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  1. Article: Candida

    Sng, Edwin Chong Yu / Tan, Ai Ling / Zhou, Peijun Yvonne / Tan, Tira J / Waduthantri, Samanthila / Chee, Soon-Phaik / Tan, Ban Hock

    Open forum infectious diseases

    2021  Volume 8, Issue 12, Page(s) ofab516

    Abstract: ... ...

    Abstract Candida
    Language English
    Publishing date 2021-10-08
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofab516
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Therapeutic drug monitoring is necessary for patients receiving posaconazole tablet.

    Zhou, Peijun Yvonne / Lim, Tze Peng / Tang, Si Lin Sarah / Lim, Jia Le / Liew, Yixin / Chua, Nathalie Grace / Lim, Li Ling Cheryl / Lee, Hui Ling Winnie / Lai, Oi Fah / Tan, Thuan Tong / Wong, Gee Chuan / Kwa, Lay Hoon Andrea

    The Journal of infection

    2021  Volume 82, Issue 6, Page(s) e18–e21

    MeSH term(s) Administration, Oral ; Antifungal Agents/therapeutic use ; Drug Monitoring ; Humans ; Tablets ; Triazoles
    Chemical Substances Antifungal Agents ; Tablets ; Triazoles ; posaconazole (6TK1G07BHZ)
    Language English
    Publishing date 2021-03-29
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 424417-5
    ISSN 1532-2742 ; 0163-4453
    ISSN (online) 1532-2742
    ISSN 0163-4453
    DOI 10.1016/j.jinf.2021.03.021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1501: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 48: Show issues

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  3. Article ; Online: Subtherapeutic posaconazole troughs despite high-dose posaconazole tablets in a patient with terminal ileum resection.

    Zhou, Peijun Yvonne / Lim, Tze Peng / Tang, Si Lin Sarah / Lee, Hui Ling Winnie / Tan, Thuan Tong / Tan, Ban Hock / Tan, Si Yun Melinda / Wong, Gee Chuan / Kwa, Lay Hoon Andrea

    The Journal of infection

    2019  Volume 78, Issue 5, Page(s) 409–421

    MeSH term(s) Humans ; Ileum ; Leukemia ; Micafungin ; Myelodysplastic Syndromes ; Tablets ; Triazoles
    Chemical Substances Tablets ; Triazoles ; posaconazole (6TK1G07BHZ) ; Micafungin (R10H71BSWG)
    Language English
    Publishing date 2019-02-27
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 424417-5
    ISSN 1532-2742 ; 0163-4453
    ISSN (online) 1532-2742
    ISSN 0163-4453
    DOI 10.1016/j.jinf.2019.02.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1501: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 48: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: The utility of voriconazole therapeutic drug monitoring in a multi-racial cohort in Southeast Asia.

    Zhou, Peijun Yvonne / Lim, Tze Peng / Tang, Si Lin Sarah / Liew, Yixin / Chua, Sy Grace Nathalie / Lim, Li Ling Cheryl / Lee, Hui Ling Winnie / Tan, Si Xuan / Lai, Oi Fah / Tan, Thuan Tong / Wong, Gee Chuan / Kwa, Lay Hoon Andrea

    Journal of global antimicrobial resistance

    2019  Volume 21, Page(s) 427–433

    Abstract: Objectives: Voriconazole serum concentration, which is affected by several factors, is associated with treatment response and toxicity. There is paucity of data on voriconazole therapeutic drug monitoring (TDM) among Southeast Asians, who exhibit a ... ...

    Abstract Objectives: Voriconazole serum concentration, which is affected by several factors, is associated with treatment response and toxicity. There is paucity of data on voriconazole therapeutic drug monitoring (TDM) among Southeast Asians, who exhibit a higher prevalence of CYP2C19-poor metabolisers compared with Caucasians and East Asians. Hence, there are concerns for higher risk of voriconazole accumulation and toxicity. We aim to determine the utility of voriconazole TDM through establishing: (1) proportion of patients achieving therapeutic troughs without dose adjustments; (2) characterisation of patients with sub-therapeutic, therapeutic and supra-therapeutic levels; (3) appropriate dose titrations/dose required for therapeutic troughs; (4) correlation between troughs and adverse events, treatment response/fungal breakthrough.
    Patients and methods: A single-centre retrospective analysis of data from adults (≥21 years old) with ≥1 voriconazole trough measured at Singapore General Hospital from 2015 to 2017 was performed.
    Results: Thirty-two patients (45.7%) among 70 patients achieved therapeutic troughs (defined as 2.0-5.5 mg/L) without dose adjustments. Eleven patients (15.7%) experienced hepatotoxicity (troughs 0.5 to >7.5 mg/L). Neurotoxicity occurred in three patients (4.3%) (troughs ≥6.7 mg/L) and all patients had symptom resolution upon dose reduction. Treatment failure of invasive fungal infection appeared less in patients with therapeutic troughs compared with sub-therapeutic troughs (11.4% vs. 14.2%). Two patients experienced treatment failure despite supra-therapeutic voriconazole troughs.
    Conclusions: TDM should be implemented due to significant unpredictability in dose exposure. TDM can reduce unnecessary switches to alternatives due to intolerability and rule in the possibility of resistant organisms in the event of treatment failure despite therapeutic troughs, alerting clinicians to switch to alternatives promptly.
    MeSH term(s) Adult ; Antifungal Agents/adverse effects ; Asia, Southeastern ; Drug Monitoring ; Humans ; Retrospective Studies ; Singapore ; Voriconazole/adverse effects ; Young Adult
    Chemical Substances Antifungal Agents ; Voriconazole (JFU09I87TR)
    Language English
    Publishing date 2019-12-14
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2710046-7
    ISSN 2213-7173 ; 2213-7165
    ISSN (online) 2213-7173
    ISSN 2213-7165
    DOI 10.1016/j.jgar.2019.12.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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