024 Society of Chemical Industry.
Language	English
Publishing date	2024-03-28
Publishing country	England
Document type	Journal Article
ZDB-ID	184116-6
ISSN	1097-0010 ; 0022-5142
ISSN (online)	1097-0010
ISSN	0022-5142
DOI	10.1002/jsfa.13490
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Article ; Online: Characterization of microbial contamination of retail washed and unwashed shell eggs in Taiwan

Hsu, Shu-Chen / Chen, Hsiu-Ling / Zhou, Junfu / Liu, Wenjun / Wu, Chen-Ting

Food Control. 2023 Feb. 27, p.109718-

2023 , Page(s) 109718–

Abstract: The retail market is the largest domestic unwashed chicken egg market in Taiwan. Being unwashed, contamination may be introduced, and internal pathogens may grow during the collection, distribution, transport, and storage stages of the eggs. Microbial ... ...

Abstract	The retail market is the largest domestic unwashed chicken egg market in Taiwan. Being unwashed, contamination may be introduced, and internal pathogens may grow during the collection, distribution, transport, and storage stages of the eggs. Microbial safety is an important factor contributing to egg quality. The purpose of this study was to assess the microbial profiles of the shell surface and internal fraction of retail washed and unwashed shell chicken eggs in Taiwan, to better understand the microbial safety and quality of retail eggs. A total of 210 unwashed and 57 washed eggs were collected and screened between July 2019 and January 2020. Pathogenic E. coli, Salmonella spp., and S. aureus were not detected in any of the sampled eggs. The prevalence of Staphylococcus spp. and Enterobacteriaceae on the surface of unwashed shelled chicken eggs was 93.81% and 13.33%, respectively. Of the unwashed shelled chicken eggs, 197 samples were positive for Staphylococcus spp., and 28 samples were positive for both Staphylococcus spp. and Enterobacteriaceae, among which four eggs were contaminated with higher levels of Enterobacteriaceae (13,000-365,000 CFU/egg) than others. On the internal fraction of unwashed shelled chicken eggs, the prevalence of Staphylococcus spp., Enterobacteriaceae and E. coli was 1.90%, 1.90%, and 0.48%, respectively. Staphylococcus spp. were detected in four samples. Enterobacteriaceae were found in four other samples, with non-pathogenic E. coli in one of the four egg samples. The prevalence of Staphylococcus spp. and Enterobacteriaceae on the surface of washed eggs was 66.67%, and 7.02%, respectively, and there were no Enterobacteriaceae, Staphylococcus spp., E. coli, S. aureus, or Salmonella spp. in the contents of washed eggs. Staphylococcus spp. were more dominant in unwashed and washed eggshells compared to Staphylococcus spp. and Enterobacteriaceae in the content of unwashed eggs. The Enterobacteriaceae and Staphylococcus spp. counts were considerably higher in unwashed eggs than in washed eggs. For unwashed egg samples, the Enterobacteriaceae counts ranged from 10 to 365,000 CFU for eggshells and two to 14,600 CFU for egg contents; the Staphylococcus spp. counts ranged from three to over 1,100 MPN for eggshells and 0.3 to 3.6 MPN for egg contents. These results indicate that washed eggs have better microbial safety and quality in Taiwan. Effective control measures are also recommended for unwashed eggs.
Keywords	Escherichia coli ; Salmonella ; Staphylococcus ; chickens ; egg quality ; eggs ; food safety ; markets ; microbial contamination ; retail marketing ; Taiwan ; Retail eggs ; Enterobacteriaceae ; Staphylococcus spp
Language	English
Dates of publication	2023-0227
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	1027805-9
ISSN	0956-7135
ISSN	0956-7135
DOI	10.1016/j.foodcont.2023.109718
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Article ; Online: Physical and chemical properties of different varieties of taiwanese bananas and their application in banana flat-rice noodles

Li, Mingzhang / Zhou, Junfu / Lin, Jen-shinn

International journal of food properties. 2021 Jan. 01, v. 24, no. 1 p.1164-1174

2021

Abstract: Three varieties of ripe and unripe bananas as well as indica rice (taichung sen no. 17) Were analyzed for the production of flat-Rice Noodles. The ripe bananas contained the lowest amylose, total starch, and resistant starch contents (rsc). The L-Value, ... ...

Abstract	Three varieties of ripe and unripe bananas as well as indica rice (taichung sen no. 17) Were analyzed for the production of flat-Rice Noodles. The ripe bananas contained the lowest amylose, total starch, and resistant starch contents (rsc). The L-Value, hardness, and rsc of the flat-rice noodles with unripe bananas were higher than the values of those prepared using ripe bananas; the opposite trend was observed for a and b values and cooking loss. the solubility and swelling power of the flat-rice noodles using ripe bananas were significantly higher than those of the noodles prepared using unripe bananas.
Keywords	amylose ; bananas ; hardness ; resistant starch ; rice ; solubility ; UNRIPE BANANA ; RIPE BANANA ; VARIETIES ; FLAT-RICE ; NOODLE
Language	English
Dates of publication	2021-0101
Size	p. 1164-1174.
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	1402715-x
ISSN	1532-2386 ; 1094-2912
ISSN (online)	1532-2386
ISSN	1094-2912
DOI	10.1080/10942912.2021.1958842
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Article ; Online: Characterization of phenylalanine hydroxylase gene variants and analysis of genotype–phenotype correlation in patients with phenylalanine hydroxylase deficiency from Fujian Province, Southeastern China

Zhou, Junfu / Zeng, Yinglin / Qiu, Xiaolong / Lin, Qingying / Chen, Weifeng / Luo, Jinying / Xu, Liangpu

Mol Biol Rep. 2022 Nov., v. 49, no. 11 p.10409-10419

2022

Abstract: BACKGROUND: Phenylalanine hydroxylase deficiency (PAHD) is the most prevalent inherited disorder of amino acid metabolism in China. Its complex phenotype includes many variants and genotypes among different populations. METHODS AND RESULTS: In this study, ...

Abstract	BACKGROUND: Phenylalanine hydroxylase deficiency (PAHD) is the most prevalent inherited disorder of amino acid metabolism in China. Its complex phenotype includes many variants and genotypes among different populations. METHODS AND RESULTS: In this study, we analyzed the phenylalanine hydroxylase gene (PAH) variants in a cohort of 93 PAHD patients from Fujian Province. We also assessed genotype and phenotype correlation in patients with PAHD. A total of 44 different pathogenic variants were identified, including five novel variants. The three most prevalent variants among all patents were c.158G > A, p.(Arg53His) (18.03%), c.721C > T, p.(Arg241Cys) (14.75%), and c.728G > A, p.(Arg243Gln) (7.65%). The frequency of the c.158G > A, p.(Arg53His) variant was highest in patients with mild hyperphenylalaninemia, whereas the frequency of the c.1197A > T, p.(Val399 =) and c.331C > T, p.(Arg111Ter) variants was highest in patients with classic phenylketonuria. The most abundant genotypes observed in PAHD patients were c.[158G > A];[728G > A], c.[158G > A];[442-1G > A], and c.[158G > A];[721C > T]. Comparing allelic phenotype to genotypic phenotype values yielded fairly accurate predictions of phenotype, with an overall consistency rate was 85.71% for PAHD patients. CONCLUSIONS: Our study identified a PAH variant spectrum in PAHD patients from Fujian Province, Southeastern China. Quantitative correlation analysis between genotype and phenotype severity is helpful for genetic counseling and management.
Keywords	amino acid metabolism ; genes ; genotype ; genotype-phenotype correlation ; phenotype ; phenylalanine 4-monooxygenase ; phenylketonuria ; China
Language	English
Dates of publication	2022-11
Size	p. 10409-10419.
Publishing place	Springer Netherlands
Document type	Article ; Online
ZDB-ID	186544-4
ISSN	1573-4978 ; 0301-4851
ISSN (online)	1573-4978
ISSN	0301-4851
DOI	10.1007/s11033-022-07579-8
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Article ; Online: Cobalt induces neurodegeneration through FTO-triggered autophagy impairment by targeting TSC1 in an m6A-YTHDF2-dependent manner

Tang, Jianping / Zheng, Fuli / Liu, Xu / Li, Yanjun / Guo, Zhenkun / Lin, Xinpei / Zhou, Junfu / Zhang, Yu / Yu, Guangxia / Hu, Hong / Shao, Wenya / Wu, Siying / Li, Huangyuan

Journal of Hazardous Materials 2023 July 5, v. 453, p. 131354

2023 , Page(s) 131354

Abstract: Cobalt is the most widely used heavy metal pollutant in medicine and industry. Excessive cobalt exposure can adversely affect human health. Neurodegenerative symptoms have been observed in cobalt-exposed populations; however, the underlying mechanisms ... ...

Abstract	Cobalt is the most widely used heavy metal pollutant in medicine and industry. Excessive cobalt exposure can adversely affect human health. Neurodegenerative symptoms have been observed in cobalt-exposed populations; however, the underlying mechanisms remain largely unknown. In this study, we demonstrate that the N6-methyladenosine (m⁶A) demethylase fat mass and obesity-associated gene (FTO) mediates cobalt-induced neurodegeneration by impairing autophagic flux. Cobalt-induced neurodegeneration was exacerbated through FTO genetic knockdown or repression of demethylase activity, but was alleviated by FTO overexpression. Mechanistically, we showed that FTO regulates TSC1/2-mTOR signaling pathway by targeting TSC1 mRNA stability in an m⁶A-YTHDF2 manner, which resulted in autophagosome accumulation. Furthermore, FTO decreases lysosome-associated membrane protein-2 (LAMP2) to inhibit the integration of autophagosomes and lysosomes, leading to autophagic flux damage. In vivo experiments further identified that central nervous system (CNS)-Fto-specific knockout resulted in serious neurobehavioral and pathological damage as well as TSC1-related autophagy impairment in cobalt-exposed mice. Interestingly, FTO-regulated autophagy impairment has been confirmed in patients with hip replacement. Collectively, our results provide novel insights into m⁶A-modulated autophagy through FTO-YTHDF2 targeted TSC1 mRNA stability, revealing cobalt is a novel epigenetic hazard that induces neurodegeneration. These findings suggest the potential therapeutic targets for hip replacement in patients with neurodegenerative damage.
Keywords	autophagosomes ; autophagy ; central nervous system ; cobalt ; epigenetics ; genes ; heavy metals ; human health ; industry ; lysosomes ; medicine ; neurodegenerative diseases ; pollutants ; prostheses ; therapeutics ; Cobalt chloride ; Autophagic flux ; MRNA stability ; Neurodegenerative damage ; Epigenetic hazard
Language	English
Dates of publication	2023-07
Size	p. 131354
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	1491302-1
ISSN	1873-3336 ; 0304-3894
ISSN (online)	1873-3336
ISSN	0304-3894
DOI	10.1016/j.jhazmat.2023.131354
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Article: Novel Characterization of Myeloid-Derived Suppressor Cells in Tumor Microenvironment.

Li, Yanan / He, Hongdan / Jihu, Ribu / Zhou, Junfu / Zeng, Rui / Yan, Hengxiu

Frontiers in cell and developmental biology

2021 Volume 9, Page(s) 698532

Abstract: Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of cells generated in various pathologic conditions, which have been known to be key components of the tumor microenvironment (TME) involving in tumor immune tolerance. So MDSCs have been ...

Abstract	Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of cells generated in various pathologic conditions, which have been known to be key components of the tumor microenvironment (TME) involving in tumor immune tolerance. So MDSCs have been extensively researched recently. As its name suggests, immunosuppression is the widely accepted function of MDSCs. Aside from suppressing antitumor immune responses, MDSCs in the TME also stimulate tumor angiogenesis and metastasis, thereby promoting tumor growth and development. Therefore, altering the recruitment, expansion, activation, and immunosuppression of MDSCs could partially restore antitumor immunity. So, this view focused on the favorable TME conditions that promote the immunosuppressive effects of MDSCs and contribute to targeted therapies with increased precision for MDSCs.
Language	English
Publishing date	2021-08-30
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2737824-X
ISSN	2296-634X
ISSN	2296-634X
DOI	10.3389/fcell.2021.698532
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Article: Targeting Signaling Pathway Networks in Several Malignant Tumors: Progresses and Challenges.

He, Hongdan / Shao, Xiaoni / Li, Yanan / Gihu, Ribu / Xie, Haochen / Zhou, Junfu / Yan, Hengxiu

Frontiers in pharmacology

2021 Volume 12, Page(s) 675675

Abstract: Malignant tumors remain the health problem of highest concern among people worldwide due to its high mortality and recurrence. Lung, gastric, liver, colon, and breast cancers are among the top five malignant tumors in terms of morbidity and mortality. In ...

Abstract	Malignant tumors remain the health problem of highest concern among people worldwide due to its high mortality and recurrence. Lung, gastric, liver, colon, and breast cancers are among the top five malignant tumors in terms of morbidity and mortality. In cancer biology, aberrant signaling pathway regulation is a prevalent theme that drives the generation, metastasis, invasion, and other processes of all malignant tumors. The Wnt/β-catenin, PI3K/AKT/mTOR, Notch and NF-kB pathways are widely concerned and signal crosstalks exist in the five solid tumors. This review provides an innovative summary of the recent progress in research on these signaling pathways, the underlying mechanism of the molecules involved in these pathways, and the important role of some miRNAs in tumor-related signaling pathways. It also presents a brief review of the antitumor molecular drugs that target these signaling pathways. This review may provide a theoretical basis for the study of the molecular biological mechanism of malignant tumors and vital information for the development of new treatment strategies with a focus on efficacy and the reduction of side effects.
Language	English
Publishing date	2021-05-31
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2021.675675
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Article ; Online: Physicochemical characteristics and resistant starch of different varieties of banana from Taiwan

Li, Mingzhang / Zhou, Junfu / Hsu, Shu-Chen / Lin, Jen-Shinn

International journal of food properties. 2020 Jan. 01, v. 23, no. 1 p.1168-1175

2020

Abstract: Banana contains high levels of resistant starch (RSC), which resists digestion. Taiwan is a major producer of banana; however, little work has been reported on their specific characteristics. This study was conducted to investigate the characteristics ... ...

Abstract	Banana contains high levels of resistant starch (RSC), which resists digestion. Taiwan is a major producer of banana; however, little work has been reported on their specific characteristics. This study was conducted to investigate the characteristics and RSC of ripe and unripe Taiwanese bananas. The characteristics and RSC significantly differed between varieties and ripening stages. The hardness, L*, pH values, swelling power, total starch, and amylose contents of unripe bananas were significantly higher than ripe bananas, while the starch content depended on the variety and ripening stage. Therefore, Taiwanese bananas could be useful RS source for manufacturing functional foods.
Keywords	amylose ; bananas ; digestion ; pH ; resistant starch ; Taiwan ; Unripe banana ; ripe banana
Language	English
Dates of publication	2020-0101
Size	p. 1168-1175.
Publishing place	Taylor & Francis
Document type	Article ; Online
Note	NAL-AP-2-clean
ZDB-ID	1402715-x
ISSN	1532-2386 ; 1094-2912
ISSN (online)	1532-2386
ISSN	1094-2912
DOI	10.1080/10942912.2020.1788077
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Article ; Online: The role of mitochondrial dynamics in disease.

Wang, Yujuan / Dai, Xinyan / Li, Hui / Jiang, Huiling / Zhou, Junfu / Zhang, Shiying / Guo, Jiacheng / Shen, Lidu / Yang, Huantao / Lin, Jie / Yan, Hengxiu

MedComm

2023 Volume 4, Issue 6, Page(s) e462

Abstract: Mitochondria are multifaceted and dynamic organelles regulating various important cellular processes from signal transduction to determining cell fate. As dynamic properties of mitochondria, fusion and fission accompanied with mitophagy, undergo constant ...

Abstract	Mitochondria are multifaceted and dynamic organelles regulating various important cellular processes from signal transduction to determining cell fate. As dynamic properties of mitochondria, fusion and fission accompanied with mitophagy, undergo constant changes in number and morphology to sustain mitochondrial homeostasis in response to cell context changes. Thus, the dysregulation of mitochondrial dynamics and mitophagy is unsurprisingly related with various diseases, but the unclear underlying mechanism hinders their clinical application. In this review, we summarize the recent developments in the molecular mechanism of mitochondrial dynamics and mitophagy, particularly the different roles of key components in mitochondrial dynamics in different context. We also summarize the roles of mitochondrial dynamics and target treatment in diseases related to the cardiovascular system, nervous system, respiratory system, and tumor cell metabolism demanding high-energy. In these diseases, it is common that excessive mitochondrial fission is dominant and accompanied by impaired fusion and mitophagy. But there have been many conflicting findings about them recently, which are specifically highlighted in this view. We look forward that these findings will help broaden our understanding of the roles of the mitochondrial dynamics in diseases and will be beneficial to the discovery of novel selective therapeutic targets.
Language	English
Publishing date	2023-12-28
Publishing country	China
Document type	Journal Article ; Review
ISSN	2688-2663
ISSN (online)	2688-2663
DOI	10.1002/mco2.462
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Article ; Online: Intercalation of nanostructured CeO

Duan, Xinping / Wen, Zhaojun / Zhao, Yuxin / Zhou, Junfu / Fang, Huihuang / Cao, Yanning / Jiang, Lilong / Ye, Linmin / Yuan, Youzhu

Nanoscale

2018 Volume 10, Issue 7, Page(s) 3331–3341

Abstract: Heterogeneous catalytic oxidation arises from the prerequisite oxygen activation and transfer ability of metal oxide catalysts. Thus, engineering intercalated nanounits and heterophase metal oxide structures, and forming interstitial catalyst supports at ...

Abstract	Heterogeneous catalytic oxidation arises from the prerequisite oxygen activation and transfer ability of metal oxide catalysts. Thus, engineering intercalated nanounits and heterophase metal oxide structures, and forming interstitial catalyst supports at the nanoscale level can drastically alter the catalytic performances of metal oxides. This is particularly important for ceria-based nanomaterial catalysts, where the interactions of reducible ceria (CeO
Language	English
Publishing date	2018-02-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2515664-0
ISSN	2040-3372 ; 2040-3364
ISSN (online)	2040-3372
ISSN	2040-3364
DOI	10.1039/c7nr07825k
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