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  1. Article ; Online: Unveiling the intricate moiré of moiré texture.

    Luo, Ruichun / Zhou, Wu

    Nature materials

    2024  Volume 23, Issue 3, Page(s) 304–305

    Language English
    Publishing date 2024-03-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2088679-2
    ISSN 1476-4660 ; 1476-1122
    ISSN (online) 1476-4660
    ISSN 1476-1122
    DOI 10.1038/s41563-024-01805-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Bladder cancer‐associated transcript 1 promotes melanoma cell proliferation and invasion via the miR‐374b‐5p/U2‐associated factor homology motif kinase 1 axis

    Zong‐Zhou Wu / Qing Xu

    Kaohsiung Journal of Medical Sciences, Vol 38, Iss 2, Pp 97-

    2022  Volume 107

    Abstract: Abstract Melanoma is a malignancy derived from melanocytes and is associated with high mortality rates worldwide. Long noncoding RNAs (lncRNAs) have been confirmed to be pivotal regulators in multiple types of cancer. Many lncRNAs are aberrantly ... ...

    Abstract Abstract Melanoma is a malignancy derived from melanocytes and is associated with high mortality rates worldwide. Long noncoding RNAs (lncRNAs) have been confirmed to be pivotal regulators in multiple types of cancer. Many lncRNAs are aberrantly expressed in tumors and perform vital functions in cancer progression. Nevertheless, the biological role of lncRNA bladder cancer‐associated transcript 1 (BLACAT1) in melanoma progression remains unexplored. In this study, the collected data showed that BLACAT1 was highly expressed in melanoma. Mechanistically, miR‐374b‐5p bound to BLACAT1, and U2‐associated factor homology motif kinase 1 (UHMK1) was a downstream target of miR‐374b‐5p. BLACAT1 upregulated UHMK1 expression by acting as a competing endogenous RNA for miR‐374‐5b. BLACAT1 deficiency resulted in the upregulation of miR‐374b‐5p expression and the downregulation of UHMK1 expression in melanoma cells. Moreover, BLACAT1 activated PI3K and AKT signaling by upregulating UHMK1 expression, as shown by western blotting analyses. Functionally, UHMK1 overexpression or miR‐374b‐5p knockdown reversed the suppressive effect of BLACAT1 depletion on melanoma cell proliferation and invasion. In conclusion, BLACAT1 promotes melanoma cell proliferation and invasion by upregulating UHMK1 expression via miR‐374b‐5p to activate the PI3K/AKT pathway. These results might provide promising insight into the investigation of prognostic biomarkers of melanoma.
    Keywords BLACAT1 ; melanoma ; miR‐374b‐5p ; PI3K/AKT signaling ; UHMK1 ; Medicine (General) ; R5-920
    Subject code 500 ; 570
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: The Online Attention to Research in Legal Medicine

    Daniele Garcovich / Angel Zhou Wu / Milagros Adobes Martin

    Forensic Sciences, Vol 3, Iss 33, Pp 478-

    An Altmetric Study on the Most Discussed Articles on the Web

    2023  Volume 490

    Abstract: Background: Online attention is a relevant research feature that can be related to its societal impact. Online attention in the field of legal medicine was explored as well as the relation between citation count and the Altmetric Attention Score (AAS). ... ...

    Abstract Background: Online attention is a relevant research feature that can be related to its societal impact. Online attention in the field of legal medicine was explored as well as the relation between citation count and the Altmetric Attention Score (AAS). Methods: A search was performed, through the free Dimensions app, during September 2020, on the journals related to legal medicine listed in the 2019 edition of the Journal Citation Reports (JCR). The 200 published items with the highest AAS were retrieved and screened for bibliometric data. Articles with related citations were gathered from Web of Science (WOS), Scopus, and Dimensions. Results: Seventy-five percent of the articles were published by five of the selected journals. Twitter and news outlets were the most prevalent Altmetric resources. Additionally, 73.5% of the articles were published between 2013 and 2020. The most frequent topics were the ones related to toxicology and pharmacology, followed by criminalistics and law and bioethics. A poor correlation was found between the citations in WOS, Dimensions, and Scopus and the AAS. Conclusions: The online attention on legal medicine-related topics can be considered high on social media. The high number of news outlets is a distinctive feature of the most discussed articles in legal medicine. In this field of medicine, citation-based metrics combined with Altmetric can allow a broader evaluation of research findings but it should be underlined that, when measuring very different aspects of a published item, the scores in classic citation databases and Altmetric do not have a direct relation.
    Keywords bibliometrics ; citation analysis ; legal medicine ; Altmetric ; Scopus ; Dimensions ; Social pathology. Social and public welfare. Criminology ; HV1-9960 ; Analytical chemistry ; QD71-142
    Subject code 001
    Language English
    Publishing date 2023-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Aberration Correction for Large-Angle Illumination Scanning Transmission Electron Microscopy by Using Iterative Electron Ptychography Algorithms.

    Ma, Yinhang / Shi, Jinan / Guzman, Roger / Li, Ang / Zhou, Wu

    Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada

    2024  Volume 30, Issue 2, Page(s) 226–235

    Abstract: Modern aberration correctors in the scanning transmission electron microscope (STEM) have dramatically improved the attainable spatial resolution and enabled atomical structure and spectroscopic analysis even at low acceleration voltages (≤80 kV). For a ... ...

    Abstract Modern aberration correctors in the scanning transmission electron microscope (STEM) have dramatically improved the attainable spatial resolution and enabled atomical structure and spectroscopic analysis even at low acceleration voltages (≤80 kV). For a large-angle illumination, achieving successful aberration correction to high angles is challenging with an aberration corrector, which limits further improvements in applications such as super-resolution, three-dimensional atomic depth resolution, or atomic surface morphology analyses. Electron ptychography based on four-dimensional STEM can provide a postprocessing strategy to overcome the current technological limitations. In this work, we have demonstrated that aberration correction for large-angle illumination is feasible by pushing the capabilities of regularized ptychographic iterative engine algorithms to reconstruct 4D data sets acquired using a relatively low-efficiency complementary metal oxide semiconductor camera. We report super resolution (0.71 Å) with large-angle illumination (50-60 mrad) and under 60 kV accelerating voltage.
    Language English
    Publishing date 2024-04-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 1385710-1
    ISSN 1435-8115 ; 1431-9276
    ISSN (online) 1435-8115
    ISSN 1431-9276
    DOI 10.1093/mam/ozae027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Unexpected breast cancer mimicking benign lesions on ultrasound-guided vacuum-assisted excision biopsy: A retrospective cross-sectional study over a 20-year period.

    Zhou, Wu / Luo, Honghao / Zhao, Haina / Peng, Yulan

    Frontiers in oncology

    2023  Volume 13, Page(s) 1108689

    Abstract: Objectives: This study investigated the occurrence rate of unexpected breast cancer (UEBC) mimicking benign lesions [Breast Imaging Reporting and Data System (BI-RADS) category 3 or 4a] using ultrasound-guided vacuum-assisted excision biopsy (US-VAEB), ... ...

    Abstract Objectives: This study investigated the occurrence rate of unexpected breast cancer (UEBC) mimicking benign lesions [Breast Imaging Reporting and Data System (BI-RADS) category 3 or 4a] using ultrasound-guided vacuum-assisted excision biopsy (US-VAEB), and explored the factors responsible for late diagnosis of T2 stage UEBC.
    Materials and methods: We collected clinicopathologic data and preoperative US imaging features within 3 months before US-VAEB of patients who were diagnosed with UEBC from January 2002 to September 2022. The UEBC were divided into T1 and T2 stageUEBC. The US imaging features as well as clinical and pathological information of T1 and T2 stage UEBC were compared to explore the factors responsible for late diagnosis of T2 stage UEBC.
    Results: Breast cancer was diagnosed in 91 of 19 306 patients who underwent US-VAEB. We excluded eight patients with breast cancer assigned to BI-RADS 4b category by preoperative US, and two for whom US imaging records were unavailable. Finally, we enrolled 81 patients. The occurrence rate of UEBC after US-VAEB was 0.42%(81/19296). Of the 81 cases of UEBC, 22 were at T2 stage. The ratio of T2 stage UEBC was 27.2%. The differences in risk factor of breast cancer and routine breast US screening between T1 and T2 stage UEBC were significant[96.6% (57/59) vs 81.8% (18/22), 44.1% (26/59) vs 13.6% (3/22), respectively,
    Conclusion: UEBC was rarely detected by US-VAEB. Most cases of T2 stage UEBC were diagnosed late because of the absence of routine US screening and risk factors for breast cancer. Stricter clinical management regulations for breast lesions and performing regular US screening may be helpful to reduce T2 stage UEBC.
    Language English
    Publishing date 2023-02-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1108689
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Epidemiological characteristics of 1,806 patients with traumatic spinal cord injury: A retrospective study.

    Wang, Zhihua / Zhou, Wu / Li, Meihua

    Frontiers in surgery

    2023  Volume 9, Page(s) 988853

    Abstract: Background: Traumatic spinal cord injury (TSCI) is a type of highly disabling central nervous system trauma. In this study, we investigated the epidemiological characteristics of 1,806 TSCI patients and compared the characteristics of patients with ... ...

    Abstract Background: Traumatic spinal cord injury (TSCI) is a type of highly disabling central nervous system trauma. In this study, we investigated the epidemiological characteristics of 1,806 TSCI patients and compared the characteristics of patients with traumatic cervical spinal cord injury (TCSCI) caused by cervical fracture/dislocation and disc herniation/bulging.
    Methods: We retrospectively reviewed the hospital records of 1,806 TSCI patients. The detailed information included gender, marital status, occupation, age, neurological level of injury, etiology, American Spinal Injury Association (ASIA) grade, combined injuries, complications, treatment, the interval between admission and surgery, intubation/tracheostomy requirement, and the length of hospital stay.
    Results: Cervical spinal cord injury (CSCI) was the most common injury. Compared to non-CSCI cases, patients with TCSCI were older, and more likely to suffer from tetraplegia and require intubation/tracheostomy, but had fewer other injuries or complications and a shorter length of hospital stay. Compared to patients with cervical fracture/dislocation, those with TCSCI caused by disc herniation/bulging were older and more likely to suffer from paraplegia, but required intubation/tracheostomy less frequently, exhibited fewer other injuries and complications, and required shorter hospitalization.
    Conclusions: Men, married individuals, manual laborers, and individuals aged 31-75 years had the highest risk of TSCI. Patients with TCSCI tended to have a shorter length of hospital stay than patients with non-CSCI. More attention should be paid to the other injuries and complications of non-CSCI patients, which may increase the length of hospital stay and delay rehabilitation. Compared to patients with cervical disc herniation, the patients with fracture/dislocation tended to be younger, but prognosis was severely compromised by tetraplegia, a greater need for intubation/tracheostomy, additional injuries, and complications.
    Language English
    Publishing date 2023-01-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2773823-1
    ISSN 2296-875X
    ISSN 2296-875X
    DOI 10.3389/fsurg.2022.988853
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Synthetic-to-real domain adaptation with deep learning for fitting the intravoxel incoherent motion model of diffusion-weighted imaging.

    Huang, Haoyuan / Liu, Baoer / Xu, Yikai / Zhou, Wu

    Medical physics

    2023  Volume 50, Issue 3, Page(s) 1614–1622

    Abstract: Background: Intravoxel incoherent motion (IVIM) is a type of diffusion-weighted imaging (DWI), and IVIM model parameters (water molecule diffusion rate D: Purpose: This study proposes a deep-learning model with synthetic-to-real domain adaptation to ... ...

    Abstract Background: Intravoxel incoherent motion (IVIM) is a type of diffusion-weighted imaging (DWI), and IVIM model parameters (water molecule diffusion rate D
    Purpose: This study proposes a deep-learning model with synthetic-to-real domain adaptation to fit the IVIM model parameters of DWI.
    Methods: Ninety-eight consecutive patients diagnosed with hepatocellular carcinoma between January 2017 and September 2020 were included in the study, and routine IVIM-DWI serial examinations were performed using a 3.0 T magnetic resonance imaging system in preoperative MR imaging. The proposed method is mainly composed of two modules: a convolutional neural network-based IVIM model fitting network to map b-value images to the IVIM parameter maps and a domain discriminator to improve the accuracy of the IVIM parameter maps in the real data. The proposed method was compared with previously reported fitting methods, including the nonlinear least squares (NLSs), IVIM-NET
    Results: The DWI reconstruction performance demonstrates that the proposed method has better reconstruction accuracy for DWI with a low signal-to-noise ratio, which implies that the proposed method improves the fitting accuracy of the IVIM parameters. Noise-corrupt experiments show that the proposed method is more robust against noise-corrupted signals. With the proposed method, no outliers were found in D
    Conclusions: IVIM parameters can be estimated using a synthetic-to-real domain-adaptation framework with deep learning, and the proposed method outperforms previously reported methods.
    MeSH term(s) Humans ; Deep Learning ; Diffusion Magnetic Resonance Imaging/methods ; Magnetic Resonance Imaging ; Motion ; Liver Neoplasms
    Language English
    Publishing date 2023-01-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 188780-4
    ISSN 2473-4209 ; 0094-2405
    ISSN (online) 2473-4209
    ISSN 0094-2405
    DOI 10.1002/mp.16031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: B7-H3/CD276: An Emerging Cancer Immunotherapy.

    Zhou, Wu-Tong / Jin, Wei-Lin

    Frontiers in immunology

    2021  Volume 12, Page(s) 701006

    Abstract: Immunotherapy aiming at suppressing tumor development by relying on modifying or strengthening the immune system prevails among cancer treatments and points out a new direction for cancer therapy. B7 homolog 3 protein (B7-H3, also known as CD276), a ... ...

    Abstract Immunotherapy aiming at suppressing tumor development by relying on modifying or strengthening the immune system prevails among cancer treatments and points out a new direction for cancer therapy. B7 homolog 3 protein (B7-H3, also known as CD276), a newly identified immunoregulatory protein member of the B7 family, is an attractive and promising target for cancer immunotherapy because it is overexpressed in tumor tissues while showing limited expression in normal tissues and participating in tumor microenvironment (TME) shaping and development. Thus far, numerous B7-H3-based immunotherapy strategies have demonstrated potent antitumor activity and acceptable safety profiles in preclinical models. Herein, we present the expression and biological function of B7-H3 in distinct cancer and normal cells, as well as B7-H3-mediated signal pathways in cancer cells and B7-H3-based tumor immunotherapy strategies. This review provides a comprehensive overview that encompasses B7-H3's role in TME to its potential as a target in cancer immunotherapy.
    MeSH term(s) Animals ; B7 Antigens ; Humans ; Immunotherapy/methods ; Neoplasms ; Tumor Microenvironment
    Chemical Substances B7 Antigens ; CD276 protein, human
    Language English
    Publishing date 2021-07-19
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.701006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Phonon vortices at heavy impurities in two-dimensional materials.

    Bao, De-Liang / Xu, Mingquan / Li, Ao-Wen / Su, Gang / Zhou, Wu / Pantelides, Sokrates T

    Nanoscale horizons

    2024  Volume 9, Issue 2, Page(s) 248–253

    Abstract: The advent of monochromated electron energy-loss spectroscopy has enabled atomic-resolution vibrational spectroscopy, which triggered interest in spatially localized or quasi-localized vibrational modes in materials. Here we report the discovery of ... ...

    Abstract The advent of monochromated electron energy-loss spectroscopy has enabled atomic-resolution vibrational spectroscopy, which triggered interest in spatially localized or quasi-localized vibrational modes in materials. Here we report the discovery of phonon vortices at heavy impurities in two-dimensional materials. We use density-functional-theory calculations for two configurations of Si impurities in graphene, Si-C
    Language English
    Publishing date 2024-01-29
    Publishing country England
    Document type Journal Article
    ISSN 2055-6764
    ISSN (online) 2055-6764
    DOI 10.1039/d3nh00433c
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Renaissance of Strong Metal-Support Interactions.

    Xu, Ming / Peng, Mi / Tang, Hailian / Zhou, Wu / Qiao, Botao / Ma, Ding

    Journal of the American Chemical Society

    2024  Volume 146, Issue 4, Page(s) 2290–2307

    Abstract: Strong metal-support interactions (SMSIs) have emerged as a significant and cutting-edge area of research in heterogeneous catalysis. They play crucial roles in modifying the chemisorption properties, interfacial structure, and electronic characteristics ...

    Abstract Strong metal-support interactions (SMSIs) have emerged as a significant and cutting-edge area of research in heterogeneous catalysis. They play crucial roles in modifying the chemisorption properties, interfacial structure, and electronic characteristics of supported metals, thereby exerting a profound influence on the catalytic properties. This Perspective aims to provide a comprehensive summary of the latest advancements and insights into SMSIs, with a focus on state-of-the-art
    Language English
    Publishing date 2024-01-18
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.3c09102
    Database MEDical Literature Analysis and Retrieval System OnLINE

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