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Article ; Online: Experimental Study on Collimation Characteristics of an ECRH System with a 28GHz/50kW Gyrotron

Zhou Qing

E3S Web of Conferences, Vol 185, p

2020 Volume 02016

Abstract: In this paper, the collimation characteristics of an electron cyclotron resonance heating (ECRH) system with a 28GHz/50kW gyrotron in EXL-50 are studied experimentally. Through using laser trackers and designing matching tooling, test errors of ... ...

Abstract	In this paper, the collimation characteristics of an electron cyclotron resonance heating (ECRH) system with a 28GHz/50kW gyrotron in EXL-50 are studied experimentally. Through using laser trackers and designing matching tooling, test errors of horizontal distances and vertical distances between the transmission line and the flange center are all within 1mm, which are less than 0.4% and 0.07% respectively. In addition, online beam spot test with a 150 ms short pulse from a 28 GHz gyrotron also proves good collimation characteristics of the ECRH system. Finally, spherical plasma is formed through injecting the microwave to the vacuum chamber.
Keywords	Environmental sciences ; GE1-350
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Dpep Inhibits Cancer Cell Growth and Survival via Shared and Context-Dependent Transcriptome Perturbations.

Zhou, Qing / Greene, Lloyd A

Cancers

2023 Volume 15, Issue 22

Abstract: Dpep is a cell-penetrating peptide targeting transcription factors ATF5, CEBPB, and CEBPD, and that selectively promotes the apoptotic death of multiple tumor cell types in vitro and in vivo. As such, it is a potential therapeutic. To better understand ... ...

Abstract	Dpep is a cell-penetrating peptide targeting transcription factors ATF5, CEBPB, and CEBPD, and that selectively promotes the apoptotic death of multiple tumor cell types in vitro and in vivo. As such, it is a potential therapeutic. To better understand its mechanism of action, we used PLATE-seq to compare the transcriptomes of six cancer cell lines of diverse origins before and after Dpep exposure. This revealed a context-dependent pattern of regulated genes that was unique to each line, but that exhibited a number of elements that were shared with other lines. This included the upregulation of pro-apoptotic genes and tumor suppressors as well as the enrichment of genes associated with responses to hypoxia and interferons. Downregulated transcripts included oncogenes and dependency genes, as well as enriched genes associated with different phases of the cell cycle and with DNA repair. In each case, such changes have the potential to lie upstream of apoptotic cell death. We also detected the regulation of unique as well as shared sets of transcription factors in each line, suggesting that Dpep may initiate a cascade of transcriptional responses that culminate in cancer cell death. Such death thus appears to reflect context-dependent, yet shared, disruption of multiple cellular pathways as well as of individual survival-relevant genes.
Language	English
Publishing date	2023-11-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15225318
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Article ; Online: Combination Therapy for

Wu, Yi-Long / Zhou, Qing

The New England journal of medicine

2023 Volume 389, Issue 21, Page(s) 2005–2007

MeSH term(s)	Humans ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/genetics ; ErbB Receptors/genetics ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Mutation ; Protein Kinase Inhibitors/therapeutic use ; Drug Therapy, Combination
Chemical Substances	EGFR protein, human (EC 2.7.10.1) ; ErbB Receptors (EC 2.7.10.1) ; Protein Kinase Inhibitors
Language	English
Publishing date	2023-11-08
Publishing country	United States
Document type	Editorial
ZDB-ID	207154-x
ISSN	1533-4406 ; 0028-4793
ISSN (online)	1533-4406
ISSN	0028-4793
DOI	10.1056/NEJMe2311559
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Ua VI Zs.34: Show issues

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Article ; Online: The lncRNA HOTAIR attenuates pyroptosis of diabetic cardiomyocytes by recruiting FUS to regulate SIRT3 expression.

Xiong, Jing / Zhou, Qing

The Kaohsiung journal of medical sciences

2023 Volume 39, Issue 5, Page(s) 458–467

Abstract: Diabetic cardiomyopathy (DCM) is a serious cardiovascular complication of diabetes that severely affects the quality of life of diabetic patients. Long noncoding RNAs (lncRNAs) play important roles in the pathogenesis of DCM. However, the role of the ... ...

Abstract	Diabetic cardiomyopathy (DCM) is a serious cardiovascular complication of diabetes that severely affects the quality of life of diabetic patients. Long noncoding RNAs (lncRNAs) play important roles in the pathogenesis of DCM. However, the role of the lncRNA homeobox transcript antisense RNA (HOTAIR) in the progression of DCM remains unclear. The present study aimed to investigate the role of HOTAIR in high glucose (HG)-induced pyroptosis in cardiomyocytes. The expression of the lncRNA HOTAIR, FUS, and SIRT3 in H9C2 cardiomyocytes was detected by RT-qPCR. Western blotting was used to evaluate the expression of FUS and SIRT3 as well as that of pyroptosis- and inflammation-related proteins. RT-qPCR and ELISA were used to determine the expression and secretion of IL-1β and IL-18. RNA pulldown and RIP experiments were used to validate the binding relationship among HOTAIR, FUS, and SIRT3. Flow cytometry was performed to detect pyroptosis. HG induced pyroptosis and elevated the expression of proteins associated with pyroptosis and inflammation (NLRP3, GSDMD-N, cleaved caspase-1, IL-1β, and IL-18) in cardiomyocytes. HOTAIR and SIRT3 levels were decreased in HG-exposed H9C2 cells. Additionally, overexpression of HOTAIR inhibited the HG-induced pyroptosis and inflammatory response in cardiomyocytes. HOTAIR upregulated SIRT3 expression in H9C2 cells by targeting FUS. Moreover, SIRT3 upregulation suppressed HG-mediated pyroptosis of cardiomyocytes. Notably, SIRT3 depletion reversed the inhibitory effect of HOTAIR on HG-triggered pyroptosis in cardiomyocytes. Our research indicates that HOTAIR alleviates pyroptosis in diabetic cardiomyocytes through the FUS/SIRT3 axis, providing a potential marker for the diagnosis and treatment of DCM.
MeSH term(s)	Humans ; Diabetes Mellitus/pathology ; Diabetic Cardiomyopathies/genetics ; DNA-Binding Proteins/genetics ; Genes, Homeobox ; Interleukin-18/genetics ; Interleukin-18/metabolism ; MicroRNAs/genetics ; Myocytes, Cardiac/metabolism ; Pyroptosis/genetics ; Quality of Life ; RNA, Antisense/metabolism ; RNA, Long Noncoding/metabolism ; RNA-Binding Protein FUS/genetics ; RNA-Binding Protein FUS/metabolism ; Sirtuin 3/genetics ; Sirtuin 3/metabolism
Chemical Substances	DNA-Binding Proteins ; FUS protein, human ; Interleukin-18 ; MicroRNAs ; RNA, Antisense ; RNA, Long Noncoding ; RNA-Binding Protein FUS ; SIRT3 protein, human (EC 3.5.1.-) ; Sirtuin 3 (EC 3.5.1.-)
Language	English
Publishing date	2023-04-19
Publishing country	China (Republic : 1949- )
Document type	Journal Article
ZDB-ID	639302-0
ISSN	2410-8650 ; 0257-5655
ISSN (online)	2410-8650
ISSN	0257-5655
DOI	10.1002/kjm2.12676
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Zs.B 3187: Show issues

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Article ; Online: Oncogenic miR-106b-5p promotes cisplatin resistance in triple-negative breast cancer by targeting GDF11.

Zhou, Qing / Hu, Qinglin

Histology and histopathology

2023 Volume 39, Issue 4, Page(s) 533–541

Abstract: Background: Cytoplatin (CDDP) is a standard treatment for triple-negative breast cancer (TNB), but patient resistance to CDDP limits its efficacy. A growing study confirms that microRNAs (miRNAs) are significantly important in breast cancer, especially ... ...

Abstract	Background: Cytoplatin (CDDP) is a standard treatment for triple-negative breast cancer (TNB), but patient resistance to CDDP limits its efficacy. A growing study confirms that microRNAs (miRNAs) are significantly important in breast cancer, especially TNBC. This research was carried out to examine the function of miR-106b-5p in CDDP resistance of TNBC as well as the downstream mechanism. Methods: The miR-106b-5p and growth-differentiation factor 11 (GDF11) expressions in the tissues from TNBC patients and CDDP-treated TNBC cell lines were measured by RT-qPCR. Thereafter, cell proliferation and migration in the presence of CDDP treatment were evaluated via CCK-8 and Transwell assays in the TNBC cells. A xenograft mice model was also established to verify the miR-106b-5p silencing effect on the growth of CDDP resistance TNBC cells in vivo. Luciferase reporter experiments were performed to predict the relationship between miR-106b-5p and GDF11 expression. Results: The results showed that miR-106b-5p was upregulated in the TNBC tumor cells and TNBC cells treated with CDDP and knockdown of this caused inhibition of the TNBC cell lines' proliferation, migration and suppressed the growth of the TNBC xenografted tumors, in the presence of CDDP treatment. In addition, it was observed that miR-106b-5p can bind to GDF11; as a result in the TNBC tissues and CDDP-treated TNBC cell lines the down-regulation of GDF11 was observed. Moreover, GDF11 silencing promoted CDDP-treated TNBC cell lines' proliferation and migration and reversed the interference effect of miR-106b-5p. Conclusions: MiR-106b-5p was upregulated in TNBC and this upregulation may promote CDDP resistance of the TNBC cells by targeting GDF11 and inhibiting its expression.
MeSH term(s)	Animals ; Humans ; Mice ; Bone Morphogenetic Proteins/metabolism ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Cisplatin/pharmacology ; Gene Expression Regulation, Neoplastic ; Growth Differentiation Factors/metabolism ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Triple Negative Breast Neoplasms/drug therapy ; Triple Negative Breast Neoplasms/genetics
Chemical Substances	Bone Morphogenetic Proteins ; Cisplatin (Q20Q21Q62J) ; GDF11 protein, human ; Growth Differentiation Factors ; MicroRNAs ; MIRN106 microRNA, human
Language	English
Publishing date	2023-10-16
Publishing country	Spain
Document type	Journal Article
ZDB-ID	83911-5
ISSN	1699-5848 ; 0213-3911
ISSN (online)	1699-5848
ISSN	0213-3911
DOI	10.14670/HH-18-668
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Zs.B 3013: Show issues

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Article ; Online: A kinesin-13 family kinesin in Trypanosoma brucei regulates cytokinesis and cytoskeleton morphogenesis by promoting microtubule bundling.

Hu, Huiqing / Kurasawa, Yasuhiro / Zhou, Qing / Li, Ziyin

PLoS pathogens

2024 Volume 20, Issue 2, Page(s) e1012000

Abstract: The early branching eukaryote Trypanosoma brucei divides uni-directionally along the longitudinal cell axis from the cell anterior toward the cell posterior, and the cleavage furrow ingresses along the cell division plane between the new and the old ... ...

Abstract	The early branching eukaryote Trypanosoma brucei divides uni-directionally along the longitudinal cell axis from the cell anterior toward the cell posterior, and the cleavage furrow ingresses along the cell division plane between the new and the old flagella of a dividing bi-flagellated cell. Regulation of cytokinesis in T. brucei involves actomyosin-independent machineries and trypanosome-specific signaling pathways, but the molecular mechanisms underlying cell division plane positioning remain poorly understood. Here we report a kinesin-13 family protein, KIN13-5, that functions downstream of FPRC in the cytokinesis regulatory pathway and determines cell division plane placement. KIN13-5 localizes to multiple cytoskeletal structures, interacts with FPRC, and depends on FPRC for localization to the site of cytokinesis initiation. Knockdown of KIN13-5 causes loss of microtubule bundling at both ends of the cell division plane, leading to mis-placement of the cleavage furrow and unequal cytokinesis, and at the posterior cell tip, causing the formation of a blunt posterior. In vitro biochemical assays demonstrate that KIN13-5 bundles microtubules, providing mechanistic insights into the role of KIN13-5 in cytokinesis and posterior morphogenesis. Altogether, KIN13-5 promotes microtubule bundle formation to ensure cleavage furrow placement and to maintain posterior cytoskeleton morphology in T. brucei.
MeSH term(s)	Cytokinesis/physiology ; Trypanosoma brucei brucei/metabolism ; Kinesins/genetics ; Kinesins/metabolism ; Cytoskeleton/metabolism ; Microtubules/metabolism ; Morphogenesis ; Protozoan Proteins/metabolism
Chemical Substances	Kinesins (EC 3.6.4.4) ; Protozoan Proteins
Language	English
Publishing date	2024-02-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2205412-1
ISSN	1553-7374 ; 1553-7374
ISSN (online)	1553-7374
ISSN	1553-7374
DOI	10.1371/journal.ppat.1012000
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Article ; Online: Cerebral Venous Sinus Thrombosis with Ipsilateral Sinus and Jugular Venous Hypoplasia in Pregnancy.

Wang, Jue / Zhou, Qing / Zhang, He

Neurology India

2024 Volume 71, Issue 6, Page(s) 1298–1299

MeSH term(s)	Pregnancy ; Female ; Humans ; Cranial Sinuses/diagnostic imaging ; Sinus Thrombosis, Intracranial/complications ; Sinus Thrombosis, Intracranial/diagnostic imaging ; Jugular Veins/diagnostic imaging
Language	English
Publishing date	2024-01-04
Publishing country	India
Document type	Letter
ZDB-ID	415522-1
ISSN	1998-4022 ; 0028-3886
ISSN (online)	1998-4022
ISSN	0028-3886
DOI	10.4103/0028-3886.391349
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Zs.A 698: Show issues

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Article ; Online: Material Properties of Fiber Bundles of the Superficial Medial Collateral Ligament of the Knee Joint.

Chen, Wentao / Zhou, Qing / Tang, Jisi

Journal of biomechanical engineering

2024 Volume 146, Issue 3

Abstract: The superficial medial collateral ligament (sMCL) of the human knee joint has functionally separate anterior and posterior fiber bundles. The two bundles are alternatively loaded as the knee flexion angle changes during walking. To date, the two bundles ... ...

Abstract	The superficial medial collateral ligament (sMCL) of the human knee joint has functionally separate anterior and posterior fiber bundles. The two bundles are alternatively loaded as the knee flexion angle changes during walking. To date, the two bundles are usually not distinguished in knee ligament simulations because there has been little information about their material properties. In this study, we conducted quasi-static tensile tests on the sMCL of matured porcine stifle joints and obtained the material properties of the anterior bundle (AB), posterior bundle (PB), and whole ligament (WL). AB and PB have similar failure stress but different threshold strain, modulus, and failure strain. As a result, we recommend assigning different material properties (i.e., modulus and failure strain) to the two fiber bundles to realize biofidelic ligament responses in human body models. However, it is often inconvenient to perform tensile tests on AB and PB. Hence, we proposed a microstructural model-based approach to predict the material properties of AB and PB from the test results of WL. Such obtained modulus values of AB and PB had an error of 2% and 0.3%, respectively, compared with those measured from the tests. This approach can reduce the experimental cost for acquiring the needed mechanical property data for simulations.
MeSH term(s)	Humans ; Animals ; Swine ; Knee Joint/physiology ; Walking ; Collateral Ligaments/physiology ; Medial Collateral Ligament, Knee/physiology ; Biomechanical Phenomena ; Cadaver ; Range of Motion, Articular/physiology
Language	English
Publishing date	2024-01-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	243094-0
ISSN	1528-8951 ; 0148-0731
ISSN (online)	1528-8951
ISSN	0148-0731
DOI	10.1115/1.4064476
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Article ; Online: Federated Learning of Generalized Linear Causal Networks.

Ye, Qiaoling / Amini, Arash A / Zhou, Qing

IEEE transactions on pattern analysis and machine intelligence

2024 Volume PP

Abstract: Causal discovery, the inference of causal relations among variables from data, is a fundamental problem of science. Nowadays, due to an increased awareness of data privacy concerns, there has been a shift towards distributed data collection, processing ... ...

Abstract	Causal discovery, the inference of causal relations among variables from data, is a fundamental problem of science. Nowadays, due to an increased awareness of data privacy concerns, there has been a shift towards distributed data collection, processing and storage. To meet the pressing need for distributed causal discovery, we propose a novel federated DAG learning method called distributed annealing on regularized likelihood score (DARLS) to learn a causal graph from data stored on multiple clients. DARLS simulates an annealing process to search over the space of topological sorts, where the optimal graphical structure compatible with a sort is found by distributed optimization. This distributed optimization relies on multiple rounds of communication between local clients and a central server to estimate the graphical structure. We establish its convergence to the solution obtained by an oracle with access to all the data. To the best of our knowledge, DARLS is the first distributed method for learning causal graphs with such finite-sample oracle guarantees. To establish the consistency of DARLS, we also derive new identifiability results for causal graphs parameterized by generalized linear models, which could be of independent interest. Through extensive simulation studies and a real-world application, we show that DARLS outperforms existing federated learning methods and is comparable to oracle methods on pooled data, demonstrating its great advantages in estimating causal networks from distributed data.
Language	English
Publishing date	2024-03-26
Publishing country	United States
Document type	Journal Article
ISSN	1939-3539
ISSN (online)	1939-3539
DOI	10.1109/TPAMI.2024.3381860
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Article: An Analysis of the Current Situation and Influence Factors of Narrative Competence Among Nurses in VIP Ward.

Wang, Lin / Zhou, Qing / Hu, Ailing

Alternative therapies in health and medicine

2024

Abstract: Objective: This study aimed to explore the proficiency level in medical narrative ability among nurses in VIP wards and identify the influencing factors. The objective was to provide valuable insights for enhancing the training and development of ... ...

Abstract	Objective: This study aimed to explore the proficiency level in medical narrative ability among nurses in VIP wards and identify the influencing factors. The objective was to provide valuable insights for enhancing the training and development of medical narrative skills among nurses in VIP wards, with the ultimate goal of promoting narrative nursing in clinical practice. Methods: A survey was conducted of 94 nurses working in VIP wards at a grade-A tertiary hospital in Zhongshan City, using the Narrative Competence Scale. Results: The findings revealed that nurses' overall medical narrative ability in VIP wards was relatively low, with a total score of (135.31±16.50). The primary factors identified as influential were professional titles and familiarity with narrative medicine or narrative nursing, which played significant roles. Specifically, nurses with higher professional titles demonstrated greater proficiency in medical storytelling. Moreover, nurses more familiar with narrative medicine or narrative nursing tended to exhibit higher levels of medical narrative ability. Conclusion: The results of this study highlight the significant opportunity for enhancing the medical narrative ability of nurses in VIP wards. To address this issue, it is recommended that training programs incorporate knowledge and skills related to narrative medicine and narrative nursing into the core competency development of VIP nurses. Additionally, there is a need to introduce narrative nursing practices gradually into clinical care. These measures will empower nurses to enhance their narrative abilities, providing superior nursing services to patients. Ultimately, such efforts will strengthen nurses' sense of professional value and increase the social benefits of nursing care.
Language	English
Publishing date	2024-03-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	1225073-9
ISSN	1078-6791
ISSN	1078-6791
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