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Article ; Online: Harmonic Phasor Estimation Method Considering Dense Interharmonic Interference.

Xiao, Xianyong / Zhou, Runze / Ma, Xiaoyang / Xu, Rui

2023 Volume 25, Issue 2

Abstract: Due to the limitation of frequency resolution and the spectrum leakage caused by signal windowing, the spectrums of harmonic and interharmonic components with close frequencies overlap each other. When the dense interharmonic (DI) components are close to ...

Abstract	Due to the limitation of frequency resolution and the spectrum leakage caused by signal windowing, the spectrums of harmonic and interharmonic components with close frequencies overlap each other. When the dense interharmonic (DI) components are close to the harmonic spectrum peaks, the harmonic phasor estimation accuracy is seriously reduced. To address this problem, a harmonic phasor estimation method considering DI interference is proposed in this paper. Firstly, based on the spectral characteristics of the dense frequency signal, the phase and amplitude characteristics are used to determine whether DI interference exists in the signal. Secondly, an autoregressive model is established by using the autocorrelation of the signal. Data extrapolation is performed on the basis of the sampling sequence to improve the frequency resolution and eliminate the interharmonic interference. Finally, the estimated values of harmonic phasor, frequency and rate of change of frequency are obtained. The simulation and some experimental results demonstrate that the proposed method can accurately estimate the parameters of harmonic phasors when DIs exist in the signal, and has a certain anti-noise capability and dynamic performance.
Language	English
Publishing date	2023-01-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2014734-X
ISSN	1099-4300 ; 1099-4300
ISSN (online)	1099-4300
ISSN	1099-4300
DOI	10.3390/e25020236
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The Molecular Mechanism Underlying the Therapeutic Effect of Dihydromyricetin on Type 2 Diabetes Mellitus Based on Network Pharmacology, Molecular Docking, and Transcriptomics.

Wen, Xinnian / Lv, Chenghao / Zhou, Runze / Wang, Yixue / Zhou, Xixin / Qin, Si

Foods (Basel, Switzerland)

2024 Volume 13, Issue 2

Abstract: Type 2 diabetes mellitus (T2DM) is a chronic and complex disease, and traditional drugs have many side effects. The active compound dihydromyricetin (DHM), derived from natural plants, has been shown in our previous study to possess the potential for ... ...

Abstract	Type 2 diabetes mellitus (T2DM) is a chronic and complex disease, and traditional drugs have many side effects. The active compound dihydromyricetin (DHM), derived from natural plants, has been shown in our previous study to possess the potential for reducing blood glucose levels; however, its precise molecular mechanism remains unclear. In the present study, network pharmacology and transcriptomics were performed to screen the molecular targets and signaling pathways of DHM disturbed associated with T2DM, and the results were partially verified by molecular docking, RT-PCR, and Western blotting at in vivo levels. Firstly, the effect of DHM on blood glucose, lipid profile, and liver oxidative stress in db/db mice was explored and the results showed that DHM could reduce blood glucose and improve oxidative stress in the liver. Secondly, GO analysis based on network pharmacology and transcriptomics results showed that DHM mainly played a significant role in anti-inflammatory, antioxidant, and fatty acid metabolism in biological processes, on lipoprotein and respiratory chain on cell components, and on redox-related enzyme activity, iron ion binding, and glutathione transferase on molecular functional processes. KEGG system analysis results showed that the PI3K-Akt signaling pathway, IL17 signaling pathway, HIF signaling pathway, MAPK signaling pathway, AGE-RAGE signaling pathway in diabetic complications, and TNF signaling pathway were typical signaling pathways disturbed by DHM in T2DM. Thirdly, molecular docking results showed that VEGFA, SRC, HIF1A, ESR1, KDR, MMP9, PPARG, and MAPK14 are key target genes, five genes of which were verified by RT-PCR in a dose-dependent manner. Finally, Western blotting results revealed that DHM effectively upregulated the expression of AKT protein and downregulated the expression of MEK protein in the liver of db/db mice. Therefore, our study found that DHM played a therapeutic effect partially by activation of the PI3K/AKT/MAPK signaling pathway. This study establishes the foundation for DHM as a novel therapeutic agent for T2DM. Additionally, it presents a fresh approach to utilizing natural plant extracts for chemoprevention and treatment of T2DM.
Language	English
Publishing date	2024-01-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods13020344
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Article: Experimental Study on the Effect of Gas Volume Fraction on the Cavitation Performance of a Low-Specific-Speed Centrifugal Pump

Jiang, Linglin / Liu, Houlin / Wang, Yong / Mao, Yanhong / Zhou, Runze / Gu, Jianbin

Water. 2022 Mar. 03, v. 14, no. 5

2022

Abstract: In order to study the cavitation performance of centrifugal pumps with low specific speeds under the condition of gas–liquid two-phase flow, a cavitation test rig for pumping gas–liquid two-phase flow was set up. The cavitation performance of the pump ... ...

Abstract	In order to study the cavitation performance of centrifugal pumps with low specific speeds under the condition of gas–liquid two-phase flow, a cavitation test rig for pumping gas–liquid two-phase flow was set up. The cavitation performance of the pump with a specific speed of 32 was studied. The variation of the head, pressure pulsation intensity, and vibration intensity with the cavitation allowance NPSHₐ (Net Positive Suction Head available) of the centrifugal pump were obtained at different inlet gas volume fraction (IGVF) conditions of 0, 1%, 2%, and 3%. The results show that the cavitation performance of a low-specific-speed centrifugal pump can be improved obviously in a certain liquid flow range when the IGVF is 1%, especially at a low liquid flow rate. When cavitation did not occur or the degree of cavitation was low, a lower IGVF can reduce pressure pulsation intensity at the pump outlet and the vibration intensity at the pump inlet under design flow rate and high flow rate conditions. Additionally, all performances of the low-specific-speed pump are more sensitive to gas when the liquid flow rate is low. The results can provide a reference for improving the cavitation performance of low-specific-speed pumps for transporting gas–liquid two-phase flow and single-phase liquids.
Keywords	head ; liquids ; vibration ; water
Language	English
Dates of publication	2022-0303
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2521238-2
ISSN	2073-4441
ISSN	2073-4441
DOI	10.3390/w14050798
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Permanent left bundle branch area pacing in a child with a third-degree atrioventricular block: A case report.

Huang, Jing / Zhou, Runze / Pan, Yesheng / Yang, Bing

Journal of cardiovascular electrophysiology

2020 Volume 31, Issue 6, Page(s) 1539–1543

Abstract: Permanent left bundle branch area pacing (LBBP) is a promising physiological pacing technique that has emerged in recent years. However, LBBP is almost exclusively clinically applied in adult patients. The feasibility and safety of the use of LBBP in ... ...

Abstract	Permanent left bundle branch area pacing (LBBP) is a promising physiological pacing technique that has emerged in recent years. However, LBBP is almost exclusively clinically applied in adult patients. The feasibility and safety of the use of LBBP in children have not been well-assessed. Here, we report the case of a 6-year-old child with a third-degree atrioventricular block after surgical aortic valve replacement who successfully received a permanent LBBP.
MeSH term(s)	Action Potentials ; Atrioventricular Block/diagnosis ; Atrioventricular Block/etiology ; Atrioventricular Block/physiopathology ; Atrioventricular Block/therapy ; Bicuspid Aortic Valve Disease/surgery ; Bundle of His/physiopathology ; Cardiac Pacing, Artificial ; Child ; Heart Rate ; Heart Valve Prosthesis Implantation/adverse effects ; Humans ; Treatment Outcome
Language	English
Publishing date	2020-05-06
Publishing country	United States
Document type	Case Reports ; Research Support, Non-U.S. Gov't
ZDB-ID	1025989-2
ISSN	1540-8167 ; 1045-3873
ISSN (online)	1540-8167
ISSN	1045-3873
DOI	10.1111/jce.14520
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Article: Prognostic significance of lncRNA AP004608.1 in prostate cancer.

Li, Wei / Zhou, Runze / Sun, Bo / Jin, Xin / Chen, Yuan / Xu, Xuefen

Frontiers in oncology

2022 Volume 12, Page(s) 1017635

Abstract: This study aimed to screen and determine the value of AP004608.1 expression as a biomarker for Prostate cancer (PCa) survival. We investigated the expression and prognosis of AP004608.1 through bioinformatics analysis. Low AP004608.1 expression predicted ...

Abstract	This study aimed to screen and determine the value of AP004608.1 expression as a biomarker for Prostate cancer (PCa) survival. We investigated the expression and prognosis of AP004608.1 through bioinformatics analysis. Low AP004608.1 expression predicted favorable Overall survival (OS) and Progression-free survival (PFS) in PCa patients, according to the Cancer Genome Atlas (TCGA) database. Cox regression demonstrated that low AP004608.1 expression were in-dependent biomarkers for OS. Moreover, Gene Expression Omnibus (GEO) database was utilized to verify the prognostic role of AP004608.1 in PCa, and the similar results were reached. A meta-analysis revealed that low AP004608.1 expression was closely relevant to better OS. AP004608.1 could constitute a promising prognostic biomarker, and probably plays an important role in PCa.
Language	English
Publishing date	2022-09-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2022.1017635
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Article ; Online: Incidence Trends, Clinicopathologic Characteristics, and Overall Survival Prediction in Retinoblastoma Children: SEER Prognostic Nomogram Analysis.

Guo, Xiaohong / Wang, Li / Beeraka, Narasimha M / Liu, Chunying / Zhao, Xiang / Zhou, Runze / Yu, Huiming / Fan, Ruitai / Liu, Junqi

The oncologist

2023 Volume 29, Issue 2, Page(s) e275–e281

Abstract: Background: Retinoblastoma is the most common intraocular malignant tumor occurring among children, with an incidence rate of 1/15 000. This study built a joinpoint regression model to assess the incidence trend of retinoblastoma from 2004 to 2015 and ... ...

Abstract	Background: Retinoblastoma is the most common intraocular malignant tumor occurring among children, with an incidence rate of 1/15 000. This study built a joinpoint regression model to assess the incidence trend of retinoblastoma from 2004 to 2015 and constructed a nomogram to predict the overall survival (OS) in children. Materials and methods: Patients less than 19 years diagnosed with retinoblastoma from 2004 to 2015 were selected from the SEER database. Joinpoint regression analysis (version 4.9.0.0) was performed to evaluate the trends in retinoblastoma incidence rates from 2004 to 2015. Cox Regression Analysis was applied to investigate prognostic risk factors that influence OS. Results: Joinpoint regression revealed that retinoblastoma incidence exhibited no significant increase or decrease from 2004 to 2015. As per the multiple Cox regression, tumor size, laterality, and residence (rural-urban continuum code) were correlated with OS and were used to construct a nomogram. The nomogram exhibited a good C-index of 0.71 (95% CI, 0.63 to 0.79), and the calibration curve for survival probability demonstrated that the predictions corresponded well with actual observations. Conclusions and relevance: A prognostic nomogram integrating the risk factors for retinoblastoma was constructed to provide comparatively accurate individual survival predictions. If validated, this type of assessment could be used to guide therapy in patients with retinoblastoma.
MeSH term(s)	Child ; Humans ; Prognosis ; Nomograms ; Incidence ; Retinoblastoma/epidemiology ; Retinal Neoplasms/epidemiology ; SEER Program
Language	English
Publishing date	2023-10-23
Publishing country	England
Document type	Journal Article
ZDB-ID	1409038-7
ISSN	1549-490X ; 1083-7159
ISSN (online)	1549-490X
ISSN	1083-7159
DOI	10.1093/oncolo/oyad286
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Article: Identification of absorbed compounds of Xiao Yao San Jia Wei and pharmacokinetic study in depressed rats by force swimming stress

Shan, Chenxiao / Li, Jia / Sun, Bo / Zhou, Runze / Xu, Min / Zhao, Qiulong / Ren, Ping / Wen, Hongmei / Huang, Xi

RSC advances. 2022 Feb. 04, v. 12, no. 8

2022

Abstract: Xiao-Yao-San-Jia-Wei (XYSJW) is a commonly prescribed formulation for depression and anorexia in the Jiang Su Province Hospital of Chinese Medicine. Unfortunately, the proper dosage of this formulation is still unclear due to its limited chemical and ... ...

Abstract	Xiao-Yao-San-Jia-Wei (XYSJW) is a commonly prescribed formulation for depression and anorexia in the Jiang Su Province Hospital of Chinese Medicine. Unfortunately, the proper dosage of this formulation is still unclear due to its limited chemical and pharmacokinetic profiles. Thus, in the present study, a sensitive, precise, and rapid procedure for the identification of absorbed compounds (Cs) in the plasma of depressed rats together with a pharmacokinetic analysis was established with the help of ultra-flow liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UFLC-Q-TOF MS/MS) and ultra-flow liquid chromatography coupled with electrospray ionization triple quadrupole tandem mass spectrometry (UFLC-QQQ MS/MS). Based on the characteristic fragmentation, neutral loss, mass defect filter, relevant literature and reference standards, 225 Cs in the XYSJW extract and 20 Cs in the plasma of the depressed rats were tentatively recognized via UFLC-Q-TOF MS/MS and UFLC-QQQ MS/MS. Then, the 12 major absorbed Cs in the depressed rats after oral XYSJW administration were chosen to further investigate its pharmacokinetic profile by UFLC-QQQ MS/MS. This study provides a systematic approach for the rapid and qualitative analysis of absorbed Cs in depressed rats and investigating the pharmacokinetics of XYSJW. More importantly, our work provides key information on the chemical and pharmacokinetic profiles of XYSJW in vitro and in vivo, which may benefit its therapeutic efficacy and further pharmacological studies involving this formulation.
Keywords	Oriental traditional medicine ; anorexia ; electrospray ionization mass spectrometry ; hospitals ; liquid chromatography ; pharmacokinetics ; qualitative analysis ; tandem mass spectrometry ; therapeutics
Language	English
Dates of publication	2022-0204
Size	p. 4455-4468.
Publishing place	The Royal Society of Chemistry
Document type	Article
ISSN	2046-2069
DOI	10.1039/d1ra08778a
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Identification of absorbed compounds of Xiao Yao San Jia Wei and pharmacokinetic study in depressed rats by force swimming stress.

Shan, Chenxiao / Li, Jia / Sun, Bo / Zhou, Runze / Xu, Min / Zhao, Qiulong / Ren, Ping / Wen, Hongmei / Huang, Xi

RSC advances

2022 Volume 12, Issue 8, Page(s) 4455–4468

Abstract	Xiao-Yao-San-Jia-Wei (XYSJW) is a commonly prescribed formulation for depression and anorexia in the Jiang Su Province Hospital of Chinese Medicine. Unfortunately, the proper dosage of this formulation is still unclear due to its limited chemical and pharmacokinetic profiles. Thus, in the present study, a sensitive, precise, and rapid procedure for the identification of absorbed compounds (Cs) in the plasma of depressed rats together with a pharmacokinetic analysis was established with the help of ultra-flow liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UFLC-Q-TOF MS/MS) and ultra-flow liquid chromatography coupled with electrospray ionization triple quadrupole tandem mass spectrometry (UFLC-QQQ MS/MS). Based on the characteristic fragmentation, neutral loss, mass defect filter, relevant literature and reference standards, 225 Cs in the XYSJW extract and 20 Cs in the plasma of the depressed rats were tentatively recognized
Language	English
Publishing date	2022-02-04
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d1ra08778a
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Noise spectrum characteristics of marine pump units induced by different excitation sources.

Liu, Houlin / Zhou, Runze / Pan, Qi / Dong, Liang / Ma, Qijiang / Cheng, ZhiMing / Wang, Xiaolin

Scientific reports

2022 Volume 12, Issue 1, Page(s) 8678

Abstract: To study the noise spectrum characteristics of marine pump units induced by different excitation sources, a computational aeroacoustic (CAA) model of the internal and external field noise of a marine pump was established. The coupled acoustic-vibration ... ...

Abstract	To study the noise spectrum characteristics of marine pump units induced by different excitation sources, a computational aeroacoustic (CAA) model of the internal and external field noise of a marine pump was established. The coupled acoustic-vibration method was used to obtain the spectrum characteristics of internal and external field noise. The accuracy and feasibility of the simulation method for noise prediction were confirmed through a noise test. Due to the different mediums in the internal and external fields of the marine pump, an external field acoustic model was established based on the automatically matched layer (AML) technology. The spectral characteristics of different excitation sources and the spatial distribution of the radiated sound field were analyzed, and the contribution of different sound source excitations to the internal and external sound field was revealed. The results show that the main frequency of the internal field noise generated by different excitations is at the blade passing frequency, and the internal field noise induced by the dipole acoustic excitations dominates at 180.6 dB. For the external field noise, the main frequency is still located at the blade passing frequency. The radiation noise induced by the fluid excitation (139.2 dB) is higher than that induced by the dipole excitations (surface dipole, 136.3 dB; rotating dipole, 137.3 dB).
Language	English
Publishing date	2022-05-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-12755-8
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Article: Novel Implications of Nanoparticle-Enhanced Radiotherapy and Brachytherapy: Z-Effect and Tumor Hypoxia.

Zhou, Runze / Zhao, Di / Beeraka, Narasimha M / Wang, Xiaoyan / Lu, Pengwei / Song, Ruixia / Chen, Kuo / Liu, Junqi

Metabolites

2022 Volume 12, Issue 10

Abstract: Radiotherapy and internal radioisotope therapy (brachytherapy) induce tumor cell death through different molecular signaling pathways. However, these therapies in cancer patients are constrained by dose-related adverse effects and local discomfort due to ...

Abstract	Radiotherapy and internal radioisotope therapy (brachytherapy) induce tumor cell death through different molecular signaling pathways. However, these therapies in cancer patients are constrained by dose-related adverse effects and local discomfort due to the prolonged exposure to the surrounding tissues. Technological advancements in nanotechnology have resulted in synthesis of high atomic elements such as nanomaterials, which can be used as radiosensitizers due to their photoelectric characteristics. The aim of this review is to elucidate the effects of novel nanomaterials in the field of radiation oncology to ameliorate dose-related toxicity through the application of ideal nanoparticle-based radiosensitizers such as Au (gold), Bi (bismuth), and Lu (Lutetium-177) for enhancing cytotoxic effects of radiotherapy via the high-Z effect. In addition, we discuss the role of nanoparticle-enhanced radiotherapy in alleviating tumor hypoxia through the nanodelivery of genes/drugs and other functional anticancer molecules. The implications of engineered nanoparticles in preclinical and clinical studies still need to be studied in order to explore potential mechanisms for radiosensitization by minimizing tumor hypoxia, operational/logistic complications and by overcoming tumor heterogeneity in radiotherapy/brachytherapy.
Language	English
Publishing date	2022-10-05
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662251-8
ISSN	2218-1989
ISSN	2218-1989
DOI	10.3390/metabo12100943
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