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  1. Article ; Online: Regulatory and Insurance Challenges Must Be Overcome in the United States to Meet Global Standards for Asthma Management.

    Arora, Nonie S / Zhou, Sherry / Baptist, Alan P

    The journal of allergy and clinical immunology. In practice

    2024  Volume 12, Issue 3, Page(s) 624–626

    MeSH term(s) United States/epidemiology ; Humans ; Insurance ; Asthma/epidemiology ; Asthma/therapy ; Insurance, Health
    Language English
    Publishing date 2024-02-24
    Publishing country United States
    Document type Editorial
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2023.10.027
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    Zs.A 7086: Show issues Location:
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  2. Article ; Online: Electronic cigarettes: How confident and effective are allergists, pulmonologists, and primary care physicians in their practice behavior?

    Zhou, Sherry S / Baptist, Alan P

    Allergy and asthma proceedings

    2020  Volume 41, Issue 3, Page(s) 192–197

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Adult ; Allergists ; Attitude of Health Personnel ; Clinical Competence ; Counseling ; Electronic Nicotine Delivery Systems ; Female ; Humans ; Logistic Models ; Male ; Middle Aged ; Patient Education as Topic ; Physicians, Primary Care ; Pulmonologists ; Self Concept ; Surveys and Questionnaires ; Tobacco Use Cessation ; United States ; Vaping
    Language English
    Publishing date 2020-07-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1312445-6
    ISSN 1539-6304 ; 1088-5412
    ISSN (online) 1539-6304
    ISSN 1088-5412
    DOI 10.2500/aap.2020.41.200009
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    Zs.A 1804: Show issues Location:
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  3. Article ; Online: The Performance of the Semigeneralized Partial Credit Model for Handling Item-Level Missingness.

    Zhou, Sherry / Huggins-Manley, Anne Corinne

    Educational and psychological measurement

    2020  Volume 80, Issue 6, Page(s) 1196–1215

    Abstract: The semi-generalized partial credit model (Semi-GPCM) has been proposed as a unidimensional modeling method for handling not applicable scale responses and neutral scale responses, and it has been suggested that the model may be of use in handling ... ...

    Abstract The semi-generalized partial credit model (Semi-GPCM) has been proposed as a unidimensional modeling method for handling not applicable scale responses and neutral scale responses, and it has been suggested that the model may be of use in handling missing data in scale items. The purpose of this study is to evaluate the ability of the unidimensional Semi-GPCM to aid in the recovery of person parameters from item response data in the presence of item-level missingness, and to compare the performance of the model with two other proposed methods for handling such missingness: a multidimensional modeling approach for missingness and full information maximum likelihood estimation. The results indicate that the Semi-GPCM performs acceptably in an absolute sense when less than 30% of the item data is missing but does not outperform the other two methods under any particular conditions. We conclude with a discussion about when practitioners may or may not want to use the Semi-GPCM to recover person parameters from item response data with missingness.
    Language English
    Publishing date 2020-05-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1500101-5
    ISSN 1552-3888 ; 0013-1644
    ISSN (online) 1552-3888
    ISSN 0013-1644
    DOI 10.1177/0013164420918392
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  4. Article ; Online: The Role of KIT Mutations in Anaphylaxis.

    Coulson, Elise / Zhou, Sherry / Akin, Cem

    Current allergy and asthma reports

    2019  Volume 19, Issue 6, Page(s) 31

    Abstract: Purpose of review: Gain of function KIT mutations are detected in clonal mast cell diseases, namely mastocytosis and monoclonal mast cell activation syndrome. Timely diagnosis and treatment of these disorders are crucial because of their association ... ...

    Abstract Purpose of review: Gain of function KIT mutations are detected in clonal mast cell diseases, namely mastocytosis and monoclonal mast cell activation syndrome. Timely diagnosis and treatment of these disorders are crucial because of their association with severe and life-threatening anaphylaxis. KIT mutations also have implications for targeted therapies of mast cell disorders. This review article strives to serve as an overview of the role of clonal mast cell disorders in anaphylaxis while elucidating current and future therapies.
    Recent findings: Clonal mast cell disease has been increasingly diagnosed in patients with severe hymenoptera allergy and those with recurrent unexplained anaphylaxis. The current state of knowledge of the epidemiology, pathophysiology, diagnosis, and treatment of mastocytosis with a particular focus on anaphylaxis and its triggers which are described in this context. Novel and forthcoming treatments are discussed including the relevance of KIT mutation status. This review provides an overview of the role of KIT mutations in mastocytosis and anaphylaxis, and highlights emerging therapies for mastocytosis, targeting these mutations.
    MeSH term(s) Anaphylaxis/genetics ; Anaphylaxis/immunology ; Anaphylaxis/therapy ; Humans ; Mast Cells/immunology ; Mastocytosis/genetics ; Mastocytosis/immunology ; Mastocytosis/therapy ; Mutation ; Proto-Oncogene Proteins c-kit/genetics
    Chemical Substances Proto-Oncogene Proteins c-kit (EC 2.7.10.1)
    Language English
    Publishing date 2019-04-26
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2057370-4
    ISSN 1534-6315 ; 1529-7322
    ISSN (online) 1534-6315
    ISSN 1529-7322
    DOI 10.1007/s11882-019-0863-5
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    Zs.A 5548: Show issues Location:
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  5. Article ; Online: Single neonatal estrogen implant sterilizes female animals by decreasing hypothalamic KISS1 expression.

    Park, Chan Jin / Minabe, Shiori / Hess, Rex A / Lin, Po-Ching Patrick / Zhou, Sherry / Bashir, Shah Tauseef / Barakat, Radwa / Gal, Arnon / Ko, CheMyong Jay

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 9627

    Abstract: Reproductive sterilization by surgical gonadectomy is strongly advocated to help manage animal populations, especially domesticated pets, and to prevent reproductive behaviors and diseases. This study explored the use of a single-injection method to ... ...

    Abstract Reproductive sterilization by surgical gonadectomy is strongly advocated to help manage animal populations, especially domesticated pets, and to prevent reproductive behaviors and diseases. This study explored the use of a single-injection method to induce sterility in female animals as an alternative to surgical ovariohysterectomy. The idea was based on our recent finding that repetitive daily injection of estrogen into neonatal rats disrupted hypothalamic expression of Kisspeptin (KISS1), the neuropeptide that triggers and regulates pulsatile secretion of GnRH. Neonatal female rats were dosed with estradiol benzoate (EB) either by daily injections for 11 days or by subcutaneous implantation of an EB-containing silicone capsule designed to release EB over 2-3 weeks. Rats treated by either method did not exhibit estrous cyclicity, were anovulatory, and became infertile. The EB-treated rats had fewer hypothalamic Kisspeptin neurons, but the GnRH-LH axis remained responsive to Kisspeptin stimulation. Because it would be desirable to use a biodegradable carrier that is also easier to handle, an injectable EB carrier was developed from PLGA microspheres to provide pharmacokinetics comparable to the EB-containing silicone capsule. A single neonatal injection of EB-microspheres at an equivalent dosage resulted in sterility in the female rat. In neonatal female Beagle dogs, implantation of an EB-containing silicone capsule also reduced ovarian follicle development and significantly inhibited KISS1 expression in the hypothalamus. None of the treatments produced any concerning health effects, other than infertility. Therefore, further development of this technology for sterilization in domestic female animals, such as dogs and cats is worthy of investigation.
    MeSH term(s) Female ; Animals ; Cats ; Dogs ; Rats ; Kisspeptins/pharmacology ; Cat Diseases ; Dog Diseases ; Hypothalamus ; Gonadotropin-Releasing Hormone ; Animals, Domestic ; Sterilization ; Infertility ; Estrogens/pharmacology
    Chemical Substances Kisspeptins ; Gonadotropin-Releasing Hormone (33515-09-2) ; Estrogens
    Language English
    Publishing date 2023-06-14
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-36727-8
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  6. Article ; Online: Nursing Education to Reduce Use of Tobacco and Alternative Tobacco Products: Change Is Imperative.

    VanDevanter, Nancy / Katigbak, Carina / Naegle, Madeline / Zhou, Sherry / Sherman, Scott / Weitzman, Michael

    Journal of the American Psychiatric Nurses Association

    2017  Volume 23, Issue 6, Page(s) 414–421

    Abstract: Background: Tobacco use continues to be the leading cause of preventable death worldwide.: Objective: To assess perceived tobacco educational preparation of undergraduate and graduate nurses in a large urban university.: Design: A cross-sectional ... ...

    Abstract Background: Tobacco use continues to be the leading cause of preventable death worldwide.
    Objective: To assess perceived tobacco educational preparation of undergraduate and graduate nurses in a large urban university.
    Design: A cross-sectional web-based survey of all nursing students in an urban college of nursing was conducted to assess perceived tobacco educational content, skills, and self-efficacy for cessation counseling with patients who smoke cigarettes and use alternative tobacco products (e.g., hookah and e-cigarettes).
    Results: Participants reported the most education about health effects of tobacco use (67%), and less than 6% reported education about alternative tobacco products. While the majority of nurses agreed that advising patients to quit is a priority, less than 40% reported receiving sufficient training in cessation counseling.
    Conclusions: There continues to be a compelling need articulated by leaders in tobacco policy and research over the past decade for a more vigorous response by nurses to the tobacco epidemic.
    MeSH term(s) Adolescent ; Adult ; Counseling/methods ; Cross-Sectional Studies ; Education, Nursing/methods ; Electronic Nicotine Delivery Systems/statistics & numerical data ; Female ; Health Education/methods ; Humans ; Male ; Middle Aged ; Smoking Cessation/methods ; Smoking Water Pipes ; Students, Nursing/statistics & numerical data ; Surveys and Questionnaires ; Young Adult
    Language English
    Publishing date 2017-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2252638-9
    ISSN 1532-5725 ; 1078-3903
    ISSN (online) 1532-5725
    ISSN 1078-3903
    DOI 10.1177/1078390317711252
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    Zs.A 6377: Show issues Location:
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  7. Article ; Online: Hookah use among U.S. high school seniors.

    Palamar, Joseph J / Zhou, Sherry / Sherman, Scott / Weitzman, Michael

    Pediatrics

    2014  Volume 134, Issue 2, Page(s) 227–234

    Abstract: Objectives: Prevalence of hookah use is increasing significantly among adolescents. This study aimed to delineate demographic and socioeconomic correlates of hookah use among high school seniors in the United States. We hypothesized that more ... ...

    Abstract Objectives: Prevalence of hookah use is increasing significantly among adolescents. This study aimed to delineate demographic and socioeconomic correlates of hookah use among high school seniors in the United States. We hypothesized that more impoverished adolescents and those who smoked cigarettes would be more likely to use hookahs.
    Methods: Data were examined for 5540 high school seniors in Monitoring the Future (years 2010-2012), an annual nationally representative survey of high school students in the United States. Using data weights provided by Monitoring the Future, we used multivariable binary logistic regression to delineate correlates of hookah use in the last 12 months.
    Results: Eighteen percent of students reported hookah use in the past year. Compared with white students, black students were at lower odds for use (adjusted odds ratio [AOR] = 0.27, P < .0001). High parent education increased the odds for use (AOR = 1.58, P < .001), and student weekly income from a job of >$50/week (AOR = 1.26, P < .05) or $11 to $50 per week from other sources (AOR = 1.35, P < .01) also increased odds for use. Males and urban students were also at higher odds for use, as were users of alcohol, marijuana, and other illicit substances. Former cigarette smokers were at higher risk, and current smokers were at highest risk for use.
    Conclusions: Adolescents of higher socioeconomic status appear to be at particularly high risk for hookah use in the United States. Prevention efforts must target this group as prevalence continues to increase.
    MeSH term(s) Adolescent ; Adolescent Behavior ; Female ; Health Surveys ; Humans ; Logistic Models ; Male ; Prevalence ; Risk Factors ; Sex Factors ; Smoking/epidemiology ; Social Class ; Socioeconomic Factors ; Students/statistics & numerical data ; United States/epidemiology
    Language English
    Publishing date 2014-07-07
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 207677-9
    ISSN 1098-4275 ; 0031-4005
    ISSN (online) 1098-4275
    ISSN 0031-4005
    DOI 10.1542/peds.2014-0538
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    Um IV Zs.131: Show issues Location:
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    Zs.MO 357: Show issues

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  8. Article ; Online: Perception of e-cigarette harm and its correlation with use among U.S. adolescents.

    Amrock, Stephen M / Zakhar, Joseph / Zhou, Sherry / Weitzman, Michael

    Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco

    2014  Volume 17, Issue 3, Page(s) 330–336

    Abstract: Introduction: U.S. adolescents increasingly use e-cigarettes. The perceived harm of e-cigarettes has not been described, nor has the correlation between harm perception and e-cigarette use been assessed. This study examines correlates of e-cigarette ... ...

    Abstract Introduction: U.S. adolescents increasingly use e-cigarettes. The perceived harm of e-cigarettes has not been described, nor has the correlation between harm perception and e-cigarette use been assessed. This study examines correlates of e-cigarette harm perception and use of e-cigarettes in a national survey.
    Methods: We used cross-sectional nationally representative data from the 2012 National Youth Tobacco Survey (n = 24,658). Cross-tabulations and multivariate ordered probit and logistic regression models were employed to assess relative harm perception and e-cigarette use.
    Results: Half of U.S. adolescents had heard of e-cigarettes. Of these, 13.2% (95% confidence interval [CI] = 11.7-14.9) and 4.0% (95% CI = 3.4-4.7) reported ever or currently using e-cigarettes, respectively. Of those aware of e-cigarettes, 34.2% (95% CI = 32.8-35.6) believed e-cigarettes were less harmful than cigarettes. Among those trying e-cigarettes, 71.8% (95% CI = 69.0-74.5) believed e-cigarettes were comparatively less harmful. Females and those ≥ 17 years old were more likely to perceive e-cigarettes as more harmful relative to cigarettes, while on average Whites, users of other tobacco products, and those with family members who used tobacco were more likely to perceive e-cigarettes as comparatively safer. Among cigarette-naive e-cigarette users, use of other tobacco products and perceived harm reduction by e-cigarettes were, respectively, on average associated with 1.6 and 4.1 percentage-point increases in e-cigarette use.
    Conclusions: Perception of e-cigarettes as less harmful than conventional cigarettes was associated with increased e-cigarette use, including among cigarette-naive e-cigarette users. These findings should prompt further scientific investigation and merit attention from regulators.
    MeSH term(s) Adolescent ; Adolescent Behavior/psychology ; Awareness ; Child ; Cross-Sectional Studies ; Electronic Nicotine Delivery Systems/psychology ; Electronic Nicotine Delivery Systems/statistics & numerical data ; Female ; Harm Reduction ; Humans ; Male ; Perception ; Smoking/epidemiology ; Smoking/psychology ; United States/epidemiology
    Language English
    Publishing date 2014-08-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 1452315-2
    ISSN 1469-994X ; 1462-2203
    ISSN (online) 1469-994X
    ISSN 1462-2203
    DOI 10.1093/ntr/ntu156
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    Zs.A 5789: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Knowledge, Beliefs, Behaviors, and Social Norms Related to Use of Alternative Tobacco Products Among Undergraduate and Graduate Nursing Students in an Urban U.S. University Setting.

    VanDevanter, Nancy / Zhou, Sherry / Katigbak, Carina / Naegle, Madeline / Sherman, Scott / Weitzman, Michael

    Journal of nursing scholarship : an official publication of Sigma Theta Tau International Honor Society of Nursing

    2016  Volume 48, Issue 2, Page(s) 147–153

    Abstract: Purpose: The purpose of the study was to assess nursing students' knowledge, beliefs, behaviors, and social norms regarding use of alternative tobacco products (ATPs).: Design and methods: This anonymous online survey was conducted with all students ... ...

    Abstract Purpose: The purpose of the study was to assess nursing students' knowledge, beliefs, behaviors, and social norms regarding use of alternative tobacco products (ATPs).
    Design and methods: This anonymous online survey was conducted with all students enrolled in a college of nursing. The survey utilized measures from several national tobacco studies to assess knowledge and beliefs about ATPs (hookahs, cigars or cigarillos, bidis, kreteks, smokeless tobacco, electronic cigarettes) compared to cigarettes, health effects of ATPs, personal use of ATPs, and social norms. Data were analyzed in SPSS 22.0 (SPSS Inc., Chicago, IL, USA). Descriptive statistics and frequencies were performed for basic sociodemographic data. Paired samples t tests were performed to determine differences for scaled measures.
    Findings: Nursing students demonstrated very low levels of knowledge about ATPs and their health consequences, despite high rates of ATP personal use. About 76% of participants reported use of one or more ATPs once or more in their lifetimes. A greater proportion of students had used hookahs or waterpipes (39.6%) compared to cigarettes (32.7%).
    Conclusions: Nurses' lack of knowledge about the emerging use and health threats associated with ATPs may undermine their ability to provide appropriate tobacco cessation counseling. Research is needed to identify gaps in nurses' education regarding tobacco cessation counseling and to develop new counseling approaches specific to use of ATPs.
    Clinical relevance: Nurses play critical roles in counseling their patients for tobacco cessation. Further research and education about the risks presented by ATPs are critical to reducing excess tobacco-related mortality.
    MeSH term(s) Adolescent ; Adult ; Education, Nursing, Baccalaureate ; Education, Nursing, Graduate ; Electronic Nicotine Delivery Systems/utilization ; Female ; Health Knowledge, Attitudes, Practice ; Humans ; Male ; Middle Aged ; Smoking/psychology ; Social Norms ; Students, Nursing/psychology ; Students, Nursing/statistics & numerical data ; Surveys and Questionnaires ; Tobacco Products/utilization ; United States ; Universities ; Urban Population ; Young Adult
    Language English
    Publishing date 2016-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2008214-9
    ISSN 1547-5069 ; 1527-6546
    ISSN (online) 1547-5069
    ISSN 1527-6546
    DOI 10.1111/jnu.12192
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    Zs.B 2842: Show issues Location:
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  10. Article ; Online: Progesterone Receptor Serves the Ovary as a Trigger of Ovulation and a Terminator of Inflammation.

    Park, Chan Jin / Lin, Po-Ching / Zhou, Sherry / Barakat, Radwa / Bashir, Shah Tauseef / Choi, Jeong Moon / Cacioppo, Joseph A / Oakley, Oliver R / Duffy, Diane M / Lydon, John P / Ko, CheMyong J

    Cell reports

    2020  Volume 31, Issue 2, Page(s) 107496

    Abstract: Ovulation is triggered by the gonadotropin surge that induces the expression of two key genes, progesterone receptor (Pgr) and prostaglandin-endoperoxide synthase 2 (Ptgs2), in the granulosa cells of preovulatory follicles. Their gene products PGR and ... ...

    Abstract Ovulation is triggered by the gonadotropin surge that induces the expression of two key genes, progesterone receptor (Pgr) and prostaglandin-endoperoxide synthase 2 (Ptgs2), in the granulosa cells of preovulatory follicles. Their gene products PGR and PTGS2 activate two separate pathways that are both essential for successful ovulation. Here, we show that the PGR plays an additional essential role: it attenuates ovulatory inflammation by diminishing the gonadotropin surge-induced Ptgs2 expression. PGR indirectly terminates Ptgs2 expression and PGE2 synthesis in granulosa cells by inhibiting the nuclear factor κB (NF-κB), a transcription factor required for Ptgs2 expression. When the expression of PGR is ablated in granulosa cells, the ovary undergoes a hyperinflammatory condition manifested by excessive PGE2 synthesis, immune cell infiltration, oxidative damage, and neoplastic transformation of ovarian cells. The PGR-driven termination of PTGS2 expression may protect the ovary from ovulatory inflammation.
    MeSH term(s) Animals ; Cyclooxygenase 2/genetics ; Cyclooxygenase 2/metabolism ; Female ; Gene Expression/genetics ; Gene Expression Regulation/genetics ; Granulosa Cells/metabolism ; Inflammation/metabolism ; Mice ; Mice, Inbred C57BL ; NF-kappa B/metabolism ; Ovarian Follicle/metabolism ; Ovary/metabolism ; Ovulation/metabolism ; Progesterone/genetics ; Progesterone/metabolism ; RNA, Messenger/genetics ; Receptors, Progesterone/genetics ; Receptors, Progesterone/metabolism ; Receptors, Progesterone/physiology ; Transcription Factors/metabolism
    Chemical Substances NF-kappa B ; RNA, Messenger ; Receptors, Progesterone ; Transcription Factors ; progesterone receptor B ; Progesterone (4G7DS2Q64Y) ; Ptgs2 protein, mouse (EC 1.14.99.-) ; Cyclooxygenase 2 (EC 1.14.99.1)
    Language English
    Publishing date 2020-04-15
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2020.03.060
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