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  1. Article ; Online: Highly Efficient Photodynamic Therapy with Mitochondria-Targeting Aggregation-Induced Emission Photosensitizer for Retinoblastoma.

    Zhou, Lingbo / Chen, Luojia / Chen, Sijie / Pu, Zeyuan / Gu, Meijia / Shen, Yin

    Advanced healthcare materials

    2022  Volume 12, Issue 3, Page(s) e2202219

    Abstract: Retinoblastoma (RB) is an aggressive eye cancer in infancy and childhood, lethal by metastasis if left untreated. Currently, the survival rate and the chance of saving vision depend on the severity of the disease. In this work, a highly efficient ... ...

    Abstract Retinoblastoma (RB) is an aggressive eye cancer in infancy and childhood, lethal by metastasis if left untreated. Currently, the survival rate and the chance of saving vision depend on the severity of the disease. In this work, a highly efficient photodynamic ophthalmic therapy for RB is reported by employing an isoquinolinium-based aggregation-induced-emission (AIE) photosensitizer (PS) TPE-IQ-2O for photodynamic inactivation (PDI). TPE-IQ-2O is an efficient mitochondria-targeting photosensitizer as an efficient guided photodynamic therapy (PDT) agent against cancer cells. Maximizing cancer-selectively damage to tumors with minimized side effects on normal tissue is essential for effective anticancer PDT and provides long-lasting protection against metastasis. In addition, TPE-IQ-2O can effectively reduce the degree of tissue inflammation by inhibiting the expression of related inflammatory factors. TPE-IQ-2O also exhibits excellent biocompatibility with a neglectable hemolysis effect on mouse red blood cells and almost no killing effect on mammalian cells, which enables its potential applications in the treatment of RB.
    MeSH term(s) Animals ; Mice ; Photosensitizing Agents/pharmacology ; Retinoblastoma/drug therapy ; Photochemotherapy ; Retinal Neoplasms/drug therapy ; Mitochondria ; Mammals
    Chemical Substances Photosensitizing Agents
    Language English
    Publishing date 2022-11-06
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2649576-4
    ISSN 2192-2659 ; 2192-2640
    ISSN (online) 2192-2659
    ISSN 2192-2640
    DOI 10.1002/adhm.202202219
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Rhizosphere soil properties of waxy sorghum under different row ratio configurations in waxy sorghum-soybean intercropping systems.

    Shao, Mingbo / Wang, Can / Zhou, Lingbo / Peng, Fangli / Zhang, Guobing / Gao, Jie / Chen, Siyu / Zhao, Qiang

    PloS one

    2023  Volume 18, Issue 7, Page(s) e0288076

    Abstract: To overcome the continuous planting obstacle and promote the sustainable production of waxy sorghum, a two-years field experiment was performed to determine the responses of waxy sorghum rhizosphere soil properties to different row ratio configurations ... ...

    Abstract To overcome the continuous planting obstacle and promote the sustainable production of waxy sorghum, a two-years field experiment was performed to determine the responses of waxy sorghum rhizosphere soil properties to different row ratio configurations in waxy sorghum-soybean intercropping systems. The treatments included five row ratio configurations, which were two rows of waxy sorghum intercropped with one row of soybean (2W1S), two rows of waxy sorghum intercropped with two rows of soybean (2W2S), three rows of waxy sorghum intercropped with one row of soybean (3W1S), three rows of waxy sorghum intercropped with two rows of soybean (3W2S), and three rows of waxy sorghum intercropped with three rows of soybean (3W3S), and sole cropping waxy sorghum (SW) was used as control. The nutrients, enzyme activities, and microbes of waxy sorghum rhizosphere soil were investigated at the jointing, anthesis, and maturity stages. Results showed that rhizosphere soil properties of waxy sorghum were significantly affected by row ratio configurations of waxy sorghum intercropped soybean. Among all treatments, the performances of rhizosphere soil nutrients contents, enzymes activities, and microbes contents were 2W1S > 3W1S > 3W2S > 3W3S > 2W2S > SW. Compared to SW treatment, the 2W1S treatment increased the organic matter, total N, total P, total K, gram-negative bacteria phospholipid fatty acids (PLFAs), and gram-positive bacteria PLFAs contents and catalase, polyphenol oxidase, and urease activities by 20.86%-25.67%, 34.33%-70.05%, 23.98%-33.83%, 44.12%-81.86%, 74.87%-194.32%, 81.59-136.59%, 91.44%-114.07%, 85.35%-146.91%, and 36.32%-63.94%, respectively. Likewise, the available N, available P, available K, total PLFAs, fungus PLFAs, actinomycetes PLFAs, and bacteria PLFAs contents under the 2W1S treatment were 1.53-2.41, 1.32-1.89, 1.82-2.05, 1.96-2.91, 3.59-4.44, 9.11-12.56, and 1.81-2.71 times than those of SW treatment, respectively. Further, the determining factors of soil microbes were total K, catalase, and polyphenol oxidase for total microbes, bacteria, and gram-negative bacteria, total P and available K for fungus, available N, available K, and polyphenol oxidase for actinomycetes, and total K and polyphenol oxidase for gram-positive bacteria. In conclusion, the 2W1S treatment was the optimal row ratio configuration of waxy sorghum intercropped with soybean, which can improve the rhizosphere soil quality and promote the sustainable production of waxy sorghum.
    MeSH term(s) Soil ; Agriculture/methods ; Glycine max ; Catalase ; Sorghum ; Waxes ; Rhizosphere ; Zea mays ; Edible Grain ; Bacteria ; Soil Microbiology
    Chemical Substances Soil ; Catalase (EC 1.11.1.6) ; Waxes
    Language English
    Publishing date 2023-07-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0288076
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A novel single-phase color tunable LiYGeO

    Zuo, Chunyu / Chen, Rujia / Jiang, Xiliang / Leng, Zhuang / Yang, Yimin / Zhang, Zhipeng / Zhou, Lingbo / Li, Chun / Yang, Weiling / Lin, Hai / Liu, Lina / Li, Shasha / Zeng, Fanming / Su, Zhongmin

    Physical chemistry chemical physics : PCCP

    2024  Volume 26, Issue 4, Page(s) 3375–3388

    Abstract: ... ...

    Abstract LiYGeO
    Language English
    Publishing date 2024-01-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 1476244-4
    ISSN 1463-9084 ; 1463-9076
    ISSN (online) 1463-9084
    ISSN 1463-9076
    DOI 10.1039/d3cp04754g
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Garnet Structure-Activated Warm White Light Phosphors Ca

    Zhou, Lingbo / Chen, Rujia / Jiang, Xiliang / Zhang, Tianqing / Shi, Xueming / Leng, Zhuang / Yang, Yimin / Zhang, Zhipeng / Zuo, Chunyu / Li, Chun / Yang, Weiling / Lin, Hai / Liu, Lina / Li, Shasha / Zeng, Fanming / Su, Zhongmin

    Inorganic chemistry

    2024  Volume 63, Issue 2, Page(s) 1274–1287

    Abstract: A series of ... ...

    Abstract A series of Ca
    Language English
    Publishing date 2024-01-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1484438-2
    ISSN 1520-510X ; 0020-1669
    ISSN (online) 1520-510X
    ISSN 0020-1669
    DOI 10.1021/acs.inorgchem.3c03739
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Changes in Nutrient Accumulation and Transportation of Waxy Sorghum in Waxy Sorghum-Soybean Intercropping Systems Under Different Row Ratio Configurations.

    Wang, Can / Zhou, Lingbo / Gao, Jie / Zhang, Guobing / Peng, Fangli / Zhang, Chunlan / Zhao, Qiang / Peng, Qiu / Shao, Mingbo

    Frontiers in plant science

    2022  Volume 13, Page(s) 921860

    Abstract: To determine the optimal row ratio configuration of waxy sorghum-soybean intercropping systems, a field experiment with seven treatments, including sole waxy sorghum (SW), sole soybean (SS), two rows of waxy sorghum alternated with one row of soybean ( ... ...

    Abstract To determine the optimal row ratio configuration of waxy sorghum-soybean intercropping systems, a field experiment with seven treatments, including sole waxy sorghum (SW), sole soybean (SS), two rows of waxy sorghum alternated with one row of soybean (2W1S), two rows of waxy sorghum alternated with two rows of soybean (2W2S), three rows of waxy sorghum alternated with one row of soybean (3W1S), three rows of waxy sorghum alternated with two rows of soybean (3W2S), and three rows of waxy sorghum alternated with three rows of soybean (3W3S), was conducted during 2019 and 2020 in Guiyang, China. Accumulation and transportation of nitrogen (N), phosphorus (P), and potassium (K) in waxy sorghum were investigated. The results showed that the row ratio configurations had significant effects on the N, P, and K accumulation and transportation of waxy sorghum. On the one hand, compared to SW treatment, intercropping treatments showed higher N, P, and K contents and accumulation amounts, N, P, and K transportation amounts before anthesis, N, P, and K transportation rates before anthesis, and contribution rates of N, P, and K transportation before anthesis to the grain of each organ in waxy sorghum. Similarly, the waxy sorghum-soybean intercropping system increased the yield components (including spike length, grain number per spike, and 1,000-grain weight) of waxy sorghum. In addition, the yields of waxy sorghum and soybean among all treatments were in the sequence of SW (SS) > 2W1S > 3W1S > 3W2S > 3W3S > 2W2S. Besides, the 2W1S treatment showed the highest land equivalent ratio and economic benefit. On the whole, the waxy sorghum-soybean intercropping system can increase the N, P, and K absorption among organs and promote the N, P, and K transportation from vegetative organs to grain in waxy sorghum so as to promote the growth and development of spike in waxy sorghum to obtain higher land equivalent ratio and economic benefits. The 2W1S treatment was recommended as the optimal row ratio configuration of the waxy sorghum-soybean system to achieve the maximum utilization of nutrient resources.
    Language English
    Publishing date 2022-07-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2022.921860
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Responses of photosynthetic characteristics and dry matter formation in waxy sorghum to row ratio configurations in waxy sorghum-soybean intercropping systems

    Wang, Can / Zhou, Lingbo / Zhang, Guobing / Gao, Jie / Peng, Fangli / Zhang, Chunlan / Xu, Yan / Zhang, Liyi / Shao, Mingbo

    Field crops research. 2021 Apr. 01, v. 263

    2021  

    Abstract: In intercropping systems, microclimate environment, especially light environment induced by row ratio configurations, is crucial to crop productivity. However, little information is available on how waxy sorghum canopy light environment is affected by ... ...

    Abstract In intercropping systems, microclimate environment, especially light environment induced by row ratio configurations, is crucial to crop productivity. However, little information is available on how waxy sorghum canopy light environment is affected by row ratio configurations in waxy sorghum-soybean intercropping systems. Hence, field experiments were conducted in 2019 and 2020 to study the responses of photosynthetic characteristics, dry matter formation, and yield performance of waxy sorghum to seven treatments: sole waxy sorghum (SW), sole soybean (SS), two rows of waxy sorghum alternated with one row of soybean (2W1S), two rows of waxy sorghum alternated with two rows of soybean (2W2S), three rows of waxy sorghum alternated with one row of soybean (3W1S), three rows of way sorghum alternated with two rows of soybean (3W2S), and three rows of way sorghum alternated with three rows of soybean (3W3S). The results showed that intercropping increased the photosynthetically active radiation (PAR) and leaf area index (LAI) of waxy sorghum compared to SW treatment. This increase in PAR and LAI increased the photosynthetic characteristics of waxy sorghum canopy, including chlorophyll content (SPAD value), net photosynthetic rate (Pₙ), stomatal conductance (Gₛ), transpiration rate (Tᵣ), and stomatal limitation value (Lₛ). These changes resulted in increased dry matter accumulation, its distribution, and promoted the dry matter transportation from vegetative organs to grain in waxy sorghum. Likewise, intercropping increased the grain number per spike and 1000-grain weight of waxy sorghum, and ultimately increased the land equivalent ratio (LER). Moreover, the 2W1S treatment showed the most suitable light environments and greatest resource utilization to obtain the highest LER and economic benefits. Based on the present results, we suggested that the 2W1S should be used as optimal row ratio configuration of waxy sorghum-soybean system to attain maximum benefits.
    Keywords Glycine max ; Sorghum bicolor ; canopy ; chlorophyll ; dry matter accumulation ; field experimentation ; grain sorghum ; grain yield ; intercropping ; leaf area index ; leaf chlorophyll content ; microclimate ; net assimilation rate ; photosynthesis ; photosynthetically active radiation ; row spacing ; sole cropping ; soybeans ; stomatal conductance
    Language English
    Dates of publication 2021-0401
    Publishing place Elsevier B.V.
    Document type Article
    Note golden set
    ZDB-ID 435684-6
    ISSN 1872-6852 ; 0378-4290
    ISSN (online) 1872-6852
    ISSN 0378-4290
    DOI 10.1016/j.fcr.2021.108077
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  7. Article: Gene Expression and Splicing QTL Analysis of Blood Cells in African American Participants from the Jackson Heart Study.

    Wen, Jia / Sun, Quan / Huang, Le / Zhou, Lingbo / Doyle, Margaret F / Ekunwe, Lynette / Olson, Nels C / Reiner, Alexander P / Li, Yun / Raffield, Laura M

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Most gene expression and alternative splicing quantitative trait loci (eQTL/sQTL) studies have been biased toward European ancestry individuals. Here, we performed eQTL and sQTL analysis using TOPMed whole genome sequencing-derived genotype data and RNA ... ...

    Abstract Most gene expression and alternative splicing quantitative trait loci (eQTL/sQTL) studies have been biased toward European ancestry individuals. Here, we performed eQTL and sQTL analysis using TOPMed whole genome sequencing-derived genotype data and RNA sequencing data from stored peripheral blood mononuclear cells in 1,012 African American participants from the Jackson Heart Study (JHS). At a false discovery rate (FDR) of 5%, we identified 4,798,604 significant eQTL-gene pairs, covering 16,538 unique genes; and 5,921,368 sQTL-gene-cluster pairs, covering 9,605 unique genes. About 31% of detected eQTL and sQTL variants with a minor allele frequency (MAF) > 1% in JHS were rare (MAF < 0.1%), and therefore unlikely to be detected, in European ancestry individuals. We also generated 17,630 eQTL credible sets and 24,525 sQTL credible sets for genes (gene-clusters) with lead QTL p < 5e-8. Finally, we created an open database, which is freely available online, allowing fast query and bulk download of our QTL results.
    Language English
    Publishing date 2023-04-29
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.04.26.538455
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Dynamic pore structure evolution of the ion adsorbed rare earth ore during the ion exchange process.

    Zhou, Lingbo / Wang, Xiaojun / Zhuo, Yulong / Hu, Kaijian / Zhong, Wen / Huang, Guangli

    Royal Society open science

    2019  Volume 6, Issue 11, Page(s) 191107

    Abstract: During the leaching process of the ion-adsorbed rare earth (RE) ore, the pore structure evolution of the ore body plays a vital role in the seepage of the leaching solution. To investigate the evolution of the pore structure during the leaching process, ... ...

    Abstract During the leaching process of the ion-adsorbed rare earth (RE) ore, the pore structure evolution of the ore body plays a vital role in the seepage of the leaching solution. To investigate the evolution of the pore structure during the leaching process, experiments have been carried out with remodelled RE ore samples based on the physical characteristics of
    Language English
    Publishing date 2019-11-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2787755-3
    ISSN 2054-5703
    ISSN 2054-5703
    DOI 10.1098/rsos.191107
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  9. Article ; Online: Genome-wide variations analysis of sorghum cultivar Hongyingzi for brewing Moutai liquor.

    Zhou, Lingbo / Wang, Can / Gao, Xu / Ding, Yanqing / Cheng, Bin / Zhang, Guobing / Cao, Ning / Xu, Yan / Shao, Mingbo / Zhang, Liyi

    Hereditas

    2020  Volume 157, Issue 1, Page(s) 19

    Abstract: Background: Hongyingzi is a sorghum (Sorghum bicolor L. Moench) cultivar for brewing Moutai liquor. For an overall understanding of the whole genome of Hongyingzi, we performed whole-genome resequencing technology to reveal its comprehensive variations.! ...

    Abstract Background: Hongyingzi is a sorghum (Sorghum bicolor L. Moench) cultivar for brewing Moutai liquor. For an overall understanding of the whole genome of Hongyingzi, we performed whole-genome resequencing technology to reveal its comprehensive variations.
    Results: Compared with the BTx623 reference genome, we uncovered 1,885,774 single nucleotide polymorphisms (SNPs), 309,381 small fragments insertions and deletions (Indels), 31,966 structural variations (SVs), and 217,273 copy number variations (CNVs). These alterations conferred 29,614 gene variations. It was also predicted that 35 gene variations were related to the multidrug and toxic efflux (MATE) transporter, chalcone synthase (CHS), ATPase isoform 10 (AHA10) transporter, dihydroflavonol-4-reductase (DFR), the laccase 15 (LAC15), flavonol 3'-hydroxylase (F3'H), flavanone 3-hydroxylase (F3H), O-methyltransferase (OMT), flavonoid 3'5' hydroxylase (F3'5'H), UDP-glucose:sterol-glucosyltransferase (SGT), flavonol synthase (FLS), and chalcone isomerase (CHI) involved in the tannin synthesis.
    Conclusions: These results would provide theoretical supports for the molecular markers developments and gene function studies related to the tannin synthesis, and the genetic improvement of liquor-making sorghum based on the genome editing technology.
    MeSH term(s) Alcoholic Beverages ; China ; DNA Copy Number Variations ; Genome, Plant ; INDEL Mutation ; Polymorphism, Single Nucleotide ; Sorghum/genetics ; Tannins/biosynthesis ; Whole Genome Sequencing
    Chemical Substances Tannins
    Language English
    Publishing date 2020-05-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 214294-6
    ISSN 1601-5223 ; 0018-0661
    ISSN (online) 1601-5223
    ISSN 0018-0661
    DOI 10.1186/s41065-020-00130-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Genome-wide variations analysis of sorghum cultivar Hongyingzi for brewing Moutai liquor

    Zhou, Lingbo / Wang, Can / Gao, Xu / Ding, Yanqing / Cheng, Bin / Zhang, Guobing / Cao, Ning / Xu, Yan / Shao, Mingbo / Zhang, Liyi

    Hereditas. 2020 Dec., v. 157, no. 1

    2020  

    Abstract: BACKGROUND: Hongyingzi is a sorghum (Sorghum bicolor L. Moench) cultivar for brewing Moutai liquor. For an overall understanding of the whole genome of Hongyingzi, we performed whole-genome resequencing technology to reveal its comprehensive variations. ... ...

    Abstract BACKGROUND: Hongyingzi is a sorghum (Sorghum bicolor L. Moench) cultivar for brewing Moutai liquor. For an overall understanding of the whole genome of Hongyingzi, we performed whole-genome resequencing technology to reveal its comprehensive variations. RESULTS: Compared with the BTx623 reference genome, we uncovered 1,885,774 single nucleotide polymorphisms (SNPs), 309,381 small fragments insertions and deletions (Indels), 31,966 structural variations (SVs), and 217,273 copy number variations (CNVs). These alterations conferred 29,614 gene variations. It was also predicted that 35 gene variations were related to the multidrug and toxic efflux (MATE) transporter, chalcone synthase (CHS), ATPase isoform 10 (AHA10) transporter, dihydroflavonol-4-reductase (DFR), the laccase 15 (LAC15), flavonol 3′-hydroxylase (F3′H), flavanone 3-hydroxylase (F3H), O-methyltransferase (OMT), flavonoid 3′5′ hydroxylase (F3′5′H), UDP-glucose:sterol-glucosyltransferase (SGT), flavonol synthase (FLS), and chalcone isomerase (CHI) involved in the tannin synthesis. CONCLUSIONS: These results would provide theoretical supports for the molecular markers developments and gene function studies related to the tannin synthesis, and the genetic improvement of liquor-making sorghum based on the genome editing technology.
    Keywords Sorghum bicolor ; adenosinetriphosphatase ; chalcone isomerase ; cultivars ; flavanone 3-dioxygenase ; flavonols ; genes ; genetic improvement ; laccase ; methyltransferases ; naringenin-chalcone synthase ; toxicity
    Language English
    Dates of publication 2020-12
    Size p. 19.
    Publishing place BioMed Central
    Document type Article
    ZDB-ID 214294-6
    ISSN 1601-5223 ; 0018-0661
    ISSN (online) 1601-5223
    ISSN 0018-0661
    DOI 10.1186/s41065-020-00130-4
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