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Book ; Online: Data-Driven Newton Raphson Controller Based on Koopman Operator Theory

Zhou, Mi

2023

Abstract: Newton-Raphson controller is a powerful prediction-based variable gain integral controller. Basically, the classical model-based Newton-Raphson controller requires two elements: the prediction of the system output and the derivative of the predicted ... ...

Abstract	Newton-Raphson controller is a powerful prediction-based variable gain integral controller. Basically, the classical model-based Newton-Raphson controller requires two elements: the prediction of the system output and the derivative of the predicted output with respect to the control input. In real applications, the model may not be known and it is infeasible to predict the system sometime ahead and calculate the derivative by finite difference method as done in simulation. To solve these problems, in this work, we utilize the Koopman operator framework to reconstruct a linear model of the original nonlinear dynamical system and then utilize the output of the new linear system as the predictor of the Newton-Raphson controller. This method is only based on collected data within some time instant thus more practical. Three examples related to highly nonlinear systems are provided to verify the effectiveness of our proposed method.
Keywords	Electrical Engineering and Systems Science - Systems and Control
Subject code	518
Publishing date	2023-09-29
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: Finite Horizon Reinforcement Learning in Solving Optimal Control of State-Dependent Switched Systems

Zhou, Mi

2023

Abstract: In this article, the deep deterministic policy gradient (DDPG) method is used to learn an optimal control policy of a multi-region state-dependent switched system. We observe good performance of this model-free method and explain it in a rigorous ... ...

Abstract	In this article, the deep deterministic policy gradient (DDPG) method is used to learn an optimal control policy of a multi-region state-dependent switched system. We observe good performance of this model-free method and explain it in a rigorous mathematical language. The performance of the learning-based methods is compared with the optimal solution given by vanilla differential dynamic programming (DDP) in three customized environments.
Keywords	Electrical Engineering and Systems Science - Systems and Control
Publishing date	2023-12-07
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: The gravitational bending of acoustic Schwarzschild black hole.

Qiao, Chen-Kai / Zhou, Mi

The European physical journal. C, Particles and fields

2023 Volume 83, Issue 4, Page(s) 271

Abstract: Acoustic black hole is becoming an attractive topic in recent years, for it open-up new direction for experimental/observational explorations of black holes. In this work, the gravitational bending of acoustic Schwarzschild black hole is investigated. ... ...

Abstract	Acoustic black hole is becoming an attractive topic in recent years, for it open-up new direction for experimental/observational explorations of black holes. In this work, the gravitational bending of acoustic Schwarzschild black hole is investigated. The gravitational deflection angle of particles traveling along null geodesics, weak gravitational lensing and Einstein ring for acoustic Schwarzschild black hole are carefully studied and analyzed. Particularly, in the calculation of gravitational deflection angle, we resort to two approaches-the Gauss-Bonnet theorem and the geodesic method. The results show that the gravitational bending effect in acoustic Schwarzschild black hole is enhanced, compared with conventional Schwarzschild black hole. This result indicates that the acoustic black holes may be more easily detectable in gravitational bending effects and weak gravitational lensing observations.
Language	English
Publishing date	2023-04-02
Publishing country	France
Document type	Journal Article
ZDB-ID	1459069-4
ISSN	1434-6052 ; 1434-6044
ISSN (online)	1434-6052
ISSN	1434-6044
DOI	10.1140/epjc/s10052-023-11376-3
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Article ; Online: Viewing RCC with a DNA Methylation Lens ENHANCES Understanding of ICI Resistance.

Zhou, Mi / Kim, William Y

Clinical cancer research : an official journal of the American Association for Cancer Research

2023 Volume 29, Issue 7, Page(s) 1170–1172

Abstract: Clear-cell renal cell carcinoma tumors with an enhancer demethylator phenotype (TED) harbor a worse prognosis and derive less clinical benefit from immunotherapy. The TED phenotype may help predict immunotherapy resistance. See related article by Lu et ... ...

Abstract	Clear-cell renal cell carcinoma tumors with an enhancer demethylator phenotype (TED) harbor a worse prognosis and derive less clinical benefit from immunotherapy. The TED phenotype may help predict immunotherapy resistance. See related article by Lu et al., p. 1279.
MeSH term(s)	Humans ; Carcinoma, Renal Cell/drug therapy ; Carcinoma, Renal Cell/genetics ; Carcinoma, Renal Cell/pathology ; DNA Methylation ; Kidney Neoplasms/drug therapy ; Kidney Neoplasms/genetics ; Kidney Neoplasms/pathology ; Immune Checkpoint Inhibitors/therapeutic use ; Phenotype ; Prognosis
Chemical Substances	Immune Checkpoint Inhibitors
Language	English
Publishing date	2023-01-24
Publishing country	United States
Document type	Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	1225457-5
ISSN	1557-3265 ; 1078-0432
ISSN (online)	1557-3265
ISSN	1078-0432
DOI	10.1158/1078-0432.CCR-22-3574
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Zs.A 4223: Show issues

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Article: Efficacy of Black Gold, Delicate Pulse Light, Super Photon Skin Rejuvenation for Pigmented Dermatoses.

Zhou, Mi / Xu, Na / Lan, Shaobo / Liu, Wenfang

Alternative therapies in health and medicine

2024

Abstract: Context: Pigmented dermatoses are skin diseases characterized by pigmentation changes in the skin's surface due to abnormal melanocyte production. Photon-skin-rejuvenation technology can be effective for the management of facial pigmented dermatoses. ... ...

Abstract	Context: Pigmented dermatoses are skin diseases characterized by pigmentation changes in the skin's surface due to abnormal melanocyte production. Photon-skin-rejuvenation technology can be effective for the management of facial pigmented dermatoses. Black Gold Delicate Pulse Light (DPL) Super Photon Skin Rejuvenation therapy is a new technology based on traditional photo rejuvenation. Objective: The study intended to evaluate the therapeutic efficacy of DPL therapy in the management of targeted pigmented skin diseases, such as melasma, solar lentigines, and postinflammatory hyperpigmentation. Design: The research team conducted a prospective cohort study. Setting: The study took place at Department of Dermatology, Affiliated Hospital of Shaoxing University, Shaoxing, China. Participants: Participants were 130 patients with facial pigmented dermatoses treated at the hospital between February 2021 and December 2021. Interventions: The research team assigned participants to one of two groups, with 65 participants in each group: (1) the control group, the intense pulsed light (IPL) group, who received IPL treatment, and (2) the intervention group, the DPL group, who received black gold DPL super photon skin rejuvenation. Both groups received the treatments once a month for 6 months. Outcome measures: At baseline and postintervention for both groups, the research team: (1) collected 5 ml of fasting venous blood from participants and measured serum concentrations of melatonin (MEL), vascular endothelial growth factor (VEGF) and endothelin-1 (ET-1) using enzyme-linked immunosorbent assay (ELISA); (2) assessed the degree of reduction of facial pigmentation using the Visia skin test and each participant's clinical results and calculated total efficacy; and (3) monitored and recorded adverse events. Results: Compared to the IPL group, the DPL group: (1) had greater symptom mitigation of the facial pigmented dermatosis, as evinced by significantly lower serum MEL (P = .001) and ET-1 (P = .020) concentrations and higher VEGF levels (P = .001); (2) for participants with freckles (P = .045), cafe-au-lait spots (P = .021), or post-acne hyperpigmentation (P = .029), had a significantly higher total efficacy; and (3) had a lower incidence of adverse events (P = .041). Conclusions: Black Gold DPL Super Photon Skin Rejuvenation offers a significantly higher safety profile and treatment efficacy for pigmented-skin diseases compared to IPL treatment. These promising results suggest potential for its use in clinical practice, but clinical adoption requires future trials.
Language	English
Publishing date	2024-01-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	1225073-9
ISSN	1078-6791
ISSN	1078-6791
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Zs.A 4504: Show issues

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Article ; Online: Impact of the host response and osteoblast lineage cells on periodontal disease.

Zhou, Mi / Graves, Dana T

Frontiers in immunology

2022 Volume 13, Page(s) 998244

Abstract: Periodontitis involves the loss of connective tissue attachment and alveolar bone. Single cell RNA-seq experiments have provided new insight into how resident cells and infiltrating immune cells function in response to bacterial challenge in periodontal ... ...

Abstract	Periodontitis involves the loss of connective tissue attachment and alveolar bone. Single cell RNA-seq experiments have provided new insight into how resident cells and infiltrating immune cells function in response to bacterial challenge in periodontal tissues. Periodontal disease is induced by a combined innate and adaptive immune response to bacterial dysbiosis that is initiated by resident cells including epithelial cells and fibroblasts, which recruit immune cells. Chemokines and cytokines stimulate recruitment of osteoclast precursors and osteoclastogenesis in response to TNF, IL-1β, IL-6, IL-17, RANKL and other factors. Inflammation also suppresses coupled bone formation to limit repair of osteolytic lesions. Bone lining cells, osteocytes and periodontal ligament cells play a key role in both processes. The periodontal ligament contains cells that exhibit similarities to tendon cells, osteoblast-lineage cells and mesenchymal stem cells. Bone lining cells consisting of mesenchymal stem cells, osteoprogenitors and osteoblasts are influenced by osteocytes and stimulate formation of osteoclast precursors through MCSF and RANKL, which directly induce osteoclastogenesis. Following bone resorption, factors are released from resorbed bone matrix and by osteoclasts and osteal macrophages that recruit osteoblast precursors to the resorbed bone surface. Osteoblast differentiation and coupled bone formation are regulated by multiple signaling pathways including Wnt, Notch, FGF, IGF-1, BMP, and Hedgehog pathways. Diabetes, cigarette smoking and aging enhance the pathologic processes to increase bone resorption and inhibit coupled bone formation to accelerate bone loss. Other bone pathologies such as rheumatoid arthritis, post-menopausal osteoporosis and bone unloading/disuse also affect osteoblast lineage cells and participate in formation of osteolytic lesions by promoting bone resorption and inhibiting coupled bone formation. Thus, periodontitis involves the activation of an inflammatory response that involves a large number of cells to stimulate bone resorption and limit osseous repair processes.
MeSH term(s)	Humans ; Hedgehog Proteins/metabolism ; Osteoblasts/metabolism ; Bone Resorption/pathology ; Periodontitis/pathology ; Periodontal Diseases/metabolism
Chemical Substances	Hedgehog Proteins
Language	English
Publishing date	2022-10-11
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.998244
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Article ; Online: Construction and validation of a robust ferroptosis-associated gene signature predictive of prognosis in lung adenocarcinoma.

Zhou, Mi / Zhu, Xin

Medicine

2022 Volume 101, Issue 16, Page(s) e29068

Abstract: Abstract: To construct and validate a ferroptosis-associated signature predictive of prognosis in lung adenocarcinoma (LUAD), and systematically evaluate the underlying molecular connections in cancer biology.We retrieved mRNAs sequencing profiles of ... ...

Abstract	Abstract: To construct and validate a ferroptosis-associated signature predictive of prognosis in lung adenocarcinoma (LUAD), and systematically evaluate the underlying molecular connections in cancer biology.We retrieved mRNAs sequencing profiles of LUAD from the cancer genome atlas (TCGA) data portal and clinical information from the cBio Cancer Genomics Portal. The differentially expressed ferroptosis-associated genes (DEFAGs) were screened between normal samples and LUAD by packages "limma" in R. Then the total TCGA cohort was randomly divided into training set and testing set. Based on the training set, a DEFAG signature was built and further validated in the test set, the total TCGA cohort and other independent cohorts from the gene expression omnibus data portal. A nomogram was constructed and validated, and the correlation between high-risk group and cancer biology was further evaluated.We initially identified 68 DEFAGs from TCGA cohort. A 6 DEFAG signature was built and further validated in the test set, the total TCGA cohort and other 2 independent cohorts including GSE31210 and GSE72094 from gene expression omnibus data portal. Further exploration indicated that high-risk group combined with TP53 mutation harbored the most unfavorable prognosis while low-risk group with TP53 wild-type status had the most favorable survival advantage over other groups. Moreover, high-risk group was associated with higher cancer stemness, tumor mutation burden, and CD274 (programmed cell death 1 ligand 1) expression.We constructed a robust ferroptosis-associated gene signature and a nomogram predictive of prognosis in LUAD, and provided a new perspective on associations between ferroptosis and cancer.
MeSH term(s)	Adenocarcinoma of Lung/pathology ; Biomarkers, Tumor/genetics ; Ferroptosis/genetics ; Humans ; Lung Neoplasms/pathology ; Prognosis
Chemical Substances	Biomarkers, Tumor
Language	English
Publishing date	2022-04-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000029068
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Ua VI Zs.171: Show issues

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Article ; Online: Complete recovery of deep venous thrombosis from Coombs (+) thrombotic thrombocytopenic purpura: case report.

Zhou, Mi / Yin, Jie

Journal of cardiothoracic surgery

2022 Volume 17, Issue 1, Page(s) 43

Abstract: Background: Acute thrombotic thrombocytopenic purpura (TTP) is an aggressive thrombotic microangiopathy that if not treated, can have a 90% mortality rate. Timely, extensive plasma exchange (PEX) has been indicated to reduce the mortality rate to < 10%, ...

Abstract	Background: Acute thrombotic thrombocytopenic purpura (TTP) is an aggressive thrombotic microangiopathy that if not treated, can have a 90% mortality rate. Timely, extensive plasma exchange (PEX) has been indicated to reduce the mortality rate to < 10%, but its side effects are not well-known. We present here a case of a patient presented with Comb (+) TTP and developed catheter-associated deep vein thrombosis (DVT). Case presentation: A 27-year-young man presented with persistent thrombocytopenia and Coombs positive anemia was firstly diagnosed with Evans syndrome. However, he was refractory to a methylprednisolone pulse therapy with a combination of platelet transfusion and eventually developed microangiopathy of central nerve system. Several pathological manifestations of the disease were prevented by PEX. The immediate start of PEX (1500 mL/d) induced a complete remission of acquired TTP and disappearance of neurological signs and symptoms. However, external iliac and femoro-popliteal venous thrombosis was diagnosed subsequently, inferior vena cava filter (IVC) filter was immediately implanted accompanied with anticoagulation therapy. Meanwhile, PEX session was sustained as well as oral anticoagulant (rivaroxaban). 14 days later, the patient got full recovery. Conclusions: Catheter-related DVT under the setting of TTP should be cautious. It is necessary to start anticoagulation and antiplatelet therapy for thrombosis early, especially in such cases when PLT count > 50 × 10
MeSH term(s)	Anticoagulants/therapeutic use ; Humans ; Male ; Plasma Exchange ; Platelet Transfusion ; Purpura, Thrombotic Thrombocytopenic/complications ; Purpura, Thrombotic Thrombocytopenic/diagnosis ; Purpura, Thrombotic Thrombocytopenic/therapy ; Thrombosis/complications
Chemical Substances	Anticoagulants
Language	English
Publishing date	2022-03-21
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2227224-0
ISSN	1749-8090 ; 1749-8090
ISSN (online)	1749-8090
ISSN	1749-8090
DOI	10.1186/s13019-022-01789-8
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Article: Valsartan attenuates LPS-induced ALI by modulating NF-κB and MAPK pathways.

Zhou, Mi / Meng, Ling / He, Qinke / Ren, Chunguang / Li, Changyi

Frontiers in pharmacology

2024 Volume 15, Page(s) 1321095

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2024-01-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2024.1321095
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Article: Integrated analysis reveals the dysfunction of intercellular communication and metabolic signals in dilated cardiomyopathy.

Shi, Rui / Ma, Xiue / Zhou, Mi / Xie, Xin / Xu, Liang

Heliyon

2024 Volume 10, Issue 5, Page(s) e26803

Abstract: Aims: Dilated cardiomyopathy refers to a heart muscle condition characterized by structural and functional irregularities in the myocardium that are not related to ischemia. Due to diverse etiologies such as genetic mutations, infections, and exposure ... ...

Abstract	Aims: Dilated cardiomyopathy refers to a heart muscle condition characterized by structural and functional irregularities in the myocardium that are not related to ischemia. Due to diverse etiologies such as genetic mutations, infections, and exposure to toxins, dilated cardiomyopathy can lead to substantial morbidity and mortality despite advances in the management of heart failure in dilated cardiomyopathy patients. We sought to analyze the characteristics of cell-cell communication and the metabolic signaling pathways in dilated cardiomyopathy. Methods and results: The single-nucleus sequencing data of left ventricle samples were acquired from two donor datasets and two dilated cardiomyopathy datasets. Three dilated cardiomyopathy bulk-sequencing datasets were included to determine the shared dilated cardiomyopathy-specific alterations in differentially expressed genes and signaling pathways. Using "CellChat," we analyzed intercellular communication to grasp how cell clusters interact and to map out the impaired signaling pathways in both donor and dilated cardiomyopathy conditions. Gene set enrichment analysis was applied to compare the metabolic signaling before and after dilated cardiomyopathy. We showcased how cell clusters exhibited abnormal cell-to-cell signaling transduction and how each cell type displayed dysfunctional metabolic signaling pathways through the integration of various datasets. The crucial ligand-receptor signaling contributing to outgoing or incoming signaling of dilated cardiomyopathy was identified in a cell-type dependent way, and the cell-specific metabolic alterations in glucose, lipid and amino acid were determined. The expression of gene pairs in BMP and NOTCH signal, as well as the gene expression in the arginine metabolism was validated. Conclusions: We reveal the key signals and metabolic pathways for dilated cardiomyopathy adaptation and maintenance, providing potential targets for dilated cardiomyopathy interference.
Language	English
Publishing date	2024-02-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e26803
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