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Article ; Online: Polysaccharide from Strongylocentrotus nudus eggs regulates intestinal epithelial autophagy through CD36/PI3K-Akt pathway to ameliorate inflammatory bowel disease

Zhou, Mengze / Zhi, Jingke / Zhi, Jiayi / Xiong, Zhenghan / Wu, Fan / Lu, Yuanyuan / Hu, Qinghua

International Journal of Biological Macromolecules. 2023 July, v. 244 p.125373-

2023

Abstract: Sea urchin is a popular food all over the world, of which eggs are main edible part. Previous studies suggested that polysaccharides from eggs of Strongylocentrotus nudus (SEP) exhibited immunomodulatory activities during anti-tumor therapy, nevertheless, ...

Abstract	Sea urchin is a popular food all over the world, of which eggs are main edible part. Previous studies suggested that polysaccharides from eggs of Strongylocentrotus nudus (SEP) exhibited immunomodulatory activities during anti-tumor therapy, nevertheless, effects of SEP on inflammatory bowel disease and its underlying mechanisms have never been reported. In the present study, we showed that the SEP inhibited dextran sodium sulfate-induced ulcerative colitis characterized by decreased disease activity index, restored colon length and body weight, improved histopathological changes, down-regulation of inflammatory cytokines levels and Th17/Treg ratios in C57BL/6 J mice. Moreover, immunofluorescence analysis suggested that SEP repaired gut barrier in UC mice, while 16S rDNA sequencing exhibited improved intestinal flora. Mechanistically, we found SEP significantly modulated autophagy-related factors in intestinal epithelial cells (IECs), while might contributed to pathogenesis of UC. Furthermore, we demonstrated PI3K/Akt pathway was involved in regulatory effect of SEP on lipopolysaccharide-induced autophagy of HT-29 cells. Besides, among possible polysaccharide binding receptors, change of the CD36 expression was most significant, which was associated with PI3K/Akt signals. Collectively, our study showed for the first time that the SEP might be used a prebiotic agent to improve IBD through regulating CD36-PI3K/Akt mediated autophagy of IECs.
Keywords	Strongylocentrotus nudus ; absorption barrier ; autophagy ; body weight ; cancer therapy ; colon ; cytokines ; dextran ; epithelium ; fluorescent antibody technique ; histopathology ; intestinal microorganisms ; pathogenesis ; prebiotics ; sodium ; ulcerative colitis ; Polysaccharides ; Inflammatory bowel disease
Language	English
Dates of publication	2023-07
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2023.125373
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Comprehensive insights into potential roles of purinergic P2 receptors on diseases: Signaling pathways involved and potential therapeutics.

Guo, Yanshuo / Mao, Tianqi / Fang, Yafei / Wang, Hui / Yu, Jiayue / Zhu, Yifan / Shen, Shige / Zhou, Mengze / Li, Huanqiu / Hu, Qinghua

Journal of advanced research

2024

Abstract: Background: Purinergic P2 receptors, which can be divided into ionotropic P2X receptors and metabotropic P2Y receptors, mediate cellular signal transduction of purine or pyrimidine nucleoside triphosphates and diphosphate. Based on the wide expression ... ...

Abstract	Background: Purinergic P2 receptors, which can be divided into ionotropic P2X receptors and metabotropic P2Y receptors, mediate cellular signal transduction of purine or pyrimidine nucleoside triphosphates and diphosphate. Based on the wide expression of purinergic P2 receptors in tissues and organs, their significance in homeostatic maintenance, metabolism, nociceptive transmission, and other physiological processes is becoming increasingly evident, suggesting that targeting purinergic P2 receptors to regulate biological functions and signal transmission holds significant promise for disease treatment. Aim of review: This review highlights the detailed mechanisms by which purinergic P2 receptors engage in physiological and pathological progress, as well as providing prospective strategies for discovering clinical drug candidates. Key scientific concepts of review: The purinergic P2 receptors regulate complex signaling and molecular mechanisms in nervous system, digestive system, immune system and as a result, controlling physical health states and disease progression. There has been a significant rise in research and development focused on purinergic P2 receptors, contributing to an increased number of drug candidates in clinical trials. A few influential pioneers have laid the foundation for advancements in the evaluation, development, and of novel purinergic P2 receptors modulators, including agonists, antagonists, pharmaceutical compositions and combination strategies, despite the different scaffolds of these drug candidates. These advancements hold great potential for improving therapeutic outcomes by specifically targeting purinergic P2 receptors.
Language	English
Publishing date	2024-03-31
Publishing country	Egypt
Document type	Journal Article ; Review
ZDB-ID	2541849-X
ISSN	2090-1224 ; 2090-1224
ISSN (online)	2090-1224
ISSN	2090-1224
DOI	10.1016/j.jare.2024.03.027
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Polysaccharide from Strongylocentrotus nudus eggs regulates intestinal epithelial autophagy through CD36/PI3K-Akt pathway to ameliorate inflammatory bowel disease.

Zhou, Mengze / Zhi, Jingke / Zhi, Jiayi / Xiong, Zhenghan / Wu, Fan / Lu, Yuanyuan / Hu, Qinghua

International journal of biological macromolecules

2023 Volume 244, Page(s) 125373

Abstract	Sea urchin is a popular food all over the world, of which eggs are main edible part. Previous studies suggested that polysaccharides from eggs of Strongylocentrotus nudus (SEP) exhibited immunomodulatory activities during anti-tumor therapy, nevertheless, effects of SEP on inflammatory bowel disease and its underlying mechanisms have never been reported. In the present study, we showed that the SEP inhibited dextran sodium sulfate-induced ulcerative colitis characterized by decreased disease activity index, restored colon length and body weight, improved histopathological changes, down-regulation of inflammatory cytokines levels and Th17/Treg ratios in C57BL/6 J mice. Moreover, immunofluorescence analysis suggested that SEP repaired gut barrier in UC mice, while 16S rDNA sequencing exhibited improved intestinal flora. Mechanistically, we found SEP significantly modulated autophagy-related factors in intestinal epithelial cells (IECs), while might contributed to pathogenesis of UC. Furthermore, we demonstrated PI3K/Akt pathway was involved in regulatory effect of SEP on lipopolysaccharide-induced autophagy of HT-29 cells. Besides, among possible polysaccharide binding receptors, change of the CD36 expression was most significant, which was associated with PI3K/Akt signals. Collectively, our study showed for the first time that the SEP might be used a prebiotic agent to improve IBD through regulating CD36-PI3K/Akt mediated autophagy of IECs.
MeSH term(s)	Animals ; Mice ; Phosphatidylinositol 3-Kinases ; Proto-Oncogene Proteins c-akt ; Mice, Inbred C57BL ; Inflammatory Bowel Diseases/drug therapy ; Inflammatory Bowel Diseases/pathology ; Colitis, Ulcerative/chemically induced ; Colitis, Ulcerative/drug therapy ; Colitis, Ulcerative/pathology ; Colon ; Autophagy ; Strongylocentrotus ; Polysaccharides/chemistry ; Dextran Sulfate/adverse effects ; Colitis/chemically induced ; Disease Models, Animal
Chemical Substances	Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Polysaccharides ; Dextran Sulfate (9042-14-2)
Language	English
Publishing date	2023-06-14
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2023.125373
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Cardiovascular Protective Effects of Plant Polysaccharides: A Review.

Dong, Xinli / Zhou, Mengze / Li, Yehong / Li, Yuxin / Ji, Hui / Hu, Qinghua

Frontiers in pharmacology

2021 Volume 12, Page(s) 783641

Abstract: Cardiovascular disease is a kind of heart, brain, and blood vessel injury disease by the interaction of various pathological factors. The pathogenesis of cardiovascular disease is complex with various risk factors, including abnormally elevated blood ... ...

Abstract	Cardiovascular disease is a kind of heart, brain, and blood vessel injury disease by the interaction of various pathological factors. The pathogenesis of cardiovascular disease is complex with various risk factors, including abnormally elevated blood pressure, glucose, and lipid metabolism disorders, atherosclerosis, thrombosis, etc. Plant polysaccharides are a special class of natural products derived from plant resources, which have the characteristics of wide sources, diverse biological activities, and low toxicity or side effects. Many studies have shown that plant polysaccharides improve cardiovascular diseases through various mechanisms such as anti-oxidative stress, restoring the metabolism of biological macromolecules, regulating the apoptosis cascade to reduce cell apoptosis, and inhibiting inflammatory signal pathways to alleviate inflammation. This article reviews the pharmacological effects and protective mechanisms of some plant polysaccharides in modulating the cardiovascular system, which is beneficial for developing more effective drugs with low side effects for management of cardiovascular diseases.
Language	English
Publishing date	2021-11-18
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2021.783641
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: GPR105-Targeted Therapy Promotes Gout Resolution as a Switch Between NETosis and Apoptosis of Neutrophils.

Liu, Chunxiao / Zhou, Mengze / Jiang, Wenjiao / Ye, Shumin / Tian, Sheng / Jiang, Cheng / Hao, Kun / Li, Huanqiu / Hu, Qinghua

Frontiers in immunology

2022 Volume 13, Page(s) 870183

Abstract: The fate of infiltrating neutrophils in inflamed joints determines the development of acute gouty arthritis (AGA). GPR105 highly expressed in human neutrophils is sensitive to monosodium urate crystals (MSU); nevertheless, the roles of GPR105 in AGA ... ...

Abstract	The fate of infiltrating neutrophils in inflamed joints determines the development of acute gouty arthritis (AGA). GPR105 highly expressed in human neutrophils is sensitive to monosodium urate crystals (MSU); nevertheless, the roles of GPR105 in AGA remain unclear. Here, we show that GPR105 is significantly upregulated in peripheral polymorphonuclear neutrophils of AGA patients. GPR105 knockout (GPR105
MeSH term(s)	Apoptosis ; Gout/metabolism ; Gout/physiopathology ; Humans ; Molecular Docking Simulation ; Neutrophils/metabolism ; Neutrophils/physiology ; Phosphatidylinositol 3-Kinases/metabolism ; Uric Acid/adverse effects
Chemical Substances	Uric Acid (268B43MJ25)
Language	English
Publishing date	2022-03-30
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.870183
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: HQL6 serves as a novel P2Y

Zhou, Mengze / Liu, Chunxiao / Guo, Yanshuo / Qian, Jialong / Wang, Yuhang / Zhang, Zhenguo / Hao, Kun / Jiang, Cheng / Hu, Qinghua

International immunopharmacology

2022 Volume 114, Page(s) 109507

Abstract: Acute gouty arthritis (AGA) has been classified as an autoinflammatory disease caused by deposition of monosodium urate crystals (MSU), accompanied by swellingofjoint and severe pain. Limited clinical therapy and highincidence indicate that the ... ...

Abstract	Acute gouty arthritis (AGA) has been classified as an autoinflammatory disease caused by deposition of monosodium urate crystals (MSU), accompanied by swellingofjoint and severe pain. Limited clinical therapy and highincidence indicate that the development of effective drugs for AGA is an urgent need. Our previous study found that P2Y
Language	English
Publishing date	2022-11-30
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2043785-7
ISSN	1878-1705 ; 1567-5769
ISSN (online)	1878-1705
ISSN	1567-5769
DOI	10.1016/j.intimp.2022.109507
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Targeting BRD4 prevents acute gouty arthritis by regulating pyroptosis.

Hao, Kun / Jiang, Wenjiao / Zhou, Mengze / Li, Hanwen / Chen, Yadong / Jiang, Fei / Hu, Qinghua

International journal of biological sciences

2020 Volume 16, Issue 16, Page(s) 3163–3173

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Animals ; Arthritis, Gouty/drug therapy ; Azepines/pharmacology ; Cell Cycle Proteins/antagonists & inhibitors ; Humans ; Inflammasomes/metabolism ; Intracellular Signaling Peptides and Proteins/metabolism ; Male ; NF-kappa B/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Phosphate-Binding Proteins/metabolism ; Pyroptosis/drug effects ; RNA, Small Interfering ; Rats ; Rats, Sprague-Dawley ; Signal Transduction ; THP-1 Cells ; Transcription Factors/antagonists & inhibitors ; Triazoles/pharmacology
Chemical Substances	(+)-JQ1 compound ; Azepines ; BRD4 protein, human ; Cell Cycle Proteins ; GSDMD protein, human ; Inflammasomes ; Intracellular Signaling Peptides and Proteins ; NF-kappa B ; NLR Family, Pyrin Domain-Containing 3 Protein ; Phosphate-Binding Proteins ; RNA, Small Interfering ; Transcription Factors ; Triazoles
Language	English
Publishing date	2020-10-17
Publishing country	Australia
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2179208-2
ISSN	1449-2288 ; 1449-2288
ISSN (online)	1449-2288
ISSN	1449-2288
DOI	10.7150/ijbs.46153
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: HJ22, a Novel derivative of piperine, Attenuates ibotenic acid-induced cognitive impairment, oxidativestress, apoptosis and inflammation via inhibiting the protein-protein interaction of Keap1-Nrf2.

Yang, Xiping / Ji, Jing / Liu, Chunxiao / Zhou, Mengze / Li, Huanqiu / Ye, Shumin / Hu, Qinghua

International immunopharmacology

2020 Volume 83, Page(s) 106383

Abstract: Kelch-like ECH-associated protein (Keap1)-nuclear factor erythroid-2-related factor 2 (Nrf2) protein-protein interaction has become an important drug target for the treatment of Alzheimer's disease. In this study, we found a novel piperine derivative ( ... ...

Abstract	Kelch-like ECH-associated protein (Keap1)-nuclear factor erythroid-2-related factor 2 (Nrf2) protein-protein interaction has become an important drug target for the treatment of Alzheimer's disease. In this study, we found a novel piperine derivative (HJ22) synthesized by our group with great ability to bind to Keap-1 and activate Keap1-Nrf2-ARE signaling pathway in vitro, driving us to investigate the beneficial effects of HJ22 on ibotenic acid (IBO)-induced neurological disorders in rats and underlying mechanisms. Interestingly, HJ22 significantly ameliorated IBO-induced cognitive impairment in Morris water maze, Y-maze and passive avoidance tests. Moreover, HJ22 significantly attenuated cholinergic dysfunction and neuronal morphological changes via inhibiting apoptotic cell death induced by IBO. Notably, HJ22 inhibited the interaction between Keap1 and Nrf2, and subsequently up-regulated nuclear Nrf2 expression, thereby inhibiting oxidative stress and Thioredoxin-interacting protein (TXNIP)-mediated Nod-like receptor protein 3 (NLRP3) inflammasome activation. These findings demonstrated that HJ22 exhibited potent therapeutic effects against IBO-induced cognitive impairment by alleviating cholinergic damage, oxidative stress, apoptosis and neuroinflammation, which might be partly attributed to its inhibitory activity on Keap1-Nrf2 protein-protein interaction.
MeSH term(s)	Animals ; Humans ; Rats ; Alkaloids/chemical synthesis ; Alkaloids/therapeutic use ; Apoptosis ; Benzodioxoles/chemical synthesis ; Benzodioxoles/therapeutic use ; Cells, Cultured ; Cognitive Dysfunction/drug therapy ; Disease Models, Animal ; Ibotenic Acid ; Inflammasomes/metabolism ; Inflammation ; Kelch-Like ECH-Associated Protein 1/metabolism ; Neurons/physiology ; Oxidative Stress ; Piperidines/chemical synthesis ; Piperidines/therapeutic use ; Polyunsaturated Alkamides/chemical synthesis ; Polyunsaturated Alkamides/therapeutic use ; Protein Binding ; Protein Interaction Domains and Motifs/genetics ; Rats, Sprague-Dawley ; NF-E2-Related Factor 2/metabolism
Chemical Substances	Alkaloids ; Benzodioxoles ; Gabpa protein, rat ; Ibotenic Acid (2552-55-8) ; Inflammasomes ; Kelch-Like ECH-Associated Protein 1 ; Piperidines ; piperine (U71XL721QK) ; Polyunsaturated Alkamides ; NF-E2-Related Factor 2
Language	English
Publishing date	2020-03-16
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2043785-7
ISSN	1878-1705 ; 1567-5769
ISSN (online)	1878-1705
ISSN	1567-5769
DOI	10.1016/j.intimp.2020.106383
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Article ; Online: Discovery of Selective P2Y

Zhu, Yifan / Zhou, Mengze / Cheng, Xiangyu / Wang, Hui / Li, Yehong / Guo, Yueyue / Wang, Yaxuan / Tian, Sheng / Mao, Tianqi / Zhang, Zhoudong / Li, Duxin / Hu, Qinghua / Li, Huanqiu

Journal of medicinal chemistry

2023 Volume 66, Issue 9, Page(s) 6315–6332

Abstract: As a member of purinoceptors, the ... ...

Abstract	As a member of purinoceptors, the P2Y
MeSH term(s)	Animals ; Mice ; Colitis/chemically induced ; Colitis/drug therapy ; Colitis, Ulcerative/chemically induced ; Colitis, Ulcerative/drug therapy ; Dextran Sulfate ; Inflammasomes/metabolism ; Mice, Inbred C57BL ; NLR Family, Pyrin Domain-Containing 3 Protein
Chemical Substances	Dextran Sulfate (9042-14-2) ; Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein ; purinoceptor P2Y6
Language	English
Publishing date	2023-04-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218133-2
ISSN	1520-4804 ; 0022-2623
ISSN (online)	1520-4804
ISSN	0022-2623
DOI	10.1021/acs.jmedchem.3c00210
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Article ; Online: The role of P2Y

Zhou, Mengze / Wang, Weiwei / Li, Yehong / Zhang, Qian / Ji, Hui / Li, Huanqiu / Hu, Qinghua

Drug discovery today

2020 Volume 25, Issue 3, Page(s) 568–573

Abstract: As a member of the P2Y receptor family with a typical 7-transmembrane structure, ... ...

Abstract	As a member of the P2Y receptor family with a typical 7-transmembrane structure, P2Y
MeSH term(s)	Animals ; Cardiovascular Diseases/drug therapy ; Cardiovascular Diseases/physiopathology ; Cytokines/metabolism ; Drug Development/methods ; Drug Discovery/methods ; Humans ; Purinergic P2 Receptor Antagonists/pharmacology ; Receptors, Purinergic P2/drug effects ; Receptors, Purinergic P2/metabolism ; Signal Transduction/drug effects
Chemical Substances	Cytokines ; Purinergic P2 Receptor Antagonists ; Receptors, Purinergic P2 ; purinoceptor P2Y6
Language	English
Publishing date	2020-01-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1324988-5
ISSN	1878-5832 ; 1359-6446
ISSN (online)	1878-5832
ISSN	1359-6446
DOI	10.1016/j.drudis.2019.12.015
Database	MEDical Literature Analysis and Retrieval System OnLINE

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