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  1. Article ; Online: Care in transition: Global norms, transnational adaptation, and family-centered gender-affirming care in China.

    Zhou, Xiaogao

    Social science & medicine (1982)

    2024  Volume 344, Page(s) 116658

    Abstract: In recent years, trans medicine has increasingly shifted towards gender-affirming care, focusing on assisting transgender people in finding safe and effective ways to support their gender identity. Through standards of care, clinical guidelines, and ... ...

    Abstract In recent years, trans medicine has increasingly shifted towards gender-affirming care, focusing on assisting transgender people in finding safe and effective ways to support their gender identity. Through standards of care, clinical guidelines, and classification systems, international experts have established global norms with profound downstream implications. However, how local providers respond to these new norms remains underexplored. Drawing on ethnographic work in clinical settings, conferences, and 30 in-depth interviews with healthcare providers, I argue that family-centered gender-affirming care has emerged in China as providers strive to balance global ideals of "good" trans medicine with the constraints of the local healthcare system. While international standards assist providers in adopting a less pathologizing and binary view of care, they provide limited practical guidance for navigating local social and institutional challenges. Faced with a lack of legal and institutional support, providers increasingly rely on family members' involvement to mitigate medical dispute risks. This reliance manifests in two forms: restrictive gatekeeping, where care is delayed or denied based on family members' attitudes and providers' assessment of transgender adults' ability to lead a "normal life," and affective gatekeeping, where providers use psychological support and gender diversity education to involve family members as caregivers. These findings enrich sociological studies in global health by illustrating how the interactions between global norms and local healthcare systems can both alleviate and reproduce barriers to care.
    MeSH term(s) Female ; Adult ; Humans ; Male ; Gender-Affirming Care ; Gender Identity ; China ; Anthropology, Cultural ; Dissent and Disputes
    Language English
    Publishing date 2024-02-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 4766-1
    ISSN 1873-5347 ; 0037-7856 ; 0277-9536
    ISSN (online) 1873-5347
    ISSN 0037-7856 ; 0277-9536
    DOI 10.1016/j.socscimed.2024.116658
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    Zs.A 625: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  2. Article ; Online: Construction of environmental vibration prediction model for subway transportation based on machine learning algorithm and database technology.

    Zhou, Xilong

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 6288

    Abstract: Vibrations generated in the metro transport environment are mainly caused by, vibrations generated by the interaction between the metro and the track during operation. and the change of vibration factors will affect the normal operation of the subway. ... ...

    Abstract Vibrations generated in the metro transport environment are mainly caused by, vibrations generated by the interaction between the metro and the track during operation. and the change of vibration factors will affect the normal operation of the subway. However, it is difficult to have a model that can achieve the characteristics of high accuracy, fast computing speed and wide range of use in the traditional metro rail transportation environment prediction. Therefore, this research uses database theory and machine learning algorithms to predict the vibration of subway transportation environment. The experimental results show that the average difference between the whole prediction value and the real value is 1.4 dB, of which the maximum difference error value is 0.29%, the maximum error difference is 8.2%, and the approximate value is 6.2 dB, and the four averages predicted in 40 m are relatively small as 1.6 dB, and the average error value of prediction ability between 40 and 100 m is 1.72 dB, and the experimental prediction value and real value are in good agreement. The agreement between the experimental prediction and the real value is very good. Therefore, the model is able to predict the vibration model of the subway transportation environment with a high degree of agreement and accuracy.
    Language English
    Publishing date 2024-03-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-56940-3
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  3. Article ; Online: Identification of important genes for human periodontal ligament cells in response to mechanical force based on WGCNA.

    Zhou, Xiaofeng

    Cellular and molecular biology (Noisy-le-Grand, France)

    2024  Volume 70, Issue 3, Page(s) 192–196

    Abstract: To identify the differentially important genes of human periodontal ligament cells (PDLC) in response to different types of force, the dataset with regard to human PDLC in response to force was retrieved from the GEO. Differentially expressed genes (DEG) ...

    Abstract To identify the differentially important genes of human periodontal ligament cells (PDLC) in response to different types of force, the dataset with regard to human PDLC in response to force was retrieved from the GEO. Differentially expressed genes (DEG) analysis between mechanical force (MF) and the control group was conducted. The gene set enrichment analysis (GSEA) was applied to identify the functional enrichment in different MF groups. Weighted gene co-expression network analysis (WGCNA) of transcriptomic data was performed to identify the highly correlated genes in human PDLC in response to MF. The Lasso regression model was applied to screen the key genes. Results showed A total of 2861 DEGs were identified between the MF group and control group, including 1470 up-regulated DEGs and 1391 down-regulated DEGs. Different biological processes were enriched between the static group and the intermittent group. The Myc targets, TGF-β signaling pathway and PI3K/AKT/MTOR signaling pathway were enriched in intermittent-MF and static-MF groups. The turquoise module (including 386 hub genes) in WGCNA was highly correlated with intermittent traits and the black module (including 33 hub genes) was positively correlated with static traits. The lasso analysis result showed that the CLIC4, NPLOC4 and PRDX6 had the greatest impact on the human PDLC with mechanic stimuli with good predictive efficiency. In conclusion, we developed important genes for human PDLC in response to MF, which might be potential markers for orthodontic tooth movement.
    Language English
    Publishing date 2024-03-31
    Publishing country France
    Document type Journal Article
    ZDB-ID 1161779-2
    ISSN 1165-158X ; 0145-5680
    ISSN (online) 1165-158X
    ISSN 0145-5680
    DOI 10.14715/cmb/2024.70.3.29
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3812: Show issues Location:
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  4. Article ; Online: Recent advances of tryptanthrin and its derivatives as potential anticancer agents.

    Zhou, Xiaofeng

    RSC medicinal chemistry

    2024  Volume 15, Issue 4, Page(s) 1127–1147

    Abstract: Tryptanthrin is one of the well-known natural alkaloids with a broad spectrum of biological activities and can act as anti-inflammatory, anticancer, antibacterial, antifungal, antiviral, antitubercular, and other agents. Owing to its potent anticancer ... ...

    Abstract Tryptanthrin is one of the well-known natural alkaloids with a broad spectrum of biological activities and can act as anti-inflammatory, anticancer, antibacterial, antifungal, antiviral, antitubercular, and other agents. Owing to its potent anticancer activity, tryptanthrin has been widely explored for the therapy of various cancers besides being effective against other diseases. Tryptanthrin with a pharmacological indoloquinazoline moiety can not only be modified by different functional groups to achieve various tryptanthrin derivatives, which may realize the improvement of anticancer activity, but also bind with different metal ions to obtain varied tryptanthrin metal complexes as potential anticancer agents, due to their higher anticancer activities in comparison with tryptanthrin (or its derivatives) and cisplatin. This review outlines the recent advances in the syntheses, structures, and anticancer activities of tryptanthrin derivatives and their metal complexes, trying to reveal their structure-activity relationships and to provide a helpful way for medicinal chemists in the development of new and effective tryptanthrin-based anticancer agents.
    Language English
    Publishing date 2024-01-04
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2632-8682
    ISSN (online) 2632-8682
    DOI 10.1039/d3md00698k
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book ; Online: Pharynx

    Zhou, Xiaoying / Zhang, Zhe

    Diagnosis and Treatment

    2021  

    Keywords Otorhinolaryngology (ENT) ; nasopharyngeal carcinoma, etiology, epidemiology, risk factors, biomarker, microbiota
    Language English
    Size 1 electronic resource (248 pages)
    Publisher IntechOpen
    Document type Book ; Online
    Note English
    HBZ-ID HT030647817
    ISBN 9781789856101 ; 1789856108
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  6. Conference proceedings ; Online: On the origin of trunk-like ion structures in the inner magnetosphere

    Zhou, X.

    XXVIII General Assembly of the International Union of Geodesy and Geophysics (IUGG)

    2023  

    Abstract: The Earth’s inner magnetosphere is a highly-coupled system in which multiple plasma populations interact with one another. The interplay between ion transport, acceleration, and loss processes results in a variety of ion spectral structures frequently ... ...

    Abstract The Earth’s inner magnetosphere is a highly-coupled system in which multiple plasma populations interact with one another. The interplay between ion transport, acceleration, and loss processes results in a variety of ion spectral structures frequently observed in the inner magnetosphere. An interesting type of these spectral structures, the trunk-like structures named after their shapes in the observed ion energy spectrum, is characterized by enhanced ion fluxes at decreasing energies (from ~10 keV to a few eV) with decreasing equatorial distance to the Earth. An outstanding puzzle for these structures is that they appear almost exclusively during the inbound but not outbound passes of the observing spacecraft. To unravel this puzzle, we propose that the ions in the trunk-like structures are not dispersed radially as usually expected, but instead, dispersed along the azimuthal direction due to the energy dependence of their gradient/curvature drift speed. Case and statistical studies are carried out to examine this hypothesis, which indicates the rich dynamics of the inner magnetosphere even during geomagnetic quiet intervals.
    Subject code 612
    Language English
    Publishing country de
    Document type Conference proceedings ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Book ; Thesis: Loss of pancreatic autophagy promotes the development of chronic pancreatitis

    Zhou, Xiadong

    2016  

    Author's details vorgelegt von Xiaodong Zhou
    Language English
    Size iv, 75 Blätter, Illustrationen, Diagramme, 30 cm
    Publishing place Heidelberg
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Ruprecht-Karls-Universität Heidelberg, 2017
    HBZ-ID HT019394919
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2017 E 1249 order for loan Magazin

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  8. Article: [Current situation and problems of extracorporeal membrane oxygenation use in China].

    Zhou, X

    Zhonghua yi xue za zhi

    2021  Volume 102, Issue 25, Page(s) 1859–1863

    Abstract: Extracorporeal membrane oxygenation (ECMO) technology has experienced from nothing, evolving from high-Tech technology with high mortality to the well-known last life-saving weapon. At present, ECMO technology is booming and widely used in the treatment ... ...

    Abstract Extracorporeal membrane oxygenation (ECMO) technology has experienced from nothing, evolving from high-Tech technology with high mortality to the well-known last life-saving weapon. At present, ECMO technology is booming and widely used in the treatment of patients with severe respiratory failure and cardiogenic shock. In recent years, the use of ECMO in China has also made great progress, but there are some problems in the construction of ECMO centers and ECMO-related technologies. The article aims to discuss the current situation and problems faced in ECMO use in China, such as insufficient cases, regional differences, centre construction and related technical issues.
    MeSH term(s) China ; Extracorporeal Membrane Oxygenation/adverse effects ; Humans ; Respiratory Insufficiency/etiology ; Respiratory Insufficiency/therapy ; Shock, Cardiogenic
    Language Chinese
    Publishing date 2021-06-24
    Publishing country China
    Document type Journal Article
    ZDB-ID 132513-9
    ISSN 0376-2491
    ISSN 0376-2491
    DOI 10.3760/cma.j.cn112137-20220318-00578
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2011: Show issues Location:
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  9. Article: [Application of advanced biomaterials in wound repair].

    Luo, G X / Zhou, X

    Zhonghua shao shang yu chuang mian xiu fu za zhi

    2024  Volume 40, Issue 1, Page(s) 26–32

    Abstract: Cutaneous wound healing is an extremely complex pathophysiological process. With the rapid development of material science and tissue engineering, the advanced biomaterials developed through multi-disciplinary integration are of multi-functions and ... ...

    Abstract Cutaneous wound healing is an extremely complex pathophysiological process. With the rapid development of material science and tissue engineering, the advanced biomaterials developed through multi-disciplinary integration are of multi-functions and effects, providing novel ideas, strategies, and methods for accelerating wound repair and improving the quality of wound repair, and even tissue regeneration. This paper summarized the application of various multi-functional advanced biomaterials in promoting wound repair.
    MeSH term(s) Biocompatible Materials/therapeutic use ; Wound Healing/physiology ; Tissue Engineering/methods
    Chemical Substances Biocompatible Materials
    Language Chinese
    Publishing date 2024-01-29
    Publishing country China
    Document type English Abstract ; Journal Article
    ISSN 2097-1109
    ISSN 2097-1109
    DOI 10.3760/cma.j.cn501225-20231128-00211
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book ; Online ; Conference proceedings: Marine Drug Research in China: Selected Papers from the 15-NASMD Conference

    Zhou, Xuefeng / Luo, Xiaowei / Liu, Yonghong

    2022  

    Keywords Medicine ; Antarctic krill (Euphausia superba) ; peptide ; antioxidant activity ; stability ; oyster ; plasma ; peptidome ; antimicrobial peptides ; cytotoxicity ; actinomycete ; piericidins ; absolute configuration ; Pestalotiopsis heterocornis ; heterocornols ; anti-inflammatory activity ; sponge-derived fungus ; sclerotides ; lipodepsipeptide ; Aspergillus sclerotiorum ; nasopharyngeal carcinoma ; AChE inhibitory ; vascular endothelial cell ; flavonoid ; oxidized low-density lipoprotein ; Nrf2 ; apoptosis ; butyrolactone I ; food allergy ; metabolism ; pharmacokinetics ; actinomycin X2 ; microbial pigments ; dyeing ; silk ; antibacterial properties ; PD-L1 ; virtual screening ; pharmacophore modeling ; ADME ; molecular dynamics ; xanthones ; ascidian-derived fungus ; Diaporthe sp ; anti-glioma activity ; antiaging ; Sonneratia apetala ; signaling pathway ; Caenorhabditis elegans ; mutants ; coral-derived fungi ; Aspergillus hiratsukae ; meroterpenoids ; antibacterial activity ; cytotoxic activity ; deep-sea-derived fungus ; Aspergillus puniceus ; isoquinoline alkaloid ; protein tyrosine phosphatase inhibitor ; antibacterial ; Aspergillus sp ; geodin ; semisynthesize ; insecticidal activity ; Arca inflata ; antitumor peptide ; MAPK signaling ; calmodulin ; colorectal cancer ; methicillin-resistant Staphylococcus aureus ; actinomycin D ; Streptomyces parvulus ; mechanism ; mangrove endophytic Pestalotiopsis ; Sdy-1 ; antitumor activity ; Wnt signaling ; β-catenin ; eremophilane sesquiterpenoids ; mangrove-derived fungus ; Penicillium sp ; Oceanapia ; sponge ; secondary metabolites ; biological activities ; drug design ; anticancer ; cyclic pentapeptide ; galaxamide analogues ; skipjack tuna (Katsuwonus pelamis) muscle ; angiotensin-I-converting enzyme (ACE) peptide ; molecular docking ; nitric oxide (NO) ; endothelin-1 (ET-1) ; Trichoderma longibrachiatum ; sesquiterpene glycoside ; antimicrobial activity ; marine fungi ; Aspergillus unguis ; depsides ; depsidones ; osteoclast differentiation ; soft-coral-derived fungus ; pyranodipyran derivatives ; tyrosyl DNA phosphodiesterase 1 inhibitory activities ; fluorescent properties ; butenolides ; enantiomers ; Aspergillus terreus ; pancreatic lipase ; NAFLD ; fucoxanthin ; adenosine monophosphate-activated protein kinase (AMPK) ; nuclear factor erythroid-2-related factor 2-mediated (Nrf2) ; Toll-like receptor 4-mediated (TLR4) ; Aspergillus flavipes HN4-13 ; emodin ; macroporous resin XAD-16 ; adsorption kinetics and isotherms ; enrichment ; tetramic acid derivatives ; deep-sea fungus ; clavipitacae ; Lecanicillium fusisporum ; chronic kidney disease ; fucoidan ; cognitive dysfunction ; neuroinflammation ; oxidative stress ; GSK3β-Nrf2-HO-1 signaling ; microglial polarization ; deep-sea actinomycetes ; aromatic acids ; oximes ; antihyperlipidemic ; phycocyanin ; microbiota ; transcriptome ; IL-17 pathway ; Hahella ; prodiginine ; chejuenlide ; genome mining ; LC-MS/MS ; CDK4/6 ; marine compounds ; pharmacophore construction ; ADMET ; mm-pbsa
    Language 0|e
    Size 1 electronic resource (512 pages)
    Publisher MDPI Books
    Publishing place Basel
    Document type Book ; Online ; Conference proceedings
    Note English ; Open Access
    HBZ-ID HT021618610
    ISBN 9783036545707 ; 3036545700
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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