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Article ; Online: Clinical significance of miR-200a in systemic lupus erythematosus and renal damage in children.

Zhang, Haiyan / Zhou, Xiaoqing / Li, Qinghu / Zheng, Min

Cellular and molecular biology (Noisy-le-Grand, France)

2024 Volume 70, Issue 1, Page(s) 94–98

Abstract: The purpose was to analyze the clinical significance of miR-200a in children with initially diagnosed SLE and renal damage. Children with initially diagnosed SLE (n=100) and healthy children (n=50) undergoing physical examinations during the same period ... ...

Abstract	The purpose was to analyze the clinical significance of miR-200a in children with initially diagnosed SLE and renal damage. Children with initially diagnosed SLE (n=100) and healthy children (n=50) undergoing physical examinations during the same period were recruited. Disease activity of SLE children was determined based on SLEDAI (systemic lupus erythematosus disease activity index), and they were divided to SLEDAI≤9 group and SLEDAI>9 group, respectively. Moreover, SLE children were divided to LN group and non-LN group based on the occurrence of lupus nephritis. Differential level of miR-200a between groups was detected by qRT-PCR. Spearman correlation test was conducted to analyze the influence of miR-200a on SLEDAI and other laboratory indexes of SLE children. Its diagnostic potential in SLE and LN was assessed through depicting ROC curves. MiR-200a level was remarkably lower in SLE children than that of healthy children. Lower level of miR-200a was detected in SLE children with high SLEDAI or accompanied LN. MiR-200a level was negatively correlated to SLEDAI (r=-0.425), ESR (r=-0.284), CRP (r=-0.338), BUN (r=-0.263) and Scr (r=-0.345), while it was positively correlated to C3 (r=0.631), C4 (r=0.524) and ALB (r=0.394) in SLE children. The AUC of miR-200a in diagnosing SLE was 0.8379 (cut-off value=2.225, sensitivity=70%, specificity=70%). Besides, the AUC of miR-200a in diagnosing LN was 0.7619 (cut-off value=2.005, sensitivity=80%, specificity=76%). MiR-200a level has a certain correlation to the disease activity of children with initially diagnosed SLE, which can be utilized as an adjuvant indicator in evaluating SLE severity. Meanwhile, miR-200a has predictive value for SLE-induced renal damage.
MeSH term(s)	Child ; Humans ; Biomarkers ; Clinical Relevance ; Lupus Erythematosus, Systemic/diagnosis ; Lupus Erythematosus, Systemic/genetics ; Lupus Nephritis/diagnosis ; Lupus Nephritis/genetics ; MicroRNAs/genetics
Chemical Substances	Biomarkers ; MicroRNAs ; MIRN200 microRNA, human
Language	English
Publishing date	2024-01-31
Publishing country	France
Document type	Journal Article
ZDB-ID	1161779-2
ISSN	1165-158X ; 0145-5680
ISSN (online)	1165-158X
ISSN	0145-5680
DOI	10.14715/cmb/2024.70.1.13
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Article ; Online: Treg-Related Genes Representing a Potential Shared Biological Mechanism Between Clear Cell Renal Carcinoma and Obesity.

Zhou, Xiaoqing / Li, Peng / Xu, Qiangqiang / Ye, Junjie

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

2024 Volume 34, Issue 2, Page(s) 193–201

Abstract: Objective: To determine the potential shared biological mechanism between obesity and clear cell renal carcinoma (ccRCC).: Study design: Observational study. Place and Duration of the Study: Department of Urology, Lishui People's Hospital, Lishui ... ...

Abstract	Objective: To determine the potential shared biological mechanism between obesity and clear cell renal carcinoma (ccRCC). Study design: Observational study. Place and Duration of the Study: Department of Urology, Lishui People's Hospital, Lishui City, China, from December 2022 to March 2023. Methodology: The test and validation cohorts were selected from the GEO database. WGCNA and PPI networks were applied to identify shared hub genes. GO/KEGG, GSEA, and ROC curve analyses were applied to explore the potential underlying mechanisms and diagnostic power. Logistic regression was used to select genes to construct the signature. The risk score and various immune-related analyses were performed to assess the clinical and immune performance of the signature. The CellMiner platform was used to screen potential FDA-approved drugs. Results: PTPRC, TYROBP, ITGB2, CD86, and ITGAM were defined as shared hub genes with good diagnostic power for obesity and ccRCC. Eight immune cells exhibited a positive correlation with the hub genes, while two immune cells showed negative associations. MDSCs and Tregs had the strongest positive associations with the hub genes. The Treg-related pathway exhibited predominant enrichment. The TYROBP, ITGB2, and CD86 genes were selected to construct an immune signature that has good clinical and immune performance. Six FDA-approved drugs were screened. Conclusion: Five Treg-related genes were identified as shared hub genes in obese patients and ccRCC patients. A signature was constructed to describe the immune features of ccRCC. Key words: Treg-related genes, Shared biological mechanism, Immune signature, Obesity, Clear cell renal carcinoma (ccRCC).
MeSH term(s)	Humans ; Carcinoma, Renal Cell/genetics ; T-Lymphocytes, Regulatory ; Obesity/genetics ; Risk Factors ; CD18 Antigens ; Kidney Neoplasms/genetics
Chemical Substances	CD18 Antigens
Language	English
Publishing date	2024-02-11
Publishing country	Pakistan
Document type	Observational Study ; Journal Article
ZDB-ID	2276646-7
ISSN	1681-7168 ; 1022-386X
ISSN (online)	1681-7168
ISSN	1022-386X
DOI	10.29271/jcpsp.2024.02.193
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Article ; Online: Protective effect of notoginsenoside and tanshinone IIA on inflammation-related colorectal cancer mice and the inhibition effect on COX-2 expression

Cao Wen / Zhou Xiaoqing

Digital Chinese Medicine, Vol 4, Iss 1, Pp 54-

2021 Volume 63

Abstract: Objective: To explore the preventive effects and possible me-chanisms of action of notoginsenoside (NGS) and tanshinone IIA (TSN) in inflammation-related colorectal cancer (IRCC) in mice. Methods: Eighty-eight male C57BL/6 mice were randomly assigned to ... ...

Abstract	Objective: To explore the preventive effects and possible me-chanisms of action of notoginsenoside (NGS) and tanshinone IIA (TSN) in inflammation-related colorectal cancer (IRCC) in mice. Methods: Eighty-eight male C57BL/6 mice were randomly assigned to 11 groups (n = 8 each group). Azomethane oxide + dextran sulfate (AOM + DSS) model control (model), NGS low-dose (l-NGS), NGS medium-dose (m-NGS), NGS high-dose (h-NGS), TSN low-dose (l-TSN), TSN medium-dose (m-TSN), TSN high-dose (h-TSN), (NGS + TSN) low-dose [l-(NGS + TSN)], (NGS + TSN) medium-dose [m-(NGS + TSN)], (NGS+TSN) high-dose [h-(NGS + TSN)], and blank groups were established. The first 10 groups were intraperitoneally injected with AOM to induce inflammatory colon cancer, whereas the blank group was intraperitoneally injected with 0.9% NaCl solution. The first 10 groups drank a 2.5% sodium DSS aqueous solution continuously from day 5 for three cycles (one cycle: five days, every three weeks), and the blank group was allowed free access to water. Drug groups were administered NGS (low, medium, or high dose), TSN (low, medium, or high dose), or NGS + TSN (low, medium, or high dose), and the model and blank groups were administered saline by lavage until the end of the experiment. The general activity, body weight, and survival rate of and incidence of adenocarcinoma in mice were detected and the expression of cyclooxygenase 2 (COX-2) was detected by immunohistochemistry. Results: (1) The survival rate of mice with IRCC in the h-NGS, m-TSN, h-TSN, m-(NGS + TSN), and h-(NGS + TSN) groups was significantly increased than that in other groups (P < 0.05). (2) The incidence of tumors in the h-(NGS + TSN), m-TSN, and l-NGS groups was significantly lower than that in the model group (P < 0.05). (3) The expression level of COX-2 in tumor tissues of mice in the m-(NGS + TSN) and h-(NGS + TSN) groups was significantly lower than that in the model group (P < 0.05). Conclusion: Tumor formation was inhibited by m-TSN and h-(NGS + TSN) treatments in mice with ...
Keywords	Colorectal cancer ; Cyclooxygenase-2 (COX-2) ; Inflammation ; Notoginsenoside ; Tanshinone IIA ; Medicine ; R ; Other systems of medicine ; RZ201-999
Subject code	616
Language	English
Publishing date	2021-03-01T00:00:00Z
Publisher	KeAi Communications Co., Ltd.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Numerical research on cross-ventilation flow of a generic building in unsheltered and sheltered conditions

Ding Puxian / Zhou Xiaoqing / Chen Weihao / Jin Wuduo

E3S Web of Conferences, Vol 356, p

impact of cross-section

2022 Volume 03060

Abstract: The performances of ventilation in the buildings with quadrate and cylindrical cross-sections are compared numerically. The incoming jet in the cylindrical unsheltered-building is more horizontal in comparison to the quadrate unsheltered-building. The ... ...

Abstract	The performances of ventilation in the buildings with quadrate and cylindrical cross-sections are compared numerically. The incoming jet in the cylindrical unsheltered-building is more horizontal in comparison to the quadrate unsheltered-building. The dimensionless volume flow rates in the quadrate and cylindrical unsheltered-buildings are respectively 0.503 and 0.553. The incoming jet in the sheltered-buildings flows to the floors immediately. The velocity near the floor in the cylindrical sheltered-building is greater than that in the quadrate sheltered-building. The dimensionless volume flow rates in the quadrate and cylindrical sheltered-buildings are respectively 0.130 and 0.210.Comparing with the quadrate buildings, the ventilation rates in the cylindrical unsheltered and sheltered buildings increased by 10% and 61%.
Keywords	Environmental sciences ; GE1-350
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Study on Improving the Modulatory Effect of Rhythmic Oscillations by Transcranial Magneto-Acoustic Stimulation.

Tan, Ruxin / Ma, Ren / Chu, Fangxuan / Zhou, Xiaoqing / Wang, Xin / Yin, Tao / Liu, Zhipeng

IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society

2024 Volume 32, Page(s) 1796–1805

Abstract: In hippocampus, synaptic plasticity and rhythmic oscillations reflect the cytological basis and the intermediate level of cognition, respectively. Transcranial ultrasound stimulation (TUS) has demonstrated the ability to elicit changes in neural response. ...

Abstract	In hippocampus, synaptic plasticity and rhythmic oscillations reflect the cytological basis and the intermediate level of cognition, respectively. Transcranial ultrasound stimulation (TUS) has demonstrated the ability to elicit changes in neural response. However, the modulatory effect of TUS on synaptic plasticity and rhythmic oscillations was insufficient in the present studies, which may be attributed to the fact that TUS acts mainly through mechanical forces. To enhance the modulatory effect on synaptic plasticity and rhythmic oscillations, transcranial magneto-acoustic stimulation (TMAS) which induced a coupled electric field together with TUS's ultrasound field was applied. The modulatory effect of TMAS and TUS with a pulse repetition frequency of 100 Hz were compared. TMAS/TUS were performed on C57 mice for 7 days at two different ultrasound intensities (3 W/cm2 and 5 W/cm [Formula: see text]. Behavioral tests, long-term potential (LTP) and local field potentials in vivo were performed to evaluate TUS/TMAS modulatory effect on cognition, synaptic plasticity and rhythmic oscillations. Protein expression based on western blotting were used to investigate the under- lying mechanisms of these beneficial effects. At 5 W/cm2, TMAS-induced LTP were 113.4% compared to the sham group and 110.5% compared to TUS. Moreover, the relative power of high gamma oscillations (50-100Hz) in the TMAS group ( 1.060±0.155 %) was markedly higher than that in the TUS group ( 0.560±0.114 %) and sham group ( 0.570±0.088 %). TMAS significantly enhanced the synchronization of theta and gamma oscillations as well as theta-gamma cross-frequency coupling. Whereas, TUS did not show relative enhancements. TMAS provides enhanced effect for modulating the synaptic plasticity and rhythmic oscillations in hippocampus.
MeSH term(s)	Animals ; Mice ; Mice, Inbred C57BL ; Transcranial Magnetic Stimulation/methods ; Acoustic Stimulation ; Male ; Hippocampus/physiology ; Neuronal Plasticity/physiology ; Cognition/physiology ; Long-Term Potentiation/physiology ; Ultrasonic Waves ; Theta Rhythm/physiology
Language	English
Publishing date	2024-05-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1166307-8
ISSN	1558-0210 ; 1063-6528 ; 1534-4320
ISSN (online)	1558-0210
ISSN	1063-6528 ; 1534-4320
DOI	10.1109/TNSRE.2024.3395641
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Article: Characterization of human tear proteome reveals differentially abundance proteins in thyroid-associated ophthalmopathy.

Zhou, Xiaoqing / Wei, Ruili / Wang, Rui

PeerJ

2022 Volume 10, Page(s) e13701

Abstract: Background: Thyroid-associated ophthalmopathy (TAO) is a common orbital inflammatory disease, but the abnormal expression of proteins in tears of TAO patients has not been systematically studied. The purpose of this study is to compare and analyze the ... ...

Abstract	Background: Thyroid-associated ophthalmopathy (TAO) is a common orbital inflammatory disease, but the abnormal expression of proteins in tears of TAO patients has not been systematically studied. The purpose of this study is to compare and analyze the total tear protein profile of TAO patients and to provide protein cues for TAO pathogenesis. Methods: Tear samples were isolated from 30 TAO patients with obvious ocular surface damage and 30 healthy control subjects. Tear samples from 30 individuals were mixed and divided into three sample pools. Easy nano-scale LC-MS/MS based on labeling-free quantitative technology was utilized to profile tear proteome. Results: Here, electrospray ionization mass spectra and SDS-PAGE results confirmed the good parallelisms among samples. A total of 313 proteins were obtained from six tear pools, among them, 103 differential abundance proteins (DAPs) were identified, including 99 up-regulated DAPs (including APOA1, HV103, IGH, and Transferrin variant) and four down-regulated DAPs (including FABA, VCC1, NUCB2, and E-cadherin) in the TAO group compared with the control group. GO analysis showed that up-regulated DAPs were mainly enriched in lipid metabolism and platelet molecular function, and down-regulated DAPs were involved in binding, cell junction, and cellular process. KEGG results indicated that DAPs were involved in 117 kinds of signal transduction pathways, among which the immune-related pathway of complement and coagulation cascades had the greatest relevance. Conclusion: In conclusion, label-free LC-MS/MS is an effective strategy for profiling tear proteins component. Our study provides proteins and pathways altered in TAO and provides protein cues for further study on the precise mechanism of TAO pathogenesis.
Language	English
Publishing date	2022-07-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2703241-3
ISSN	2167-8359
ISSN	2167-8359
DOI	10.7717/peerj.13701
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Book ; Online: Home equity extraction and the boom-bust cycle in consumption and residential investment

Zhou, Xiaoqing

(Staff working paper / Bank of Canada ; 2018, 6 (February 2018))

2018

Abstract: The consumption boom-bust cycle in the 2000s coincided with large fluctuations in the volume of home equity borrowing. Contrary to conventional wisdom, I show that homeowners largely borrowed for residential investment and not consumption. I rationalize ... ...

Author's details	by Xiaoqing Zhou
Series title	Staff working paper / Bank of Canada ; 2018, 6 (February 2018)
Abstract	The consumption boom-bust cycle in the 2000s coincided with large fluctuations in the volume of home equity borrowing. Contrary to conventional wisdom, I show that homeowners largely borrowed for residential investment and not consumption. I rationalize this empirical finding using a calibrated two-goods, multiple-assets, heterogeneous-agent life-cycle model with borrowing frictions. The model replicates key features of the household-level and aggregate data. The model offers an alternative explanation of the consumption boom-bust cycle. This cycle is caused by large fluctuations in the number of borrowers and hence in total home equity borrowing, even though the fraction of borrowed funds spent on consumption is small.
Keywords	Economic models ; Housing ; Credit and credit aggregates
Language	English
Size	1 Online-Ressource (circa 59 Seiten), Illustrationen
Document type	Book ; Online
Note	Zusammenfassung in französischer Sprache
Database	ECONomics Information System

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Article ; Online: The Role of Attitudes, Social Norms, and Perceived Behavioral Control as Factors Influencing Urban and Suburban Residential Adoption of Stormwater Best Management Practices.

Eanes, Francis R / Zhou, Xiaoqing

Environmental management

2020 Volume 65, Issue 6, Page(s) 737–747

Abstract: Nonpoint source pollution conveyed by stormwater in urban areas poses a significant threat to quality of waterbodies in the US. In the absence of systematic regulations on household stormwater management, municipalities rely largely on educational ... ...

Abstract	Nonpoint source pollution conveyed by stormwater in urban areas poses a significant threat to quality of waterbodies in the US. In the absence of systematic regulations on household stormwater management, municipalities rely largely on educational programs to encourage voluntary adoption of lawncare best management practices (BMPs) by residents who slow down and temporarily capture excess stormwater and filter out pollutants entering waterways. The current literature on factors influencing urban dwellers' adoption of lawncare BMPs mostly focuses on demographics, barriers to adoption, and effectiveness of education and outreach programs. This study applies the reasoned action approach (RAA) behavioral theory to investigate how the combination of individuals' attitudes, social norms, and perceived behavioral control may affect their decision to adopt three lawncare BMPs, including mulching and fertilizer/pesticide avoidance, and support a municipal ban on lawncare chemicals. We use survey data (n = 235) from residents in two neighboring cities in central Maine, USA. We found that perceived behavioral control predicted fertilizer/pesticide avoidance and mulching, and that beliefs and attitudes toward the outcomes of adopting lawncare BMPS were positively associated with mulching and support for a municipal ban on lawncare chemicals. We observed statistically significant but inconsistent associations between several independent variables-including descriptive and injunctive social norms, gender, level of education, age, and home ownership status-and our dependent variables of interest. The findings provide insights into an underexplored set of factors and confirmatory evidence for previously tested factors influencing urban residents' BMP adoption, and suggest new strategies and communication frames for environmental managers and researchers.
MeSH term(s)	Attitude ; Behavior Control ; Cities ; Humans ; Rain ; Social Norms
Language	English
Publishing date	2020-04-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	1478932-2
ISSN	1432-1009 ; 0364-152X
ISSN (online)	1432-1009
ISSN	0364-152X
DOI	10.1007/s00267-020-01286-5
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Article ; Online: Study on the difference of pore structure of anthracite under different particle sizes using low-temperature nitrogen adsorption method

Qi, Lingling / Zhou, Xiaoqing / Peng, Xinshan / Chen, Xiangjun / Wang, Zhaofeng / An, Fenghua

Environ Sci Pollut Res. 2023 Jan., v. 30, no. 2 p.5216-5230

2023

Abstract: The low-temperature nitrogen adsorption test was used to study anthracite from Jiulishan coal mine with different particle size ranges of 60–80 mesh, 150–200 mesh, and > 200 mesh. The adsorption isotherm, adsorption capacity, pore volume, pore specific ... ...

Abstract	The low-temperature nitrogen adsorption test was used to study anthracite from Jiulishan coal mine with different particle size ranges of 60–80 mesh, 150–200 mesh, and > 200 mesh. The adsorption isotherm, adsorption capacity, pore volume, pore specific surface area, and average pore diameter of coal samples were analyzed by BET and DFT models in order to study the influence of particle size on the pore structure of anthracite and determine the optimal range of particle size for low-temperature nitrogen adsorption test. The results indicate that the particle size plays a significant effect on the pore structure of anthracite and the adsorption capacity of soft coal is less affected by particle size, while hard coal is substantially affected by particle size. The adsorption capacity of hard coal with particle size of > 200 mesh is increased by 7 times when compared with the particle size of 60–80 mesh, indicating that the gas molecular mobility hindrance decline and pore connectivity improves with the decrease of particle size. The average pore diameter of hard coal decreases continuously from 3.1424 to 2.854 nm, while that of soft coal expands from 2.8947 to 3.2515 nm and then to 3.0362 nm with the decrease of particle size. The effects of particle size on the pore surface area of soft and hard coal are concentrated within the < 10 nm pore aperture. Effect of particle size on hard coal pore volume is mainly focused in the pore size < 10 nm, whereas that of soft coal is primarily concentrated in the pore with aperture ranges of 2–100 nm. When the particle sizes varies from 60–80 mesh to 150–200 mesh, the collapse of large pore of hard coal appears better than that of closed pore. When the particle size of hard coal reaches > 200 mesh, the collapse of closed pores and the damage to small pores are stronger than the collapse of large pores. The fractal dimensions with relative pressure of 0–0.20 and 0.20–0.995 are defined as D₁ and D₂, respectively, and when the fractal dimension D₁ increases, the surface roughness and structural complexity of coal samples increase with the decrease of anthracite particle size, while the fractal dimension D₂ shows the opposite trend, which indicates that anthracite of smaller particle size possess higher adsorption capacity. Therefore, 150–200 mesh is recommended as the preferred anthracite particle size in low-temperature nitrogen adsorption test.
Keywords	adsorption ; coal ; decline ; fractal dimensions ; nitrogen ; particle size ; porosity ; sorption isotherms ; surface area ; surface roughness
Language	English
Dates of publication	2023-01
Size	p. 5216-5230.
Publishing place	Springer Berlin Heidelberg
Document type	Article ; Online
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-022-22533-8
Database	NAL-Catalogue (AGRICOLA)

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Article: The Role of Attitudes, Social Norms, and Perceived Behavioral Control as Factors Influencing Urban and Suburban Residential Adoption of Stormwater Best Management Practices

Eanes, Francis R / Zhou, Xiaoqing

Environmental management. 2020 June, v. 65, no. 6

2020

Abstract	Nonpoint source pollution conveyed by stormwater in urban areas poses a significant threat to quality of waterbodies in the US. In the absence of systematic regulations on household stormwater management, municipalities rely largely on educational programs to encourage voluntary adoption of lawncare best management practices (BMPs) by residents who slow down and temporarily capture excess stormwater and filter out pollutants entering waterways. The current literature on factors influencing urban dwellers’ adoption of lawncare BMPs mostly focuses on demographics, barriers to adoption, and effectiveness of education and outreach programs. This study applies the reasoned action approach (RAA) behavioral theory to investigate how the combination of individuals’ attitudes, social norms, and perceived behavioral control may affect their decision to adopt three lawncare BMPs, including mulching and fertilizer/pesticide avoidance, and support a municipal ban on lawncare chemicals. We use survey data (n = 235) from residents in two neighboring cities in central Maine, USA. We found that perceived behavioral control predicted fertilizer/pesticide avoidance and mulching, and that beliefs and attitudes toward the outcomes of adopting lawncare BMPS were positively associated with mulching and support for a municipal ban on lawncare chemicals. We observed statistically significant but inconsistent associations between several independent variables—including descriptive and injunctive social norms, gender, level of education, age, and home ownership status—and our dependent variables of interest. The findings provide insights into an underexplored set of factors and confirmatory evidence for previously tested factors influencing urban residents’ BMP adoption, and suggest new strategies and communication frames for environmental managers and researchers.
Keywords	demographic statistics ; educational status ; environmental management ; fertilizers ; gender ; home ownership ; nonpoint source pollution ; outreach ; pesticides ; stormwater ; stormwater management ; surface water ; surveys ; Maine
Language	English
Dates of publication	2020-06
Size	p. 737-747.
Publishing place	Springer US
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	1478932-2
ISSN	1432-1009 ; 0364-152X
ISSN (online)	1432-1009
ISSN	0364-152X
DOI	10.1007/s00267-020-01286-5
Database	NAL-Catalogue (AGRICOLA)

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