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  1. Article ; Online: Colon perforation caused by the shunt tube after the operation for normal-pressure-hydrocephalus: A case report.

    Huang, Keru / He, Jiaojiang / Zhou, Liangxue

    Asian journal of surgery

    2023  Volume 47, Issue 3, Page(s) 1705–1706

    MeSH term(s) Humans ; Hydrocephalus/complications ; Hydrocephalus/surgery ; Colonic Diseases ; Intestinal Perforation/etiology ; Intestinal Perforation/surgery
    Language English
    Publishing date 2023-12-21
    Publishing country Netherlands
    Document type Case Reports ; Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2023.12.044
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  2. Article ; Online: IL4I1 in M2-like macrophage promotes glioma progression and is a promising target for immunotherapy.

    Ye, Feng / Wang, Lichong / Li, Yuanyou / Dong, Chengyuan / Zhou, Liangxue / Xu, Jianguo

    Frontiers in immunology

    2024  Volume 14, Page(s) 1338244

    Abstract: Background: Glioma is the prevailing malignant intracranial tumor, characterized by an abundance of macrophages. Specifically, the infiltrating macrophages often display the M2 subtype and are known as tumor-associated macrophages (TAMs). They have a ... ...

    Abstract Background: Glioma is the prevailing malignant intracranial tumor, characterized by an abundance of macrophages. Specifically, the infiltrating macrophages often display the M2 subtype and are known as tumor-associated macrophages (TAMs). They have a critical role in promoting the oncogenic properties of tumor cells. Interleukin-4-induced-1 (IL4I1) functions as an L-phenylalanine oxidase, playing a key part in regulating immune responses and the progression of various tumors. However, there is limited understanding of the IL4I1-mediated cross-talk function between TAMs and glioma cell in the glioma microenvironment.
    Methods: TCGA, GTEx, and HPA databases were applied to assess the IL4I1 expression, clinical characteristics, and prognostic value of pan-cancer. The link between IL4I1 levels and the prognosis, methylation, and immune checkpoints (ICs) in gliomas were explored through Kaplan-Meier curve, Cox regression, and Spearman correlation analyses. The IL4I1 levels and their distribution were investigated by single-cell analysis and the TIMER 2 database. Additionally, validation of IL4I1 expression was performed by WB, RT-qPCR, IHC, and IF. Co-culture models between glioma cells and M2-like macrophages were used to explore the IL4I1-mediated effects on tumor growth, invasion, and migration of glioma cells. Moreover, the function of IL4I1 on macrophage polarization was evaluated by ELISA, RT-qPCR, WB, and siRNA transfection.
    Results: Both transcriptome and protein levels of IL4I1 were increased obviously in various tumor types, and correlated with a dismal prognosis. Specifically, IL4I1 was implicated in aggressive progression and a dismal prognosis for patients with glioma. A negative association was noticed between the glioma grade and DNA promoter methylation of IL4I1. Enrichment analyses in glioma patients suggested that IL4I1 was linked to cytokine and immune responses, and was positively correlated with ICs. Single-cell analysis, molecular experiments, and
    Conclusion: IL4I1 could be a promising immunotherapy target for selective modulation of TAMs and stands as a novel macrophage-related prognostic biomarker in glioma.
    MeSH term(s) Humans ; Macrophages ; Glioma/genetics ; Glioma/therapy ; Tumor-Associated Macrophages ; Brain Neoplasms/genetics ; Brain Neoplasms/therapy ; Immunotherapy ; Tumor Microenvironment ; L-Amino Acid Oxidase
    Chemical Substances IL4I1 protein, human (EC 1.4.3.2) ; L-Amino Acid Oxidase (EC 1.4.3.2)
    Language English
    Publishing date 2024-01-05
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1338244
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  3. Article ; Online: Advances in objective assessment of ergonomics in endoscopic surgery: a review.

    Liu, Shuang / Li, Yuan-You / Li, Dan / Wang, Feng-Yi / Fan, Ling-Jie / Zhou, Liang-Xue

    Frontiers in public health

    2024  Volume 11, Page(s) 1281194

    Abstract: Background: Minimally invasive surgery, in particular endoscopic surgery, has revolutionized the benefits for patients, but poses greater challenges for surgeons in terms of ergonomics. Integrating ergonomic assessments and interventions into the multi- ... ...

    Abstract Background: Minimally invasive surgery, in particular endoscopic surgery, has revolutionized the benefits for patients, but poses greater challenges for surgeons in terms of ergonomics. Integrating ergonomic assessments and interventions into the multi-stage endoscopic procedure contributes to the surgeon's musculoskeletal health and the patient's intraoperative safety and postoperative recovery.
    Objective: The purpose of this study was to overview the objective assessment techniques, tools and assessment settings involved in endoscopic procedures over the past decade and to identify the potential factors that induce differences in high workloads in endoscopic procedures and ultimately to design a framework for ergonomic assessment in endoscopic surgery.
    Methods: Literature searches were systematically conducted in the OVID, pubmed and web of science database before October 2022, and studies evaluating ergonomics during the process of endoscopic procedures or simulated procedures were both recognized.
    Results: Our systematic review of 56 studies underscores ergonomic variations in endoscopic surgery. While endoscopic procedures, predominantly laparoscopy, typically incur less physical load than open surgery, extended surgical durations notably elevate ergonomic risks. Surgeon characteristics, such as experience level and gender, significantly influence these risks, with less experienced and female surgeons facing greater challenges. Key assessment tools employed include electromyography for muscle fatigue and motion analysis for postural evaluation.
    Conclusion: This review aims to provide a comprehensive analysis and framework of objective ergonomic assessments in endoscopic surgery, and suggesting avenues for future research and intervention strategies. By improving the ergonomic conditions for surgeons, we can enhance their overall health, mitigate the risk of WMSDs, and ultimately improve patient outcomes.
    MeSH term(s) Humans ; Female ; Endoscopy ; Databases, Factual ; Ergonomics ; Workload
    Language English
    Publishing date 2024-01-05
    Publishing country Switzerland
    Document type Systematic Review
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2023.1281194
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  4. Article ; Online: Letter to the Editor Regarding "A Predictive Nomogram for Postoperative Hydrocephalus After Intra- and Paraventricular Tumor Resection: A Retrospective Study of 196 Patients".

    Huang, Keru / Ran, Yang / Deng, Ziang / Liu, Yu / Zhou, Liangxue

    World neurosurgery

    2023  Volume 170, Page(s) 252–253

    MeSH term(s) Humans ; Retrospective Studies ; Nomograms ; Hydrocephalus/surgery ; Postoperative Complications ; Neoplasms
    Language English
    Publishing date 2023-02-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2022.10.124
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  5. Article ; Online: Primary versus secondary endoscopic ventriculostomy for patients with obstructive hydrocephalus: A meta-analysis and systematic review.

    Huang, Keru / Zhou, Liangxue / Liu, Yu

    Asian journal of surgery

    2022  Volume 46, Issue 4, Page(s) 1837–1838

    MeSH term(s) Humans ; Ventriculostomy ; Hydrocephalus/surgery ; Endoscopy ; Patients ; Neuroendoscopy ; Treatment Outcome
    Language English
    Publishing date 2022-11-02
    Publishing country Netherlands
    Document type Meta-Analysis ; Letter ; Systematic Review
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2022.10.060
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  6. Article: Treatment of Familial Hypercholesterolemia with Intracranial Xanthoma: Case Report.

    Kou, XiaoBo / Liu, LunXin / Zhou, LiangXue

    Frontiers in surgery

    2022  Volume 9, Page(s) 875422

    Abstract: Intracranial xanthoma is a rare benign intracranial tumor. It often occurs in patients with hyperlipidemia. Intracranial xanthomas grow slowly, and clinical symptoms only appear when the mass compresses the surrounding tissues, so early diagnosis of the ... ...

    Abstract Intracranial xanthoma is a rare benign intracranial tumor. It often occurs in patients with hyperlipidemia. Intracranial xanthomas grow slowly, and clinical symptoms only appear when the mass compresses the surrounding tissues, so early diagnosis of the disease is difficult.
    Language English
    Publishing date 2022-05-03
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2773823-1
    ISSN 2296-875X
    ISSN 2296-875X
    DOI 10.3389/fsurg.2022.875422
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  7. Article ; Online: Healthcare economics of hydrocephalus: A single-center experience.

    Huang, Keru / Ziang, Deng / Zhou, Liangxue

    Asian journal of surgery

    2022  Volume 46, Issue 5, Page(s) 2176–2177

    MeSH term(s) Humans ; Hydrocephalus/surgery ; Retrospective Studies ; Delivery of Health Care
    Language English
    Publishing date 2022-11-28
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2022.11.083
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  8. Article ; Online: Effect of endoscopic craniopharyngioma resection with pituitary-stalk preservation on symptom relief and surgical complications.

    Huang, Keru / Liu, Yu / Zhou, Liangxue

    Asian journal of surgery

    2022  Volume 46, Issue 4, Page(s) 1869–1870

    MeSH term(s) Humans ; Craniopharyngioma/surgery ; Craniopharyngioma/complications ; Craniopharyngioma/diagnosis ; Pituitary Gland/surgery ; Pituitary Neoplasms/surgery ; Endoscopy/adverse effects ; Postoperative Complications/etiology ; Postoperative Complications/prevention & control ; Postoperative Complications/surgery ; Neuroendoscopy/adverse effects
    Language English
    Publishing date 2022-11-01
    Publishing country China
    Document type Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2022.10.075
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  9. Article ; Online: The current status of diagnosis, treatment, and hospital information for hydrocephalus: A single medical center experience.

    Huang, Keru / Zhou, Liangxue / Ran, Yang

    Asian journal of surgery

    2022  Volume 46, Issue 4, Page(s) 1854–1855

    MeSH term(s) Humans ; Hydrocephalus/diagnosis ; Hydrocephalus/surgery ; Retrospective Studies ; Hospitals
    Language English
    Publishing date 2022-11-01
    Publishing country China
    Document type Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2022.10.061
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  10. Article ; Online: Anterior endoscopic transcortical approach to a pineal region cavernous hemangioma.

    Li, Jiuhong / He, Jiaojiang / Liu, Lunxin / Zhou, Liangxue

    Neurosurgical focus: Video

    2021  Volume 5, Issue 1, Page(s) V15

    Abstract: A 57-year-old female presented with headache and dizziness for 3 months. Preoperative MRI revealed a lesion located at the pineal region and back side of the third ventricle, accompanied by hydrocephalus. The infratentorial supracerebellar approach may ... ...

    Abstract A 57-year-old female presented with headache and dizziness for 3 months. Preoperative MRI revealed a lesion located at the pineal region and back side of the third ventricle, accompanied by hydrocephalus. The infratentorial supracerebellar approach may cause visuomotor, acousticomotor, and hearing disturbances. With the patient in a supine position, the authors used a frontal linear incision that was 3 cm anterior to the coronal suture and 2 cm away from the midline and an anterior endoscopic transcortical approach, which could achieve endoscopic third ventriculostomy, alleviating and preventing hydrocephalus due to postoperative adhesion and resection of the lesion at the same time. The pathological diagnosis was cavernous hemangioma. The video can be found here: https://stream.cadmore.media/r10.3171/2021.4.FOCVID215.
    Language English
    Publishing date 2021-07-01
    Publishing country United States
    Document type Journal Article
    ISSN 2643-5217
    ISSN (online) 2643-5217
    DOI 10.3171/2021.4.FOCVID215
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