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Article ; Online: Co-assembly of Amphiphilic Triblock Copolymers with Nanodrugs and Drug Release Kinetics in Solution.

Zhou, Junwei / Tang, Hao / Wang, Rong

The journal of physical chemistry. B

2024 Volume 128, Issue 11, Page(s) 2841–2852

Abstract: Polymeric vesicles present great potential in disease treatment as they can be featured as a structurally stable and easily functionalized drug carrier that can simultaneously encapsulate multiple drugs and release them on-demand. Based on the ... ...

Abstract	Polymeric vesicles present great potential in disease treatment as they can be featured as a structurally stable and easily functionalized drug carrier that can simultaneously encapsulate multiple drugs and release them on-demand. Based on the dissipative particle dynamics (DPD) simulation, the drug-loaded vesicles were designed by the co-assembly process of linear amphiphilic triblock copolymers and hydrophobic nanodrugs in solvents, and most importantly, the drug release behavior of drug-loaded vesicles were intensively investigated. The drug-loaded aggregates, such as vesicles, spherical micelles, and disk-like micelles, were observed by varying the size and concentration of nanodrugs and the length of the hydrophobic block. The distribution of nanodrugs in the vesicles was intensively analyzed. As the size of the nanodrugs increases, the localization of nanodrugs change from being unable to fully wrap in the vesicle wall to the uniform distribution and finally to the aggregation in the vesicles at the fixed concentration of nanodrugs. The membrane thickness of the drug-loaded polymeric vesicle can be increased, and the nanodrugs localized closer to the center of the vesicle by increasing the length of the hydrophobic block. The nanodrugs will be released from vesicles by varying the interactions between the nanodrug and the solvent or the hydrophobic block and the solvent, respectively. We found that the release kinetics conforms to the first-order kinetic model, which can be used to fit the cumulative release rate of nanodrugs over time. The results showed that increasing the size of nanodrugs, the length of hydrophobic block, and the interaction parameters between the hydrophobic block and the solvent will slow down the release rate of the nanodrug and change the drug release process from monophasic to biphasic release model.
MeSH term(s)	Drug Liberation ; Micelles ; Polymers/chemistry ; Drug Carriers/chemistry ; Nanoparticles ; Solvents ; Hydrophobic and Hydrophilic Interactions
Chemical Substances	Micelles ; Polymers ; Drug Carriers ; Solvents
Language	English
Publishing date	2024-03-07
Publishing country	United States
Document type	Journal Article
ISSN	1520-5207
ISSN (online)	1520-5207
DOI	10.1021/acs.jpcb.4c00230
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Effect of ionic liquid on structure and properties of carbon black filled natural rubber vulcanizates

Zhou, Junwei / Wang, Wanjie / Song, Yihu / Zheng, Qiang

Composites Part A. 2023 Apr., v. 167 p.107432-

2023

Abstract: Rubber nanocomposites exhibit marked strain softening upon large-amplitude oscillation shear and large-strain cyclic tension while there are rare ways developed for solving the awkward paradox between improving elasticity and weakening softening. Herein ... ...

Abstract	Rubber nanocomposites exhibit marked strain softening upon large-amplitude oscillation shear and large-strain cyclic tension while there are rare ways developed for solving the awkward paradox between improving elasticity and weakening softening. Herein ionic liquid (IL), 1-ethyl-3-methylimidazolium acetate, at a content as low as 0.2 parts per hundred parts of rubber was introduced into carbon black (CB)/natural rubber (NR) nanocomposites for regulating the microstructure and viscoelasticity. The results show that IL could accelerate NR vulcanization, improve proportion of polysulfide crosslinking bonds and promote CB dispersity without marked influence on crosslinking density. It is of significance that IL could weaken Mullins effect by reducing dissipation and softening energies. It is fascinating that at CB volume fraction 0.231, IL could improve tensile strength and extensibility and weaken the Mullins effect simultaneously. The investigation is enlightening for tailoring elasticity and dissipation of vulcanizate nanocomposites by regulating the crosslinking network and CB dispersity.
Keywords	acetates ; crosslinking ; extensibility ; ionic liquids ; microstructure ; nanocomposites ; rubber ; soot ; tensile strength ; viscoelasticity ; Rheology ; Softening ; Natural rubber
Language	English
Dates of publication	2023-04
Publishing place	Elsevier Ltd
Document type	Article ; Online
ZDB-ID	2012223-8
ISSN	1359-835X
ISSN	1359-835X
DOI	10.1016/j.compositesa.2023.107432
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Article ; Online: Designing Multimodal ON-OFF Nanoswitches of DNA-Functionalized Nanoparticles by Stimuli-Responsive Polymers.

Zhang, Yixin / Tang, Hao / Zhou, Junwei / Zhang, Liangshun / Wang, Rong

The journal of physical chemistry. B

2023 Volume 127, Issue 37, Page(s) 8049–8056

Abstract: It is a challenging task to realize highly reversible ON-OFF nanoswitches over a wide range of temperatures, which emerge as a versatile toolbox for use in nanobiotechnology. Herein, nanoparticles (NPs) bifunctionalized by DNA strands and stimuli- ... ...

Abstract	It is a challenging task to realize highly reversible ON-OFF nanoswitches over a wide range of temperatures, which emerge as a versatile toolbox for use in nanobiotechnology. Herein, nanoparticles (NPs) bifunctionalized by DNA strands and stimuli-responsive polymers are proposed to construct multimodal ON-OFF nanoswitches by the coarse-grained model. The successful achievement of multimodal ON-OFF nanoswitches for bifunctionalized NPs at lower temperatures is attributed to the synergistic effects of the contraction and expansion configurations of stimuli-responsive polymers, combined with the hybridization-dehybridization event of DNA strands. Importantly, our simulations isolate the conditions of programmable self-assembly of bifunctionalized NPs to realize the multimodal ON-OFF nanoswitches by the changes of temperature and chain rigidity. In addition, it is found that the bifunctionalized NPs in the ON state display anisotropic and patchy features due to an introduction of stimuli-responsive polymers. Our simulation results provide fundamental insights on qualitative predictions of ON/OFF states of DNA-based NPs, which can aid in realizing a set of ON-OFF nanoswitches by the rational design of functionalization molecules.
MeSH term(s)	Stimuli Responsive Polymers ; DNA ; Anisotropy ; Computer Simulation ; Nanoparticles
Chemical Substances	Stimuli Responsive Polymers ; DNA (9007-49-2)
Language	English
Publishing date	2023-09-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1520-5207
ISSN (online)	1520-5207
DOI	10.1021/acs.jpcb.3c04409
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Article ; Online: Simulation of scour and deposition in the flow field and adaptability of fishes around eco-friendly notched groins

Ma, Dianguang / Zhou, Junwei / Wang, Zhenhong

Journal of Hydrology. 2022 June, v. 609 p.127754-

2022

Abstract: Over the past few decades, eco-friendly channel construction has gained wide attention around the world including China, as it considers both navigational and ecological functions. The Groin system is a hydraulic structure that can effectively increase ... ...

Abstract	Over the past few decades, eco-friendly channel construction has gained wide attention around the world including China, as it considers both navigational and ecological functions. The Groin system is a hydraulic structure that can effectively increase the area of fish habitats. Groin shape has an influence on the local flow field and the scour and deposition pattern near the structure, thereby affecting the adaptability of fishes to the groin fields. In this study, a new groin structure with a notch in its middle part was proposed. A lab experiment was conducted on a physical model to investigate the characteristics of the flow field including patterns of water level distribution, flow velocity distribution, and scour and deposition on different submergence levels and incoming flows. This experiment used four notch depths: 0 (unnotched), 1/3 of groin height, 2/3 of groin height, and full groin height. Then the distribution of habitat suitability index (HSI) was calculated based on the assessment index system of the indicator fish species (Cyprinidae). The results showed that the notches created in the middle of localized overflow groins had a significant effect on the surrounding flow pattern. Due to localized overflow, both the flow velocity and the velocity gradient behind each groin increased. The flow velocity behind each groin was positively correlated with notch depth, while the flow velocity in the main channel was negatively correlated with notch depth. Under the complex flow conditions, depositional features did not occur along the edges of the groin fields, ensuring connectivity between groin fields and the main channel. An analysis of water depth and flow velocity suitability indexes of Cyprinidae suggests when notch depth is 2/3 of groin height, the notched groins have good ecological effects, especially in the groin fields.
Keywords	Cyprinidae ; fish ; habitats ; models ; submergence ; water analysis ; China ; New groin structure ; Localized overflow groin ; Flow velocity distribution ; Scour and deposition ; Ecological effects
Language	English
Dates of publication	2022-06
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	1473173-3
ISSN	1879-2707 ; 0022-1694
ISSN (online)	1879-2707
ISSN	0022-1694
DOI	10.1016/j.jhydrol.2022.127754
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Clueless: An ethnographic study of young men who participate in the seduction community with a focus on their psychosocial well-being and mental health.

Whitley, Rob / Zhou, JunWei

PloS one

2020 Volume 15, Issue 2, Page(s) e0229719

Abstract: In the last decade, a cross-national community of like-minded young men has emerged, commonly known as 'the seduction community'. This community is led by professional 'pick-up artists' who teach these young men a variety of techniques and mindsets with ... ...

Abstract	In the last decade, a cross-national community of like-minded young men has emerged, commonly known as 'the seduction community'. This community is led by professional 'pick-up artists' who teach these young men a variety of techniques and mindsets with the stated aim of improving their success with women, or 'game'. There has been little research on the men who participate in this community, and none from a mental health angle. As such, this study is propelled by two specific objectives, namely documenting and understanding (i) the reasons why young men join the seduction community; and (ii) the impacts of community involvement on participants' lives. To meet these aims, we used an inductive qualitative methodology giving ample scope for bottom-up understandings to emerge. Specifically, we recruited young men participating in the seduction community for an in-depth qualitative interview (N = 34) to explore self-reported motives and impacts. Interviews were augmented by lengthy participant observation, and data was analyzed by content analysis techniques. The results reveal that men often join the community to address a range of psychosocial deficits, and that community involvement successfully equips participants with numerous valued social and communication skills. The community appears to fill a void in providing a place of hope, fellowship and learning for young (often immigrant) men. The findings are summarized in five themes (i) loneliness and social inclusion; (ii) lack of male role models and need for guidance; (iii) mental health and well-being issues; (iv) skill acquisition and personal development; and (v) the dark side of pick-up. Interestingly, some of the practices commonly taught and utilized within the community resemble aspects of Cognitive Behavioral Therapy and mental health peer support. This may explain its evident appeal. We conclude by reflecting on the implications of the findings for official mental health service provision for young men.
MeSH term(s)	Adolescent ; Adult ; Anthropology, Cultural/methods ; Counseling/methods ; Humans ; Male ; Marriage/psychology ; Men/psychology ; Mental Health/trends ; Mental Health Services/trends ; Qualitative Research ; Self Report ; United Kingdom ; Young Adult
Language	English
Publishing date	2020-02-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0229719
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Article ; Online: Deep profiling of potential substrate atlas of porcine epidemic diarrhea virus 3C-like protease.

Zhou, Junwei / Sun, Peng / Wang, Yuanqing / Qiu, Runhui / Yang, Zhixiang / Guo, Jiahui / Li, Zhuang / Xiao, Shaobo / Fang, Liurong

Journal of virology

2024 , Page(s) e0025324

Abstract: Coronavirus (CoV) 3C-like protease ( ... ...

Abstract	Coronavirus (CoV) 3C-like protease (3CL
Language	English
Publishing date	2024-04-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	80174-4
ISSN	1098-5514 ; 0022-538X
ISSN (online)	1098-5514
ISSN	0022-538X
DOI	10.1128/jvi.00253-24
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Article ; Online: Cleavage of HDAC6 to dampen its antiviral activity by nsp5 is a common strategy of swine enteric coronaviruses.

Li, Zhuang / Xiao, Wenwen / Yang, Zhixiang / Guo, Jiahui / Zhou, Junwei / Xiao, Shaobo / Fang, Puxian / Fang, Liurong

Journal of virology

2024 Volume 98, Issue 2, Page(s) e0181423

Abstract: HDAC6, a structurally and functionally unique member of the histone deacetylase (HDAC) family, is an important host factor that restricts viral infection. The broad-spectrum antiviral activity of HDAC6 makes it a potent antiviral agent. Previously, we ... ...

Abstract	HDAC6, a structurally and functionally unique member of the histone deacetylase (HDAC) family, is an important host factor that restricts viral infection. The broad-spectrum antiviral activity of HDAC6 makes it a potent antiviral agent. Previously, we found that HDAC6 functions to antagonize porcine deltacoronavirus (PDCoV), an emerging enteropathogenic coronavirus with zoonotic potential. However, the final outcome is typically a productive infection that materializes as cells succumb to viral infection, indicating that the virus has evolved sophisticated mechanisms to combat the antiviral effect of HDAC6. Here, we demonstrate that PDCoV nonstructural protein 5 (nsp5) can cleave HDAC6 at glutamine 519 (Q519), and cleavage of HDAC6 was also detected in the context of PDCoV infection. More importantly, the anti-PDCoV activity of HDAC6 was damaged by nsp5 cleavage. Mechanistically, the cleaved HDAC6 fragments (amino acids 1-519 and 520-1159) lost the ability to degrade PDCoV nsp8 due to their impaired deacetylase activity. Furthermore, nsp5-mediated cleavage impaired the ability of HDAC6 to activate RIG-I-mediated interferon responses. We also tested three other swine enteric coronaviruses (transmissible gastroenteritis virus, porcine epidemic diarrhea virus, and swine acute diarrhea syndrome-coronavirus) and found that all these coronaviruses have adopted similar mechanisms to cleave HDAC6 in both an overexpression system and virus-infected cells, suggesting that cleavage of HDAC6 is a common strategy utilized by swine enteric coronaviruses to antagonize the host's antiviral capacity. Together, these data illustrate how swine enteric coronaviruses antagonize the antiviral function of HDAC6 to maintain their infection, providing new insights to the interaction between virus and host.IMPORTANCEViral infections and host defenses are in constant opposition. Once viruses combat or evade host restriction, productive infection is achieved. HDAC6 is a broad-spectrum antiviral protein that has been demonstrated to inhibit many viruses, including porcine deltacoronavirus (PDCoV). However, whether HDAC6 is reciprocally targeted and disabled by viruses remains unclear. In this study, we used PDCoV as a model and found that HDAC6 is targeted and cleaved by nsp5, a viral 3C-like protease. The cleaved HDAC6 loses its deacetylase activity as well as its ability to degrade viral proteins and activate interferon responses. Furthermore, this cleavage mechanism is shared among other swine enteric coronaviruses. These findings shed light on the intricate interplay between viruses and HDAC6, highlighting the strategies employed by viruses to evade host antiviral defenses.
MeSH term(s)	Animals ; Coronavirus/physiology ; Coronavirus Infections/veterinary ; Coronavirus Infections/virology ; Deltacoronavirus ; Interferons/metabolism ; Swine ; Swine Diseases/virology
Chemical Substances	Interferons (9008-11-1)
Language	English
Publishing date	2024-01-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	80174-4
ISSN	1098-5514 ; 0022-538X
ISSN (online)	1098-5514
ISSN	0022-538X
DOI	10.1128/jvi.01814-23
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Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Coinfection and nonrandom recombination drive the evolution of swine enteric coronaviruses.

Guo, Jiahui / Lai, Yinan / Yang, Zhixiang / Song, Wenbo / Zhou, Junwei / Li, Zhuang / Su, Wen / Xiao, Shaobo / Fang, Liurong

Emerging microbes & infections

2024 Volume 13, Issue 1, Page(s) 2332653

Abstract: Coinfection with multiple viruses is a common phenomenon in clinical settings and is a crucial driver of viral evolution. Although numerous studies have demonstrated viral recombination arising from coinfections of different strains of a specific species, ...

Abstract	Coinfection with multiple viruses is a common phenomenon in clinical settings and is a crucial driver of viral evolution. Although numerous studies have demonstrated viral recombination arising from coinfections of different strains of a specific species, the role of coinfections of different species or genera during viral evolution is rarely investigated. Here, we analyzed coinfections of and recombination events between four different swine enteric coronaviruses that infect the jejunum and ileum in pigs, including porcine epidemic diarrhea virus (PEDV), transmissible gastroenteritis virus (TGEV), and swine acute diarrhea syndrome coronavirus (SADS-CoV), and a deltacoronavirus, porcine deltacoronavirus (PDCoV). Various coinfection patterns were observed in 4,468 fecal and intestinal tissue samples collected from pigs in a 4-year survey. PEDV/PDCoV was the most frequent coinfection. However, recombination analyses have only detected events involving PEDV/TGEV and SADS-CoV/TGEV, indicating that inter-species recombination among coronaviruses is most likely to occur within the same genus. We also analyzed recombination events within the newly identified genus
MeSH term(s)	Humans ; Swine ; Animals ; Coronavirus ; Coinfection/veterinary ; Swine Diseases ; Coronavirus Infections/veterinary ; Porcine epidemic diarrhea virus/genetics ; Transmissible gastroenteritis virus/genetics ; Recombination, Genetic ; Alphacoronavirus
Language	English
Publishing date	2024-03-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	2681359-2
ISSN	2222-1751 ; 2222-1751
ISSN (online)	2222-1751
ISSN	2222-1751
DOI	10.1080/22221751.2024.2332653
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Article ; Online: Stretchable PEDOT:PSS/Li-TFSI/XSB Composite Films for Electromagnetic Interference Shielding.

Jiang, Xin / Zhou, Junwei / Zhong, Xinke / Hu, Zhaopeng / Hu, Rongyan / Song, Yihu / Zheng, Qiang

ACS applied materials & interfaces

2023 Volume 15, Issue 6, Page(s) 8521–8529

Abstract: Electromagnetic interference (EMI) shielding materials with stretchability are important for developing wearable and flexible appliances. Herein, lithium bis(trifloromethanesulfonyl)imide (Li-TFSI)-doped poly(3,4-ethylenedioxythiophene):poly(styrene ... ...

Abstract	Electromagnetic interference (EMI) shielding materials with stretchability are important for developing wearable and flexible appliances. Herein, lithium bis(trifloromethanesulfonyl)imide (Li-TFSI)-doped poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) and carboxylated styrene-butadiene rubber (XSB) latex are used to prepare stretchable EMI shielding composite films of 0.2 mm in thickness. In these films, the doped PEDOT:PSS nanoparticles form tenuous conductive pathways between the hexagonally packed latex particles, resulting in higher EMI shielding efficiency (EMI SE) compared with the films containing traditional dopant ethylene glycol. For the purpose of stretchable EMI shielding, the films containing 6 wt % PEDOT:PSS and 6 wt % Li-TFSI demonstrate EMI SE of 50 and 30 dB (12.4 GHz) at 0 and 100% strains, respectively, being the highest values among the reported shielding composites except for those using liquid metal as the filler. The investigation also provides a simple and environmentally friendly preparation method being highlighted for the development of lightweight stretchable EMI shielding materials for applications in flexible electronics in the near future.
Language	English
Publishing date	2023-02-06
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.2c21604
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Article: STSGAN: Spatial-Temporal Global Semantic Graph Attention Convolution Networks for Urban Flow Prediction

Zhou, Junwei / Qin, Xizhong / Yu, Kun / Jia, Zhenhong / Du, Yan

ISPRS international journal of geo-information. 2022 July 08, v. 11, no. 7

2022

Abstract: Accurate urban traffic flow prediction plays a vital role in Intelligent Transportation System (ITS). The complex long-term and long-range spatiotemporal correlations of traffic flow pose a significant challenge to the prediction task. Most current ... ...

Abstract	Accurate urban traffic flow prediction plays a vital role in Intelligent Transportation System (ITS). The complex long-term and long-range spatiotemporal correlations of traffic flow pose a significant challenge to the prediction task. Most current research methods focus only on spatial correlations in local areas, ignoring global geographic contextual information. It is challenging to capture spatial information from distant nodes using shallow graph neural networks (GNNs) to model long-range spatial correlations. To handle this problem, we design a novel spatiotemporal global semantic graph-attentive convolutional network model (STSGAN), which is a deep-level network to achieve the simultaneous modelling of spatiotemporal correlations. First, we propose a graph-attentive convolutional network (GACN) to extract the importance of different spatial features and learn the spatial correlation of local regions and the global spatial semantic information. The temporal causal convolution structure (TCN) is utilized to capture the causal relationships between long-short times, thus enabling an integrated consideration of local and overall spatiotemporal correlations. Several experiments are conducted on two real-world traffic flow datasets, and the results show that our approach outperforms several state-of-the-art baselines.
Keywords	data collection ; prediction ; spatial data ; traffic
Language	English
Dates of publication	2022-0708
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2655790-3
ISSN	2220-9964
ISSN	2220-9964
DOI	10.3390/ijgi11070381
Database	NAL-Catalogue (AGRICOLA)

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