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Article ; Online: Microfluidic-Assisted Self-Assembly of 2D Nanosheets toward in situ Generation of Robust Nanofiber Film.

Zhou, Liangliang / Han, Jingtao / Xiao, Jijun / Yang, Xiaoning / Chen, Su

Small (Weinheim an der Bergstrasse, Germany)

2023 Volume 19, Issue 33, Page(s) e2301310

Abstract: Methods allow the enhancement of nanofibers via self-assembly are potentially important for new disciplines with many advantages, including multi-anchor interaction, intrinsic mechanical properties and versatility. Herein, a microfluidic-assisted self- ... ...

Abstract	Methods allow the enhancement of nanofibers via self-assembly are potentially important for new disciplines with many advantages, including multi-anchor interaction, intrinsic mechanical properties and versatility. Herein, a microfluidic-assisted self-assembly process to construct hydroxyl functionalized boron nitride nanosheets (OH-BNNS)/graphene oxide (GO)/thermoplastic polyurethane (TPU) composite nanofiber film, in which stable and precisely controlled self-assembly is fulfilled by the confined ultra-small-volume chip is demonstrated. Multiple fine structural analyses alongside with the density-functional theory (DFT) calculations are implemented to confirm the synergistic effect of noncovalent interactions (hydrogen bonding interaction, π - π stacking interaction, and van der Waals attraction) plays a critical role in the robust micro-structure and a massive 700% enhancement of mechanical strength via adding only 0.3 wt% OH-BNNS and GO. Importantly, profiled from broadband optical absorption ability, robust mechanical properties and outstanding flexibility, the self-assembled 3D OH-BNNS/GO/TPU nanofiber film reveals an adorable evaporation rate of 4.04 kg m
Language	English
Publishing date	2023-04-20
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2168935-0
ISSN	1613-6829 ; 1613-6810
ISSN (online)	1613-6829
ISSN	1613-6810
DOI	10.1002/smll.202301310
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Behavioral abnormalities in C57BL/6 mice with chronic ulcerative colitis induced by DSS.

Zhou, Yuxin / Ji, Gang / Yang, Xiaoyi / Chen, Zhenhua / Zhou, Liangliang

BMC gastroenterology

2023 Volume 23, Issue 1, Page(s) 84

Abstract: Background: Clinical epidemiological studies have found that some patients with ulcerative colitis (UC) are prone to mental disorders. DSS-induced acute and chronic UC models are often used to evaluate the efficacy of anti-UC drugs. However, whether DSS ...

Abstract	Background: Clinical epidemiological studies have found that some patients with ulcerative colitis (UC) are prone to mental disorders. DSS-induced acute and chronic UC models are often used to evaluate the efficacy of anti-UC drugs. However, whether DSS has an effect on mouse behavior has not been reported. Methods: Acute and chronic UC models were induced by 3% DSS and 1.5% DSS, respectively. The bloody stool, the changes in the colon length, and histopathological changes in the colon were used to evaluate the success of the animal model. The behavior of mice was evaluated by open field experiment, tail suspension experiment and Sucrose preference test. Results: The weight of mice in 3% DSS group decreased significantly, the DAI score increased significantly, the colon length of mice was significantly shortened, and the structure of colonic crypts was abnormal, which showed inflammatory cell infiltration and shrinkage of crypts. Compared with the control group, the immobility time of 3%DSS group mice in the tail suspension test and forced swimming test had no effect, the number of running and grooming times was significantly reduced, and there was no significant difference in the number of standing times. No abnormality was observed in HE staining of the hippocampus. However, in 1.5% DSS-induced chronic UC model, behavioral and hippocampal abnormalities were observed not only UC symptoms. Conclusions: The acute UC model induced by 3% DSS has certain influence on the behavior of mice, but the mental state of mice is normal, which may be the abnormal behavior caused by UC symptoms; However, the chronic UC model induced by 1.5% DSS has a significant effect on the behavior of mice, and the mice have mental disorders, which are caused by mental disorders.
MeSH term(s)	Animals ; Mice ; Colitis, Ulcerative/chemically induced ; Colitis, Ulcerative/pathology ; Mice, Inbred C57BL ; Colon/pathology ; Disease Models, Animal ; Dextran Sulfate/adverse effects ; Colitis/chemically induced
Chemical Substances	Dextran Sulfate (9042-14-2)
Language	English
Publishing date	2023-03-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2041351-8
ISSN	1471-230X ; 1471-230X
ISSN (online)	1471-230X
ISSN	1471-230X
DOI	10.1186/s12876-023-02718-2
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Article: [Research progress of coarse-grained molecular dynamics in drug carrier materials].

Zhang, Minquan / Gong, Mingcheng / Wang, Jin / Chen, Zhenhua / Zhou, Liangliang

Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi

2023 Volume 40, Issue 4, Page(s) 799–804

Abstract: As one of the traditional computer simulation techniques, molecular simulation can intuitively display and quantify molecular structure and explain experimental phenomena from the microscopic molecular level. When the simulation system increases, the ... ...

Abstract	As one of the traditional computer simulation techniques, molecular simulation can intuitively display and quantify molecular structure and explain experimental phenomena from the microscopic molecular level. When the simulation system increases, the amount of calculation will also increase, which will cause a great burden on the simulation system. Coarse-grained molecular dynamics is a method of mesoscopic molecular simulation, which can simplify the molecular structure and improve computational efficiency, as a result, coarse-grained molecular dynamics is often used when simulating macromolecular systems such as drug carrier materials. In this article, we reviewed the recent research results of using coarse-grained molecular dynamics to simulate drug carriers, in order to provide a reference for future pharmaceutical preparation research and accelerate the entry of drug research into the era of precision drug design.
MeSH term(s)	Molecular Dynamics Simulation ; Drug Carriers
Chemical Substances	Drug Carriers
Language	Chinese
Publishing date	2023-09-04
Publishing country	China
Document type	Review ; English Abstract ; Journal Article
ZDB-ID	2576847-5
ISSN	1001-5515
ISSN	1001-5515
DOI	10.7507/1001-5515.202303008
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Article ; Online: Endoplasmic reticulum stress in innate immune cells - a significant contribution to non-alcoholic fatty liver disease.

Zhou, Liangliang / Shen, Haiyuan / Li, Xiaofeng / Wang, Hua

Frontiers in immunology

2022 Volume 13, Page(s) 951406

Abstract: Liver disease and its complications affect millions of people worldwide. NAFLD (non-alcoholic fatty liver disease) is the liver disease associated with metabolic dysfunction and consists of four stages: steatosis with or without mild inflammation (NAFLD), ...

Abstract	Liver disease and its complications affect millions of people worldwide. NAFLD (non-alcoholic fatty liver disease) is the liver disease associated with metabolic dysfunction and consists of four stages: steatosis with or without mild inflammation (NAFLD), non-alcoholic steatohepatitis (NASH), fibrosis, and cirrhosis. With increased necroinflammation and progression of liver fibrosis, NAFLD may progress to cirrhosis or even hepatocellular carcinoma. Although the underlying mechanisms have not been clearly elucidated in detail, what is clear is that complex immune responses are involved in the pathogenesis of NASH, activation of the innate immune system is critically involved in triggering and amplifying hepatic inflammation and fibrosis in NAFLD/NASH. Additionally, disruption of endoplasmic reticulum (ER) homeostasis in cells, also known as ER stress, triggers the unfolded protein response (UPR) which has been shown to be involved to inflammation and apoptosis. To further develop the prevention and treatment of NAFLD/NASH, it is imperative to clarify the relationship between NAFLD/NASH and innate immune cells and ER stress. As such, this review focuses on innate immune cells and their ER stress in the occurrence of NAFLD and the progression of cirrhosis.
MeSH term(s)	Endoplasmic Reticulum Stress/physiology ; Humans ; Immunity, Innate ; Inflammation/metabolism ; Liver Cirrhosis/complications ; Liver Neoplasms ; Non-alcoholic Fatty Liver Disease/pathology
Language	English
Publishing date	2022-07-22
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.951406
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Article ; Online: The enantioselective environmental fate of mandipropamid in water-sediment microcosms: Distribution, degradation, degradation pathways and toxicity assessment

Zhang, Jing / Li, Yanhong / Tan, Yuting / Zhang, Yu / Li, Rui / Zhou, Liangliang / Wang, Minghua

Science of the Total Environment. 2023 Sept., v. 891 p.164650-

2023

Abstract: Mandipropamid (MDP) is a chiral fungicide that has been widely used to control oomycete pathogens. Currently, a comprehensive study of its environmental fate in aquatic ecosystems at the enantiomer level is still lacking. Here, the enantioselective ... ...

Abstract	Mandipropamid (MDP) is a chiral fungicide that has been widely used to control oomycete pathogens. Currently, a comprehensive study of its environmental fate in aquatic ecosystems at the enantiomer level is still lacking. Here, the enantioselective environmental behaviors of MDP in four types of water-sediment microcosms were investigated. The concentrations of MDP enantiomers decreased over time in water due to sedimentation and degradation, while the concentrations in sediment increased to a peak and then slowly decreased because of adsorption and degradation. There were no enantioselective distribution behaviors in all kinds of microcosms. Moreover, R-MDP was preferentially degraded in lake water and Yangtze River water with half-lives of 5.92 d and 25.67 d, respectively. S-MDP was preferentially degraded in Yangtze River sediments, Yellow River sediments, and Yangtze River microcosm system, with half-lives ranging from 36.47 d to 77 d. Five degradation products of MDP in the sediment via hydrolysis and reduction were identified, and potential degradation pathways were proposed. Ecological Structure Activity Relationships (ECOSAR) prediction showed that the acute and chronic toxicities of all the products were higher than those of MDP except CGA 380778, which might pose a potential threat to aquatic ecosystems. This result offers new insights into the fate of chiral MDP in water-sediment ecosystems and will be conducive to the environmental and ecological risk assessment of MDP.
Keywords	Oomycetes ; adsorption ; enantiomers ; enantioselectivity ; environment ; environmental assessment ; environmental fate ; half life ; hydrolysis ; lakes ; mandipropamid ; prediction ; river water ; sediments ; toxicity ; Yangtze River ; Yellow River ; Degradation pathways ; Ecological risk
Language	English
Dates of publication	2023-09
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2023.164650
Database	NAL-Catalogue (AGRICOLA)

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Article: Quality Evaluation of

Chen, Long / Liu, Suzhen / Feng, Shuhan / Zhou, Liangliang / Chen, Zhenhua

Journal of analytical methods in chemistry

2022 Volume 2022, Page(s) 6777409

Abstract: Chinese medicine extracts are complex in composition. The combination of the quantitative analysis of multicomponents by single marker (QAMS) and the systematic quantified fingerprint method (SQFM) can be used for better quantitative analysis. The ... ...

Abstract	Chinese medicine extracts are complex in composition. The combination of the quantitative analysis of multicomponents by single marker (QAMS) and the systematic quantified fingerprint method (SQFM) can be used for better quantitative analysis. The contents of
Language	English
Publishing date	2022-03-09
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	2654178-6
ISSN	2090-8873 ; 2090-8865
ISSN (online)	2090-8873
ISSN	2090-8865
DOI	10.1155/2022/6777409
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Article ; Online: Retraction Notice to "Vascular permeability and hemodynamic effects of ulinastatin on organs affected by shock during early burn injury" [The American Journal of Emergency Medicine, 37/2 (2019), 249-253].

Li, Shiyan / Yang, Weixi / Zhou, Liangliang / Nie, Dekang / Yu, Haizhou

The American journal of emergency medicine

2022 Volume 60, Page(s) 230

Language	English
Publishing date	2022-09-28
Publishing country	United States
Document type	Journal Article ; Retraction of Publication
ZDB-ID	605890-5
ISSN	1532-8171 ; 0735-6757
ISSN (online)	1532-8171
ISSN	0735-6757
DOI	10.1016/j.ajem.2022.07.003
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Zs.A 2005: Show issues

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Article ; Online: Neutrophil-to-Lymphocyte ratio on admission predicts gastrointestinal bleeding in acute basal ganglia hemorrhage.

Jiang, Xuewei / Zhou, Liangliang / Chen, Yinuo / Tang, Yuqing / Jiang, Xiaodong

Journal of clinical laboratory analysis

2022 Volume 36, Issue 10, Page(s) e24679

Abstract: Background: Gastrointestinal bleeding (GIB) is a potential contributing factor for poor prognosis of spontaneous basal ganglia hemorrhage (BGH). This study aimed to investigate the predictive value of new inflammatory biomarkers including neutrophil to ... ...

Abstract	Background: Gastrointestinal bleeding (GIB) is a potential contributing factor for poor prognosis of spontaneous basal ganglia hemorrhage (BGH). This study aimed to investigate the predictive value of new inflammatory biomarkers including neutrophil to lymphocytes (NLR) on admission and construct a nomogram for rapidly predicting GIB in acute BGH. Methods: The retrospective study included all patients with acute BGH admitted from the emergency department in Huashan Hospital from July 2017 to January 2019. Multivariate analysis was conducted to evaluate the correlation between factors within 24 h and the occurrence of GIB within 7 days after BGH. The receiver operating characteristic (ROC) curve was performed to estimate the prediction ability of inflammatory biomarkers. A nomogram based on significant predictors was validated by ROC curve and calibration curve. Results: A total of 122 patients were enrolled in this study, and the incidence of GIB was 23.0%. Patients with GIB had larger hematoma volume (≥30 ml), lower Glasgow Coma Scale (GCS) score (≤8) and increased inflammatory biomarkers on admission. ROC curve revealed that NLR had a high predictive value to the complication (area under the curve = 0.87). According to multivariate analysis, NLR, GCS score, and hematoma volume were main factors for nomogram, with good calibration and discrimination. Conclusions: Neutrophil-to-lymphocyte ratio and GCS score within 24 h after the onset of acute BGH are the independent risk factors for GIB. The nomogram developed by these predictors may assist surgeons in rapidly assessing and preventing of GIB for BGH patients in earlier stage.
MeSH term(s)	Basal Ganglia Hemorrhage ; Biomarkers ; Gastrointestinal Hemorrhage/epidemiology ; Hematoma ; Humans ; Lymphocytes ; Neutrophils ; Prognosis ; ROC Curve ; Retrospective Studies
Chemical Substances	Biomarkers
Language	English
Publishing date	2022-08-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	645095-7
ISSN	1098-2825 ; 0887-8013
ISSN (online)	1098-2825
ISSN	0887-8013
DOI	10.1002/jcla.24679
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Zs.A 2471: Show issues

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Article ; Online: Enantioselective aquatic toxicity and degradation in soil of the chiral fungicide oxathiapiprolin.

Zhou, Liangliang / Wu, Qiqi / Gao, Yingying / Shi, Haiyan / Wang, Minghua

The Science of the total environment

2022 Volume 836, Page(s) 155632

Abstract: Oxathiapiprolin is an efficient and chiral fungicide for peronosporomycetes. The enantioselective environmental behavior and ecotoxicity of oxathiapiprolin are still unclear. The enantioselectivity of oxathiapiprolin enantiomers was explored, including ... ...

Abstract	Oxathiapiprolin is an efficient and chiral fungicide for peronosporomycetes. The enantioselective environmental behavior and ecotoxicity of oxathiapiprolin are still unclear. The enantioselectivity of oxathiapiprolin enantiomers was explored, including their acute toxicity toward aquatic plants (Auxenochlorella pyrenoidosa and Soirodela polyrhiza) along with their influence on photosynthetic pigment production, the acute toxicity and morphological differences for the embryos, larvae and adult stages of zebrafish (Danio rerio), and the degradation in four typical soils (aerobic, anaerobic and sterilized conditions). The enantioselective toxicity of oxathiapiprolin showed that the toxicity of R-oxathiapiprolin was 1.8-2.1 times higher than that of S-oxathiapiprolin toward the two aquatic plants. In particular, the content of photosynthetic pigments decreased significantly stronger after exposure to R-oxathiapiprolin compared with S-oxathiapiprolin. The LC
MeSH term(s)	Animals ; Fungicides, Industrial/analysis ; Fungicides, Industrial/toxicity ; Hydrocarbons, Fluorinated ; Pyrazoles ; Soil ; Stereoisomerism ; Zebrafish
Chemical Substances	Fungicides, Industrial ; Hydrocarbons, Fluorinated ; Pyrazoles ; Soil ; oxathiapiprolin (56498AIV8R)
Language	English
Publishing date	2022-05-04
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2022.155632
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Zs.A 949: Show issues

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Article ; Online: Combined toxicity of acetamiprid and cadmium to larval zebrafish (Danio rerio) based on metabolomic analysis.

Hu, Guixian / Wang, Hao / Zhu, Jiahong / Zhou, Liangliang / Li, Xue / Wang, Qiang / Wang, Yanhua

The Science of the total environment

2023 Volume 867, Page(s) 161539

Abstract: Emerging contaminants, such as neonicotinoid pesticide acetamiprid (Ace), are frequently detected in the water environment, which can interact with existing heavy metal cadmium (Cd) to produce unpredicted influence. Limited studies have evaluated the ... ...

Abstract	Emerging contaminants, such as neonicotinoid pesticide acetamiprid (Ace), are frequently detected in the water environment, which can interact with existing heavy metal cadmium (Cd) to produce unpredicted influence. Limited studies have evaluated the effects of multiple pollutant exposures on aquatic animals. Here, we characterized the joint toxicity of Ace and Cd exposure to zebrafish (Danio rerio). The results revealed that Cd and its combined exposure with Ace had an inhibitory effect on the growth of larval zebrafish and induced morphological defects. Combined exposure to high doses of Ace and Cd could significantly reduce the levels of TG, glucose, and pyruvate in larval zebrafish. Untargeted metabolomics revealed that Cd treatment (285) produced more differentially expressed metabolites (DEMs) than Ace treatment (115), and combined treatment produced the most DEMs (294). The KEGG pathway enrichment analysis showed that they could disrupt riboflavin metabolism, amino acid metabolism, and glycolipid metabolism in the larvae of D. rerio. ELISA showed that VB2, FMN, and FAD levels were significantly increased. In addition, gene expression analysis exhibited that the mRNA levels of essential genes related to glycolipid metabolism were substantially affected, such as PK, PEPckc, PPAR-α, and FABP6. Furthermore, targeted amino acid metabolomics confirmed that both single exposure to Cd and combined exposure to Ace and Cd altered the levels of amino acids in larvae, including ALA, ARG, MET, PRO, TYR, VAL, GLY, ORN, and PHE. Taken together, exposure to Ace and Cd, alone or in combination, exerted harmful effects on the individual development, riboflavin metabolism, glycolipid metabolism, and amino acid metabolism disorder of D. rerio. These findings highlighted that more attention should be paid to the compound toxicity of chemical mixtures to aquatic organisms.
MeSH term(s)	Animals ; Zebrafish/metabolism ; Cadmium/metabolism ; Larva ; Neonicotinoids/toxicity ; Neonicotinoids/metabolism ; Amino Acids/metabolism ; Glycolipids/metabolism ; Riboflavin ; Water Pollutants, Chemical/metabolism
Chemical Substances	Cadmium (00BH33GNGH) ; acetamiprid (5HL5N372P0) ; Neonicotinoids ; Amino Acids ; Glycolipids ; Riboflavin (TLM2976OFR) ; Water Pollutants, Chemical
Language	English
Publishing date	2023-01-13
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2023.161539
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