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  1. Article ; Online: Isotope Effects on State-to-State Photodissociation Dynamics of D

    Chen, Junjie / Gao, Qian / Zhou, Linsen / Hu, Xixi / Xie, Daiqian

    The journal of physical chemistry. A

    2024  Volume 128, Issue 10, Page(s) 1892–1901

    Abstract: State-to-state photodissociation dynamics of ... ...

    Abstract State-to-state photodissociation dynamics of D
    Language English
    Publishing date 2024-03-02
    Publishing country United States
    Document type Journal Article
    ISSN 1520-5215
    ISSN (online) 1520-5215
    DOI 10.1021/acs.jpca.4c00255
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: New accurate diabatic potential energy surfaces for the two lowest

    Chen, Junjie / Zhang, Hanzi / Zhou, Linsen / Hu, Xixi / Xie, Daiqian

    Physical chemistry chemical physics : PCCP

    2023  Volume 25, Issue 38, Page(s) 26032–26042

    Abstract: In this work, state-to-state photodissociation dynamics of ... ...

    Abstract In this work, state-to-state photodissociation dynamics of H
    Language English
    Publishing date 2023-10-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 1476244-4
    ISSN 1463-9084 ; 1463-9076
    ISSN (online) 1463-9084
    ISSN 1463-9076
    DOI 10.1039/d3cp03026a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: MicroRNA-642b-3p functions as an oncomiR in gastric cancer by down-regulating the CUB and sushi multiple domains protein 1/smad axis.

    Liu, Haofeng / Chen, Yuan / Zhou, Linsen / Jiang, Xiaohui / Zhou, Xiaojun

    Bioengineered

    2022  Volume 13, Issue 4, Page(s) 9613–9627

    Abstract: Aberrant expression of microRNAs (miRNAs or miRs) has been involved in the progression of gastric cancer (GC). Our analysis of GC-related gene expression profiles identified the significantly up-regulated miR-642b-3p expression, which has been reported ... ...

    Abstract Aberrant expression of microRNAs (miRNAs or miRs) has been involved in the progression of gastric cancer (GC). Our analysis of GC-related gene expression profiles identified the significantly up-regulated miR-642b-3p expression, which has been reported as a mediator in various cancers but rarely mentioned in researches on GC. Herein, this study intends to investigate the role of miR-642b-3p in GC development. Bioinformatics analysis was conducted to predict the downstream target gene of miR-642b-3p. Expression patterns of miR-642b-3p and CUB and sushi multiple domains protein 1 (CSMD1) in GC tissues and cell lines was then determined. Immunofluorescence, wound healing and Transwell invasion assays were performed to observe the malignant behaviors of GC cells with altered expression of miR-642b-3p and CSMD1. Nude mice with xenograft tumors were developed for
    MeSH term(s) Animals ; Cell Line, Tumor ; Cell Movement/genetics ; Cell Proliferation/genetics ; Humans ; Membrane Proteins/metabolism ; Mice ; Mice, Nude ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Smad Proteins/metabolism ; Stomach Neoplasms/pathology ; Tumor Suppressor Proteins/metabolism
    Chemical Substances Membrane Proteins ; MicroRNAs ; Smad Proteins ; Tumor Suppressor Proteins
    Language English
    Publishing date 2022-05-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2737830-5
    ISSN 2165-5987 ; 2165-5979
    ISSN (online) 2165-5987
    ISSN 2165-5979
    DOI 10.1080/21655979.2022.2056813
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Electronic Structure and External Electric Field Modulation of Polyethylene/Graphene Interface.

    Li, Hongfei / Qu, Zhaoming / Chen, Yazhou / Zhou, Linsen / Wang, Yan

    Polymers

    2022  Volume 14, Issue 14

    Abstract: Polymer nanocomposites can serve as promising electrostatic shielding materials; however, the underlying physical mechanisms governing the carrier transport properties between nanofillers and polymers remain unclear. Herein, the structural and electronic ...

    Abstract Polymer nanocomposites can serve as promising electrostatic shielding materials; however, the underlying physical mechanisms governing the carrier transport properties between nanofillers and polymers remain unclear. Herein, the structural and electronic properties of two polyethylene/graphene (PE/G) interfaces, i.e., type-H and type-A, have been systematically investigated under different electric fields using first principle calculations. The results testify that the bandgaps of 128.6 and 67.8 meV are opened at the Dirac point for type-H and type-A PE/G interfaces, respectively, accompanied by an electron-rich area around the graphene layer, and a hole-rich area around the PE layer. Moreover, the Fermi level shifts towards the valence band maximum (VBM) of the PE layer, forming a p-type Schottky contact at the interface. Upon application of an electric field perpendicular to the PE/G interface, the Schottky contact can be transformed into an Ohmic contact via the tuning of the Schottky barrier height (SBH) of the PE/G interface. Compared with the A-type PE/G interfaces, the H-type requires a lower electric field to induce an Ohmic contact. All these results can provide deeper insights into the conduction mechanism of graphene-based polymer composites as field-shielding materials.
    Language English
    Publishing date 2022-07-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym14142949
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Unraveling CO adsorption behaviors and its poisoning effects on ZrCo surface.

    Lan, Yuejing / Tang, Ru / Ye, Rongxing / Su, Minan / Lei, Qianghua / Li, Fei / Tian, Xiaofeng / Song, Jiangfeng / Zhou, Linsen

    Physical chemistry chemical physics : PCCP

    2024  Volume 26, Issue 12, Page(s) 9617–9627

    Abstract: Theoretical calculations are performed to elucidate the adsorption behaviors and poisoning effects of CO gas on the ZrCo surface, which drastically limits its application in hydrogen isotopic storage. Specifically, the ionic Zr-Co bond on the surface ... ...

    Abstract Theoretical calculations are performed to elucidate the adsorption behaviors and poisoning effects of CO gas on the ZrCo surface, which drastically limits its application in hydrogen isotopic storage. Specifically, the ionic Zr-Co bond on the surface leads to unique CO adsorption structures on different sites. The CO molecule tends to prefer a tilted adsorption configuration on the Co-Co bridge site. The electronic structures, charge distributions, and bonding characteristics are further explored to study the CO adsorption properties, which obey the electron density donation and back-donation mechanism. For different CO coverages, the stepwise adsorption energies of CO increase with the increasing of coverage, reaching the saturated coverage at
    Language English
    Publishing date 2024-03-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 1476244-4
    ISSN 1463-9084 ; 1463-9076
    ISSN (online) 1463-9084
    ISSN 1463-9076
    DOI 10.1039/d3cp06251a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Rational design and construction of hierarchical porous quasi-hexagonal Co

    Hu, Cun / Ding, Fengyun / Liu, Aojie / Zhou, Linsen / Zeng, Ning / Lv, Chao / Zhang, Xin / Yong, Wenwen / Cai, Jinguang / Tang, Tao

    Journal of colloid and interface science

    2024  Volume 666, Page(s) 331–345

    Abstract: Constructing heterostructured electrocatalysts has proven effective in enhancing intrinsic catalytic activity. Herein, under guidance of theoretical calculations, hierarchical porous quasi-hexagonal ... ...

    Abstract Constructing heterostructured electrocatalysts has proven effective in enhancing intrinsic catalytic activity. Herein, under guidance of theoretical calculations, hierarchical porous quasi-hexagonal Co
    Language English
    Publishing date 2024-04-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241597-5
    ISSN 1095-7103 ; 0021-9797
    ISSN (online) 1095-7103
    ISSN 0021-9797
    DOI 10.1016/j.jcis.2024.04.027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 71/707: Show issues

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  7. Article ; Online: Highly Effective H₂/D₂ Separation within the Stable Cu(I)Cu(II)-BTC: The Effect of Cu(I) Structure on Quantum Sieving

    Hu, Xiaoyu / Ding, Fengyun / Xiong, Renjin / An, Yongtao / Feng, Xingwen / Song, Jiangfeng / Zhou, Linsen / Li, Peilong / Chen, Changlun

    ACS Applied Materials & Interfaces. 2023 Jan. 09, v. 15, no. 3 p.3941-3952

    2023  

    Abstract: Realizing ideal deuterium separation from isotopic mixtures remains a daunting challenge because of their almost identical sizes, shapes, and physicochemical properties. Using the quantum sieving effect in porous materials with suitable pore size and ... ...

    Abstract Realizing ideal deuterium separation from isotopic mixtures remains a daunting challenge because of their almost identical sizes, shapes, and physicochemical properties. Using the quantum sieving effect in porous materials with suitable pore size and open metal sites (OMSs) enables efficient hydrogen isotope separation. Herein, synthetic HKUST-1-derived microporous mixed-valence Cu­(I)­Cu­(II)-BTC (BTC = benzene-1,3,5-tricarboxylate), featuring a unique network of distinct Cu­(I) and Cu­(II) coordination sites, can remarkably boost the D₂/H₂ isotope separation, which has a high selectivity (S D₂/H₂) of 37.9 at 30 K, in comparison with HKUST-1 and other porous materials. Density functional theory (DFT) calculations indicate that the introduction of Cu­(I) macrocycles in the framework decreases the pore size and further leads to relatively enhanced interaction of H₂/D₂ molecules on Cu­(II) sites. The significantly enhanced selectivity of Cu­(I)­Cu­(II)-BTC at 30 K can be mainly attributed to the synergistic effect of kinetic quantum sieving (KQS) and chemical affinity quantum sieving (CAQS). The results reveal that Cu­(I) OMSs exhibit counterintuitive behaviors and play a crucial role in tuning quantum sieving without a complex structural design, which provides a deeper insight into quantum sieving mechanisms and a new strategy for the intelligent design of highly efficient isotope systems.
    Keywords density functional theory ; deuterium ; isotope separation ; isotopes ; porosity ; porous media ; synergism ; hydrogen isotope separation ; Cu(I) ions ; quantum sieving ; thermal desorption spectroscopy ; DFT calculation
    Language English
    Dates of publication 2023-0109
    Size p. 3941-3952.
    Publishing place American Chemical Society
    Document type Article ; Online
    ISSN 1944-8252
    DOI 10.1021/acsami.2c18221
    Database NAL-Catalogue (AGRICOLA)

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  8. Article: Dynamics Studies of O₂ Collision on Pt(111) Using a Global Potential Energy Surface

    Zhou, Yipeng / Zhou, Linsen / Hu, Xixi / Xie, Daiqian

    Journal of physical chemistry. 2020 Apr. 20, v. 124, no. 19

    2020  

    Abstract: The dynamics of O₂ collision on Pt(111) has been studied by molecular dynamics simulations using a global potential energy surface (PES), which was developed by fitting ∼4800 plane-wave density functional theory points using the permutation invariant ... ...

    Abstract The dynamics of O₂ collision on Pt(111) has been studied by molecular dynamics simulations using a global potential energy surface (PES), which was developed by fitting ∼4800 plane-wave density functional theory points using the permutation invariant polynomial-neural network method. The simulations were performed for the normal and off-normal incidences at a wide range of incident energies and surface temperatures. A generalized Langevin oscillator model was used to incorporate the molecule–surface coupling that plays an important role in this collision process. The trapping probability, final energy distribution, scattering angle distributions of scattered molecules, and the energy transfer to surface distribution were determined and analyzed. The PES shows an activated path to the chemisorption states, as the trapping probability directly increases with incident energy (larger than 0.1 eV) to reach a maximum and then decreases at high incident energy. The trapping probability obviously reduces by raising surface temperature at low incident energy because the initial kinetic energy of molecule is more likely to be dissipated into surface motions than molecular internal ro-vibrational modes. Additional parallel momentum of off-normal incidence leads to a strong suppression of the trapping probability, caused by the energetic corrugation of the lateral barrier heights. The scattering angular distributions are found to be quasispecular and the final translational energy slightly increases with scattering angle deviating significantly from the hard-cube model, indicating the nonconservation of parallel momentum during the collision on the corrugate PES.
    Keywords density functional theory ; energy transfer ; kinetic energy ; molecular dynamics ; momentum ; potential energy ; probability ; surface temperature
    Language English
    Dates of publication 2020-0420
    Size p. 10573-10583.
    Publishing place American Chemical Society
    Document type Article
    Note NAL-AP-2-clean
    ISSN 1932-7455
    DOI 10.1021/acs.jpcc.0c01247
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: The synergistic therapeutic effect of imatinib and protein kinase CK2 Inhibition correlates with PI3K-AKT activation in gastrointestinal stromal tumors.

    Zhou, Linsen / Wang, Hao / Liu, Haofeng / Huang, Zhijun / Wang, Zhiqiang / Zhou, Xiaojun / Mu, Xiangming

    Clinics and research in hepatology and gastroenterology

    2022  Volume 46, Issue 6, Page(s) 101886

    Abstract: Background: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. Casein kinase 2 (CK2) has been reported to be involved in several cellular processes in multiple cancers. However, the role of CK2 ... ...

    Abstract Background: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. Casein kinase 2 (CK2) has been reported to be involved in several cellular processes in multiple cancers. However, the role of CK2 in GIST remains unclear.
    Aim: We aimed to investigate the combinatorial treatment of imatinib (IM) and CK2 inhibition on the progression of GISTs.
    Methods: GIST biopsies and adjacent normal tissues were collected from patients. GIST882 and GIST48 cell lines were subjected to investigate the effect of IM and CK2 inhibition in GIST cells. CCK-8 assay, Caspase-3 activity assay, western blotting, and flow cytometry analysis were employed in the present investigation.
    Results: Our results showed that CK2 was highly expressed in GIST biopsies, and inhibition of CK2 resulted in decrease in cell viability and increase in apoptosis of GIST cells. Moreover, the combination treatment with CX-4945 (CX) and IM resulted in a more significant decrease in cell viability and increase in cell apoptosis compared with mono-treatment. Mechanistically, the combination treatment influenced the activation of the PI3K/AKT pathway. The activation of the PI3K/AKT pathway reversed the synergistic impacts of the combined treatment on cell viability and apoptosis.
    Conclusion: Our results demonstrated that inhibition of CK2 combined with IM exhibited a synergistic anti-cancer effect on GIST cells through inactivation of the PI3K/AKT pathway.
    MeSH term(s) Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Apoptosis ; Casein Kinase II/pharmacology ; Cell Line, Tumor ; Gastrointestinal Neoplasms/drug therapy ; Gastrointestinal Neoplasms/pathology ; Gastrointestinal Stromal Tumors/drug therapy ; Gastrointestinal Stromal Tumors/pathology ; Humans ; Imatinib Mesylate/pharmacology ; Imatinib Mesylate/therapeutic use ; Phosphatidylinositol 3-Kinases/metabolism ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use ; Proto-Oncogene Proteins c-akt
    Chemical Substances Antineoplastic Agents ; Protein Kinase Inhibitors ; Imatinib Mesylate (8A1O1M485B) ; Casein Kinase II (EC 2.7.11.1) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
    Language English
    Publishing date 2022-02-18
    Publishing country France
    Document type Journal Article
    ZDB-ID 2594333-9
    ISSN 2210-741X ; 2210-7401
    ISSN (online) 2210-741X
    ISSN 2210-7401
    DOI 10.1016/j.clinre.2022.101886
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Pd-doped HKUST-1 MOFs for enhanced hydrogen storage: effect of hydrogen spillover.

    Hu, Xiaoyu / Wang, Jinchuan / Li, Shangkun / Hu, Xuanhao / Ye, Rongxing / Zhou, Linsen / Li, Peilong / Chen, Changlun

    RSC advances

    2023  Volume 13, Issue 22, Page(s) 14980–14990

    Abstract: Extensive research has been devoted to developing metal nanoparticle (NP) doped porous materials with large hydrogen storage capacity and high hydrogen release pressure at ambient temperature. The ultra-sound assisted double-solvent approach (DSA) was ... ...

    Abstract Extensive research has been devoted to developing metal nanoparticle (NP) doped porous materials with large hydrogen storage capacity and high hydrogen release pressure at ambient temperature. The ultra-sound assisted double-solvent approach (DSA) was applied for sample synthesis. In this study, tiny Pd NPs are confined into the pore space of HKUST-1, affording Pd@HKUST-1-DS with minimizing the aggregation of Pd NPs and subsequently the formation of Pd NPs on the external surface of HKUST-1. The experimental data reveal that the obtained Pd NP doped Pd@HKUST-1-DS possessed an outstanding hydrogen storage capacity of 3.68 wt% (and 1.63 wt%) at 77 K and 0.2 MPa H
    Language English
    Publishing date 2023-05-16
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d3ra01788e
    Database MEDical Literature Analysis and Retrieval System OnLINE

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