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  1. Article: Traditional Chinese Medicine in the treatment of hemorrhoids-a review of preparations used and their mechanism of action.

    Zhou, Meng'en / Jin, Wenqi / Li, Peng / Wang, Ruolin / Guo, Xiutian

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1270339

    Abstract: Hemorrhoids are a proctological disease primarily characterized by bleeding, prolapse, edema, and pain, severely affecting the quality of life. Surgery is an effective treatment for hemorrhoids, but the cost is relatively high, and complications such as ... ...

    Abstract Hemorrhoids are a proctological disease primarily characterized by bleeding, prolapse, edema, and pain, severely affecting the quality of life. Surgery is an effective treatment for hemorrhoids, but the cost is relatively high, and complications such as difficulty in defecation, persistent pain, and heavy bleeding may occur postoperatively. Traditional Chinese Medicine (TCM) has a distinctive advantage in alleviating the clinical symptoms of hemorrhoid patients, reducing pain, and improving the quality of life. However, there are few summary literature about the mechanism of TCM in the prevention and treatment of hemorrhoids. Based on the etiology of hemorrhoids in both traditional Chinese and Western medicine, this paper reviews the recent research on the mechanism of TCM in the treatment of hemorrhoids, hoping to provide a basis for the better application of TCM in clinical and experimental research.
    Language English
    Publishing date 2023-10-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1270339
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Saikosaponin d Alleviates Liver Fibrosis by Negatively Regulating the ROS/NLRP3 Inflammasome Through Activating the ERβ Pathway.

    Zhang, Kehui / Lin, Liubing / Zhu, Yingying / Zhang, Na / Zhou, Meng'en / Li, Yong

    Frontiers in pharmacology

    2022  Volume 13, Page(s) 894981

    Abstract: Background and aims: ...

    Abstract Background and aims:
    Language English
    Publishing date 2022-05-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.894981
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Xuebijing injection inhibited neutrophil extracellular traps to reverse lung injury in sepsis mice

    Shang, Ting / Zhang, Zhi-Sen / Wang, Xin-Tong / Chang, Jing / Zhou, Meng-En / Lyu, Ming / He, Shuang / Yang, Jian / Chang, Yan-Xu / Wang, Yuefei / Li, Ming-Chun / Gao, Xiumei / Zhu, Yan / Feng, Yuxin

    Frontiers in pharmacology

    2022  Volume 13, Page(s) 1054176

    Abstract: The mortality of sepsis and septic shock remains high worldwide. Neutrophil extracellular traps (NETs) release is a major cause of organ failure and mortality in sepsis. Targeting Gasdermin D (GSDMD) can restrain NETs formation, which is promising for ... ...

    Abstract The mortality of sepsis and septic shock remains high worldwide. Neutrophil extracellular traps (NETs) release is a major cause of organ failure and mortality in sepsis. Targeting Gasdermin D (GSDMD) can restrain NETs formation, which is promising for sepsis management. However, no medicine is identified without severe safety concerns for this purpose. Xuebijing injection (XBJ) has been demonstrated to alleviate the clinical symptoms of COVID-19 and sepsis patients, but there are not enough animal studies to reveal its mechanisms in depth. Therefore, we wondered whether XBJ relieved pulmonary damage in sepsis by suppressing NETs formation and adopted a clinically relevant polymicrobial infection model to test this hypothesis. Firstly, XBJ effectively reversed lung injury caused by sepsis and restrained neutrophils recruitment to lung by down-regulating proinflammatory chemokines, such as CSF-3, CXCL-2, and CXCR-2. Strikingly, we found that XBJ significantly reduced the expressions of NETs component proteins, including citrullinated histone H3 (CitH3), myeloperoxidase (MPO), and neutrophil elastase (NE). GSDMD contributes to the production of NETs in sepsis. Notably, XBJ exhibited a reduced effect on the expressions of GSDMD and its upstream regulators. Besides, we also revealed that XBJ reversed NETs formation by inhibiting the expressions of GSDMD-related genes. Collectively, we demonstrated XBJ protected against sepsis-induced lung injury by reversing GSDMD-related pathway to inhibit NETs formation.
    Language English
    Publishing date 2022-11-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.1054176
    Database MEDical Literature Analysis and Retrieval System OnLINE

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