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Article: [Repeated stellate ganglion blockade for the treatment of ventricular tachycardia storm in patients with nonischemic cardiomyopathy: a new therapeutic option for patients with malignant arrhythmias].

Cui, C / Zhou, X K / Zhu, Y / Shen, Y M / Chen, L D / Ju, W Z / Chen, H W / Gu, K / Li, M F / Pan, Y B / Chen, M L

2023 Volume 51, Issue 5, Page(s) 521–525

Abstract: Objectives: ...

Abstract	Objectives:
MeSH term(s)	Humans ; Male ; Adult ; Middle Aged ; Aged ; Female ; Stroke Volume ; Stellate Ganglion/surgery ; Ventricular Function, Left ; Cardiomyopathies/therapy ; Cardiomyopathies/complications ; Tachycardia, Ventricular/therapy ; Treatment Outcome ; Catheter Ablation
Language	Chinese
Publishing date	2023-05-17
Publishing country	China
Document type	Observational Study ; English Abstract ; Journal Article
ZDB-ID	603425-1
ISSN	0253-3758
ISSN	0253-3758
DOI	10.3760/cma.j.cn112148-20220525-00411
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Zs.B 2276: Show issues

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Article: [Intercepted orthopedic treatment of skeletal maxillary protrusion deformity].

Zhou, X K

Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology

1989 Volume 24, Issue 4, Page(s) 208–11, 254–5

Abstract: Maxillary protrusion deformity may be divided into three types: functional, skeletal and their combination. The diagnosis of which should be differentiated carefully. The treatment of skeletal maxillary protrusion is very difficult. It must be diagnosed ... ...

Abstract	Maxillary protrusion deformity may be divided into three types: functional, skeletal and their combination. The diagnosis of which should be differentiated carefully. The treatment of skeletal maxillary protrusion is very difficult. It must be diagnosed in the growing stage of children and treated with intercepted orthopedic appliance in time. In order to bring the mandible into harmony with maxilla, the growth of maxilla should be inhibited while the mandible is stimulated. In this article an efficient orthopedic appliance using orthopedic force to inhibit the growth of maxilla was introduced. The factors which influenced the orthopedic effect were introduced by cases report. The use of the roentgenography cephalometric in diagnosing the maxillary protrusion deformity was discussed.
MeSH term(s)	Adolescent ; Child ; Female ; Humans ; Male ; Malocclusion/therapy ; Malocclusion, Angle Class II/therapy ; Maxilla/abnormalities ; Orthodontic Appliances ; Orthodontics, Interceptive
Language	Chinese
Publishing date	1989-07
Publishing country	China
Document type	Case Reports ; English Abstract ; Journal Article
ZDB-ID	1027950-7
ISSN	1002-0098
ISSN	1002-0098
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Zs.B 2507: Show issues

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Article ; Online: Genes relevant with osteoarthritis by comparison gene expression profiles of synovial membrane of osteoarthritis patients at different stages.

Ma, C-H / Lv, Q / Cao, Y / Wang, Q / Zhou, X-K / Ye, B-W / Yi, C-Q

European review for medical and pharmacological sciences

2014 Volume 18, Issue 3, Page(s) 431–439

Abstract: Background: This study aimed to identify biological markers about osteoarthritis (OA) which is a polygenic disease by investigating the gene expression profiles of the synovium samples from early-stage and end-stage OA patients for the diagnosis and ... ...

Abstract	Background: This study aimed to identify biological markers about osteoarthritis (OA) which is a polygenic disease by investigating the gene expression profiles of the synovium samples from early-stage and end-stage OA patients for the diagnosis and treatment of OA. Methods: The gene expression profile of GSE32317 was downloaded from Gene Expression Omnibus (GEO) database, including 10 samples from early-stage OA patients and 9 samples from end-stage OA patients. The differentially expressed genes (DEGs) were identified by Significance Analysis of Microarrays. The co-expression network of DEGs was constructed by Pearson correlation test. Then, modules in the constructed co-expression network were selected by MCODE Plugin. What's more, EASE (Expression Analysis Systematic Explorer) was used to define the significant functions and pathways in the identified modules. Results: Total 419 DEGs were identified, among which 112 were up-regulated and 307 down-regulated. We selected 7 statistically significant modules with gene number above 10 and phenotypic correlation test of modules showed that all the modules had significant correlation with OA (p < 0.05). The genes of module 1, module 2 and module 7 were significantly related to immune system functions, protein glycosylation functions, bone, chondrocytes and cartilage functions, respectively. The most significant pathway in module 3 and module 5 was Wnt signal pathway, and in module 4 was Toll-like receptor signal pathway. Conclusions: DEGs related to immune response, cartilage development, protein glycosylation, muscle development, and DEGs participated in the Wnt signaling pathway and Toll-like receptor (TLR) signaling pathway might be the potential target genes for the OA treatment.
MeSH term(s)	Disease Progression ; Gene Expression Profiling ; Gene Regulatory Networks ; Genetic Association Studies ; Humans ; Microarray Analysis ; Multigene Family ; Osteoarthritis, Knee/genetics ; Osteoarthritis, Knee/metabolism ; Osteoarthritis, Knee/pathology ; Synovial Membrane/metabolism ; Synovial Membrane/pathology ; Transcriptome
Language	English
Publishing date	2014
Publishing country	Italy
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	605550-3
ISSN	2284-0729 ; 1128-3602 ; 0392-291X
ISSN (online)	2284-0729
ISSN	1128-3602 ; 0392-291X
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Zs.A 1887: Show issues

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Article ; Online: Leptin regulation of the p53-HIF1α/PKM2-aromatase axis in breast adipose stromal cells: a novel mechanism for the obesity-breast cancer link.

Zahid, H / Subbaramaiah, K / Iyengar, N M / Zhou, X K / Chen, I-C / Bhardwaj, P / Gucalp, A / Morrow, M / Hudis, C A / Dannenberg, A J / Brown, K A

International journal of obesity (2005)

2017 Volume 42, Issue 4, Page(s) 711–720

Abstract: Background/objectives: Obesity (body mass index (BMI)⩾30 kg m: Subjects/methods: Human breast ASCs were used to characterize the p53-HIF1α/PKM2-aromatase axis in response to leptin. The effect of pharmacological or genetic modulation of protein ... ...

Abstract	Background/objectives: Obesity (body mass index (BMI)⩾30 kg m Subjects/methods: Human breast ASCs were used to characterize the p53-HIF1α/PKM2-aromatase axis in response to leptin. The effect of pharmacological or genetic modulation of protein kinase C (PKC), mitogen-activated protein kinase (MAPK), p53, Aha1, Hsp90, HIF1α and PKM2 on aromatase promoter activity, expression and enzyme activity was examined. Semiquantitative immunofluorescence and confocal imaging were used to assess ASC-specific protein expression in formalin-fixed paraffin-embedded tissue sections of breast of women and mammary tissue of mice following a low-fat (LF) or high-fat (HF) diet for 17 weeks. Results: Leptin-mediated induction of aromatase was dependent on PKC/MAPK signaling and the suppression of p53. This, in turn, was associated with an increase in Aha1 protein expression, activation of Hsp90 and the stabilization of HIF1α and PKM2, known stimulators of aromatase expression. Consistent with these findings, ASC-specific immunoreactivity for p53 was inversely associated with BMI in breast tissue, while HIF1α, PKM2 and aromatase were positively correlated with BMI. In mice, HF feeding was associated with significantly lower p53 ASC-specific immunoreactivity compared with LF feeding, while immunoreactivity for HIF1α, PKM2 and aromatase were significantly higher. Conclusions: Overall, findings demonstrate a novel mechanism for the obesity-associated increase in aromatase in ASCs of the breast and support the study of lifestyle interventions, including weight management, which may reduce breast cancer risk via effects on this pathway.
MeSH term(s)	Adipocytes/metabolism ; Animals ; Aromatase/genetics ; Aromatase/metabolism ; Body Mass Index ; Breast/cytology ; Breast/metabolism ; Breast Neoplasms/metabolism ; Carrier Proteins/metabolism ; Cells, Cultured ; Female ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Leptin/metabolism ; Mammary Glands, Animal/metabolism ; Membrane Proteins/metabolism ; Mice ; Obesity/metabolism ; Signal Transduction ; Thyroid Hormones/metabolism ; Tumor Suppressor Protein p53/metabolism ; Thyroid Hormone-Binding Proteins
Chemical Substances	Carrier Proteins ; HIF1A protein, human ; Hypoxia-Inducible Factor 1, alpha Subunit ; Leptin ; Membrane Proteins ; TP53 protein, human ; Thyroid Hormones ; Tumor Suppressor Protein p53 ; Aromatase (EC 1.14.14.1)
Language	English
Publishing date	2017-11-06
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	752409-2
ISSN	1476-5497 ; 0307-0565
ISSN (online)	1476-5497
ISSN	0307-0565
DOI	10.1038/ijo.2017.273
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Zs.A 1325: Show issues

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Article: [Morphological study of primary dentition and occlusion].

Zhou, X K

Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology

1987 Volume 22, Issue 6, Page(s) 337–40, 370

MeSH term(s)	Child ; Child, Preschool ; Dental Occlusion ; Dentition ; Female ; Humans ; Male ; Tooth, Deciduous
Language	Chinese
Publishing date	1987-11
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	1027950-7
ISSN	1002-0098
ISSN	1002-0098
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Article: [Orthodontic treatment of crowded dentition: distal traction of the posterior teeth].

Zhou, X K

Zhonghua kou qiang ke za zhi [Chinese journal of stomatology

1985 Volume 20, Issue 6, Page(s) 326–30, 382

MeSH term(s)	Child ; Dentition ; Extraoral Traction Appliances ; Female ; Humans ; Male ; Malocclusion/therapy ; Orthodontics, Corrective
Language	Chinese
Publishing date	1985-11
Publishing country	China
Document type	Case Reports ; English Abstract ; Journal Article
ISSN	0412-4014
ISSN	0412-4014
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Article ; Online: Comparative genome-wide gene expression analysis of rheumatoid arthritis and osteoarthritis.

Yi, C Q / Ma, C H / Xie, Z P / Cao, Y / Zhang, G Q / Zhou, X K / Liu, Z Q

Genetics and molecular research : GMR

2013 Volume 12, Issue 3, Page(s) 3136–3145

Abstract: Both rheumatoid arthritis (RA) and osteoarthritis (OA) are complex diseases. Studies and treatment of RA and OA have mainly focused on individual factors. However, there is still no clear understanding of their causes and adequate treatment alternatives ... ...

Abstract	Both rheumatoid arthritis (RA) and osteoarthritis (OA) are complex diseases. Studies and treatment of RA and OA have mainly focused on individual factors. However, there is still no clear understanding of their causes and adequate treatment alternatives are still being sought. We applied gene set-enrichment analysis to microarray datasets of RA and OA to look for regulatory mechanisms. We found 32 highly significant pathways, including 18 downregulated and 14 upregulated pathways associated with RA. We also identified 18 highly significant pathways, including 7 downregulated and 11 up-regulated pathways associated with OA. Several such pathways were found in both RA and OA, including an upregulated PPAR signaling pathway and downregulated leukocyte transendothelial migration. Regulatory mechanisms in RA seem to be more complex than in OA. This information could be useful for diagnosis and treatment of these two diseases.
MeSH term(s)	Arthritis, Rheumatoid/genetics ; Arthritis, Rheumatoid/pathology ; Down-Regulation ; Fibroblasts/cytology ; Fibroblasts/metabolism ; Gene Expression Regulation/genetics ; Genome, Human ; Humans ; Metabolic Networks and Pathways/genetics ; Oligonucleotide Array Sequence Analysis ; Osteoarthritis/genetics ; Osteoarthritis/pathology ; Peroxisome Proliferator-Activated Receptors/genetics ; Signal Transduction/genetics ; Up-Regulation
Chemical Substances	Peroxisome Proliferator-Activated Receptors
Language	English
Publishing date	2013-03-11
Publishing country	Brazil
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2114039-X
ISSN	1676-5680 ; 1676-5680
ISSN (online)	1676-5680
ISSN	1676-5680
DOI	10.4238/2013.March.11.3
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Article: [Orthodontic treatment of crowded teeth---treatment by extraction of teeth (author's transl)].

Zhou, X K

Zhonghua kou qiang ke za zhi [Chinese journal of stomatology

1981 Volume 16, Issue 3, Page(s) 129–133

MeSH term(s)	Adolescent ; Child ; Female ; Humans ; Male ; Malocclusion/therapy ; Orthodontics, Corrective ; Tooth Abnormalities/therapy ; Tooth Extraction
Language	Chinese
Publishing date	1981-09
Publishing country	China
Document type	Case Reports ; Journal Article
ISSN	0412-4014
ISSN	0412-4014
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Article ; Online: Periprostatic adipose inflammation is associated with high-grade prostate cancer.

Gucalp, A / Iyengar, N M / Zhou, X K / Giri, D D / Falcone, D J / Wang, H / Williams, S / Krasne, M D / Yaghnam, I / Kunzel, B / Morris, P G / Jones, L W / Pollak, M / Laudone, V P / Hudis, C A / Scher, H I / Scardino, P T / Eastham, J A / Dannenberg, A J

Prostate cancer and prostatic diseases

2017 Volume 20, Issue 4, Page(s) 418–423

Abstract: Background: Obesity, a cause of subclinical inflammation, is associated with increased risk of high-grade prostate cancer (PC) and poor outcomes. Whether inflammation occurs in periprostatic white adipose tissue (WAT), and contributes to the negative ... ...

Abstract	Background: Obesity, a cause of subclinical inflammation, is associated with increased risk of high-grade prostate cancer (PC) and poor outcomes. Whether inflammation occurs in periprostatic white adipose tissue (WAT), and contributes to the negative impact of obesity on PC aggressiveness, is unknown. Methods: In a single-center, cross-sectional design, men with newly diagnosed PC undergoing radical prostatectomy were eligible for study participation. The primary objective was to examine the prevalence of periprostatic WAT inflammation defined by the presence of crown-like structures (CLS-P) as detected by CD68 immunohistochemistry. Secondary objectives were to explore the clinical and systemic correlates of periprostatic WAT inflammation. Tumor characteristics and host factors including BMI, adipocyte diameter, and circulating levels of lipids, adipokines, and other metabolic factors were measured. Wilcoxon rank-sum, Chi-square, or Fisher's exact tests, and generalized linear regression were used to examine the association between WAT inflammation and tumor and host characteristics. Results: Periprostatic fat was collected from 169 men (median age 62 years; median BMI 28.3). Periprostatic WAT inflammation was identified in 49.7% of patients and associated with higher BMI (P=0.02), larger adipocyte size (P=0.004) and Gleason grade groups IV/V tumors (P=0.02). The relationship between WAT inflammation and high Gleason grade remained significant after adjusting for BMI (P=0.04). WAT inflammation correlated with higher circulating levels of insulin, triglycerides, and leptin/adiponectin ratio, and lower high density lipoprotein cholesterol, compared to those without WAT inflammation (P's <0.05). Conclusion: Periprostatic WAT inflammation is common in this cohort of men with PC and is associated with high-grade PC.
MeSH term(s)	Adipose Tissue, White/metabolism ; Adipose Tissue, White/pathology ; Aged ; Body Mass Index ; Humans ; Inflammation/complications ; Inflammation/metabolism ; Inflammation/pathology ; Inflammation/surgery ; Male ; Middle Aged ; Neoplasm Grading ; Obesity/complications ; Obesity/metabolism ; Obesity/pathology ; Obesity/surgery ; Prostate/metabolism ; Prostate/pathology ; Prostate/surgery ; Prostatectomy ; Prostatic Neoplasms/complications ; Prostatic Neoplasms/metabolism ; Prostatic Neoplasms/pathology ; Prostatic Neoplasms/surgery
Language	English
Publishing date	2017
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1419277-9
ISSN	1476-5608 ; 1365-7852
ISSN (online)	1476-5608
ISSN	1365-7852
DOI	10.1038/pcan.2017.31
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Zs.A 5277: Show issues

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Article: Haplotype frequencies of three Y-chromosome STR loci in Tibetan ethnic group of Chinese population.

Ying, B W / Tang, J P / Gao, Y Z / Chen, Y L / Li, Y B / Wu, J / Zhang, J / Shi, M S / Zhu, Q F / Zhou, X K / Hou, Y P

Journal of forensic sciences

2003 Volume 48, Issue 2, Page(s) 449–450

MeSH term(s)	China ; Chromosomes, Human, Y ; DNA Fingerprinting/methods ; Gene Frequency ; Genetics, Population ; Haplotypes ; Humans ; Male ; Tandem Repeat Sequences ; Tibet/ethnology
Language	English
Publishing date	2003-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	219216-0
ISSN	1556-4029 ; 0022-1198
ISSN (online)	1556-4029
ISSN	0022-1198
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