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  1. Article ; Online: Functional magnetic resonance imaging is a powerful approach to probing the mechanism of action of therapeutic drugs that act on the central nervous system.

    Zhou, Shu-Feng

    Drug design, development and therapy

    2015  Volume 9, Page(s) 3863–3865

    MeSH term(s) Acetaminophen/pharmacology ; Analgesics, Non-Narcotic/pharmacology ; Brain/drug effects ; Humans ; Male ; Pain/drug therapy
    Chemical Substances Analgesics, Non-Narcotic ; Acetaminophen (362O9ITL9D)
    Language English
    Publishing date 2015
    Publishing country New Zealand
    Document type Comment ; Editorial
    ZDB-ID 2451346-5
    ISSN 1177-8881 ; 1177-8881
    ISSN (online) 1177-8881
    ISSN 1177-8881
    DOI 10.2147/DDDT.S83038
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Multi-strategy orthogonal enhancement and analysis of aldo-keto reductase thermal stability.

    Zhang, Lingzhi / Zhou, Rui / Liu, Dekai / Zhu, Meinan / Zhang, Guangya / Zhang, Lijuan / Zhou, Shu-Feng / Jiang, Wei

    International journal of biological macromolecules

    2024  Volume 264, Issue Pt 2, Page(s) 130691

    Abstract: Given their outstanding efficiency and selectivity, enzymes are integral in various domains such as drug synthesis, the food industry, and environmental management. However, the inherent instability of natural enzymes limits their widespread industrial ... ...

    Abstract Given their outstanding efficiency and selectivity, enzymes are integral in various domains such as drug synthesis, the food industry, and environmental management. However, the inherent instability of natural enzymes limits their widespread industrial application. In this study, we underscore the efficacy of enhancing protein thermal stability through comprehensive protein design strategies, encompassing elements such as the free energy of protein folding, internal forces within proteins, and the overall structural design. We also demonstrate the efficiency and precision of combinatorial screening in the thermal stability design of aldo-keto reductase (AKR7-2-1). In our research, three single-point mutations and five combinatorial mutations were strategically introduced into AKR7-2-1, using multiple computational techniques. Notably, the E12I/S235I mutant showed a significant increase of 25.4 °C in its melting temperature (Tm). Furthermore, the optimal mutant, E12V/S235I, maintained 80 % of its activity while realizing a 16.8 °C elevation in Tm. Remarkably, its half-life at 50 °C was increased to twenty times that of the wild type. Structural analysis indicates that this enhanced thermal stability primarily arises from reduced oscillation in the loop region and increased internal hydrogen bonding. The promising results achieved with AKR7-2-1 demonstrate that our strategy could serve as a valuable reference for enhancing the thermal stability of other industrial enzymes.
    MeSH term(s) Aldo-Keto Reductases/genetics ; Temperature ; Protein Stability ; Mutation ; Point Mutation ; Enzyme Stability
    Chemical Substances Aldo-Keto Reductases (EC 1.1.1.-)
    Language English
    Publishing date 2024-03-06
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2024.130691
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Visible light-induced selenylative spirocyclization of biaryl ynones toward the formation of selenated spiro[5.5]trienones.

    Chen, Zhichao / Zheng, Xinran / Zhou, Shu-Feng / Cui, Xiuling

    Organic & biomolecular chemistry

    2022  Volume 20, Issue 29, Page(s) 5779–5783

    Abstract: A visible-light induced dearomative cascade cyclization of biaryl ynones with diselenides under photocatalyst and external additive-free conditions has been explored, giving a series of selenated spiro[5.5]trienones in moderate to good yields. The Se-Se ... ...

    Abstract A visible-light induced dearomative cascade cyclization of biaryl ynones with diselenides under photocatalyst and external additive-free conditions has been explored, giving a series of selenated spiro[5.5]trienones in moderate to good yields. The Se-Se bond in diselenides could be cleaved to generate arylselenyl radicals under visible light irradiation in the absence of a photocatalyst. This protocol provides a facile and green method for the synthesis of spiro[5.5]trienones.
    MeSH term(s) Cyclization ; Light ; Spiro Compounds/chemistry
    Chemical Substances Spiro Compounds
    Language English
    Publishing date 2022-07-27
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2097583-1
    ISSN 1477-0539 ; 1477-0520
    ISSN (online) 1477-0539
    ISSN 1477-0520
    DOI 10.1039/d2ob01006b
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Afterglow Electrochemiluminescence from Nitrogen-Deficient Graphitic Carbon Nitride

    Chen, Lichan / Zhu, Xiaodi / Wei, Jingjing / Tian, Libing / Hu, Chenxi / Xiang, Xinzhu / Zhou, Shu-Feng

    Analytical Chemistry. 2023 Jan. 27, v. 95, no. 5 p.2917-2924

    2023  

    Abstract: Almost all current electrochemiluminescent reagents require real-time electrochemical stimulation to emit light. Here, we report a novel electrochemiluminescent reagent, nitrogen-deficient graphitic carbon nitride (CNₓ), that can emit afterglow ... ...

    Abstract Almost all current electrochemiluminescent reagents require real-time electrochemical stimulation to emit light. Here, we report a novel electrochemiluminescent reagent, nitrogen-deficient graphitic carbon nitride (CNₓ), that can emit afterglow electrochemiluminescence (ECL) after cessation of electric excitation. CNₓ obtained by post-thermal treatment of graphitic carbon nitride (CN) with KSCN has a cyanamide group and a nitrogen vacancy, which created defects to trap electrically injected electrons. The trapped electrons can slowly release and react with coreactants to emit light with longevity. The cathodic afterglow ECL lasts for 70 s after pulsing the CNₓ nanosheet (CNₓNS-1.6)-modified glassy carbon electrode at −1.0 V for 20 s in 2.0 M PBS containing 1 mM K₂S₂O₈. The afterglow ECL mechanism is revealed by investigation of its influencing factors and ECL wavelength. The discovery of afterglow ECL may open a new doorway for new significant applications of the ECL technique and provide a deeper understanding of the structure–property relationships of CN.
    Keywords analytical chemistry ; carbon nitride ; electrochemiluminescence ; electrochemistry ; glassy carbon electrode ; graphene ; longevity ; nanosheets ; nitrogen ; wavelengths
    Language English
    Dates of publication 2023-0127
    Size p. 2917-2924.
    Publishing place American Chemical Society
    Document type Article ; Online
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.2c04566
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  5. Article: Cobalt Phthalocyanine Supported on Mesoporous CeO₂ as an Active Molecular Catalyst for CO Oxidation

    Song, Yibo / Hu, Siyuan / Cai, Dongren / Xiao, Jingran / Zhou, Shu-Feng / Zhan, Guowu

    ACS applied materials & interfaces. 2022 Feb. 08, v. 14, no. 7

    2022  

    Abstract: Heterogenization of biomolecules by immobilizing on a metal oxide support could greatly enhance their catalytic activity and stability, but their interactions are generally weak. Herein, cobalt phthalocyanine (CoPc) molecules were firmly anchored on a Ce- ...

    Abstract Heterogenization of biomolecules by immobilizing on a metal oxide support could greatly enhance their catalytic activity and stability, but their interactions are generally weak. Herein, cobalt phthalocyanine (CoPc) molecules were firmly anchored on a Ce-based metal–organic framework (Ce-BTC) due to π–π stacking interaction between CoPc and aromatic frameworks of the BTC linker, which was followed by a calcination treatment to convert Ce-BTC to mesoporous CeO₂ and realize a molecular-level dispersion of CoPc on the surface of CeO₂. Various characterization results confirm the successful fabrication of molecular-based CoPc/CeO₂ catalysts which exhibited good CO oxidation performance. Importantly, we found that the mixing manner of Ce-BTC and CoPc remarkably affects the physicochemical properties which then determined the catalytic performance of the resultant CoPc/CeO₂ catalysts. In contrast, the direct physical mixing of CoPc and CeO₂ led to poor performance toward CO oxidation, manifesting that the Ce-BTC-mediated CoPc loading strategy is promising for the heterogenization of catalytic biomolecules.
    Keywords biochemical compounds ; catalysts ; catalytic activity ; cobalt ; coordination polymers ; oxidation ; porous media
    Language English
    Dates of publication 2022-0208
    Size p. 9151-9160.
    Publishing place American Chemical Society
    Document type Article
    ISSN 1944-8252
    DOI 10.1021/acsami.1c23582
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  6. Article: Enhancing the biocatalytic synthesis of chiral drug intermediate by rational design an aldo-keto reductase from Bacillus megaterium YC4-R4

    Pei, Rui / Fu, Xiaoli / Tian, Libing / Zhou, Shu-Feng / Jiang, Wei

    Enzyme and microbial technology. 2022 Oct., v. 160

    2022  

    Abstract: In recent years, with the increasing number of patients with depression, the efficient synthesis of the first-line antidepressant drug duloxetine intermediate (S-N,N-dimethyl-3-hydroxy-3-(2-thienyl)−1-propanamine, S-DHTP) has attracted great attention. ... ...

    Abstract In recent years, with the increasing number of patients with depression, the efficient synthesis of the first-line antidepressant drug duloxetine intermediate (S-N,N-dimethyl-3-hydroxy-3-(2-thienyl)−1-propanamine, S-DHTP) has attracted great attention. The wild-type AKR3–2–9 from Bacillus megaterium YC4-R4 exhibits high application potential of catalyzing N,N-dimethyl-3-keto-3-(2-thienyl)−1-propanamine (DKTP) to prepare S-DHTP, but there is still much room for improvement. In this work, rational design was carried out to enhance the catalytic potential of AKR3–2–9. Notably, compared to the wild-type AKR3–2–9, three mutants (Ile189Val, Asn256Asp, and Ile189Val + Asn256Asp) were obtained, and their catalytic efficiencies were increased by 1.3 times, 2.3 times, and 1.31 times, respectively. Besides, the thermal stability and organic solvent resistance were improved. More importantly, when the concentration of the substrate DKTP was 0.5 g/L, the catalytic yields of Ile189Val, Asn256Asp and Ile189Val + Asn256Asp were increased by 1.45 times, 1.86 times, and 2.05 times, respectively. Besides, the corresponding optical purities of the three mutants were 92.7 %, 94.3 % and 93.8 %. The above results indicated that the rational design of the AKR of Bacillus megaterium YC4-R4 enhanced its potential for biocatalytic preparation of S-DHTP.
    Keywords Bacillus megaterium ; aldo-keto reductases ; antidepressants ; solvents ; technology ; thermal stability
    Language English
    Dates of publication 2022-10
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 423729-8
    ISSN 1879-0909 ; 0141-0229
    ISSN (online) 1879-0909
    ISSN 0141-0229
    DOI 10.1016/j.enzmictec.2022.110074
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    Zs.B 2182: Show issues Location:
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  7. Article ; Online: Intercalation of laminar Cu-Al LDHs with molecular TCPP(M) (M = Zn, Co, Ni, and Fe) towards high-performance CO

    Zhao, Feigang / Zhan, Guowu / Zhou, Shu-Feng

    Nanoscale

    2020  Volume 12, Issue 24, Page(s) 13145–13156

    Abstract: A confined space is broadly applied to enhance the dispersion and limit the aggregation of catalytically active sites, especially at high temperatures. In this work, we provided an efficient approach to immobilize transition metal ions (e.g., Zn2+, Co2+, ...

    Abstract A confined space is broadly applied to enhance the dispersion and limit the aggregation of catalytically active sites, especially at high temperatures. In this work, we provided an efficient approach to immobilize transition metal ions (e.g., Zn2+, Co2+, Ni2+, and Fe2+) into the confined space of laminar Cu-Al layered double hydroxides (LDHs) using a range of molecular metalloporphyrins (viz., TCPP(M)) as shuttles. The deprotonated TCPP(M) not only provides nitrogen-based coordination sites to anchor a series of transition metal ions, but also intercalates and diffuses facilely into the interlayer gallery of LDHs by ion exchange. The obtained TCPP(M)@Cu-Al LDHs were then used as solid precursors for the fabrication of a series of heterogeneous catalysts for CO2 hydrogenation via high-temperature calcination. Two restriction forces contributed to the enhanced dispersion of the active species over the catalyst surface structures. Remarkably, the transition metals positioned within the confined space of LDHs significantly affected the catalytic performance of CO2 hydrogenation. Mainly CO, methanol, and methane were found as the C1 products, and their selectivities are highly dependent on the reaction intermediates, as suggested by the in situ DRIFTS study. Moreover, the designed catalysts fabricated via molecular TCPP(M) intercalation exhibited much better performance than the conventional catalysts derived from surface-supported CA-LDHs, due to their better metal dispersion and smaller particle size.
    Language English
    Publishing date 2020-06-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 2515664-0
    ISSN 2040-3372 ; 2040-3364
    ISSN (online) 2040-3372
    ISSN 2040-3364
    DOI 10.1039/d0nr01916j
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Metal-Free Sulfonylative Spirocyclization of Indolyl-ynones via Insertion of Sulfur Dioxide: Access to Sulfonated Spiro[cyclopentenone-1,3'-indoles].

    Chen, Zhichao / Zhang, Hong / Zhou, Shu-Feng / Cui, Xiuling

    Organic letters

    2021  Volume 23, Issue 20, Page(s) 7992–7995

    Abstract: A three-component sulfonylative spirocyclization of indolyl ynones with aryldiazonium salts and a sulfur dioxide surrogate of DABCO·( ... ...

    Abstract A three-component sulfonylative spirocyclization of indolyl ynones with aryldiazonium salts and a sulfur dioxide surrogate of DABCO·(SO
    Language English
    Publishing date 2021-09-28
    Publishing country United States
    Document type Journal Article
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.1c02999
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  9. Article ; Online: Cobalt Phthalocyanine Supported on Mesoporous CeO

    Song, Yibo / Hu, Siyuan / Cai, Dongren / Xiao, Jingran / Zhou, Shu-Feng / Zhan, Guowu

    ACS applied materials & interfaces

    2022  Volume 14, Issue 7, Page(s) 9151–9160

    Abstract: Heterogenization of biomolecules by immobilizing on a metal oxide support could greatly enhance their catalytic activity and stability, but their interactions are generally weak. Herein, cobalt phthalocyanine (CoPc) molecules were firmly anchored on a Ce- ...

    Abstract Heterogenization of biomolecules by immobilizing on a metal oxide support could greatly enhance their catalytic activity and stability, but their interactions are generally weak. Herein, cobalt phthalocyanine (CoPc) molecules were firmly anchored on a Ce-based metal-organic framework (Ce-BTC) due to π-π stacking interaction between CoPc and aromatic frameworks of the BTC linker, which was followed by a calcination treatment to convert Ce-BTC to mesoporous CeO
    Language English
    Publishing date 2022-02-08
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.1c23582
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Biocompatible 2D Cu-TCPP Nanosheets Derived from Cu

    Gao, Le / Song, Yibo / Zhong, Jun / Lin, Xiaofeng / Zhou, Shu-Feng / Zhan, Guowu

    ACS biomaterials science & engineering

    2022  Volume 8, Issue 3, Page(s) 1074–1086

    Abstract: Two-dimensional (2D) metal-organic frameworks (MOFs) could serve as multifunctional nanoplatforms to load small-molecule drugs and enzyme-mimicking nanoparticles (NPs) with a high efficiency for combined cancer therapy. Herein, we have prepared novel 2D ... ...

    Abstract Two-dimensional (2D) metal-organic frameworks (MOFs) could serve as multifunctional nanoplatforms to load small-molecule drugs and enzyme-mimicking nanoparticles (NPs) with a high efficiency for combined cancer therapy. Herein, we have prepared novel 2D Cu-tetrakis (4-carboxyphenyl) porphyrin (TCPP) nanosheets with an average thickness of 1.2 ± 0.1 nm using Cu
    MeSH term(s) Glucose/therapeutic use ; Humans ; Hydrogen Peroxide/therapeutic use ; Neoplasms/drug therapy ; Porphyrins/pharmacology ; Porphyrins/therapeutic use
    Chemical Substances Porphyrins ; tetracarboxyphenylporphine (14609-54-2) ; Hydrogen Peroxide (BBX060AN9V) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2022-02-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2373-9878
    ISSN (online) 2373-9878
    DOI 10.1021/acsbiomaterials.1c01430
    Database MEDical Literature Analysis and Retrieval System OnLINE

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