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Article: Invertebrate genetic models of amyotrophic lateral sclerosis.

Zhou, LiJun / Xu, RenShi

2024 Volume 17, Page(s) 1328578

Abstract: Amyotrophic lateral sclerosis (ALS) is a common adult-onset neurodegenerative disease characterized by the progressive death of motor neurons in the cerebral cortex, brain stem, and spinal cord. The exact mechanisms underlying the pathogenesis of ALS ... ...

Abstract	Amyotrophic lateral sclerosis (ALS) is a common adult-onset neurodegenerative disease characterized by the progressive death of motor neurons in the cerebral cortex, brain stem, and spinal cord. The exact mechanisms underlying the pathogenesis of ALS remain unclear. The current consensus regarding the pathogenesis of ALS suggests that the interaction between genetic susceptibility and harmful environmental factors is a promising cause of ALS onset. The investigation of putative harmful environmental factors has been the subject of several ongoing studies, but the use of transgenic animal models to study ALS has provided valuable information on the onset of ALS. Here, we review the current common invertebrate genetic models used to study the pathology, pathophysiology, and pathogenesis of ALS. The considerations of the usage, advantages, disadvantages, costs, and availability of each invertebrate model will also be discussed.
Language	English
Publishing date	2024-03-04
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2452967-9
ISSN	1662-5099
ISSN	1662-5099
DOI	10.3389/fnmol.2024.1328578
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A New Cell Model Overexpressing sTGFBR3 for Studying Alzheimer's Disease in vitro.

Chen, Jiangxia / Zhou, Lijun / Zhao, Qingchun / Qi, Zhentong

Current pharmaceutical design

2024

Abstract: Background: Recent studies have suggested that abnormal microglial hyperactivation has an important role in the progression of Alzheimer's disease (AD). sTGFBR3 (a shed extracellular domain of the transforming growth factor type III receptor) is a newly ...

Abstract	Background: Recent studies have suggested that abnormal microglial hyperactivation has an important role in the progression of Alzheimer's disease (AD). sTGFBR3 (a shed extracellular domain of the transforming growth factor type III receptor) is a newly identified target of microglia polarization dysregulation, whose overexpression can cause abnormal accumulation of transforming growth factor β1 (TGF-β1), promoting Aβ, tau, and neuroinflammatory pathology. Objective: The objective of this study is to develop and validate a new cell model overexpressing sTGFBR3 for studying AD in vitro. Methods: BV2 cells (a microglial cell derived from C57/BL6 murine) were used as a cell model. Cells were then treated with different concentrations of lipopolysaccharide (LPS) (0, 1, or 0.3 μg/mL) for 12, 24, or 48h and then with or without sodium pervanadate (100 μM) for 30 min. Next, the effect surface optimization method was used to determine optimal experimental conditions. Finally, the optimized model was used to assess the effect of ZQX series compounds and vasicine on cell viability and protein expression. Expression of TGFBR3 and TNF-α was assessed using Western blot. MTT assay was used to assess cell viability, and enzyme- linked immunosorbent assay (ELISA) was employed to evaluate extracellular TGF-β1 and sTGFBR3. Results: LPS (0.3 μg/mL) treatment for 11 h at a cell density of 60% and pervanadate concentration (100 μM) incubation for 30 min were the optimal experimental conditions for increasing membrane protein TGFBR3 overexpression, as well as extracellular sTGFBR3 and TGF-β1. Applying ZQX-5 and vasicine reversed this process by reducing extracellular TGF-β1, promoting the phosphorylation of Smad2/3, a protein downstream of TGF-β1, and inhibiting the release of the inflammatory factor TNF-α. Conclusion: This new in vitro model may be a useful cell model for studying Alzheimer's disease in vitro.
Language	English
Publishing date	2024-02-15
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	1304236-1
ISSN	1873-4286 ; 1381-6128
ISSN (online)	1873-4286
ISSN	1381-6128
DOI	10.2174/0113816128278324240115104615
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Article ; Online: The learning curve of robot-assisted laparoscopic pyeloplasty in children.

Zhou, Lijun / Huang, Jin / Xie, Hua / Chen, Fang

Journal of robotic surgery

2024 Volume 18, Issue 1, Page(s) 97

Abstract: To explore the learning curve of robot-assisted laparoscopic pyeloplasty (RALP) in children. The clinical data, surgical information, and postoperative complications of consecutive cases of RALP performed by the same surgeon in Shanghai Children's ... ...

Abstract	To explore the learning curve of robot-assisted laparoscopic pyeloplasty (RALP) in children. The clinical data, surgical information, and postoperative complications of consecutive cases of RALP performed by the same surgeon in Shanghai Children's Hospital from January 2014 to July 2020 were retrospectively analyzed; the surgeon is a senior pediatric urologists who is proficient in laparoscopic pyeloplasty; the data consist of console time (CT), suture method when anastomosing ureteropelvic junction (UPJ), number of stitches (N), anastomosis time per stitch (t
MeSH term(s)	Child ; Humans ; Ureteral Obstruction/surgery ; Retrospective Studies ; Learning Curve ; Robotics ; Treatment Outcome ; Laparoscopy/methods ; Urologic Surgical Procedures/methods ; Robotic Surgical Procedures/methods ; China ; Kidney Pelvis/surgery ; Postoperative Complications/epidemiology ; Postoperative Complications/surgery
Language	English
Publishing date	2024-02-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2268283-1
ISSN	1863-2491 ; 1863-2483
ISSN (online)	1863-2491
ISSN	1863-2483
DOI	10.1007/s11701-024-01856-3
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Article: The usage and advantages of several common amyotrophic lateral sclerosis animal models.

Zhou, Lijun / Xie, Meng / Wang, Xinxin / Xu, Renshi

Frontiers in neuroscience

2024 Volume 18, Page(s) 1341109

Abstract: Amyotrophic lateral sclerosis is a fatal, multigenic, multifactorial neurodegenerative disease characterized by upper and lower motor neuron loss. Animal models are essential for investigating pathogenesis and reflecting clinical manifestations, ... ...

Abstract	Amyotrophic lateral sclerosis is a fatal, multigenic, multifactorial neurodegenerative disease characterized by upper and lower motor neuron loss. Animal models are essential for investigating pathogenesis and reflecting clinical manifestations, particularly in developing reasonable prevention and therapeutic methods for human diseases. Over the decades, researchers have established a host of different animal models in order to dissect amyotrophic lateral sclerosis (ALS), such as yeast, worms, flies, zebrafish, mice, rats, pigs, dogs, and more recently, non-human primates. Although these models show different peculiarities, they are all useful and complementary to dissect the pathological mechanisms of motor neuron degeneration in ALS, contributing to the development of new promising therapeutics. In this review, we describe several common animal models in ALS, classified by the naturally occurring and experimentally induced, pointing out their features in modeling, the onset and progression of the pathology, and their specific pathological hallmarks. Moreover, we highlight the pros and cons aimed at helping the researcher select the most appropriate among those common experimental animal models when designing a preclinical ALS study.
Language	English
Publishing date	2024-02-26
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2411902-7
ISSN	1662-453X ; 1662-4548
ISSN (online)	1662-453X
ISSN	1662-4548
DOI	10.3389/fnins.2024.1341109
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Article: Composite dietary antioxidant index is associated with reduced prevalence of metabolic syndrome but not mortality in metabolic syndrome: Results from NHANES 2001-2018.

Zhou, Qing / Zhou, Lijun / Chen, Xi / Chen, Qiuyan / Hao, Lu

Preventive medicine reports

2024 Volume 41, Page(s) 102704

Abstract: The relationship between the composite dietary antioxidant index (CDAI), a comprehensive measure of individual dietary antioxidants, and the prevalence and mortality of metabolic syndrome (MetS) remains unknown. We aimed to explore these relationships in ...

Abstract	The relationship between the composite dietary antioxidant index (CDAI), a comprehensive measure of individual dietary antioxidants, and the prevalence and mortality of metabolic syndrome (MetS) remains unknown. We aimed to explore these relationships in the National Health and Nutrition Examination Survey (NHANES). We explored these relationships using two independent cohorts. First, we addressed CDAI and the prevalence of MetS in the general population; second, we explored the association between CDAI and mortality in patients with MetS by following NHANES 2001-2018 participants through December 31, 2019. In addition, restricted cubic spline (RCS), stratified analysis, and sensitivity analysis were used for further interpretation. We included 24,514 participants aged 20-85 years, in which the prevalence of MetS was 27.61 %. CDAI was negatively and dose-responsively associated with the prevalence of MetS, however it was not associated with mortality in patients with MetS. In addition, CDAI was associated with a reduced prevalence of certain components of MetS, including dyslipidemia and central obesity. RCS showed a linear correlation between CDAI and MetS and the above components. Stratified analyses indicated that alcohol consumption was a significant influence of CDAI-MetS and that socioeconomic status and lifestyle specificity existed. Sensitivity analysis confirmed the stability of the results. CDAI was protective against the development of MetS in the general population, but not against mortality in patients with MetS. Clinicians need to develop individualized prevention strategies to reduce the development of MetS by modifying CDAI.
Language	English
Publishing date	2024-03-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	2785569-7
ISSN	2211-3355
ISSN	2211-3355
DOI	10.1016/j.pmedr.2024.102704
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Article ; Online: In Vitro Models of Amyotrophic Lateral Sclerosis.

Zhou, Lijun / Chen, Wenzhi / Jiang, Shishi / Xu, Renshi

Cellular and molecular neurobiology

2023 Volume 43, Issue 8, Page(s) 3783–3799

Abstract: Amyotrophic Lateral Sclerosis (ALS) is one of the commonest neurodegenerative diseases of adult-onset, which is characterized by the progressive death of motor neurons in the cerebral cortex, brain stem and spinal cord. The dysfunction and death of motor ...

Abstract	Amyotrophic Lateral Sclerosis (ALS) is one of the commonest neurodegenerative diseases of adult-onset, which is characterized by the progressive death of motor neurons in the cerebral cortex, brain stem and spinal cord. The dysfunction and death of motor neurons lead to the progressive muscle weakness, atrophy, fasciculations, spasticity and ultimately the whole paralysis of body. Despite the identification of several genetic mutations associated with the pathogenesis of ALS, including mutations in chromosome 9 open reading frame 72 leading to the abnormal expansion of GGGGCC repeat sequence, TAR DNA-binding protein 43, fused in sarcoma/translocated in liposarcoma, copper/zinc superoxide dismutase 1 (SOD1) and TANK-binding kinase 1, the exact mechanisms underlying the specific degeneration of motor neurons that causes ALS remain incompletely understood. At present, since the transgenic model expressed SOD1 mutants was established, multiple in vitro models of ALS have been developed for studying the pathology, pathophysiology and pathogenesis of ALS as well as searching the effective neurotherapeutics. This review reviewed the details of present established in vitro models used in studying the pathology, pathophysiology and pathogenesis of ALS. Meanwhile, we also discussed the advantages, disadvantages, cost and availability of each models.
MeSH term(s)	Animals ; Humans ; Mice ; Amyotrophic Lateral Sclerosis/metabolism ; Superoxide Dismutase-1/genetics ; Superoxide Dismutase-1/metabolism ; Disease Models, Animal ; Motor Neurons/metabolism ; Mutation/genetics ; Superoxide Dismutase/metabolism ; Mice, Transgenic
Chemical Substances	Superoxide Dismutase-1 (EC 1.15.1.1) ; Superoxide Dismutase (EC 1.15.1.1)
Language	English
Publishing date	2023-10-23
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	283404-2
ISSN	1573-6830 ; 0272-4340
ISSN (online)	1573-6830
ISSN	0272-4340
DOI	10.1007/s10571-023-01423-8
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Zs.A 1727: Show issues

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Article ; Online: HOTAIR: A potential therapeutic target in the treatment of hepatocellular carcinoma?

Zhou, Li-Jun / Tan, Jun-Ying / Zhang, Fu-Qian

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

2023 Volume 55, Issue 11, Page(s) 1581

MeSH term(s)	Humans ; Carcinoma, Hepatocellular/pathology ; Liver Neoplasms/pathology ; Cell Line, Tumor ; Hep G2 Cells ; RNA, Long Noncoding/genetics ; Gene Expression Regulation, Neoplastic ; Cell Proliferation ; Cell Movement
Chemical Substances	RNA, Long Noncoding
Language	English
Publishing date	2023-07-03
Publishing country	Netherlands
Document type	Letter ; Comment
ZDB-ID	1459373-7
ISSN	1878-3562 ; 1125-8055
ISSN (online)	1878-3562
ISSN	1125-8055
DOI	10.1016/j.dld.2023.06.027
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Zs.A 1134: Show issues

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Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Clinical efficacy of Liuweiwuling tablets in treatment of non-alcoholic fatty liver disease

ZHOU Lijun

Journal of Clinical Hepatology, Vol 31, Iss 7, Pp 1068-

a meta-analysis

2015 Volume 1072

Abstract: ObjectiveTo systematically evaluate the clinical efficacy of Liuweiwuling tablets in the treatment of non-alcoholic fatty liver disease (NAFLD), and to provide an evidence-based medicine basis for its clinical application. MethodsLiterature about ... ...

Abstract	ObjectiveTo systematically evaluate the clinical efficacy of Liuweiwuling tablets in the treatment of non-alcoholic fatty liver disease (NAFLD), and to provide an evidence-based medicine basis for its clinical application. MethodsLiterature about Liuweiwuling tablets in the treatment of NAFLD published up to January 30, 2015 was searched for in Cochrane Library, CNKI, Wanfang Data, and PubMed. And the randomized controlled trials (RCTs) of Liuweiwuling tablets combined with conventional therapy (experimental group) versus conventional therapy (control group) for NAFLD were included in the analysis. The quality of included studies was assessed, and the data were extracted. And then they were subjected to meta-analysis using RevMan 5.2 to analyze the improvements in alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transpeptidase (GGT), triglyceride (TG), clinical overall response rate, and imaging indices. ResultsA total of six RCTs were included in the analysis, involving 228 cases in the experimental group and 205 cases in the control group. The analysis results showed that the experimental group had significantly reduced levels of ALT, AST, GGT, and TG compared with the control group (standardized mean difference ［SMD］=-1.29, 95% confidence interval ［CI］: -1.69~-089, P＜0.01; SMD=-1.15, 95% CI:-1.85~-0.45, P＜0.01; SMD=-1.47, 95% CI: -1.68~-1.25, P＜0.01; SMD=-0.48, 95% CI: -0.60~-0.35, P＜0.01). The experimental group had significantly higher clinical overall response rate and better improvements in imaging indices than the control group (relative risk ［RR］=1.48, 95% CI: 1.29-1.70, P＜001; RR=1.43, 95% CI: 1.21-1.68, P＜0.01). ConclusionFor patients with NAFLD, Liuweiwuling tablets combined with conventional therapy can significantly improve the liver function, reduce the blood lipid level, and increase the clinical overall response rate. However, since the quality of included literature is low, the reliability of the current meta-analysis conclusions should be further verified.
Keywords	fatty liver; Liuweiwuling Tablet; treatment outcome; Meta-analysis ; Medicine (General) ; R5-920 ; Medicine ; R
Subject code	610
Language	Chinese
Publishing date	2015-07-01T00:00:00Z
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Evaluation of a novel lysis-based sample processing method to optimize Vibrio vulnificus detecting by loop-mediated isothermal amplification assay.

Zhang, Lei / Liu, Jianfei / Qin, Kewei / Wu, Chenglin / Ma, Hui / Zhou, Lijun

BMC microbiology

2024 Volume 24, Issue 1, Page(s) 37

Abstract: Background: Vibrio vulnificus exists as one of the most serious foodborne pathogens for humans, and rapid and sensitive detection methods are needed to control its infections. As an emerging method, The Loop-Mediated Isothermal Amplification (LAMP) ... ...

Abstract	Background: Vibrio vulnificus exists as one of the most serious foodborne pathogens for humans, and rapid and sensitive detection methods are needed to control its infections. As an emerging method, The Loop-Mediated Isothermal Amplification (LAMP) assay has been applied to the early detection of various foodborne pathogens due to its high efficiency, but sample preprocessing still prolongs the complete detection. To optimize the detection process, our study established a novel sample preprocessing method that was more efficient compared to common methods. Result: Using V. vulnificus as the detecting pathogen, the water-lysis-based detecting LAMP method shortened the preprocessing time to ≤ 1 min with 100% LAMP specificity; the detection limits of the LAMP assay were decreased to 1.20 × 10 Conclusion: Our study provided a novel LAMP preprocessing method that was more efficient compared to common methods and possessed the practical potential for LAMP application in the future.
MeSH term(s)	Humans ; Vibrio vulnificus/genetics ; Nucleic Acid Amplification Techniques/methods ; Water ; Specimen Handling ; Sensitivity and Specificity ; Molecular Diagnostic Techniques
Chemical Substances	Water (059QF0KO0R)
Language	English
Publishing date	2024-01-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2041505-9
ISSN	1471-2180 ; 1471-2180
ISSN (online)	1471-2180
ISSN	1471-2180
DOI	10.1186/s12866-024-03186-8
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Article: Copper homeostasis and cuproptosis in atherosclerosis: metabolism, mechanisms and potential therapeutic strategies.

Yang, Shengjie / Li, Yujuan / Zhou, Lijun / Wang, Xinyue / Liu, Longtao / Wu, Min

Cell death discovery

2024 Volume 10, Issue 1, Page(s) 25

Abstract: Copper is an essential micronutrient that plays a pivotal role in numerous physiological processes in virtually all cell types. Nevertheless, the dysregulation of copper homeostasis, whether towards excess or deficiency, can lead to pathological ... ...

Abstract	Copper is an essential micronutrient that plays a pivotal role in numerous physiological processes in virtually all cell types. Nevertheless, the dysregulation of copper homeostasis, whether towards excess or deficiency, can lead to pathological alterations, such as atherosclerosis. With the advent of the concept of copper-induced cell death, termed cuproptosis, researchers have increasingly focused on the potential role of copper dyshomeostasis in atherosclerosis. In this review, we provide a broad overview of cellular and systemic copper metabolism. We then summarize the evidence linking copper dyshomeostasis to atherosclerosis and elucidate the potential mechanisms underlying atherosclerosis development in terms of both copper excess and copper deficiency. Furthermore, we discuss the evidence for and mechanisms of cuproptosis, discuss its interactions with other modes of cell death, and highlight the role of cuproptosis-related mitochondrial dysfunction in atherosclerosis. Finally, we explore the therapeutic strategy of targeting this novel form of cell death, aiming to provide some insights for the management of atherosclerosis.
Language	English
Publishing date	2024-01-13
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2058-7716
ISSN	2058-7716
DOI	10.1038/s41420-023-01796-1
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