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Book ; Online: Urban and Regional Cooperation and Development

Zhou, Long / Li, Bin / Li, Sihong / Lei, Ngan Leng / Cheong, Kengfong

Challenges and Strategies for the Planning and Development of the Guangdong-Macao Intensive Cooperation Zone in Hengqin Island

(SpringerBriefs in Geography)

2023

Series title	SpringerBriefs in Geography
Keywords	Human geography ; Geography ; Urban economics ; Regional Cooperation ; Regional Planning and Development ; Collaborative Urban Development ; Sustainable Cities ; Hengqin Guangdong-Macao Intensive Cooperation Zone ; City Cluster ; Urban Planning ; Urban Studies ; Regional Research ; Cross Border Cooperation
Language	English
Size	1 electronic resource (94 pages)
Publisher	Springer Nature
Publishing place	Singapore
Document type	Book ; Online
Note	English
HBZ-ID	HT030379934
ISBN	9789811980619 ; 9811980616
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Book ; Online: Urban and Regional Cooperation and Development

Zhou, Long / Li, Bin / Li, Sihong / Lei, Ngan Leng / Cheong, Kengfong

Challenges and Strategies for the Planning and Development of the Guangdong–Macao Intensive Cooperation Zone in Hengqin Island

(SpringerBriefs in Geography)

2023

Author's details	by Long Zhou, Bin Li, Sihong Li, Ngan Leng Lei, Kengfong Cheong
Series title	SpringerBriefs in Geography
Keywords	Human geography ; Geography ; Urban economics
Subject code	304.2
Language	English
Size	1 Online-Ressource (IX, 94 p. 30 illus., 29 illus. in color)
Edition	1st ed. 2023
Publisher	Springer Nature Singapore ; Imprint: Springer
Publishing place	Singapore
Document type	Book ; Online
HBZ-ID	HT021626151
ISBN	978-981-19-8061-9 ; 9789811980602 ; 9789811980626 ; 9789811980633 ; 981-19-8061-6 ; 9811980608 ; 9811980624 ; 9811980632
DOI	10.1007/978-981-19-8061-9
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Association of statin use with osteoporosis risk: a drug-targeted Mendelian randomization study.

Ren, Zhaozhou / Zhou, Long

Inflammopharmacology

2024 Volume 32, Issue 2, Page(s) 1253–1261

Abstract: Background: Hypercholesterolemia and the related inflammatory response promote the development of osteoporosis, but whether targeted interventions are protective against this bone metabolic disease remains unknown. The aim of this study was to ... ...

Abstract	Background: Hypercholesterolemia and the related inflammatory response promote the development of osteoporosis, but whether targeted interventions are protective against this bone metabolic disease remains unknown. The aim of this study was to investigate the association between the use of statins (one well-recognized cholesterol-lowering drug with anti-inflammatory properties) and the risk of osteoporosis using a drug-targeted Mendelian randomization (MR) approach. Methods: Instrumental variables predicting three cholesterol-lowering target genes (including HGMCR) and the cholesterol effectors mediated by these genes (i.e., total cholesterol, LDL cholesterol, and non-HDL cholesterol) were extracted from expression quantitative trait loci and genome-wide association studies. Inverse variance-weighted (IVW), summary data-based MR (SMR), multivariate MR, and colocalization analysis were used to determine the association of the interventions represented by these instrumental variables with heel bone mineral density (one diagnostic indicator of osteoporosis). Results: The IVW reported that increased levels of HGMCR-mediated total cholesterol, LDL cholesterol, and non-HDL cholesterol were associated with the decreased level of heel bone mineral density (P = 4.086e-10, P = 1.487e-09, P = 1.967e-09). The colocalization analysis supported the relationship between HGMCR-mediated non-HDL cholesterol and heel bone mineral density. The SMR reported that higher expression of HGMCR was associated with the decreased level of this osteoporosis indicator (P = 0.036). The multivariate MR further confirmed the role of HGMCR in the correlation between cholesterol traits and heel bone mineral density, and also reported that estrogen played a mediating role in the above correlations. Conclusion: These evidence supported a protective effect of HMGCR-mediated non-HDL cholesterol reduction or statin use against osteoporosis.
MeSH term(s)	Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects ; Cholesterol, LDL ; Genome-Wide Association Study ; Mendelian Randomization Analysis ; Osteoporosis/drug therapy ; Osteoporosis/genetics ; Polymorphism, Single Nucleotide
Chemical Substances	Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Cholesterol, LDL
Language	English
Publishing date	2024-02-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1080058-x
ISSN	1568-5608 ; 0925-4692
ISSN (online)	1568-5608
ISSN	0925-4692
DOI	10.1007/s10787-024-01441-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Helicobacter pylori infection induces POU5F1 upregulation and SPP1 activation to promote chemoresistance and T cell inactivation in gastric cancer cells.

Song, Hanyi / Yao, Xinjie / Zheng, Yuqi / Zhou, Long

Biochemical pharmacology

2024 , Page(s) 116253

Abstract: Infection with Helicobacter pylori (H. pylori or Hp) is associated with an increased susceptibility to gastric diseases, notably gastric cancer (GC). This study investigates the impact of Hp infection on chemoresistance and immune activity in GC cells. ... ...

Abstract	Infection with Helicobacter pylori (H. pylori or Hp) is associated with an increased susceptibility to gastric diseases, notably gastric cancer (GC). This study investigates the impact of Hp infection on chemoresistance and immune activity in GC cells. Hp infection in AGS and MKN-74 cells promoted proliferation, migration and invasion, apoptosis resistance, and tumorigenic activity of cells under cisplatin (DDP) plus gemcitabine (GEM) treatment. Additionally, it dampened activity of the co-cultured CD8
Language	English
Publishing date	2024-05-01
Publishing country	England
Document type	Journal Article
ZDB-ID	208787-x
ISSN	1873-2968 ; 0006-2952
ISSN (online)	1873-2968
ISSN	0006-2952
DOI	10.1016/j.bcp.2024.116253
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Article ; Online: Numerical study on fiber waviness defect and sensitivity analysis of the parameters

Zhou Long / Zhu Shuhua

E3S Web of Conferences, Vol 360, p

2022 Volume 01084

Abstract: The presence of fiber waviness defects is well-known to reduce the compressive strength. A FE model was established and the results of failure load and mode were compared with the test results to demonstrate the validity and accuracy. The influence of ... ...

Abstract	The presence of fiber waviness defects is well-known to reduce the compressive strength. A FE model was established and the results of failure load and mode were compared with the test results to demonstrate the validity and accuracy. The influence of two parameters L and offset Angle θ of fiber waviness defect was studied. The simulation results show that the compression failure load increases with the increasing of L at constant A/H for convex and concave fiber fold by 33.0% and 20.1% respectively, but there is no significant effect on the failure load with θ within 5%.
Keywords	Environmental sciences ; GE1-350
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Construction of a Ceramic Appearance Design System Based on Technology for Internet of Things

Zhou Long / Junzhe Ouyang

Computational Intelligence and Neuroscience, Vol

2022 Volume 2022

Abstract: The planning and design of intelligent storage systems in ceramic parks based on the industrial Internet of Things technology are proposed. Based on the analysis of the storage demand of ceramic parks, information transformation is carried out according ... ...

Abstract	The planning and design of intelligent storage systems in ceramic parks based on the industrial Internet of Things technology are proposed. Based on the analysis of the storage demand of ceramic parks, information transformation is carried out according to the original manual operation mode. The RFID technology is applied to the overall planning of the warehouse area and the deployment of the software; it is applied to the overall planning of the RFID system, the hardware deployment of the two-dimensional warehouse system, and the integration of the RFID technology and the software deployment of the two-dimensional warehouse system. It realizes the close cooperation between the information system and hardware equipment, optimizes the system process, and improves the level of warehouse management.In addition, smart terminal ceramics refer to those with fine ceramic appearances or functionalities in smart terminal products, such as smartphones, smart watches, and other wearable devices, in the field of consumer electronics, including ceramic back plates, middle frames, buttons, fingerprint recognition sheets on mobile phones and ceramic cases, bracelets, and back covers on smart watches. Aside the excellent performance and aesthetic properties of ceramic materials, they can also be adapted to the trends in 5G and wireless communication technology. From the perspective of high strength, high toughness, and colorful nano-zirconia ceramics, this article was aimed to review the development process and industrialization application process.
Keywords	Computer applications to medicine. Medical informatics ; R858-859.7 ; Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571
Subject code	600
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Association of serum 25-hydroxyvitamin D concentrations with all-cause and cardiovascular mortality among US adults with prehypertension: a prospective cohort study.

Zhou, Yongmei / Chen, Yu / Chen, Fuli / Li, Gang / Zhou, Long

Journal of health, population, and nutrition

2024 Volume 43, Issue 1, Page(s) 24

Abstract: Background: Prehypertension affects 25-50% of adults worldwide and no prior study has examined the relationship between serum 25-hydroxyvitamin D [25(OH)D] concentrations and mortality risk in individuals with prehypertension. This study aims to ... ...

Abstract	Background: Prehypertension affects 25-50% of adults worldwide and no prior study has examined the relationship between serum 25-hydroxyvitamin D [25(OH)D] concentrations and mortality risk in individuals with prehypertension. This study aims to investigate the association of serum 25(OH)D concentrations with all-cause and CVD mortality among prehypertensive adults by utilizing data from the US National Health and Nutrition Examination Survey (NHANES) 2007-2014 and linked 2019 mortality file. Methods: We included 4345 prehypertensive adults who participated in the NHANES between 2007 and 2014 and were followed up until 31 December 2019. Weighted Cox proportional hazards models were used with adjustments for multiple covariates to calculate the hazard ratio (HR) and 95% confidence interval (CI) for the risks of dying from any cause and CVD. Results: During a median follow-up of 8.8 years, 335 deaths from any causes were documented, of which 88 participants died from CVD. Compared with participants with sufficient 25(OH)D (≥ 75 nmol/L), the multivariate-adjusted HRs and 95% CIs for participants with severe deficiency (< 25 nmol/L), moderate deficiency (25-49.9 nmol/L), and insufficient concentrations (50-74.9 nmol/L) of serum 25(OH)D for all-cause death were 2.83 (1.46-5.52), 1.17 (0.74-1.86), and 1.36 (0.93-1.98), respectively. Similarly, the multivariable-adjusted HRs and 95%CIs for CVD death were 4.14 (1.10-15.51), 1.23 (0.46-3.28), and 1.73 (0.96-3.14), respectively. We found that there was a 9% reduction in the risk of death from all causes and a 14% reduction in the risk of death from CVD for every 10 nmol/L increase in serum 25(OH)D concentrations. Conclusion: Severe serum 25(OH)D deficiency among prehypertensive adults was associated with increased risk of mortality from all causes as well as from CVD. Our work suggests that supplementing with vitamin D may prevent premature death in severely deficient individuals with prehypertension.
MeSH term(s)	Adult ; Humans ; Nutrition Surveys ; Cardiovascular Diseases ; Vitamin D Deficiency ; Prospective Studies ; Prehypertension ; Vitamin D ; Calcifediol ; Risk Factors
Chemical Substances	25-hydroxyvitamin D (A288AR3C9H) ; Vitamin D (1406-16-2) ; Calcifediol (P6YZ13C99Q)
Language	English
Publishing date	2024-02-06
Publishing country	Bangladesh
Document type	Journal Article
ZDB-ID	2025045-9
ISSN	2072-1315 ; 1606-0997
ISSN (online)	2072-1315
ISSN	1606-0997
DOI	10.1186/s41043-024-00515-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Inhibition of Liver Cancer Cell Viability by Triazole through Up-regulation of p38 Phosphorylation and Targeting the Activation of p-ERK1/2 and Akt Protein Expression.

Shanfeng Li / Zhou, Long / Zhao, Feng / Wang, Haisong / Sun, Meng

Doklady. Biochemistry and biophysics

2024

Abstract: The present study was aimed to explore the effect of triazole on growth and viability of liver cancer cells. Cell growth was examined using the MTT test and expression of several proteins was assessed by western blotting assay. The Matrigel-coated ... ...

Abstract	The present study was aimed to explore the effect of triazole on growth and viability of liver cancer cells. Cell growth was examined using the MTT test and expression of several proteins was assessed by western blotting assay. The Matrigel-coated Transwell assay was employed to examine the infiltration of cells. The data from MTT assay showed that MHCC97H and H4TG liver cancer cell viability was inhibited by triazole in a concentration-dependent manner. After treatment with 0.5, 1.0, 2.0, 4, 8, and 16 µM doses of triazole, the rate of H4TG cell viability was decreased to 96, 73, 58, 39, 29, and 28%, respectively. Treatment of MHCC97H cells with 0.5, 1.0, 2.0, 4, 8, and 16 µM doses of triazole resulted in a reduction in cell viability to 94, 70, 53, 35, 22, and 21%, respectively. Triazole treatment also led to a significant reduction in MHCC97H cell invasiveness compared to the control cells. In MHCC97H cells treated with triazole, there was a noticeable decrease in the levels of p-ERK1/2, and p-Akt protein expression. Treatment of MHCC97H cells with triazole resulted in a prominent increase in p-p38 level. In summary, triazole inhibits growth and viability of liver cancer cells through targeting the activation of p-ERK1/2 and Akt proteins. Therefore, triazole may be investigated further as a therapeutic agent for the treatment of liver cancer.
Language	English
Publishing date	2024-05-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2062390-2
ISSN	1608-3091 ; 1607-6729
ISSN (online)	1608-3091
ISSN	1607-6729
DOI	10.1134/S1607672923600525
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Article ; Online: Aspirin versus low-molecular-weight heparin for thromboprophylaxis after orthopaedic surgery: a systematic review and meta-analysis.

Wu, Haichao / Zhou, Long / Wang, Qiang / Wang, Tao / Liang, Siyuan

Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis

2024

Abstract: The article aimed to compare the efficiency and safety of aspirin with low-molecular-weight heparin (LMWH) for thromboprophylaxis in orthopaedic surgery patients. According to the inclusion and exclusion criteria, PubMed, Embase and Cochrane Library ... ...

Abstract	The article aimed to compare the efficiency and safety of aspirin with low-molecular-weight heparin (LMWH) for thromboprophylaxis in orthopaedic surgery patients. According to the inclusion and exclusion criteria, PubMed, Embase and Cochrane Library database were searched for studies comparing aspirin and LMWH in venous thromboembolism (VTE) prophylaxis until 25 April 2023. The outcome measures included deep venous thrombosis(DVT)/Pulmonary embolism(PE) events, major bleeding events, wound complications, wound infection and death. Six studies met the requirements of our meta-analysis, including 12 470 patients in the aspirin group and 10 857 patients in the LMWH group. The meta-analysis showed that results showed that LMWH was superior to aspirin in preventing VTE events (odds ratio (OR) 1.44, 95% CI 1.24-1.68, P < 0.00001), whereas there was no significant difference between them in bleeding events (OR 0.95, 95% CI 0.86-1.05, P = 0.33), wound complication (OR 0.58, 95% CI 0.28-1.17, P = 0.13), wound infection (OR 1.12, 95% CI 0.86-1.47, P = 0.39) and mortality (OR 1.04, 95% CI 0.70-1.55, P = 0.83). In addition, subgroup analysis showed that compared with aspirin, LMWH was more likely to reduce the incidence of DVT events in orthopaedic surgery patients (OR 1.59, 95% CI 1.33-1.91, P < 0.00001), whereas there was no advantage in reducing the incidence of PE events (OR 1.22, 95% CI 0.62-2.40, P = 0.56). Despite the similar safety profiles, this meta-analysis showed that LMWH was significantly superior to aspirin in thromboprophylaxis after orthopaedic surgery. LMWH was still the first-line drug for thrombosis prevention in patients who underwent major orthopaedic surgeries.
Language	English
Publishing date	2024-04-17
Publishing country	England
Document type	Journal Article
ZDB-ID	1033551-1
ISSN	1473-5733 ; 0957-5235
ISSN (online)	1473-5733
ISSN	0957-5235
DOI	10.1097/MBC.0000000000001300
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Article ; Online: Simultaneous remediation of co-contaminated soil by ball-milled zero-valent iron coupled with persulfate oxidation.

Xue, Chengjie / Yi, Yunqiang / Zhou, Long / Fang, Zhanqiang

Journal of environmental management

2023 Volume 340, Page(s) 118004

Abstract: The problem of co-contaminated soil at e-waste dismantling sites is serious and constitutes a critical threat to human health and the ecological environment. Zero-valent iron (ZVI) has been proven to be effective in the stabilization of heavy metals and ... ...

Abstract	The problem of co-contaminated soil at e-waste dismantling sites is serious and constitutes a critical threat to human health and the ecological environment. Zero-valent iron (ZVI) has been proven to be effective in the stabilization of heavy metals and the removal of halogenated organic compounds (HOCs) from soils. However, for the remediation of co-contamination of heavy metals with HOCs, ZVI has disadvantages such as high remediation cost and inability to take into account both pollutants, which limits its large-scale application. In this paper, boric acid and commercial zero-valent iron (cZVI) were used as raw materials to prepare boric acid-modified zero-valent iron (B-ZVI
MeSH term(s)	Humans ; Iron/chemistry ; Metals, Heavy/analysis ; Boric Acids ; Soil/chemistry ; Water Pollutants, Chemical/chemistry
Chemical Substances	Iron (E1UOL152H7) ; boric acid (R57ZHV85D4) ; Metals, Heavy ; Boric Acids ; Soil ; Water Pollutants, Chemical
Language	English
Publishing date	2023-04-27
Publishing country	England
Document type	Journal Article
ZDB-ID	184882-3
ISSN	1095-8630 ; 0301-4797
ISSN (online)	1095-8630
ISSN	0301-4797
DOI	10.1016/j.jenvman.2023.118004
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