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Article ; Online: Association between serum uric acid levels and depressive symptoms according to menopausal status.

Chen, Junzhi / Zhou, Wenjing / Huang, Yan

2024 Volume 350, Page(s) 240–246

Abstract: Introduction: The menopause-specific relationship between serum uric acid (SUA) and depressive symptoms were not known. We aimed to explore the association between SUA and depressive symptoms stratified by menopausal status.: Methods: This is a cross- ...

Abstract	Introduction: The menopause-specific relationship between serum uric acid (SUA) and depressive symptoms were not known. We aimed to explore the association between SUA and depressive symptoms stratified by menopausal status. Methods: This is a cross-sectional study, a total of 4845 females were enrolled from China health and retirement longitudinal study (CHARLS) in China. The Center for Epidemiologic Studies Depression Scale (CESD) were used to measure depressive symptoms. A cut-off score of CES-D ≥ 10 was defined as depression. Multiple regression models were used to assess the relationship between SUA and depression stratified by menopausal status. Results: Overall, SUA was significantly associated with depressive symptoms/depression in post-menopause women (β = -0.39, 95 % CI: -0.60, -0.17) after adjusted potential confounders. Compared with those whose SUA levels were in the first tertile, participants with their SUA in the second (β = -0.76, 95 % CI: -1.30, -0.22) and third tertile (β = -1.24, 95 % CI: -1.80, -0.68) had milder depressive symptoms. However, SUA was not associated with depressive symptoms in pre-menopause women (β = 0.1, 95 % CI: -0.25, 0.46). An interaction between menopausal status and SUA on depressive symptoms were found in this study (P = 0.02). Similar results were found for depression. Limitations: Some potential covariates like diet that could affect SUA levels were not considered in this study. Conclusions: Higher SUA was associated with depressive symptoms/depression in post-menopause women. An interaction between menopausal status and SUA on depressive symptoms were found. SUA was not associated with depressive symptoms/depression in pre-menopause women.
MeSH term(s)	Humans ; Female ; Uric Acid ; Depression/epidemiology ; Longitudinal Studies ; Cross-Sectional Studies ; Menopause
Chemical Substances	Uric Acid (268B43MJ25)
Language	English
Publishing date	2024-01-12
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	135449-8
ISSN	1573-2517 ; 0165-0327
ISSN (online)	1573-2517
ISSN	0165-0327
DOI	10.1016/j.jad.2024.01.108
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Article ; Online: Correlation between Sputum Bacterial Culture Positive Rate and Drug Sensitivity Test Results and Disease Severity inInpatients and Its Clinical Significance: A SystematicReview and Meta-Analysis.

Zhou, Wenjing / Li, Jing

publication RETRACTED

Computational intelligence and neuroscience

2022 Volume 2022, Page(s) 5102100

Abstract: Objective: To systematically evaluate the correlation between the positive rate of sputum bacterial culture and the results of drug sensitivity test and the severity of the disease and its clinical significance, so as to provide evidence-based medicine ... ...

Abstract	Objective: To systematically evaluate the correlation between the positive rate of sputum bacterial culture and the results of drug sensitivity test and the severity of the disease and its clinical significance, so as to provide evidence-based medicine for clinical application. Methods: PubMed, Embase, ScienceDirect, Cochrane Library, China Knowledge Network Database (CNKI), China VIP Database, Wanfang Database, and China Biomedical Literature Database (CBM) online database were used. The retrieval time limit was from the establishment of the database to the present. Data for all included studies were extracted by two independent researchers, and the risk of bias for the quality of each included study was assessed by the Cochrane Handbook 5.1.0 criteria. RevMan5.4 statistical software was used to analyze the collected data by meta. Results: In the end, 6 RCT articles were included. Overall, 613 samples were included in 6 RCT studies. The correlation between the positive rate of sputum bacterial culture in inpatients and the severity of the disease was meta-analyzed. The heterogeneity test results showed that Chi2 = 177.20, df = 3, Conclusion: There is a correlation between positive sputum culture and drug sensitivity test results and the severity of the disease in hospitalized patients. In clinical practice, for hospitalized patients, the positive sputum bacterial culture rate and drug sensitivity test results can be used to guide the appropriate use of antibiotics. Due to the low input from the literature, more studies with higher methodological quality and longer follow-up are needed for further validation.
MeSH term(s)	China ; Humans ; Severity of Illness Index ; Sputum
Language	English
Publishing date	2022-07-14
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Systematic Review ; Retracted Publication
ZDB-ID	2388208-6
ISSN	1687-5273 ; 1687-5273
ISSN (online)	1687-5273
ISSN	1687-5273
DOI	10.1155/2022/5102100
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Article ; Online: Molecular characteristics of Echinococcus multilocularis FABP1 and its regulatory functions on murine macrophages.

Li, Xiang / Liao, Peng / Zhou, Wenjing / Yang, Xinqi / Ye, Bin

Acta tropica

2024 Volume 255, Page(s) 107247

Abstract: Fatty acid binding proteins (FABPs) have emerged as attractive vaccination candidates for several platyhelminth species. To explore the physiological functions of Echinococcus multilocularis (E. multilocularis) FABP, the molecular characteristics of ... ...

Abstract	Fatty acid binding proteins (FABPs) have emerged as attractive vaccination candidates for several platyhelminth species. To explore the physiological functions of Echinococcus multilocularis (E. multilocularis) FABP, the molecular characteristics of EmFABP1 were analyzed by online software, and the regulatory roles of rEmFABP1 protein in murine macrophages were further investigated. The emfabp1 gene encodes 133 amino acids with the characteristic β-barrel shape of the cytoplasmic FABP family. Natural EmFABP1 protein is predominantly expressed in protoscoleces tegument and germinal layer cells and is also detected in cyst fluid and exosomes of E. multilocularis. rEmFABP1 protein demonstrated a notable suppression of phagocytic activity and nitric oxide production in murine macrophages. Additionally, the protein was observed to promote apoptosis and regulate cytokine expression in macrophages. These findings suggested that E. multilocularis FABP1 is critical in modifying macrophage physiological processes and that this protein may have immunomodulatory roles during infection.
Language	English
Publishing date	2024-05-08
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	210415-5
ISSN	1873-6254 ; 0001-706X
ISSN (online)	1873-6254
ISSN	0001-706X
DOI	10.1016/j.actatropica.2024.107247
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Article ; Online: Clinical outcome analysis of sequential transplantation of frozen-thawed embryo transfer cycle: a retrospective study.

Zhou, Wenjing / Cheng, Zhaojun / Wang, Chong / Feng, Ying

Medicine

2023 Volume 102, Issue 8, Page(s) e33042

Abstract: The sequential transplantation was a new mode of in vitro fertilization and embryo transfer. To compare the clinical outcomes of sequential transplantation, embryo transplantation and blastocyst transplantation during freeze-thaw embryo transfer cycle. ... ...

Abstract	The sequential transplantation was a new mode of in vitro fertilization and embryo transfer. To compare the clinical outcomes of sequential transplantation, embryo transplantation and blastocyst transplantation during freeze-thaw embryo transfer cycle. The retrospective study was conducted on 767 patients who received freeze-thaw embryo transfer at Reproductive Medicine Center of Hangzhou Women Hospital from July 1, 2020 to June 30, 2021. According to the age of transplanted embryos, all patients were divided into sequential transplantation, embryo embryo transplantation group and blastocyst stage transplantation group. The clinical data, embryo status and pregnancy outcome of the 3 groups were compared, the number of transplanted embryos in the sequential group was significantly higher than that in the other 2 groups (P < .05). The implantation rate of blastocyst transplantation group was the highest, there was no statistical significance between the sequential transplantation group and the other 2 groups (39.13% vs 30.00%, 39.13 vs 43.50%). The multiple birth rate (30.77%) and spontaneous abortion rate (20.51%) were higher in the sequential transplantation group, and there was no significant difference among the 3 groups (P > .05). The sequential transplantation cycle can obtain a higher clinical pregnancy rate than the conventional single cycle transplantation, without causing the waste of transplanted embryos, and can be used as the choice mode of resuscitation transplantation cycle for some patients.
MeSH term(s)	Pregnancy ; Humans ; Female ; Retrospective Studies ; Embryo Transfer ; Pregnancy Outcome ; Pregnancy Rate ; Fertilization in Vitro ; Embryo Implantation ; Blastocyst ; Cryopreservation
Language	English
Publishing date	2023-02-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000033042
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Article: Analyzing EFL learners' demotivating factors in blended learning context.

Zhou, Wenjing / Zhan, Yan / Jawing, Esther

Frontiers in psychology

2023 Volume 14, Page(s) 1290034

Abstract: In second language and foreign language learning, demotivation in learning is a common occurrence. Almost all previous studies on learners' demotivation focused on traditional classroom learning environment rather than blended learning setting. This ... ...

Abstract	In second language and foreign language learning, demotivation in learning is a common occurrence. Almost all previous studies on learners' demotivation focused on traditional classroom learning environment rather than blended learning setting. This paper investigates learner perceptions of demotivating factors for Chinese EFL college students in blended learning context. 272 college sophomores with varied majors from a university in Mid-East China took part in a questionnaire survey. The questionnaire, consisted of 34 4-point Likert type items about learners' demotivation in a blended EFL learning environment, was adapted from Kikuchi's demotivation questionnaire and Xie's LPDS (Learner Perceptions of Demotivator Scale). An exploratory factor analysis was performed to explore the factor structure of the questionnaire items. Then mean scores of items loading on each factor were calculated and independent samples t-test analysis was adopted to examine the differences of demotivating factors between different groups of participants. Five demotivating factors from the questionnaire were extracted. The findings reveal a newly discovered factor: learners' lack of self-discipline in online learning. The paper indicates that there is no significant difference of these five demotivating factors between male and female learners, and between rural and urban learners. Whereas less motivated learners perceive four among the five factors to be more demotivating than more motivated learners.
Language	English
Publishing date	2023-10-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2023.1290034
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Article ; Online: Phase aberration adaptive compensation in digital holography based on phase imitation and metric optimization.

Chen, Zhenkai / Zhou, Wenjing / Zhang, Hongbo / Yu, Yingjie

Optics express

2023 Volume 31, Issue 13, Page(s) 21048–21062

Abstract: We proposed a numerical and accurate quadratic phase aberration compensation method in digital holography. A phase imitation method based on Gaussian 1σ-criterion is used to obtain the morphological features of the object phase using partial differential, ...

Abstract	We proposed a numerical and accurate quadratic phase aberration compensation method in digital holography. A phase imitation method based on Gaussian 1σ-criterion is used to obtain the morphological features of the object phase using partial differential, filtering and integration successively. We also propose an adaptive compensation method based on a maximum-minimum-average- α-standard deviation (MMAαSD) evaluation metric to obtain optimal compensated coefficients by minimizing the above metric of the compensation function. The effectiveness and robustness of our method are demonstrated by simulation and experiments.
Language	English
Publishing date	2023-06-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	1491859-6
ISSN	1094-4087 ; 1094-4087
ISSN (online)	1094-4087
ISSN	1094-4087
DOI	10.1364/OE.494302
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Article ; Online: Mobile healthcare platforms' sustainability: The perspective of health information quality.

Sun, Xiaoyang / Zhou, Wenjing / Feng, Ying

Frontiers in public health

2023 Volume 10, Page(s) 1059252

Abstract: As an emerging form of medical organization, Chinese mobile healthcare (mHealth) platforms are inherently linked to the continuous use of users, which depends on the quality of the health information provided. However, improving the health information ... ...

Abstract	As an emerging form of medical organization, Chinese mobile healthcare (mHealth) platforms are inherently linked to the continuous use of users, which depends on the quality of the health information provided. However, improving the health information quality of mHealth platforms is still a problem that needs to be studied and solved in order to make the platforms sustainable. Based on the reputation mechanism, this study creates a behavioral evolutionary game model for health information providers (physicians) and managers (mHealth platforms), explores the evolution process and evolutionarily stable strategy of the behaviors in various situations, and uses numerical simulation technology to analyze mHealth platforms' constraints and the influencing factors of health information quality. This study presents three key findings. First, considering reputation, health information managers and mHealth platform providers should not unilaterally optimize health information. Instead, mHealth platforms should have active quality control, and physician groups should provide high-quality health information, which is the ideal evolution of the model. Second, the rewards that physicians receive from patients and mHealth platforms for providing quality health information, the reputation benefits, the penalties that physicians suffer for providing low-quality health information, and the increased probability and cost of rent-seeking behavior that physicians may choose can effectively promote the choice of physicians to provide high-quality health information. Third, the reputation gain of mHealth platforms, the probability of mHealth platforms being exposed, and increased losses suffered from exposure can effectively promote the choice of mHealth platforms to control the quality of health information. This study can provide a theoretical basis for mHealth platforms' health information quality control, which is conducive to the healthy and sustainable development of mHealth platforms and the improvement of user satisfaction.
MeSH term(s)	Humans ; Telemedicine ; Delivery of Health Care ; Physicians ; Health Personnel
Language	English
Publishing date	2023-01-06
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2022.1059252
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Article ; Online: Dynamic coupling of ferrihydrite transformation and associated arsenic desorption/redistribution mediated by sulfate-reducing bacteria

Zhou, Wenjing / Zhu, Huiyan / Hu, Shiwen / Zhang, Bowei / Gao, Kun / Dang, Zhi / Liu, Chongxuan

Journal of Environmental Sciences. 2024 Jan., v. 135 p.39-50

2024

Abstract: Sulfate-reducing bacteria play an important role in the geochemistry of iron (oxyhydr)oxide and arsenic (As) in natural environments; however, the associated reaction processes are yet to be fully understood. In this study, batch experiments coupled with ...

Abstract	Sulfate-reducing bacteria play an important role in the geochemistry of iron (oxyhydr)oxide and arsenic (As) in natural environments; however, the associated reaction processes are yet to be fully understood. In this study, batch experiments coupled with geochemical, spectroscopic, microscopic, and thermodynamic analyses were conducted to investigate the dynamic coupling of ferrihydrite transformation and the associated As desorption/redistribution mediated by Desulfovibrio vulgaris (D. vulgaris). The results indicated that D. vulgaris could induce ferrihydrite transformation via S²⁻-driven and direct reduction processes. In the absence of SO₄²⁻, D. vulgaris directly reduced ferrihydrite, and As desorption and re-sorption occurred simultaneously during the partial transformation of ferrihydrite to magnetite. The increase in SO₄²⁻ loading promoted the S²⁻-driven reduction of ferrihydrite and accelerated the subsequent mineralogical transformation. In the low and medium SO₄²⁻ treatments, ferrihydrite was completely transformed to a mixture of magnetite and mackinawite, which increased the fraction of As in the residual phase and stabilized As. In the high SO₄²⁻ treatment, although the replacement of ferrihydrite by only mackinawite also increased the fraction of As in the residual phase, 22.1% of the total As was released into the solution due to the poor adsorption affinity of As to mackinawite and the conversion of As⁵⁺ to As³⁺. The mechanisms of ferrihydrite reduction, mineralogy transformation, and As mobilization and redistribution mediated by sulfate-reducing bacteria are closely related to the surrounding SO₄²⁻ loadings. These results advance our understanding of the biogeochemical behavior of Fe, S, and As, and are helpful for the risk assessment and remediation of As contamination.
Keywords	Desulfovibrio vulgaris ; adsorption ; arsenic ; desorption ; ferrihydrite ; geochemistry ; iron ; magnetite ; remediation ; risk assessment ; spectroscopy ; thermodynamics ; Sulfate-reducing bacteria ; Transformation ; Redistribution
Language	English
Dates of publication	2024-01
Size	p. 39-50.
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	1092300-7
ISSN	1878-7320 ; 1001-0742
ISSN (online)	1878-7320
ISSN	1001-0742
DOI	10.1016/j.jes.2022.12.007
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Reaction mechanism and dynamics for C8-hydroxylation of 9-methylguanine radical cation by water molecules.

Zhou, Wenjing / Liu, Jianbo

Physical chemistry chemical physics : PCCP

2021 Volume 23, Issue 42, Page(s) 24464–24477

Abstract: In contrast to their spontaneous deprotonation in aqueous solution, reactions of guanine and guanosine radical cations with water in the gas phase are exclusively initiated by hydration of the radical cations as reported in recent work (Y. ... ...

Abstract	In contrast to their spontaneous deprotonation in aqueous solution, reactions of guanine and guanosine radical cations with water in the gas phase are exclusively initiated by hydration of the radical cations as reported in recent work (Y. Sun
MeSH term(s)	Cations/chemistry ; Free Radicals/chemistry ; Guanine/analogs & derivatives ; Guanine/chemistry ; Hydroxylation ; Mass Spectrometry ; Molecular Dynamics Simulation ; Water/chemistry
Chemical Substances	Cations ; Free Radicals ; Water (059QF0KO0R) ; 9-methylguanine (397W61ZHWY) ; Guanine (5Z93L87A1R)
Language	English
Publishing date	2021-11-03
Publishing country	England
Document type	Journal Article
ZDB-ID	1476244-4
ISSN	1463-9084 ; 1463-9076
ISSN (online)	1463-9084
ISSN	1463-9076
DOI	10.1039/d1cp03884b
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Article: Exploration of validity evidence for core residency entrustable professional activities in Chinese pediatric residency.

Li, Shan / Qi, Xin / Li, Haichao / Zhou, Wenjing / Jiang, Zhehan / Qi, Jianguang

Frontiers in medicine

2024 Volume 10, Page(s) 1301356

Abstract: Introduction: This study seeks to explore validity and reliability evidence for core residency entrustable professional activities (CR-EPAs) that were developed by Peking University First Hospital (PKUFH) in 2020.: Methods: A prospective cohort study ...

Abstract	Introduction: This study seeks to explore validity and reliability evidence for core residency entrustable professional activities (CR-EPAs) that were developed by Peking University First Hospital (PKUFH) in 2020. Methods: A prospective cohort study was conducted in PKUFH. Trainers (raters) assessed pediatric residents on CR-EPAs over 1 academic year, bi-annually. Critical components within a validity evidence framework were examined: response process (rater perceptions), the internal structure (reliability and contributions of different variance sources), and consequences (potential use of a cutoff score). Results: In total, 37 residents were enrolled, and 111 and 99 trainers' ratings were collected in Fall 2020 and Spring 2021, respectively. For rater perceptions, all the raters considered CR-EPAs highly operational and convenient. In all ratings, individual EPAs correlate with total EPA moderately, with Spearman correlation coefficients spanning from 0.805 to 0.919. EPA 2 (select and interpret the auxiliary examinations), EPA 5 (prepare and complete medical documents), EPA 6 (provide an oral presentation of a case or a clinical encounter), and EPA 7 (identify and manage the general clinical conditions) were EPAs correlated with other EPAs significantly. The results of the generalizability theory indicated that the variability due to residents is the highest (nearly 78.5%), leading to a large size of the reliability estimates. The matching results indicate that the lowest error locates at 5.933. Conclusion: The rating showed good validity and reliability. The ratings were reliable based on G-theory. CR-EPAs have a magnificent internal structure and have promising consequences. Our results indicate that CR-EPAs are a robust assessment tool in workplace-based training in a carefully designed setting.
Language	English
Publishing date	2024-01-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2023.1301356
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